Parkson Lee Gau Chong

Summary

Affiliation: Temple University
Country: USA

Publications

  1. pmc On physical properties of tetraether lipid membranes: effects of cyclopentane rings
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Archaea 2012:138439. 2012
  2. pmc Compressibilities and volume fluctuations of archaeal tetraether liposomes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Biophys J 99:3319-26. 2010
  3. doi request reprint Archaebacterial bipolar tetraether lipids: Physico-chemical and membrane properties
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, United States
    Chem Phys Lipids 163:253-65. 2010
  4. doi request reprint On the lateral structure of model membranes containing cholesterol
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biochim Biophys Acta 1788:2-11. 2009
  5. pmc Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells
    Peng Huang
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, United States
    Biochem Pharmacol 73:534-49. 2007
  6. ncbi request reprint Critical factors for detection of biphasic changes in membrane properties at specific sterol mole fractions for maximal superlattice formation
    Berenice Venegas
    Department of Biochemistry, Temple University School of Medicine, 3420 N Broad St, Philadelphia, Pennsylvania 19140, USA
    J Phys Chem B 111:5180-92. 2007
  7. ncbi request reprint Fluorescence studies of lipid regular distribution in membranes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, 3420 N Broad St, Philadelphia, PA 19140, USA
    Chem Phys Lipids 116:153-75. 2002
  8. ncbi request reprint Fluorometric assay for detection of sterol oxidation in liposomal membranes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 400:145-58. 2007
  9. pmc Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells
    Berenice Venegas
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Biophys J 102:2086-94. 2012
  10. ncbi request reprint Fluorescence detection of signs of sterol superlattice formation in lipid membranes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 400:159-70. 2007

Collaborators

Detail Information

Publications15

  1. pmc On physical properties of tetraether lipid membranes: effects of cyclopentane rings
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Archaea 2012:138439. 2012
    ....
  2. pmc Compressibilities and volume fluctuations of archaeal tetraether liposomes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Biophys J 99:3319-26. 2010
    ..The obtained results may help to establish new strategies for rational design of stable BTL-based liposomes for drug/vaccine delivery...
  3. doi request reprint Archaebacterial bipolar tetraether lipids: Physico-chemical and membrane properties
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, United States
    Chem Phys Lipids 163:253-65. 2010
    ..Special attention of this article is focused on how the number of cyclopentane rings varies with environmental factors and affects membrane properties...
  4. doi request reprint On the lateral structure of model membranes containing cholesterol
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Biochim Biophys Acta 1788:2-11. 2009
    ..The last part of this article discusses the use of the knowledge gained from model membrane studies of cholesterol superlattice to investigate membrane lateral organization in cells and to develop new liposome applications...
  5. pmc Cholesterol reduction by methyl-beta-cyclodextrin attenuates the delta opioid receptor-mediated signaling in neuronal cells but enhances it in non-neuronal cells
    Peng Huang
    Department of Pharmacology, Center for Substance Abuse Research, Temple University School of Medicine, 3420 N Broad Street, Philadelphia, PA 19140, United States
    Biochem Pharmacol 73:534-49. 2007
    ..Cholesterol-dependent association of caveolin-1 with and the resulting inhibition of G proteins may be a contributing factor...
  6. ncbi request reprint Critical factors for detection of biphasic changes in membrane properties at specific sterol mole fractions for maximal superlattice formation
    Berenice Venegas
    Department of Biochemistry, Temple University School of Medicine, 3420 N Broad St, Philadelphia, Pennsylvania 19140, USA
    J Phys Chem B 111:5180-92. 2007
    ..These results improve our mechanistic understanding of sterol superlattice formation and explain why some studies, especially those requiring high lipid concentrations, did not detect a biphasic change in membrane properties at Cr...
  7. ncbi request reprint Fluorescence studies of lipid regular distribution in membranes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, 3420 N Broad St, Philadelphia, PA 19140, USA
    Chem Phys Lipids 116:153-75. 2002
    ..g. sterols and pyrene-containing acyl chains) in the vicinities of the critical mole fractions for superlattice formation...
  8. ncbi request reprint Fluorometric assay for detection of sterol oxidation in liposomal membranes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 400:145-58. 2007
    ..In agreement with the sterol regular distribution model, it is found that both free radical- and enzyme-induced sterol oxidation vary with membrane sterol content in a well defined alternating manner...
  9. pmc Cholesterol superlattice modulates CA4P release from liposomes and CA4P cytotoxicity on mammary cancer cells
    Berenice Venegas
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Biophys J 102:2086-94. 2012
    ....
  10. ncbi request reprint Fluorescence detection of signs of sterol superlattice formation in lipid membranes
    Parkson Lee Gau Chong
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA, USA
    Methods Mol Biol 400:159-70. 2007
    ..The principles and methodologies described here can be extended to other probes or bioactive molecules, such as enzymes, and can be applied to study sterol lateral organization in multicomponent lipid membranes...
  11. pmc High vapor pressure perfluorocarbons cause vesicle fusion and changes in membrane packing
    Berenice Venegas
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biophys J 95:4737-47. 2008
    ..The finding that chemically inert PFCs exhibited fusogenic activity and marked changes in membrane surface packing is novel, and should be considered when using PFCs for biomedical applications...
  12. doi request reprint Bipolar tetraether archaeosomes exhibit unusual stability against autoclaving as studied by dynamic light scattering and electron microscopy
    Desmond A Brown
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Chem Phys Lipids 159:95-103. 2009
    ....
  13. pmc Agonist treatment did not affect association of mu opioid receptors with lipid rafts and cholesterol reduction had opposite effects on the receptor-mediated signaling in rat brain and CHO cells
    Peng Huang
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Brain Res 1184:46-56. 2007
    ..However, MCD treatment had opposite impacts on MOR signaling in the two tissues: it attenuated MOR-mediated [(35)S]GTPgammaS binding in CPu but enhanced it in CHO-HA-rMOR...
  14. doi request reprint Targeting VEGF-encapsulated immunoliposomes to MI heart improves vascularity and cardiac function
    Robert C Scott
    Department of Mechanical Engineering, Temple University, 1947 N 12th St, Philadelphia, PA 19122, USA
    FASEB J 23:3361-7. 2009
    ..Targeted delivery of low doses of proangiogenic compounds to post-MI tissue results in significant improvements in cardiac function and vascular structure...
  15. doi request reprint Sterol superlattice affects antioxidant potency and can be used to assess adverse effects of antioxidants
    Michelle Olsher
    Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Anal Biochem 382:1-8. 2008
    ..The threshold antioxidant concentration (C th) to abolish biphasic change in tau at C r may vary with antioxidant and could be used to assess potential adverse effects of other lipid-soluble antioxidants...