Research Topics
Species | D Bar-OrSummaryAffiliation: Swedish Medical Center Country: USA Publications
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Publications
Heterogeneity and oxidation status of commercial human albumin preparations in clinical useDavid Bar-Or
Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
Crit Care Med 33:1638-41. 2005..Also, the variability within lots from the same manufacturer is significant. Consequences of the administration of these oxidized forms of human serum albumin to critically ill patients warrants further investigation...- Characterization of the Co(2+) and Ni(2+) binding amino-acid residues of the N-terminus of human albumin. An insight into the mechanism of a new assay for myocardial ischemiaD Bar-Or
Department of Trauma Research, Swedish Medical Center Englewood, CO 80110, USA
Eur J Biochem 268:42-7. 2001.... 
Reduced mortality at a community hospital trauma center: the impact of changing trauma level designation From II to IKristin Scarborough
Trauma Research Department, Swedish Medical Center, 501 E Hampden Ave, Room 4 454, Englewood, CO 80113
Arch Surg 143:22-7; discussion 27-8. 2008..To determine if a change in trauma designation from level II (L2) to level I (L1) in the same institution reduces mortality. Design, Setting, and..- The cobalt-albumin binding assay: insights into its mode of actionDavid Bar-Or
Swedish Medical Center, Trauma Research Laboratory, Englewood, CO, USA Swedish Medical Center, Emergency Department, Englewood, CO 80113, USA
Clin Chim Acta 387:120-7. 2008..In this investigation, we attempt to clarify the mode of action of the cobalt-HSA binding assay by direct observations of cobalt binding to HSA... - Mass spectrometry analysis of urine and catheter of a patient with purple urinary bag syndromeDavid Bar-Or
Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
Clin Chim Acta 378:216-8. 2007..Purple urinary bag syndrome (PUBS) is considered to be a benign condition observed in the urinary catheter and bag in some catheterized patients with urinary tract infections. This syndrome is usually reported to occur in alkaline urine... - Severe systemic immune response syndrome, low plasma paraoxonase activity, and a new albumin species in a traumatized patient with Gaucher's diseaseDavid Bar-Or
Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
Clin Chim Acta 374:135-9. 2006..Gaucher's disease (GD) is an inborn error, autosomal recessive lysosomal lipid storage disorder characterized by the lack of the enzyme glucocerebrosidase. We observed some abnormalities in the plasma of a traumatized patient with GD... - The formation and rapid clearance of a truncated albumin species in a critically ill patientDavid Bar-Or
Swedish Medical Center, Trauma Research Laboratory, 501 E Hampden Ave, Englewood, CO 80113, USA
Clin Chim Acta 365:346-9. 2006..Hypoalbuminemia is known to occur in critically ill patients and is associated with increased mortality. We observed a potentially novel, partial explanation for the hypoalbuminemia noticed in a severely traumatized patient... - Diagnostic potential of phosphorylated cardiac troponin I as a sensitive, cardiac-specific marker for early acute coronary syndrome: preliminary reportDavid Bar-Or
Swedish Medical Center, Trauma Research Dept, Englewood, CO 80113, USA
Clin Chim Acta 362:65-70. 2005..Cardiac troponin I (cTnI) has low sensitivity in the early hours of acute coronary syndrome (ACS). For patients with early ACS symptoms, we determined the diagnostic potential of an immunoassay for phosphorylated cTnI (PO(4)-cTnI)... - Cysteinylation of maternal plasma albumin and its association with intrauterine growth restrictionDavid Bar-Or
Swedish Medical Center, Trauma Research Department, Englewood, CO 80113, USA
Prenat Diagn 25:245-9. 2005..High-risk pregnancies and uteroplacental insufficiency (UPI) have been associated with elevated levels of homocysteine, and, in oxidizing environments, homocysteine is converted to cysteine, resulting in cysteinylation of proteins... - Plasma albumin cysteinylation is regulated by cystathionine beta-synthaseDavid Bar-Or
Trauma Research Department, Swedish Medical Center, Englewood, CO, USA
Biochem Biophys Res Commun 325:1449-53. 2004..CysAlb may serve as a biomarker for the severity of gut ischemia, and high Hcy may explain endothelial damage associated with this model. Additionally, active CBS is essential for the formation of CysAlb... - Asp-Ala-His-Lys (DAHK) inhibits copper-induced oxidative DNA double strand breaks and telomere shorteningD Bar-Or
Trauma Research, Swedish Medical Center, Englewood, Colorado, 80110, USA
