G Boden

Summary

Affiliation: Temple University
Country: USA

Publications

  1. ncbi request reprint Nutritional effects of fat on carbohydrate metabolism
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Best Pract Res Clin Endocrinol Metab 17:399-410. 2003
  2. ncbi request reprint Gluconeogenesis and glycogenolysis in health and diabetes
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Investig Med 52:375-8. 2004
  3. pmc Effects of hyperinsulinemia on hepatic metalloproteinases and their tissue inhibitors
    Guenther Boden
    Temple University Hospital, Philadelphia, PA 19140, USA
    Am J Physiol Endocrinol Metab 295:E692-7. 2008
  4. pmc Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:1208-14. 2013
  5. ncbi request reprint Why does obesity increase the risk for cardiovascular disease?
    Guenther Boden
    Division of Endocrinology, Diabetes, Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, PA, USA
    Curr Pharm Des 19:5678-83. 2013
  6. pmc Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia
    Anamika Singh
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 35:1322-7. 2012
  7. ncbi request reprint Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the Clinical Research Center, Temple University Hospital, 3401 N Broad Street, Philadelphia, PA 19140, USA
    Curr Diab Rep 7:223-7. 2007
  8. ncbi request reprint Differential effects of somatostatin on circulating tissue factor procoagulant activity and protein
    Guenther Boden
    Division of Endocrinology, Diabetes, and Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Endocrinol Metab 292:E1333-9. 2007
  9. ncbi request reprint Combined use of rosiglitazone and fenofibrate in patients with type 2 diabetes: prevention of fluid retention
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Clinical Research Unit, Temple University School of Medicine, Philadelphia, PA, USA
    Diabetes 56:248-55. 2007
  10. ncbi request reprint Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Diab Rep 6:177-81. 2006

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Nutritional effects of fat on carbohydrate metabolism
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Best Pract Res Clin Endocrinol Metab 17:399-410. 2003
    ..As increased plasma levels account for up to 50% of insulin resistance in obese patients with T2DM, lowering of plasma FFAs could be a new and promising approach to the treatment of T2DM...
  2. ncbi request reprint Gluconeogenesis and glycogenolysis in health and diabetes
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Philadelphia, PA 19140, USA
    J Investig Med 52:375-8. 2004
    ....
  3. pmc Effects of hyperinsulinemia on hepatic metalloproteinases and their tissue inhibitors
    Guenther Boden
    Temple University Hospital, Philadelphia, PA 19140, USA
    Am J Physiol Endocrinol Metab 295:E692-7. 2008
    ..We conclude that hyperinsulinemia, whether or not associated with insulin resistance, shifts the MMP/TIMP balance toward reduction of extracellular matrix degradation and thus may promote the development of hepatic fibrosis...
  4. pmc Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:1208-14. 2013
    ..To test this hypothesis, we have examined effects of insulin on activation of SREBP-1c in liver of rats and in adipose tissue of rats and human subjects...
  5. ncbi request reprint Why does obesity increase the risk for cardiovascular disease?
    Guenther Boden
    Division of Endocrinology, Diabetes, Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, PA, USA
    Curr Pharm Des 19:5678-83. 2013
    ....
  6. pmc Whole-blood tissue factor procoagulant activity is elevated in type 1 diabetes: effects of hyperglycemia and hyperinsulinemia
    Anamika Singh
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 35:1322-7. 2012
    ..To determine tissue factor procoagulant activity (TF-PCA) in patients with type 1 diabetes and to examine effects of hyperglycemia and hyperglycemia plus hyperinsulinemia on TF-PCA...
  7. ncbi request reprint Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulation
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the Clinical Research Center, Temple University Hospital, 3401 N Broad Street, Philadelphia, PA 19140, USA
    Curr Diab Rep 7:223-7. 2007
    ....
  8. ncbi request reprint Differential effects of somatostatin on circulating tissue factor procoagulant activity and protein
    Guenther Boden
    Division of Endocrinology, Diabetes, and Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Endocrinol Metab 292:E1333-9. 2007
    ..We conclude that SMS completely prevented HG/HI-induced TF activation in normal volunteers and may be of use to reduce the procoagulant state and acute vascular events in hyperinsulinemic insulin-resistant patients with type 2 diabetes...
