B Borowsky

Summary

Affiliation: Synaptic Pharmaceutical Corporation
Country: USA

Publications

  1. ncbi Cloning and characterization of the human galanin GALR2 receptor
    B Borowsky
    Department of Molecular Biology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Peptides 19:1771-81. 1998
  2. pmc Trace amines: identification of a family of mammalian G protein-coupled receptors
    B Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Proc Natl Acad Sci U S A 98:8966-71. 2001
  3. ncbi Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs
    B Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Regul Pept 75:45-53. 1998
  4. ncbi Identification and characterization of two G protein-coupled receptors for neuropeptide FF
    J A Bonini
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 275:39324-31. 2000
  5. ncbi Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels
    K E Smith
    Departments of Molecular Biology and Pharmacology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 273:23321-6. 1998
  6. ncbi Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system
    R Raddatz
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 275:32452-9. 2000
  7. ncbi GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
    K A Jones
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Nature 396:674-9. 1998
  8. ncbi An in situ hybridization study of the distribution of the GABA(B2) protein mRNA in the rat CNS
    M M Durkin
    Department of Pharmacology, Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, NJ 07652, USA
    Brain Res Mol Brain Res 71:185-200. 1999
  9. ncbi The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia
    T D Wolinsky
    Neuroscience, Lundbeck Research USA, Inc, Paramus, NJ 07652, USA
    Genes Brain Behav 6:628-39. 2007
  10. ncbi Analysis of a gene encoding two glycine transporter variants reveals alternative promoter usage and a novel gene structure
    B Borowsky
    Unit on Molecular Pharmacology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:29077-85. 1998

Collaborators

Detail Information

Publications11

  1. ncbi Cloning and characterization of the human galanin GALR2 receptor
    B Borowsky
    Department of Molecular Biology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Peptides 19:1771-81. 1998
    ..A weak GALR2 mRNA signal was detected in human retina, and no signal was detected in cerebral cortex, lung, spleen, stomach, or pituitary...
  2. pmc Trace amines: identification of a family of mammalian G protein-coupled receptors
    B Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Proc Natl Acad Sci U S A 98:8966-71. 2001
    ..The identification of this family of receptors should rekindle the investigation of the roles of trace amines in mammalian nervous systems and may potentially lead to the development of novel therapeutics for a variety of indications...
  3. ncbi Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs
    B Borowsky
    Synaptic Pharmaceutical Corporation, Paramus, NJ 07652, USA
    Regul Pept 75:45-53. 1998
    ..These Y5 species homologs along with corresponding animal models may be useful in the search for novel therapeutics in the treatment of obesity and related feeding disorders...
  4. ncbi Identification and characterization of two G protein-coupled receptors for neuropeptide FF
    J A Bonini
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 275:39324-31. 2000
    ..The identification of NPFF1 and NPFF2 will help delineate their roles in these and other physiological functions...
  5. ncbi Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels
    K E Smith
    Departments of Molecular Biology and Pharmacology, Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 273:23321-6. 1998
    ..These data confirm the functional efficacy of GALR3 receptors and further suggest that GALR3 signaling pathways resemble those of GALR1 in that both can activate potassium channels linked to the regulation of neurotransmitter release...
  6. ncbi Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system
    R Raddatz
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    J Biol Chem 275:32452-9. 2000
    ..Identification of neuromedin U receptor subtypes will greatly aid in the determination of the physiological roles of this peptide...
  7. ncbi GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
    K A Jones
    Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652, USA
    Nature 396:674-9. 1998
    ..We have now shown that co-expression of two GPCR structures, GABA(B)R1 and GABA(B)R2, belonging to the same subfamily is essential for signal transduction by GABA(B) receptors...
  8. ncbi An in situ hybridization study of the distribution of the GABA(B2) protein mRNA in the rat CNS
    M M Durkin
    Department of Pharmacology, Synaptic Pharmaceutical Corporation, 215 College Road, Paramus, NJ 07652, USA
    Brain Res Mol Brain Res 71:185-200. 1999
    ..However, differences between GABA(B2) expression levels and GABA(B) binding sites were observed in the basal ganglia...
  9. ncbi The Trace Amine 1 receptor knockout mouse: an animal model with relevance to schizophrenia
    T D Wolinsky
    Neuroscience, Lundbeck Research USA, Inc, Paramus, NJ 07652, USA
    Genes Brain Behav 6:628-39. 2007
    ..Furthermore, the TA1 KO mouse may provide a useful model for the development of treatments for some positive symptoms of schizophrenia...
  10. ncbi Analysis of a gene encoding two glycine transporter variants reveals alternative promoter usage and a novel gene structure
    B Borowsky
    Unit on Molecular Pharmacology, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Biol Chem 273:29077-85. 1998
    ....
  11. ncbi Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene
    B Borowsky
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892
    Neuron 10:851-63. 1993
    ..The anatomic distribution of GLYT-2 mRNA supports the emerging status of glycine as a supraspinal neurotransmitter and suggests that glycine may function as a chemical messenger outside the CNS...