D Bar-Or

Summary

Affiliation: Swedish Medical Center
Country: USA

Publications

  1. ncbi request reprint Heterogeneity and oxidation status of commercial human albumin preparations in clinical use
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
    Crit Care Med 33:1638-41. 2005
  2. ncbi request reprint Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia
    D Bar-Or
    Department of Trauma Research, Swedish Medical Center Englewood, CO 80110, USA
    Eur J Biochem 268:42-7. 2001
  3. doi request reprint Reduced mortality at a community hospital trauma center: the impact of changing trauma level designation From II to I
    Kristin Scarborough
    Trauma Research Department, Swedish Medical Center, 501 E Hampden Ave, Room 4 454, Englewood, CO 80113
    Arch Surg 143:22-7; discussion 27-8. 2008
  4. ncbi request reprint The cobalt-albumin binding assay: insights into its mode of action
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO, USA Swedish Medical Center, Emergency Department, Englewood, CO 80113, USA
    Clin Chim Acta 387:120-7. 2008
  5. ncbi request reprint Mass spectrometry analysis of urine and catheter of a patient with purple urinary bag syndrome
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
    Clin Chim Acta 378:216-8. 2007
  6. ncbi request reprint Severe systemic immune response syndrome, low plasma paraoxonase activity, and a new albumin species in a traumatized patient with Gaucher's disease
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
    Clin Chim Acta 374:135-9. 2006
  7. ncbi request reprint The formation and rapid clearance of a truncated albumin species in a critically ill patient
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, 501 E Hampden Ave, Englewood, CO 80113, USA
    Clin Chim Acta 365:346-9. 2006
  8. ncbi request reprint Diagnostic potential of phosphorylated cardiac troponin I as a sensitive, cardiac-specific marker for early acute coronary syndrome: preliminary report
    David Bar-Or
    Swedish Medical Center, Trauma Research Dept, Englewood, CO 80113, USA
    Clin Chim Acta 362:65-70. 2005
  9. ncbi request reprint Cysteinylation of maternal plasma albumin and its association with intrauterine growth restriction
    David Bar-Or
    Swedish Medical Center, Trauma Research Department, Englewood, CO 80113, USA
    Prenat Diagn 25:245-9. 2005
  10. ncbi request reprint Plasma albumin cysteinylation is regulated by cystathionine beta-synthase
    David Bar-Or
    Trauma Research Department, Swedish Medical Center, Englewood, CO, USA
    Biochem Biophys Res Commun 325:1449-53. 2004

Collaborators

  • Leonard T Rael
  • JAN KRAUS
  • Kenneth N Maclean
  • Raphael Bar-Or
  • Kristin Salottolo
  • Adrian Pearl
  • Charles Mains
  • Denetta Sue Slone
  • Michael Craun
  • Richard Shimonkevitz
  • Kristin Scarborough
  • Andrew Stewart Levy
  • April Settell
  • Charles W Mains
  • Phyllis Uribe
  • Jonathan D Polk
  • Raymond E Garrett
  • Lisbeth Harris
  • Richard L Yukl
  • Angela Roberts
  • James V Winkler
  • Michael Sullivan
  • PATRICK OFFNER
  • Erika O'Neal
  • Gen Maruyama
  • Pamela Bourg
  • Allison Hawkes
  • Jeffery Huber
  • Matthew Fleishman
  • Patricia Howell
  • Shelley Akin
  • Michael L Craun
  • Deborah Davis-Merritt
  • Gregory Thomas
  • Reuben Caspi
  • Jobeth Northrop
  • Howard Shapiro

