Geoffrey C Dunbar

Summary

Affiliation: Targacept Inc
Country: USA

Publications

  1. ncbi Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)
    Geoffrey C Dunbar
    Clinical Development and Regulatory Affairs, Targacept Inc, Winston Salem, NC 27101, USA
    J Psychopharmacol 21:171-8. 2007
  2. ncbi A randomized double-blind study comparing 25 and 50 mg TC-1734 (AZD3480) with placebo, in older subjects with age-associated memory impairment
    Geoffrey C Dunbar
    Targacept Inc, Winston Salem, NC, USA
    J Psychopharmacol 25:1020-9. 2011
  3. ncbi Cognitive enhancement in man with ispronicline, a nicotinic partial agonist
    Geoffrey C Dunbar
    Targacept Inc, Winston Salem, NC 27101, USA
    J Mol Neurosci 30:169-72. 2006

Detail Information

Publications3

  1. ncbi Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)
    Geoffrey C Dunbar
    Clinical Development and Regulatory Affairs, Targacept Inc, Winston Salem, NC 27101, USA
    J Psychopharmacol 21:171-8. 2007
    ..Ispronicline also had a beneficial effect on cognition in subjects with AAMI. This was seen most strongly in a Cmax range that had been predicted from pre-clinical animal studies...
  2. ncbi A randomized double-blind study comparing 25 and 50 mg TC-1734 (AZD3480) with placebo, in older subjects with age-associated memory impairment
    Geoffrey C Dunbar
    Targacept Inc, Winston Salem, NC, USA
    J Psychopharmacol 25:1020-9. 2011
    ..2 to 1.8), p = 0.015. As all three co-primary outcomes were positive it can be concluded the compound likely had a beneficial effect on cognition. TC-1734 (AZD3480) appeared safe and well tolerated in this study...
  3. ncbi Cognitive enhancement in man with ispronicline, a nicotinic partial agonist
    Geoffrey C Dunbar
    Targacept Inc, Winston Salem, NC 27101, USA
    J Mol Neurosci 30:169-72. 2006
    ..Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d) (Gatto et al., 2004)...