Research Topics
Species | Parkson Lee Gau ChongSummaryAffiliation: Temple University Country: USA Publications
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Publications
On physical properties of tetraether lipid membranes: effects of cyclopentane ringsParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
Archaea 2012:138439. 2012....- Compressibilities and volume fluctuations of archaeal tetraether liposomesParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
Biophys J 99:3319-26. 2010..The obtained results may help to establish new strategies for rational design of stable BTL-based liposomes for drug/vaccine delivery... 
Archaebacterial bipolar tetraether lipids: Physico-chemical and membrane propertiesParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, United States
Chem Phys Lipids 163:253-65. 2010..Special attention of this article is focused on how the number of cyclopentane rings varies with environmental factors and affects membrane properties...- On the lateral structure of model membranes containing cholesterolParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
Biochim Biophys Acta 1788:2-11. 2009..The last part of this article discusses the use of the knowledge gained from model membrane studies of cholesterol superlattice to investigate membrane lateral organization in cells and to develop new liposome applications... - Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cellsPeng Huang
Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, United States
Biochem Pharmacol 73:534-49. 2007..Cholesterol-dependent association of caveolin-1 with and the resulting inhibition of G proteins may be a contributing factor... 
Critical factors for detection of biphasic changes in membrane properties at specific sterol mole fractions for maximal superlattice formationBerenice Venegas
Department of Biochemistry, Temple University School of Medicine, 3420 N Broad St, Philadelphia, Pennsylvania 19140, USA
J Phys Chem B 111:5180-92. 2007..These results improve our mechanistic understanding of sterol superlattice formation and explain why some studies, especially those requiring high lipid concentrations, did not detect a biphasic change in membrane properties at Cr...- Fluorescence studies of lipid regular distribution in membranesParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, 3420 N Broad St, Philadelphia, PA 19140, USA
Chem Phys Lipids 116:153-75. 2002..g. sterols and pyrene-containing acyl chains) in the vicinities of the critical mole fractions for superlattice formation... - Fluorometric assay for detection of sterol oxidation in liposomal membranesParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
Methods Mol Biol 400:145-58. 2007..In agreement with the sterol regular distribution model, it is found that both free radical- and enzyme-induced sterol oxidation vary with membrane sterol content in a well defined alternating manner... - Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cellsBerenice Venegas
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
Biophys J 102:2086-94. 2012.... - Fluorescence detection of signs of sterol superlattice formation in lipid membranesParkson Lee Gau Chong
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
Methods Mol Biol 400:159-70. 2007..The principles and methodologies described here can be extended to other probes or bioactive molecules, such as enzymes, and can be applied to study sterol lateral organization in multicomponent lipid membranes... - High vapor pressure perfluorocarbons cause vesicle fusion and changes in membrane packingBerenice Venegas
Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
Biophys J 95:4737-47. 2008..The finding that chemically inert PFCs exhibited fusogenic activity and marked changes in membrane surface packing is novel, and should be considered when using PFCs for biomedical applications... - Bipolar tetraether archaeosomes exhibit unusual stability against autoclaving as studied by dynamic light scattering and electron microscopyDesmond A Brown
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
Chem Phys Lipids 159:95-103. 2009.... - Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cellsPeng Huang
Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
Brain Res 1184:46-56. 2007..However, MCD treatment had opposite impacts on MOR signaling in the two tissues: it attenuated MOR-mediated [(35)S]GTPgammaS binding in CPu but enhanced it in CHO-HA-rMOR... - Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac functionRobert C Scott
Department of Mechanical Engineering, Temple University, 1947 N 12th St, Philadelphia, PA 19122, USA
FASEB J 23:3361-7. 2009..Targeted delivery of low doses of proangiogenic compounds to post-MI tissue results in significant improvements in cardiac function and vascular structure... - Sterol superlattice affects antioxidant potency and can be used to assess adverse effects of antioxidantsMichelle Olsher
Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
Anal Biochem 382:1-8. 2008..The threshold antioxidant concentration (C th) to abolish biphasic change in tau at C r may vary with antioxidant and could be used to assess potential adverse effects of other lipid-soluble antioxidants...