- Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)Geoffrey C Dunbar
Clinical Development and Regulatory Affairs, Targacept Inc, Winston Salem, NC 27101, USA
J Psychopharmacol 21:171-8. 2007..Ispronicline also had a beneficial effect on cognition in subjects with AAMI. This was seen most strongly in a Cmax range that had been predicted from pre-clinical animal studies...
- A randomized double-blind study comparing 25 and 50 mg TC-1734 (AZD3480) with placebo, in older subjects with age-associated memory impairmentGeoffrey C Dunbar
Targacept Inc, Winston Salem, NC, USA
J Psychopharmacol 25:1020-9. 2011..2 to 1.8), p = 0.015. As all three co-primary outcomes were positive it can be concluded the compound likely had a beneficial effect on cognition. TC-1734 (AZD3480) appeared safe and well tolerated in this study...
- Cognitive enhancement in man with ispronicline, a nicotinic partial agonistGeoffrey C Dunbar
Targacept Inc, Winston Salem, NC 27101, USA
J Mol Neurosci 30:169-72. 2006..Ispronicline pharmacokinetics (half-life of 2 h in rats) contrasts with the long-lasting improvement of working memory (18 h to 2 d) (Gatto et al., 2004)...