Detail Information

Publications35

  1. ncbi request reprint Heterogeneity and oxidation status of commercial human albumin preparations in clinical use
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
    Crit Care Med 33:1638-41. 2005
    ..We sought to analyze various commercially available albumin preparations for common, posttranslational modifications...
  2. ncbi request reprint Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemia
    D Bar-Or
    Department of Trauma Research, Swedish Medical Center Englewood, CO 80110, USA
    Eur J Biochem 268:42-7. 2001
    ....
  3. doi request reprint Reduced mortality at a community hospital trauma center: the impact of changing trauma level designation From II to I
    Kristin Scarborough
    Trauma Research Department, Swedish Medical Center, 501 E Hampden Ave, Room 4 454, Englewood, CO 80113
    Arch Surg 143:22-7; discussion 27-8. 2008
    ..To determine if a change in trauma designation from level II (L2) to level I (L1) in the same institution reduces mortality. Design, Setting, and..
  4. ncbi request reprint The cobalt-albumin binding assay: insights into its mode of action
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO, USA Swedish Medical Center, Emergency Department, Englewood, CO 80113, USA
    Clin Chim Acta 387:120-7. 2008
    ..In this investigation, we attempt to clarify the mode of action of the cobalt-HSA binding assay by direct observations of cobalt binding to HSA...
  5. ncbi request reprint Mass spectrometry analysis of urine and catheter of a patient with purple urinary bag syndrome
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
    Clin Chim Acta 378:216-8. 2007
    ..Purple urinary bag syndrome (PUBS) is considered to be a benign condition observed in the urinary catheter and bag in some catheterized patients with urinary tract infections. This syndrome is usually reported to occur in alkaline urine...
  6. ncbi request reprint Severe systemic immune response syndrome, low plasma paraoxonase activity, and a new albumin species in a traumatized patient with Gaucher's disease
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
    Clin Chim Acta 374:135-9. 2006
    ..Gaucher's disease (GD) is an inborn error, autosomal recessive lysosomal lipid storage disorder characterized by the lack of the enzyme glucocerebrosidase. We observed some abnormalities in the plasma of a traumatized patient with GD...
  7. ncbi request reprint The formation and rapid clearance of a truncated albumin species in a critically ill patient
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, 501 E Hampden Ave, Englewood, CO 80113, USA
    Clin Chim Acta 365:346-9. 2006
    ..Hypoalbuminemia is known to occur in critically ill patients and is associated with increased mortality. We observed a potentially novel, partial explanation for the hypoalbuminemia noticed in a severely traumatized patient...
  8. ncbi request reprint Diagnostic potential of phosphorylated cardiac troponin I as a sensitive, cardiac-specific marker for early acute coronary syndrome: preliminary report
    David Bar-Or
    Swedish Medical Center, Trauma Research Dept, Englewood, CO 80113, USA
    Clin Chim Acta 362:65-70. 2005
    ..Cardiac troponin I (cTnI) has low sensitivity in the early hours of acute coronary syndrome (ACS). For patients with early ACS symptoms, we determined the diagnostic potential of an immunoassay for phosphorylated cTnI (PO(4)-cTnI)...
  9. ncbi request reprint Cysteinylation of maternal plasma albumin and its association with intrauterine growth restriction
    David Bar-Or
    Swedish Medical Center, Trauma Research Department, Englewood, CO 80113, USA
    Prenat Diagn 25:245-9. 2005
    ..High-risk pregnancies and uteroplacental insufficiency (UPI) have been associated with elevated levels of homocysteine, and, in oxidizing environments, homocysteine is converted to cysteine, resulting in cysteinylation of proteins...
  10. ncbi request reprint Plasma albumin cysteinylation is regulated by cystathionine beta-synthase
    David Bar-Or
    Trauma Research Department, Swedish Medical Center, Englewood, CO, USA
    Biochem Biophys Res Commun 325:1449-53. 2004
    ..CysAlb may serve as a biomarker for the severity of gut ischemia, and high Hcy may explain endothelial damage associated with this model. Additionally, active CBS is essential for the formation of CysAlb...
  11. ncbi request reprint Asp-Ala-His-Lys (DAHK) inhibits copper-induced oxidative DNA double strand breaks and telomere shortening
    D Bar-Or
    Trauma Research, Swedish Medical Center, Englewood, Colorado, 80110, USA
    Biochem Biophys Res Commun 282:356-60. 2001
    ..The human albumin N-terminus analog, d-DAHK, protects DNA and telomeres against copper-mediated ROS damage and may be a useful therapeutic adjunct in ROS disease processes...
