Haruo Tanaka

Summary

Country: USA

Publications

  1. pmc Mechanism by which the lectin actinohivin blocks HIV infection of target cells
    Haruo Tanaka
    Faculty of Pharmacy and College of Science and Engineering, Iwaki Meisei University, Iwaki, Fukushima 970 8551, Japan
    Proc Natl Acad Sci U S A 106:15633-8. 2009
  2. doi request reprint Actinohivin: specific amino acid residues essential for anti-HIV activity
    Atsushi Takahashi
    Faculty of Pharmacy and College of Science and Engineering, Iwaki Meisei University, Fukushima, Japan
    J Antibiot (Tokyo) 63:661-5. 2010
  3. pmc Structural insights into the specific anti-HIV property of actinohivin: structure of its complex with the α(1-2)mannobiose moiety of gp120
    M Mominul Hoque
    Faculty of Pharmacy, Iwaki Meisei University, 5 5 1 Chuodai Iino, Iwaki, Fukushima, Japan
    Acta Crystallogr D Biol Crystallogr 68:1671-9. 2012
  4. doi request reprint Peculiarity in crystal packing of anti-HIV lectin actinohivin in complex with α(1-2)mannobiose
    Kaoru Suzuki
    College of Science and Engineering, Iwaki Meisei University, Iwaki, Fukushima 970 8551, Japan
    Acta Crystallogr D Biol Crystallogr 69:1818-25. 2013
  5. doi request reprint The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity
    Atsushi Takahashi
    Faculty of Pharmacy and College of Science and Engineering, Iwaki Meisei University, 5 5 1 Chuodai Iino, Iwaki, Fukushima, Japan
    J Antibiot (Tokyo) 64:551-7. 2011
  6. pmc Crystallographic study of the interaction of the anti-HIV lectin actinohivin with the α(1-2)mannobiose moiety of gp120 HMTG
    Kaoru Suzuki
    College of Science and Engineering, Iwaki Meisei University, Iwaki, Fukushima 970 8551, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1060-3. 2012

Collaborators

Detail Information

Publications6

  1. pmc Mechanism by which the lectin actinohivin blocks HIV infection of target cells
    Haruo Tanaka
    Faculty of Pharmacy and College of Science and Engineering, Iwaki Meisei University, Iwaki, Fukushima 970 8551, Japan
    Proc Natl Acad Sci U S A 106:15633-8. 2009
    ..Thus, AH is a good candidate for investigation as a safe microbicide to help prevent HIV transmission...
  2. doi request reprint Actinohivin: specific amino acid residues essential for anti-HIV activity
    Atsushi Takahashi
    Faculty of Pharmacy and College of Science and Engineering, Iwaki Meisei University, Fukushima, Japan
    J Antibiot (Tokyo) 63:661-5. 2010
    ..These data will be useful for predicting the detailed mechanism of AH-Man-α(1-2)-Man/HMTG/gp120 interaction by computational analysis and for possible development of more potent microbicides for prevention of HIV transmission...
  3. pmc Structural insights into the specific anti-HIV property of actinohivin: structure of its complex with the α(1-2)mannobiose moiety of gp120
    M Mominul Hoque
    Faculty of Pharmacy, Iwaki Meisei University, 5 5 1 Chuodai Iino, Iwaki, Fukushima, Japan
    Acta Crystallogr D Biol Crystallogr 68:1671-9. 2012
    ..These structural features provide strong evidence indicating that AH is only highly specific for MB and would facilitate the highly specific affinity of AH for any glycoprotein carrying many HMTGs, such as HIV-1 gp120...
  4. doi request reprint Peculiarity in crystal packing of anti-HIV lectin actinohivin in complex with α(1-2)mannobiose
    Kaoru Suzuki
    College of Science and Engineering, Iwaki Meisei University, Iwaki, Fukushima 970 8551, Japan
    Acta Crystallogr D Biol Crystallogr 69:1818-25. 2013
    ..2011). J. Antibiot. 64, 551-557]. ..
  5. doi request reprint The high mannose-type glycan binding lectin actinohivin: dimerization greatly improves anti-HIV activity
    Atsushi Takahashi
    Faculty of Pharmacy and College of Science and Engineering, Iwaki Meisei University, 5 5 1 Chuodai Iino, Iwaki, Fukushima, Japan
    J Antibiot (Tokyo) 64:551-7. 2011
    ..A dimer with improved anti-HIV activity would be a good candidate for investigation as a potential microbicide to prevent HIV transmission...
  6. pmc Crystallographic study of the interaction of the anti-HIV lectin actinohivin with the α(1-2)mannobiose moiety of gp120 HMTG
    Kaoru Suzuki
    College of Science and Engineering, Iwaki Meisei University, Iwaki, Fukushima 970 8551, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1060-3. 2012
    ..The crystal diffracted well to beyond 1.90 Å resolution and the crystallographic data suggested that it contained no packing disorder...