Affiliation: Temple University
- Carnosine protects erythrocytes from the oxidative stress caused by homocysteic acidE S Arzumanyan
International Biotechnology Center, Moscow State University, Moscow 119992, Russia
Dokl Biochem Biophys 418:44-6. 2008
- Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancerA Arzumanyan
Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Oncogene 31:563-72. 2012..Thus, histone deacetylation of CDH1 and downregulation of miR-373, together with the previously demonstrated hypermethylation of CDH1 by HBx, may be important for the understanding of HBV-related carcinogenesis...
- Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells?Alla Arzumanyan
Department of Biology, Sbarro Health Research Organization, College of Science and Technology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Res 71:3701-8. 2011..HBx-associated upregulated expression of multiple "stemness" markers supports the hypothesis that HBx contributes to hepatocarcinogenesis, at least in part, by promoting changes in gene expression that are characteristics of CSCs...
- Preclinical characterization of GLS4, an inhibitor of hepatitis B virus core particle assemblyGuoyi Wu
Department of Biology, College of Science and Technology, Temple University, Philadelphia, Pennsylvania, USA
Antimicrob Agents Chemother 57:5344-54. 2013..Thus, GLS4 was as potent as the prototype, BAY 41-4109, and was superior to lamivudine, in that there was little virus relapse after the end of treatment and no indication of toxicity. ..
- Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X proteinAlla Arzumanyan
Department of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA
Cancer Res 72:5912-20. 2012..This work could be central to designing specific treatments that target early development and progression of HBx-mediated HCC...
- Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinomaAlla Arzumanyan
Department of Biology and Sbarro Health Research Organization, College of Science and Technology, Temple University, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, USA
Nat Rev Cancer 13:123-35. 2013..This Review outlines pathogenic mechanisms that seem to be common to both viruses and which suggest innovative approaches to the prevention and treatment of HCC...
- The roles of hepatitis B virus-encoded X protein in virus replication and the pathogenesis of chronic liver diseaseMark A Feitelson
Temple University, College of Science and Technology, Department of Biology, Room 409 BioLife Science Building, 1900 N 12th Street, Philadelphia, PA 19122, USA 1 215 204 8434 1 215 204 8359
Expert Opin Ther Targets 18:293-306. 2014..This review suggests that the HBV-encoded X protein, HBx, would be an outstanding target because it contributes to the biology and pathogenesis of HBV in three fundamental ways...