James L Daniel

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation
    James L Daniel
    Department of Anatomy, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 285:17282-91. 2010
  2. pmc RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets
    Jianguo Jin
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Biochem Pharmacol 77:835-44. 2009
  3. pmc Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets
    Soochong Kim
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 284:33763-72. 2009
  4. pmc Rapid ubiquitination of Syk following GPVI activation in platelets
    Carol A Dangelmaier
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad St, Philadelphia, PA 19140, USA
    Blood 105:3918-24. 2005
  5. pmc A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets
    Dafydd H Thomas
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 116:2570-8. 2010
  6. pmc Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion
    Ramya Chari
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 114:3056-63. 2009
  7. pmc Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets
    Kamala Bhavaraju
    Department of Physiology, Temple University, School of Medicine, Philadelphia, PA, USA
    Eur J Pharmacol 580:285-90. 2008
  8. doi request reprint Curcumin inhibits GPVI-mediated platelet activation by interfering with the kinase activity of Syk and the subsequent activation of PLCgamma2
    Azad Mayanglambam
    Department of Physiology, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Platelets 21:211-20. 2010
  9. pmc Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation
    Bryan N Kahner
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 110:2449-56. 2007
  10. ncbi request reprint Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase)
    Benjamin Z S Paul
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Platelets 14:159-69. 2003

Collaborators

  • Fatih Ozdener
  • Daisuke Kitamura
  • Todd M Quinton
  • Lawrence F Brass
  • Satya P Kunapuli
  • Soochong Kim
  • Jianguo Jin
  • Carol A Dangelmaier
  • Yingying Mao
  • Azad Mayanglambam
  • Dafydd H Thomas
  • Dafydd Thomas
  • Ramya Chari
  • Kamala Bhavaraju
  • Alexander Y Tsygankov
  • Bryan N Kahner
  • Carol Dangelmaier
  • Benjamin Z S Paul
  • C Damodar Reddy
  • Nick Carpino
  • Tiffanny N Newman
  • Todd M Getz
  • Archana Sanjay
  • Pierre Mangin
  • Rivka Lillian
  • Swaminathan Murugappan
  • Shaun P Jackson
  • Robert T Dorsam
  • Timothy J Stalker
  • Sripal R Mada
  • Patricia G Quinter
  • John H Hartwig
  • John W Weisel
  • Chandrasekaran Nagaswami

Detail Information

Publications14

  1. pmc Cbl-b is a novel physiologic regulator of glycoprotein VI-dependent platelet activation
    James L Daniel
    Department of Anatomy, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 285:17282-91. 2010
    ..These data indicate that Cbl-b plays a positive modulatory role in GPVI-dependent platelet signaling, which translates to an important regulatory role in hemostasis and thrombosis in vivo...
  2. pmc RhoA downstream of G(q) and G(12/13) pathways regulates protease-activated receptor-mediated dense granule release in platelets
    Jianguo Jin
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Biochem Pharmacol 77:835-44. 2009
    ..We conclude that G(12/13) pathways, through RhoA, regulate dense granule release and fibrinogen receptor activation in platelets...
  3. pmc Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets
    Soochong Kim
    Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 284:33763-72. 2009
    ..In addition, a significant portion of GPVI-dependent, ADP-independent Akt activation also exists, and PI3Kbeta plays an essential role in GPVI-mediated platelet aggregation and Akt activation...
  4. pmc Rapid ubiquitination of Syk following GPVI activation in platelets
    Carol A Dangelmaier
    Department of Pharmacology, Temple University School of Medicine, 3420 N Broad St, Philadelphia, PA 19140, USA
    Blood 105:3918-24. 2005
    ..Furthermore, Syk is not dephosphorylated in these mice. We propose that c-Cbl plays a regulatory role in glycoprotein VI (GPVI)/Fc receptor gamma (FcRgamma)-chain-dependent platelet activation through its interaction with Syk...
  5. pmc A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets
    Dafydd H Thomas
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 116:2570-8. 2010
    ..We therefore propose that TULA-2 is the primary tyrosine phosphatase mediating the dephosphorylation of Syk and thus functions as a negative regulator of GPVI signaling in platelets...
  6. pmc Lyn, PKC-delta, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion
    Ramya Chari
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 114:3056-63. 2009
    ..Therefore, we conclude that Lyn-mediated phosphorylations of PKC-delta and SHIP-1 and their associations negatively regulate GPVI-mediated dense granule secretion in platelets...
  7. pmc Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets
    Kamala Bhavaraju
    Department of Physiology, Temple University, School of Medicine, Philadelphia, PA, USA
    Eur J Pharmacol 580:285-90. 2008
    ..In contrast, OXSI-2, unlike PKC inhibitors, did not inhibit secretion. Therefore, we conclude that OXSI-2 is not a Syk-selective inhibitor in platelets because of its unexplained non-specific effects...
  8. doi request reprint Curcumin inhibits GPVI-mediated platelet activation by interfering with the kinase activity of Syk and the subsequent activation of PLCgamma2
    Azad Mayanglambam
    Department of Physiology, Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Platelets 21:211-20. 2010
    ..We conclude that curcumin inhibits platelet activation induced by GPVI agonists through interfering with the kinase activity of Syk and the subsequent activation of PLCgamma2...
  9. pmc Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation
    Bryan N Kahner
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 110:2449-56. 2007
    ..These results demonstrate that phosphorylation of the HS1 protein occurs downstream of GPVI stimulation and that HS1 plays a significant functional role in platelet activation downstream of GPVI and PARs...
  10. ncbi request reprint Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase)
    Benjamin Z S Paul
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Platelets 14:159-69. 2003
    ..Continued disruption of the cytoskeletal microtubule ring, appears to be a Rhokinase-dependent event involved in the transformation of discoid platelets into spheres...
  11. ncbi request reprint Expression of enzymatically-active phospholipase Cgamma2 in E. coli
    Fatih Ozdener
    Department of Pharmacology, Temple University Medical School, Philadelphia, PA, USA
    J Biochem Mol Biol 35:508-12. 2002
    ..Similar to previous reports on PLCgamma2 that is isolated from mammalian tissue, the recombinant enzyme was Ca2+ dependent with optimal activity at 1-10 microM Ca2+...
  12. doi request reprint Regulation of plasmin-induced protease-activated receptor 4 activation in platelets
    Yingying Mao
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA, USA
    Platelets 20:191-8. 2009
    ..In contrast to thrombin-dependent activation of platelets, wherein PAR3 acts as a co-receptor, mPAR3 inhibits plasmin-induced PAR4 activation...
  13. ncbi request reprint Activation of phospholipase Cgamma2 by tyrosine phosphorylation
    Fatih Ozdener
    Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA
    Mol Pharmacol 62:672-9. 2002
    ..These studies demonstrate the importance of these two tyrosine residues in regulating the activity of PLCgamma2...
  14. ncbi request reprint Glycoprotein VI-mediated platelet fibrinogen receptor activation occurs through calcium-sensitive and PKC-sensitive pathways without a requirement for secreted ADP
    Todd M Quinton
    Department of Physiology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 99:3228-34. 2002
    ..Furthermore, protein kinase C- and calcium-regulated pathways independently contribute to GPVI-mediated platelet aggregation...