  9. ncbi request reprint Combined use of rosiglitazone and fenofibrate in patients with type 2 diabetes: prevention of fluid retention
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Clinical Research Unit, Temple University School of Medicine, Philadelphia, PA, USA
    Diabetes 56:248-55. 2007
    ..5%) and increasing G(Rd) (442 vs. 330%). We conclude that RGZ/FFB is a promising new therapy for type 2 diabetes that lowers plasma FFA more than RGZ alone and in contrast to RGZ does not cause water retention and weight gain...
  10. ncbi request reprint Fatty acid-induced inflammation and insulin resistance in skeletal muscle and liver
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Diab Rep 6:177-81. 2006
    ....
  11. ncbi request reprint Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver
    Guenther Boden
    Division of Endocrinology, Diabetes, and Metabolism, Temple University School of Medicine, 3401 North Broad St, Philadelphia, Pennsylvania 19140, USA
    Diabetes 54:3458-65. 2005
    ....
  12. ncbi request reprint Free fatty acids and insulin secretion in humans
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Diab Rep 5:167-70. 2005
    ..Therefore, obesity, if associated with elevated fatty acid levels, may lead to hyperglycemia in prediabetic but not in normal individuals...
  13. ncbi request reprint Recent findings concerning thiazolidinediones in the treatment of diabetes
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Philadelphia, PA, USA
    Expert Opin Investig Drugs 15:243-50. 2006
    ....
  14. ncbi request reprint Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients
    Guenther Boden
    Division of Endocrinology, Diabetes and Metabolism, Temple University School of Medicine, Philadelphia, PA, USA
    Diabetes 54:880-5. 2005
    ....
  15. ncbi request reprint Circulating tissue factor procoagulant activity and thrombin generation in patients with type 2 diabetes: effects of insulin and glucose
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Clin Endocrinol Metab 92:4352-8. 2007
    ..Type 2 diabetes mellitus (T2DM) is a hypercoagulable state. Tissue factor (TF) is the principal initiator of blood coagulation...
  16. ncbi request reprint In vivo effects of insulin and free fatty acids on matrix metalloproteinases in rat aorta
    Guenther Boden
    Temple University Hospital, 3401 North Broad St, Philadelphia, PA 19140, USA
    Diabetes 57:476-83. 2008
    ..Here, we have examined the effects of physiologically elevated levels of insulin and FFA on three MMPs and their inhibitors (tissue inhibitors of MMP [TIMPs]) in aortic tissue of male rats during euglycemic-hyperinsulinemic clamping...
  17. doi request reprint Infusion of glucose and lipids at physiological rates causes acute endoplasmic reticulum stress in rat liver
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 19:1366-73. 2011
    ..We conclude that this type of acute ER stress is likely to occur during normal daily nutrient intake...
  18. pmc Obesity, insulin resistance and free fatty acids
    Guenther Boden
    Division of Endocrinology, Diabetes, Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Endocrinol Diabetes Obes 18:139-43. 2011
    ..To describe the role of free fatty acid (FFA) as a cause for insulin resistance in obese people...
  19. pmc Acute tissue injury caused by subcutaneous fat biopsies produces endoplasmic reticulum stress
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the Clinical Research, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Clin Endocrinol Metab 95:349-52. 2010
    ..It is not known whether acute tissue injury is associated with endoplasmic reticulum (ER) stress...
  20. pmc Obesity and free fatty acids
    Guenther Boden
    Department of Medicine, Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Endocrinol Metab Clin North Am 37:635-46, viii-ix. 2008
    ....
  21. ncbi request reprint Effects of insulin and free fatty acids on matrix metalloproteinases
    Guenther Boden
    Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Diab Rep 8:239-42. 2008
    ..The insulin- and FFA-induced hyperactivity of three proatherogenic MMPs in vascular tissues may promote degradation of extracellular matrix over time, leading to thinning of atherosclerotic capsules and acute vascular problems...
  22. pmc Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals
    Guenther Boden
    Division of Endocrinology, Diabetes, and Metabolism and the Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 57:2438-44. 2008
    ..To examine fat biopsy samples from lean insulin-sensitive and obese insulin-resistant nondiabetic individuals for evidence of endoplasmic reticulum (ER) stress...
