Affiliation: Temple University
- Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancerA Arzumanyan
Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Oncogene 31:563-72. 2012..Thus, histone deacetylation of CDH1 and downregulation of miR-373, together with the previously demonstrated hypermethylation of CDH1 by HBx, may be important for the understanding of HBV-related carcinogenesis...
- Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?Alla Arzumanyan
Department of Biology, Sbarro Health Research Organization, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Res 71:3701-8. 2011..HBx-associated upregulated expression of multiple "stemness" markers supports the hypothesis that HBx contributes to hepatocarcinogenesis, at least in part, by promoting changes in gene expression that are characteristics of CSCs...
- Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X proteinAlla Arzumanyan
Department of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Res 72:5912-20. 2012..This work could be central to designing specific treatments that target early development and progression of HBx-mediated HCC...
- Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinomaAlla Arzumanyan
Department of Biology and Sbarro Health Research Organization, College of Science and Technology, Temple University, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, USA
Nat Rev Cancer 13:123-35. 2013..This Review outlines pathogenic mechanisms that seem to be common to both viruses and which suggest innovative approaches to the prevention and treatment of HCC...