  12. ncbi request reprint Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin I
    D Bar-Or
    Swedish Medical Center
    Am Heart J 141:985-91. 2001
    ..We then compared ACB assay results with creatine kinase isoenzyme (CK-MB), myoglobin, and cardiac troponin I (cTn-I) values after PTCA...
  13. ncbi request reprint An analog of the human albumin N-terminus (Asp-Ala-His-Lys) prevents formation of copper-induced reactive oxygen species
    D Bar-Or
    Department of Trauma Research, Swedish Medical Center, Englewood, Colorado 80110, USA
    Biochem Biophys Res Commun 284:856-62. 2001
    ....
  14. doi request reprint Staff commitment to trauma care improves mortality and length of stay at a level I trauma center
    Charles Mains
    Trauma Services Department, St Anthony Central Hospital, Denver, Colorado, USA
    J Trauma 66:1315-20. 2009
    ..The purpose of this study was to assess whether staffing changes within a Level I trauma center improved mortality and shortened length of stay (LOS) for trauma patients...
  15. ncbi request reprint Low albumin level in the emergency department: a potential independent predictor of delayed mortality in blunt trauma
    Richard L Yukl
    Department of Trauma Research, Swedish Medical Center, 501 E Hampden Avenue, Englewood, CO 80110 2795, USA
    J Emerg Med 25:1-6. 2003
    ....
  16. doi request reprint Dehydroalanine derived from cysteine is a common post-translational modification in human serum albumin
    Raphael Bar-Or
    Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA
    Rapid Commun Mass Spectrom 22:711-6. 2008
    ..The presence of this common PTM of HSA has potential effects on ligand binding to HSA, plasma clearance of this oxidized form of HSA, protein-protein interactions, and oxidation-reduction potential...
  17. doi request reprint Clinical utility of the cobalt-albumin binding assay in the diagnosis of intestinal ischemia
    Jonathan D Polk
    Saint Joseph Hospital, Denver, Colorado, USA
    J Trauma 64:42-5. 2008
    ..This resulted in a sensitivity of 100% and a specificity of 85.7% for the CABA test for these particular samples. The CABA test could be a useful tool for clinicians in the risk stratification of intestinal ischemia...
  18. ncbi request reprint Oxidation-reduction potential and paraoxonase-arylesterase activity in trauma patients
    Leonard T Rael
    Swedish Medical Center, Trauma Research Laboratory, 501 E Hampden Avenue Rm 4 454, Englewood, CO 80113, USA
    Biochem Biophys Res Commun 361:561-5. 2007
    ..Monitoring ORP could be a useful tool for assessing the degree of oxidative stress, inflammation, severity of injury, and potential efficacy of treatment...
  19. doi request reprint The impact of the AIS 2005 revision on injury severity scores and clinical outcome measures
    Kristin Salottolo
    Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA
    Injury 40:999-1003. 2009
    ..The abbreviated injury scale (AIS) was updated in 2005 from the AIS 1998 version. The purpose of this study is to describe the effects of this change on injury severity scoring and outcome measures...
  20. doi request reprint Effects of a nonsurgical hospitalist service on trauma patient outcomes
    Kristin Salottolo
    Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA
    Surgery 145:355-61. 2009
    ..We hypothesized outcomes would be equivalent for patients treated under TMED versus a surgical service...
  21. ncbi request reprint Inhibitory effect of copper on cystathionine beta-synthase activity: protective effect of an analog of the human albumin N-terminus
    David Bar-Or
    Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E Hampden Avenue, Englewood, CO 80113, USA
    Protein Pept Lett 12:271-3. 2005
    ..The use of copper chelators could significantly reduce in vivo homocysteine levels...
  22. doi request reprint Plasma oxidation-reduction potential and protein oxidation in traumatic brain injury
    Leonard T Rael
    Trauma Research Laboratory, Swedish Medical Center, Englewood, CO 80113, USA
    J Neurotrauma 26:1203-11. 2009
    ..Therefore monitoring ORP is a potentially useful tool for assessing the degree of oxidative stress, inflammation, severity of injury, and potential efficacy of treatment in ITBI patients...
  23. doi request reprint The effect of storage on the accumulation of oxidative biomarkers in donated packed red blood cells
    Leonard T Rael
    Swedish Medical Center, Trauma Research Laboratory, Englewood, Colorado 80113, USA
    J Trauma 66:76-81. 2009
    ..Longer storage times of packed red blood cells (PRBC) and other blood products have been implicated with an increased risk in developing TRALI in transfused patients...