  23. ncbi request reprint Ceramide: a contributor to insulin resistance or an innocent bystander?
    G Boden
    Division of Endocrinology, Diabetes and Metabolism, Temple University Hospital, Philadelphia, PA 19140, USA
    Diabetologia 51:1095-6. 2008
  24. ncbi request reprint Lipids and glucose in type 2 diabetes: what is the cause and effect?
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University Hospital, 3401 N Broad St, Philadelphia, PA 19140, USA
    Diabetes Care 27:2253-9. 2004
  25. ncbi request reprint Interaction between free fatty acids and glucose metabolism
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Curr Opin Clin Nutr Metab Care 5:545-9. 2002
    ..Free fatty acids (FFAs) have emerged as a major link between obesity and insulin resistance/type 2 diabetes mellitus. A review of the interaction between FFAs and glucose metabolism is therefore timely and relevant...
  26. ncbi request reprint Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction
    G Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University Hospital, Philadelphia PA 19140, USA
    Eur J Clin Invest 32:14-23. 2002
    ....
  27. ncbi request reprint Effects of free fatty acids (FFA) on glucose metabolism: significance for insulin resistance and type 2 diabetes
    G Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Exp Clin Endocrinol Diabetes 111:121-4. 2003
    ..Thus, elevated plasma levels of FFAs are not only a major cause of insulin resistance in skeletal muscle and liver but may, in addition, play a role in the pathogenesis of coronary artery disease...
  28. ncbi request reprint Pathogenesis of type 2 diabetes. Insulin resistance
    G Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Endocrinol Metab Clin North Am 30:801-15, v. 2001
    ..Lastly, normalizing plasma FFA levels is proposed as a new approach to reducing insulin resistance and the risk for type 2 diabetes mellitus, and atherosclerotic vascular disease...
  29. ncbi request reprint Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects
    G Boden
    Division of Endocrinology Diabetes Metabolism, General Clinical Research Center, Temple University School of Medicine, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Diabetes 50:1612-7. 2001
    ....
  30. ncbi request reprint Effects of free fatty acids on gluconeogenesis and autoregulation of glucose production in type 2 diabetes
    G Boden
    Division of Endocrinology, Diabetes, and Metabolism, and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 50:810-6. 2001
    ....
  31. ncbi request reprint Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus
    G Boden
    Division of Endocrinology Diabetes Metabolism, Temple University Hospital, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Endocrinol Metab 280:E23-30. 2001
    ....
  32. ncbi request reprint Free fatty acids, insulin resistance, and pregnancy
    Eyal Sivan
    Division of Endocrinology Diabetes Metabolism, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Curr Diab Rep 3:319-22. 2003
    ..This results in reduction of tyrosine phosphorylation of the insulin receptor substrate-1 and inhibits activation of phosphoinositol-3 kinase, an enzyme that is essential for normal insulin-stimulated glucose uptake...
  33. ncbi request reprint Effects of free fatty acids on gluconeogenesis and glycogenolysis
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, School of Medicine, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Life Sci 72:977-88. 2003
  34. ncbi request reprint Free fatty acids-the link between obesity and insulin resistance
    G Boden
    Division of Endocrinology/Diabetes/Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Endocr Pract 7:44-51. 2001
    ..This situation will lead to an increase in blood glucose concentration and eventually to type 2 diabetes. CONCLUSION: FFA have been shown to have an important contributing role in the pathogenesis of insulin resistance in human obesity...
  35. ncbi request reprint Activation of the tissue factor pathway of blood coagulation during prolonged hyperglycemia in young healthy men
    A K Rao
    Division of Hematology and Thromboembolic Diseases, Sol Sherry Thrombosis Research Center, Temple University, Philadelphia, Pennsylvania 19140, USA
    Diabetes 48:1156-61. 1999
    ....
  36. ncbi request reprint Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand
    Vijender R Vaidyula
    Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA
    Diabetes 55:202-8. 2006
    ....
  37. ncbi request reprint Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    Samar I Itani
    Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Diabetes 51:2005-11. 2002
    ..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
  38. ncbi request reprint Milrinone, a selective phosphodiesterase 3 inhibitor, stimulates lipolysis, endogenous glucose production, and insulin secretion
    Peter Cheung
    Division of Endocrinology Diabetes Metabolism, Clinical Research Center, Temple University School of Medicine, Philadelphia, PA 19141, USA
    Metabolism 52:1496-500. 2003
    ..We conclude that PDE-3 plays a major role in the inhibitory action of insulin on lipolysis in fat and on glucose production in liver and, in addition, seems to be involved in insulin secretion in pancreatic beta cells...