Biochem Biophys Res Commun 282:356-60. 2001..The human albumin N-terminus analog, d-DAHK, protects DNA and telomeres against copper-mediated ROS damage and may be a useful therapeutic adjunct in ROS disease processes... - Reduced albumin-cobalt binding with transient myocardial ischemia after elective percutaneous transluminal coronary angioplasty: a preliminary comparison to creatine kinase-MB, myoglobin, and troponin ID Bar-Or
Swedish Medical Center
Am Heart J 141:985-91. 2001..We then compared ACB assay results with creatine kinase isoenzyme (CK-MB), myoglobin, and cardiac troponin I (cTn-I) values after PTCA... - An analog of the human albumin N-terminus (Asp-Ala-His-Lys) prevents formation of copper-induced reactive oxygen speciesD Bar-Or
Department of Trauma Research, Swedish Medical Center, Englewood, Colorado 80110, USA
Biochem Biophys Res Commun 284:856-62. 2001.... - Staff commitment to trauma care improves mortality and length of stay at a level I trauma centerCharles Mains
Trauma Services Department, St Anthony Central Hospital, Denver, Colorado, USA
J Trauma 66:1315-20. 2009..The purpose of this study was to assess whether staffing changes within a Level I trauma center improved mortality and shortened length of stay (LOS) for trauma patients... - Low albumin level in the emergency department: a potential independent predictor of delayed mortality in blunt traumaRichard L Yukl
Department of Trauma Research, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80110-2795, USA
J Emerg Med 25:1-6. 2003.... - Dehydroalanine derived from cysteine is a common post-translational modification in human serum albuminRaphael Bar-Or
Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA
Rapid Commun Mass Spectrom 22:711-6. 2008..The presence of this common PTM of HSA has potential effects on ligand binding to HSA, plasma clearance of this oxidized form of HSA, protein-protein interactions, and oxidation-reduction potential... - Clinical utility of the cobalt-albumin binding assay in the diagnosis of intestinal ischemiaJonathan D Polk
Saint Joseph Hospital, Denver, Colorado, USA
J Trauma 64:42-5. 2008..This resulted in a sensitivity of 100% and a specificity of 85.7% for the CABA test for these particular samples. The CABA test could be a useful tool for clinicians in the risk stratification of intestinal ischemia... - Oxidation-reduction potential and paraoxonase-arylesterase activity in trauma patientsLeonard T Rael
Swedish Medical Center, Trauma Research Laboratory, 501 E Hampden Avenue Rm 4 454, Englewood, CO 80113, USA
Biochem Biophys Res Commun 361:561-5. 2007..Monitoring ORP could be a useful tool for assessing the degree of oxidative stress, inflammation, severity of injury, and potential efficacy of treatment... - The impact of the AIS 2005 revision on injury severity scores and clinical outcome measuresKristin Salottolo
Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA
Injury 40:999-1003. 2009..The abbreviated injury scale (AIS) was updated in 2005 from the AIS 1998 version. The purpose of this study is to describe the effects of this change on injury severity scoring and outcome measures... - Effects of a nonsurgical hospitalist service on trauma patient outcomesKristin Salottolo
Trauma Research Department, Swedish Medical Center, Englewood, CO 80113, USA
Surgery 145:355-61. 2009..We hypothesized outcomes would be equivalent for patients treated under TMED versus a surgical service... - Inhibitory effect of copper on cystathionine beta-synthase activity: protective effect of an analog of the human albumin N-terminusDavid Bar-Or
Department of Trauma Research and Trauma Services, Swedish Medical Center, 501 E. Hampden Avenue, Englewood, CO 80113, USA
Protein Pept Lett 12:271-3. 2005..The use of copper chelators could significantly reduce in vivo homocysteine levels... - Plasma oxidation-reduction potential and protein oxidation in traumatic brain injuryLeonard T Rael
Trauma Research Laboratory, Swedish Medical Center, Englewood, CO 80113, USA
J Neurotrauma 26:1203-11. 2009..Therefore monitoring ORP is a potentially useful tool for assessing the degree of oxidative stress, inflammation, severity of injury, and potential efficacy of treatment in ITBI patients... - The effect of storage on the accumulation of oxidative biomarkers in donated packed red blood cellsLeonard T Rael
Swedish Medical Center, Trauma Research Laboratory, Englewood, Colorado 80113, USA
J Trauma 66:76-81. 2009..Longer storage times of packed red blood cells (PRBC) and other blood products have been implicated with an increased risk in developing TRALI in transfused patients... - Copper-induced oxidation of epinephrine: protective effect of D-DAHK, a synthetic analogue of the high affinity copper binding site of human albuminAngela Roberts
