Pier Paolo Claudio

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance
    Pier Paolo Claudio
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 10:3509-17. 2004
  2. ncbi Cdk9 phosphorylates p53 on serine 392 independently of CKII
    Pier Paolo Claudio
    Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:602-12. 2006
  3. ncbi Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122 6099, USA
    Clin Cancer Res 11:3265-73. 2005
  4. ncbi Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cells
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:141-8. 2004
  5. ncbi Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 23:4930-7. 2004
  6. ncbi Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:155-7. 2004
  7. ncbi Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancer
    Eliseo Mattioli
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 210:183-91. 2007
  8. ncbi pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysis
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 22:6959-69. 2003
  9. ncbi pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation
    Bruna Pucci
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Oncogene 21:5897-905. 2002
  10. ncbi Ultrasound guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast agents
    Candace M Howard
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Cell Physiol 209:413-21. 2006

Collaborators

Detail Information

Publications30

  1. ncbi pRb2/p130, vascular endothelial growth factor, p27(KIP1), and proliferating cell nuclear antigen expression in hepatocellular carcinoma: their clinical significance
    Pier Paolo Claudio
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    Clin Cancer Res 10:3509-17. 2004
    ..Additional studies with larger numbers of patient data would allow the use of multivariable techniques and would be able to further identify patients with poorer survival...
  2. ncbi Cdk9 phosphorylates p53 on serine 392 independently of CKII
    Pier Paolo Claudio
    Center for Biotechnology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 208:602-12. 2006
    ..These studies demonstrate the existence of a feedback-loop between p53 and cdk9, pinpointing a novel mechanism by which p53 regulates the basal transcriptional machinery...
  3. ncbi Expression of cell cycle-regulated proteins pRB2/p130, p107, E2F4, p27, and pCNA in salivary gland tumors: prognostic and diagnostic implications
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122 6099, USA
    Clin Cancer Res 11:3265-73. 2005
    ..Additionally, E2F4 showed an identical localization pattern as to that of pRb2/p130. These data suggests an important role for pRb2/p130 in the pathogenesis and progression of certain salivary gland cancers...
  4. ncbi Transient production of retroviral- and lentiviral-based vectors for the transduction of Mammalian cells
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:141-8. 2004
  5. ncbi Ezh2 reduces the ability of HDAC1-dependent pRb2/p130 transcriptional repression of cyclin A
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 23:4930-7. 2004
    ..In this study, we propose a new mechanism for the functional inactivation of pRb2/p130 that ultimately contributes to cell cycle progression and malignant transformation...
  6. ncbi Retroviral and lentiviral vector titration by the analysis of the activity of viral reverse transcriptase
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:155-7. 2004
  7. ncbi Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancer
    Eliseo Mattioli
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 210:183-91. 2007
    ..05). Altogether, these data may help shed some additional light on the pathogenetic mechanisms related to the two main gastric cancer histotypes and their invasive potentials...
  8. ncbi pRB2/p130 target genes in non-small lung cancer cells identified by microarray analysis
    Giuseppe Russo
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 22:6959-69. 2003
    ..Our results may also contribute to identifying novel therapeutic biomarkers in lung carcinoma...
  9. ncbi pRb2/p130 promotes radiation-induced cell death in the glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation
    Bruna Pucci
    Department of Pathology, Anatomy and Cell Biology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Oncogene 21:5897-905. 2002
    ..Our data suggest a role for pRb2/p130 in glioblastoma gamma-radiation-induced cell death, indicating that the antitumoral action of pRb2/p130 can regulate both inhibition of cell cycle progression and induction of cell death...
  10. ncbi Ultrasound guided site specific gene delivery system using adenoviral vectors and commercial ultrasound contrast agents
    Candace M Howard
    Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Cell Physiol 209:413-21. 2006
    ..This approach enhances target specificity of US microbubble destruction as a delivery vehicle for viral-mediated gene transfer...
  11. pmc The retinoblastoma family: twins or distant cousins?
    Pier Paolo Claudio
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technologies, Temple University, Philadelphia, PA 19122, USA
    Genome Biol 3:reviews3012. 2002
    ....
  12. ncbi Interplay between the retinoblastoma related pRb2/p130 and E2F-4 and -5 in relation to JCV-TAg
    Valentina Caracciolo
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Cell Physiol 212:96-104. 2007
    ..Moreover, Small interference RNA experiments directed toward silencing the Rb2/p130 gene demonstrated that pRb2/p130 does not play a predominant role in the nuclear transportation of E2F4 and E2F5...
  13. ncbi Determination of functional viral titer by drug-resistance colony assay, expression of green fluorescent protein, and beta-galactoside staining
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA
    Methods Mol Biol 285:149-53. 2004
  14. ncbi Expression of cell-cycle-regulated proteins pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) in prostatic gland adenocarcinoma
    Pier Paolo Claudio
    Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, 1900 North 12th Street, Philadelphia, PA 19122, USA
    Clin Cancer Res 8:1808-15. 2002