  24. ncbi request reprint Copper-induced oxidation of epinephrine: protective effect of D-DAHK, a synthetic analogue of the high affinity copper binding site of human albumin
    Angela Roberts
    Department of Trauma Research, Swedish Medical Center, 501 E Hampden Avenue, Englewood, CO 80110, USA
    Biochem Biophys Res Commun 304:755-7. 2003
    ..These in vitro results indicate that copper-induced epinephrine oxidation is greatest at the physiological pH 7.4 as well as in severe acidosis, pH 7.0, and that D-DAHK completely inhibits this oxidation...
  25. ncbi request reprint Artificial neural network versus subjective scoring in predicting mortality in trauma patients
    Adrian Pearl
    Swedish Medical Center, Trauma Research Dept, Englewood, Colorado USA
    Stud Health Technol Inform 124:1019-24. 2006
    ..This project aims to develop a neural network for predicting survival of trauma patients using standard, measured, physiological variables, and compare its predictive power with that obtained from current trauma scores...
  26. ncbi request reprint Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHK
    David Bar-Or
    Trauma Research Department, Swedish Medical Center, 501 East Hampden Avenue, Englewood, Colorado 80110, USA
    Biochem Biophys Res Commun 290:1388-92. 2002
    ..4 microM copper, which helps explain the increased APC activity with HSA and d-DAHK alone. These in vitro results indicate that copper inhibits APC activity and that albumin and d-DAHK reverse the copper-induced APC deactivation...
  27. ncbi request reprint Interleukin-16 expression in the peripheral blood and CD8 T lymphocytes after traumatic injury
    Richard Shimonkevitz
    Trauma Research Department, HealthOne Swedish Medical Center, Englewood, CO 80113, USA
    J Trauma 58:252-8. 2005
    ..This study investigated the expression of IL-16 in trauma patient plasma and peripheral blood leukocytes to determine its involvement in the physiologic response to injury...
  28. ncbi request reprint Using artificial neural networks to predict potential complications during trauma patients' hospitalization period
    Adrian Pearl
    Trauma Research Department, Swedish Medical Center, Englewood, CO, USA
    Stud Health Technol Inform 150:610-4. 2009
    ..Predicting Urinary Tract Infections (UTI) cases is not good enough using these input variables. Both VAP and UTI relate to those aged over 55 years, while ARDS related more to those under 16 years. The models need improving...
  29. doi request reprint A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through rap1
    Richard Shimonkevitz
    Trauma Research Department, HealthOne Swedish Medical Center, Englewood, Colorado, USA
    J Trauma 64:35-41. 2008
    ..Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP...
  30. doi request reprint Current utilization and radiation dose from computed tomography in patients with trauma
    Kristin Salottolo
    Department of Trauma Research, Swedish Medical Center, Englewood, CO, USA
    Crit Care Med 37:1336-40. 2009
    ..To quantify the cumulative effective dose of radiation received during hospitalization after traumatic injury and to compare the computed tomography (CT) utilization practices for two time periods in patients with trauma...
  31. doi request reprint Pharmacologic thromboprophylaxis is a risk factor for hemorrhage progression in a subset of patients with traumatic brain injury
    Andrew Stewart Levy
    InterMountain Neurosurgery, St Anthony Central Hospital, Denver, Colorado, USA
    J Trauma 68:886-94. 2010
    ..We examined risk factors for hemorrhage progression in patients with blunt TBI and hypothesized that PTP would increase ICH progression in a subset of these patients...
  32. ncbi request reprint Commercial human albumin preparations for clinical use are immunosuppressive in vitro
    David Bar-Or
    Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
    Crit Care Med 34:1707-12. 2006
    ..In this report, we investigated what effect the presence of HSA products have on the immune response in vitro...
  33. ncbi request reprint Anemia associated with critical illness: is the erythropoietin receptor a culprit?
    David Bar-Or
    Crit Care Med 32:1234-5. 2004
  34. doi request reprint Constipation, critical illness and mortality: gut-derived toxidromes--real and now imagined
    Raymond E Garrett
    Crit Care Med 36:2710-1; author reply 2711. 2008
  35. ncbi request reprint An artificial neural network derived trauma outcome prediction score as an aid to triage for non-clinicians
    Adrian Pearl
    Swedish Medical Center and St Anthonys Central Hospital Trauma Research Lab, Englewood, Colorado USA
    Stud Health Technol Inform 136:253-8. 2008
    ..Possible additional variables such as gender or ethnicity might improve the Neural Network predictive ability. Pulse appears an essential variable not recorded by the NTDB...