  39. ncbi request reprint Effects of free fatty acids on glucose uptake and utilization in healthy women
    Carol J Homko
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 52:487-91. 2003
    ..We conclude that at insulin and FFA levels in the postprandial range, women and men were susceptible to FFA-induced peripheral and hepatic insulin resistance...
  40. ncbi request reprint Insulin secretion during and after pregnancy in patients with gestational diabetes mellitus
    C Homko
    Department of Obstetrics and Gynecology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    J Clin Endocrinol Metab 86:568-73. 2001
    ..We concluded that the women with GDM had a major ss-cell defect that made it impossible for them to compensate for their increased level of insulin resistance, which occurred during late pregnancy...
  41. ncbi request reprint Effects of acute insulin excess and deficiency on gluconeogenesis and glycogenolysis in type 1 diabetes
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Diabetes 52:133-7. 2003
    ..We conclude that in type 1 diabetes acute regulation of EGP by insulin is mainly via changes in GL while GNG changes little during the early hours of acute insulin excess or deficiency...
  42. ncbi request reprint Free fatty acids (FFA), a link between obesity and insulin resistance
    G Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, PA, USA
    Front Biosci 3:d169-75. 1998
    ..In obesity, however, there is no need to spare carbohydrate and the FFA induced insulin resistance may result in type 2 diabetes and other cardiovascular risk factors...
  43. ncbi request reprint Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Metabolism 52:753-9. 2003
    ..We conclude that TZDs have multiple actions and that many, but perhaps not all, can be accounted for by their action on adipose tissue...
  44. ncbi request reprint Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjects
    Vijender R Vaidyula
    Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Platelets 17:577-85. 2006
    ..Platelet responsiveness to activation with ADP or SFLLRN appears not to be altered by hyperglycemia-hyperinsulinemia...
  45. ncbi request reprint Effect of a low-carbohydrate diet on appetite, blood glucose levels, and insulin resistance in obese patients with type 2 diabetes
    Guenther Boden
    Temple University School of Medicine, Philadelphia, Pennsylvania, and University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey
    Ann Intern Med 142:403-11. 2005
    ..It is not known how a low-carbohydrate, high-protein, high-fat diet causes weight loss or how it affects blood glucose levels in patients with type 2 diabetes...
  46. ncbi request reprint Effect of high protein vs high carbohydrate intake on insulin sensitivity, body weight, hemoglobin A1c, and blood pressure in patients with type 2 diabetes mellitus
    Karin R Sargrad
    Nutrition Center, Department of Bioscience and Biotechnology, Drexel University, Philadelphia, PA 19104, USA
    J Am Diet Assoc 105:573-80. 2005
    ..Extremely low carbohydrate/high protein diets are popular methods of weight loss. Compliance with these diets is poor and long-term effectiveness and the safety of these diets for patients with type 2 diabetes is not known...
  47. ncbi request reprint Insulin-sensitivity response to a single bout of resistive exercise in type 1 diabetes mellitus
    Carolyn Jimenez
    Dept of Sports Medicine, West Chester University, West Chester, PA, USA
    J Sport Rehabil 18:564-71. 2009
    ..Little is known about the acute effects of resistance exercise on insulin sensitivity in people with type 1 diabetes...
  48. ncbi request reprint Comparison of insulin aspart and lispro: pharmacokinetic and metabolic effects
    Carol Homko
    General Clinical Research Center and Division of Endocrinology Diabetes Metabolism, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 26:2027-31. 2003
    ....
  49. ncbi request reprint Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia
    S G Rane
    Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Nat Genet 22:44-52. 1999
    ..These results establish Cdk4 as an essential regulator of specific cell types...
  50. ncbi request reprint FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis
    Guenther Boden
    Division of Endocrinology Diabetes Metabolism and the General Clinical Research Center, Temple University Health Sciences Center, Philadelphia, Pennsylvania 19140, USA
    Am J Physiol Endocrinol Metab 283:E12-9. 2002
    ..9.2 micromol x kg(-1). min(-1), P < 0.05). We conclude that insulin suppressed EGP by inhibiting GL more than GNG and that elevated plasma FFA levels attenuated the suppression of EGP by interfering with insulin suppression of GL...
