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Genomes and Genes | Pier Paolo ClaudioSummaryAffiliation: Temple University Country: USA Publications
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Publications
pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significancePier Paolo Claudio
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Clin Cancer Res 10:3509-17. 2004..Additional studies with larger numbers of patient data would allow the use of multivariable techniques and would be able to further identify patients with poorer survival...- Cdk9 phosphorylates p53 on serine 392 independently of CKIIPier Paolo Claudio
Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 208:602-12. 2006..These studies demonstrate the existence of a feedback-loop between p53 and cdk9, pinpointing a novel mechanism by which p53 regulates the basal transcriptional machinery... - Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implicationsGiuseppe Russo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122-6099, USA
Clin Cancer Res 11:3265-73. 2005..Additionally, E2F4 showed an identical localization pattern as to that of pRb2/p130. These data suggests an important role for pRb2/p130 in the pathogenesis and progression of certain salivary gland cancers... - Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptaseTiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Methods Mol Biol 285:155-7. 2004 - Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cellsTiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Methods Mol Biol 285:141-8. 2004 - Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancerEliseo Mattioli
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 210:183-91. 2007..05). Altogether, these data may help shed some additional light on the pathogenetic mechanisms related to the two main gastric cancer histotypes and their invasive potentials... - Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin ATiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
Oncogene 23:4930-7. 2004..In this study, we propose a new mechanism for the functional inactivation of pRb2/p130 that ultimately contributes to cell cycle progression and malignant transformation... - pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulationBruna Pucci
Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Oncogene 21:5897-905. 2002..Our data suggest a role for pRb2/p130 in glioblastoma gamma-radiation-induced cell death, indicating that the antitumoral action of pRb2/p130 can regulate both inhibition of cell cycle progression and induction of cell death... - pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysisGiuseppe Russo
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Oncogene 22:6959-69. 2003..Our results may also contribute to identifying novel therapeutic biomarkers in lung carcinoma... - Determination of functional viral titer by drug-resistance colony assay, expression of green fluorescent protein, and beta-galactoside stainingTiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Methods Mol Biol 285:149-53. 2004 - Ultrasound guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast agentsCandace M Howard
Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
J Cell Physiol 209:413-21. 2006..This approach enhances target specificity of US microbubble destruction as a delivery vehicle for viral-mediated gene transfer... 
The retinoblastoma family: twins or distant cousins?Pier Paolo Claudio
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technologies, Temple University, Philadelphia, PA 19122, USA
Genome Biol 3:reviews3012. 2002....- Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAgValentina Caracciolo
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
J Cell Physiol 212:96-104. 2007..Moreover, Small interference RNA experiments directed toward silencing the Rb2/p130 gene demonstrated that pRb2/p130 does not play a predominant role in the nuclear transportation of E2F4 and E2F5... - Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27, and PCNA in Barrett's esophagusElettra Merola
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122-6099, USA
J Cell Physiol 207:512-9. 2006.... - Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinomaPier Paolo Claudio
Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
Clin Cancer Res 8:1808-15. 2002.... - Human immunodeficiency virus type 1 (HIV-1) derived vectors: safety considerations and controversy over therapeutic applicationsGaetano Romano
Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, College Building, Suite 501, 1025 Walnut Street, Philadelphia, PA 19107, USA
Eur J Dermatol 13:424-9. 2003..On these grounds, it seems necessary to improve the design of other lentiviral vectors, which derive from viruses that are not pathogenic in humans and are distantly related to primate retroviridae... - Antiangiogenic drugs currently used for colorectal cancer: what other pathways can we target to prolong responses?Giovanni Abbadessa
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
Drug News Perspect 20:307-13. 2007.... - Transcriptional regulation of HIV-1 gene expression by p53Ruma Mukerjee
Molecular Virology Lab, Department of Neurology, Temple University School of Medicine, Philadelphia, PA, USA
Cell Cycle 9:4569-78. 2010..Therefore, we suggest that p53 may be a novel therapeutic target for the inhibition of HIV-1 gene expression and replication and the treatment of AIDS... - Epigenetic information and estrogen receptor alpha expression in breast cancerLaura Giacinti
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania 19122-6009, USA
Oncologist 11:1-8. 2006..This paper reviews the current understanding of the role of epigenetic information in the development of cancer and its significance in breast cancer as predictive markers of ER status and as new targets of anticancer therapy... - Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancerPier Paolo Claudio
Department of Biotechnology, Temple University, Philadelphia, PA, USA
Methods Mol Med 75:591-605. 2003 - TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptorGianluigi Condorelli
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
FASEB J 16:1732-7. 2002..Altogether, the data presented evidence the role of AKT and JUN in TNF-alpha-induced cardiomyocyte hypertrophy and apoptosis... - p53 and the malignant progression of Barrett's esophagusElettra Merola
Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Center for Biotechnology, Philadelphia 19122-6099, USA
J Cell Physiol 206:574-7. 2006..The aim of this review is to examine the published data regarding the role that assessment of p53 may play in the management of BE, trying to understand if it may be a useful marker to early diagnose BE malignant transformation... - Molecular basis of angiogenesis and cancerTiziana Tonini
Department of Biotechnology, Temple University, Philadelphia, PA 19122, USA
Oncogene 22:6549-56. 2003..In this review, we discuss the molecular basis of angiogenesis during tumor growth and we also illustrate some of the molecules that are involved in this angiogenic switch... - Interview with the retinoblastoma family members: do they help each other?Tiziana Tonini
Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania, USA
J Cell Physiol 192:138-50. 2002..In this review, we will emphasize our current understanding of how the cell cycle machinery maintains cellular homeostasis by studying the consequences of its deregulation... - The limitless role of p53 in cell cycle machinery: good news or bad news?Paraskevi Vogiatzi
Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvannia, USA
Cancer Biol Ther 5:1090-3. 2006.... - Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesisStefano Lazzi
Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
Hum Pathol 33:723-31. 2002..In conclusion, our results seem to suggest that pRb2/p130 oncosuppressor protein may be a target in the interaction between the HIV-1 gene products and host proteins... - Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumorsGiulia De Falco
Department of Human Pathology and Oncology, University of Siena, Italy
Blood 110:1301-7. 2007..In conclusion, these data suggest that, as RBL2/p130 modulates the expression of target genes, which are important for cell growth and viability, its inactivation may be relevant for the occurrence of BL... - pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor gradeFrancesca Sanseverino
Department of Gynecology, University of Siena, Nuovo Policlinico Le Scotte, Siena, Italy
Cancer Biol Ther 5:84-8. 2006..005). CONCLUSIONS: These results open up a new perspective including novel markers that, combined together, may be useful in patient screening for endometrial cancer aggressiveness... - Tumor suppressor genes as cancer therapeuticsEmanuela Vattemi
Division of Medical Oncology, Central Regional Hospital, Bolzano, Italy
Drug News Perspect 20:511-20. 2007..Methods of gene delivery are described, particularly those that have commonly be used in clinical trials. We discuss efforts to achieve tissue-specific gene delivery and improved efficiency of gene delivery...