Department of Trauma Research, Swedish Medical Center, 501 E Hampden Avenue, Englewood, CO 80110, USA
Biochem Biophys Res Commun 304:755-7. 2003..These in vitro results indicate that copper-induced epinephrine oxidation is greatest at the physiological pH 7.4 as well as in severe acidosis, pH 7.0, and that D-DAHK completely inhibits this oxidation... - Artificial neural network versus subjective scoring in predicting mortality in trauma patientsAdrian Pearl
Swedish Medical Center, Trauma Research Dept, Englewood, Colorado. USA
Stud Health Technol Inform 124:1019-24. 2006..CONCLUSIONS: An ANN developed using pre-hospital physiological variables without using subjective scores resulted in good mortality prediction when applied to a test set. Its performance was too sensitive and requires refinement... - Copper inhibits activated protein C: protective effect of human albumin and an analogue of its high-affinity copper-binding site, d-DAHKDavid Bar-Or
Trauma Research Department, Swedish Medical Center, 501 East Hampden Avenue, Englewood, Colorado 80110, USA
Biochem Biophys Res Commun 290:1388-92. 2002..4 microM copper, which helps explain the increased APC activity with HSA and d-DAHK alone. These in vitro results indicate that copper inhibits APC activity and that albumin and d-DAHK reverse the copper-induced APC deactivation... - Interleukin-16 expression in the peripheral blood and CD8 T lymphocytes after traumatic injuryRichard Shimonkevitz
Trauma Research Department, HealthOne Swedish Medical Center, Englewood, CO 80113, USA
J Trauma 58:252-8. 2005..CONCLUSION: Posttraumatic changes in IL-16 expression were found to be associated with worse patient outcome, suggesting an innate immune mechanism with a role in regulation of the T lymphocyte response to injury... - Using artificial neural networks to predict potential complications during trauma patients' hospitalization periodAdrian Pearl
Trauma Research Department, Swedish Medical Center, Englewood, CO, USA
Stud Health Technol Inform 150:610-4. 2009..Predicting Urinary Tract Infections (UTI) cases is not good enough using these input variables. Both VAP and UTI relate to those aged over 55 years, while ARDS related more to those under 16 years. The models need improving... - A diketopiperazine fragment of human serum albumin modulates T-lymphocyte cytokine production through rap1Richard Shimonkevitz
Trauma Research Department, HealthOne Swedish Medical Center, Englewood, Colorado, USA
J Trauma 64:35-41. 2008..Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP... - Current utilization and radiation dose from computed tomography in patients with traumaKristin Salottolo
Department of Trauma Research, Swedish Medical Center, Englewood, CO, USA
Crit Care Med 37:1336-40. 2009..To quantify the cumulative effective dose of radiation received during hospitalization after traumatic injury and to compare the computed tomography (CT) utilization practices for two time periods in patients with trauma... - Pharmacologic thromboprophylaxis is a risk factor for hemorrhage progression in a subset of patients with traumatic brain injuryAndrew Stewart Levy
InterMountain Neurosurgery, St Anthony Central Hospital, Denver, Colorado, USA
J Trauma 68:886-94. 2010..We examined risk factors for hemorrhage progression in patients with blunt TBI and hypothesized that PTP would increase ICH progression in a subset of these patients... - Commercial human albumin preparations for clinical use are immunosuppressive in vitroDavid Bar-Or
Swedish Medical Center, Trauma Research Laboratory, Englewood, CO 80113, USA
Crit Care Med 34:1707-12. 2006..In view of these findings, administering HSA to immunocompromised critically ill patients might be reevaluated... - Anemia associated with critical illness: is the erythropoietin receptor a culprit?David Bar-Or
Crit Care Med 32:1234-5. 2004 - Constipation, critical illness and mortality: gut-derived toxidromes--real and now imaginedRaymond E Garrett
Crit Care Med 36:2710-1; author reply 2711. 2008 - An artificial neural network derived trauma outcome prediction score as an aid to triage for non-cliniciansAdrian Pearl
Swedish Medical Center and St Anthonys Central Hospital Trauma Research Lab, Englewood, Colorado USA
Stud Health Technol Inform 136:253-8. 2008..Possible additional variables such as gender or ethnicity might improve the Neural Network predictive ability. Pulse appears an essential variable not recorded by the NTDB...