  51. ncbi request reprint A radioimmunoassay for human insulin receptor correlation between insulin binding and receptor mass
    G Boden
    Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania
    Horm Metab Res 23:117-21. 1991
    ..Our data are most compatible with binding of one insulin molecule per human placental insulin receptor...
  52. ncbi request reprint Nerves, fat, and insulin resistance
    Guenther Boden
    Department of Medicine, Temple University Hospital, Philadelphia, USA
    N Engl J Med 349:1966-7. 2003
  53. ncbi request reprint Obesity and diabetes mellitus--how are they linked?
    Guenther Boden
    West Indian Med J 51:51-4. 2002
    ..Normalizing plasma FFA levels is, therefore, proposed as a novel approach to reduce insulin resistance, the risk of Type 2 diabetes mellitus and atherosclerotic vascular disease...
  54. ncbi request reprint Short-term pioglitazone treatment prevents free fatty acid-induced hepatic insulin resistance in normal rats: possible role of the resistin and adiponectin
    Gangyi Yang
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China
    Biochem Biophys Res Commun 339:1190-6. 2006
    ..We conclude that short-term treatment of rats with Pio prevented lipid-induced hepatic insulin resistance and that Pio mediated lowering of blood resistin and raising of adiponectin levels may have contributed to that effect...
  55. ncbi request reprint Effects of free fatty acids on plasma resistin and insulin resistance in awake rats
    Gangyi Yang
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China
    Metabolism 54:1142-6. 2005
    ..We conclude that FFA-induced release of resistin may contribute to the development of FFA-induced insulin resistance in rats...
  56. ncbi request reprint Circulating obestatin levels in normal subjects and in patients with impaired glucose regulation and type 2 diabetes mellitus
    Xiaoya Qi
    Department of Endocrinology, The Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing, China
    Clin Endocrinol (Oxf) 66:593-7. 2007
    ..This new ghrelin-associated peptide behaves as a physiological opponent of ghrelin in rodent animals, but its pathophysiological role in humans remains unknown..
  57. ncbi request reprint Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force
    Lee M Kaplan
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 132:2272-5. 2007
  58. ncbi request reprint New benefits of statin treatment
    Guenther Boden
    Curr Diab Rep 5:165; discussion 165-6. 2005

Research Grants24

  1. ANTIOXIDANT & HYPERGLYCEMIA INDUCED PROCOAGULANT STATE
    Guenther Boden; Fiscal Year: 2005
    ....
  2. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 1999
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  3. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2005
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  4. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2006
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. ..
  5. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2006
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  6. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2007
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. ..
  7. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2007
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  8. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2007
    ....
  9. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2009
    ....
  10. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2010
    ....
  11. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2009
    ....
  12. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2005
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. ..
  13. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2000
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  14. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2001
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  15. ANTIOXIDANT & HYPERGLYCEMIA INDUCED PROCOAGULANT STATE
    Guenther Boden; Fiscal Year: 2002
    ....
  16. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2002
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  17. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2003
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  18. ANTIOXIDANT & HYPERGLYCEMIA INDUCED PROCOAGULANT STATE
    Guenther Boden; Fiscal Year: 2003
    ....
  19. FAT MEDIATED INSULIN SECRETION AND DIABETES IN ELDERLY
    Guenther Boden; Fiscal Year: 2003
    ..We hope that this project will help to better understand the mechanisms by which obesity contributes to the development of NIDDM. ..
  20. Free Fatty Acids and Hepatic Insulin Resistance
    Guenther Boden; Fiscal Year: 2004
    ..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. ..
  21. ANTIOXIDANT & HYPERGLYCEMIA INDUCED PROCOAGULANT STATE
    Guenther Boden; Fiscal Year: 2004
    ....
  22. Fat Induced Insulin Resistance and Atherosclerosis
    Guenther Boden; Fiscal Year: 2004
    ..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
  23. Hyperglycemia and Hyperinsulinemia Induced Procoagulant State
    Guenther Boden; Fiscal Year: 2010
    ....