    ..In this study, we evaluated the expression of pRb2/p130, p107, p27(kip1), p53, mdm-2, and Ki-67 (MIB-1) by immunohistochemistry in 24 prostate carcinomas compared with the paired expression of normal prostates...
  15. ncbi Immunohistochemical evaluation of pRb2/p130, VEGF, EZH2, p53, p16, p21waf-1, p27, and PCNA in Barrett's esophagus
    Elettra Merola
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122 6099, USA
    J Cell Physiol 207:512-9. 2006
    ....
  16. ncbi Human immunodeficiency virus type 1 (HIV-1) derived vectors: safety considerations and controversy over therapeutic applications
    Gaetano Romano
    Department of Neurosurgery, The Farber Institute for the Neurosciences, Jefferson Medical College, Thomas Jefferson University, College Building, Suite 501, 1025 Walnut Street, Philadelphia, PA 19107, USA
    Eur J Dermatol 13:424-9. 2003
    ..On these grounds, it seems necessary to improve the design of other lentiviral vectors, which derive from viruses that are not pathogenic in humans and are distantly related to primate retroviridae...
  17. ncbi Antiangiogenic drugs currently used for colorectal cancer: what other pathways can we target to prolong responses?
    Giovanni Abbadessa
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
    Drug News Perspect 20:307-13. 2007
    ....
  18. pmc Transcriptional regulation of HIV-1 gene expression by p53
    Ruma Mukerjee
    Molecular Virology Lab, Department of Neurology, Temple University School of Medicine, Philadelphia, PA, USA
    Cell Cycle 9:4569-78. 2010
    ..Therefore, we suggest that p53 may be a novel therapeutic target for the inhibition of HIV-1 gene expression and replication and the treatment of AIDS...
  19. ncbi Epigenetic information and estrogen receptor alpha expression in breast cancer
    Laura Giacinti
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania 19122 6009, USA
    Oncologist 11:1-8. 2006
    ..This paper reviews the current understanding of the role of epigenetic information in the development of cancer and its significance in breast cancer as predictive markers of ER status and as new targets of anticancer therapy...
  20. pmc Cdk9 phosphorylates Pirh2 protein and prevents degradation of p53 protein
    Asen Bagashev
    Molecular Studies of Neurodegenerative Diseases Lab, The Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, PA, USA
    Cell Cycle 12:1569-77. 2013
    ..Hence, we suggest that phosphorylation of Pirh2 may be a novel target for the inhibition of HIV-1 gene expression...
  21. ncbi Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancer
    Pier Paolo Claudio
    Department of Biotechnology, Temple University, Philadelphia, PA, USA
    Methods Mol Med 75:591-605. 2003
  22. ncbi TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor
    Gianluigi Condorelli
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    FASEB J 16:1732-7. 2002
    ..Altogether, the data presented evidence the role of AKT and JUN in TNF-alpha-induced cardiomyocyte hypertrophy and apoptosis...
  23. ncbi p53 and the malignant progression of Barrett's esophagus
    Elettra Merola
    Sbarro Institute for Cancer Research and Molecular Medicine, Department of Biology, Temple University, Center for Biotechnology, Philadelphia 19122 6099, USA
    J Cell Physiol 206:574-7. 2006
    ..The aim of this review is to examine the published data regarding the role that assessment of p53 may play in the management of BE, trying to understand if it may be a useful marker to early diagnose BE malignant transformation...
  24. ncbi The limitless role of p53 in cell cycle machinery: good news or bad news?
    Paraskevi Vogiatzi
    Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, Pennsylvannia, USA
    Cancer Biol Ther 5:1090-3. 2006
    ....
  25. ncbi Interview with the retinoblastoma family members: do they help each other?
    Tiziana Tonini
    Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, Temple University, Philadelphia, Pennsylvania, USA
    J Cell Physiol 192:138-50. 2002
    ..In this review, we will emphasize our current understanding of how the cell cycle machinery maintains cellular homeostasis by studying the consequences of its deregulation...
  26. ncbi Molecular basis of angiogenesis and cancer
    Tiziana Tonini
    Department of Biotechnology, Temple University, Philadelphia, PA 19122, USA
    Oncogene 22:6549-56. 2003
    ..In this review, we discuss the molecular basis of angiogenesis during tumor growth and we also illustrate some of the molecules that are involved in this angiogenic switch...
  27. ncbi Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesis
    Stefano Lazzi
    Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
    Hum Pathol 33:723-31. 2002
    ..In conclusion, our results seem to suggest that pRb2/p130 oncosuppressor protein may be a target in the interaction between the HIV-1 gene products and host proteins...
  28. ncbi pRb2/p130 and VEGF expression in endometrial carcinoma in relation to angiogenesis and histopathologic tumor grade
    Francesca Sanseverino
    Department of Gynecology, University of Siena, Nuovo Policlinico Le Scotte, Siena, Italy
    Cancer Biol Ther 5:84-8. 2006
    ..The pathogenesis of the angiogenetic phenotype may involve the inactivation of different tumor suppressor genes...
  29. ncbi Tumor suppressor genes as cancer therapeutics
    Emanuela Vattemi
    Division of Medical Oncology, Central Regional Hospital, Bolzano, Italy
    Drug News Perspect 20:511-20. 2007
    ..Methods of gene delivery are described, particularly those that have commonly be used in clinical trials. We discuss efforts to achieve tissue-specific gene delivery and improved efficiency of gene delivery...
  30. ncbi Gene-expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt lymphoma cell lines and primary tumors
    Giulia De Falco
    Department of Human Pathology and Oncology, University of Siena, Italy
    Blood 110:1301-7. 2007
    ..In conclusion, these data suggest that, as RBL2/p130 modulates the expression of target genes, which are important for cell growth and viability, its inactivation may be relevant for the occurrence of BL...