Research Topics
| Sheena K AuroraSummaryAffiliation: Swedish Medical Center Country: USA Publications
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Detail Information
Publications
The brain is hyperexcitable in migraineS K Aurora
Centre for Vision Research, York University, Toronto, Canada
Cephalalgia 27:1442-53. 2007..This is a review of the neurophysiological studies which have provided an insight to migraine pathogenesis supporting the theory of hyperexcitability...
Risk of placental abruption in relation to migraines and headachesSixto E Sanchez
Department of Obstetrics and Gynecology, Hospital Nacional Dos de Mayo, and Universidad San Martin de Porres, Lima, Peru
BMC Womens Health 10:30. 2010..We assessed risk of placental abruption in relation to maternal history of migraine before and during pregnancy in Peruvian women...
Sleep duration, vital exhaustion and perceived stress among pregnant migraineurs and non-migraineursMichelle A Williams
Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA
BMC Pregnancy Childbirth 10:72. 2010..Migraine has been associated with sleep disorders in men and non-pregnant women, but little is known about sleep complaints among pregnant migraineurs...
OnabotulinumtoxinA for treatment of chronic migraine: results from the double-blind, randomized, placebo-controlled phase of the PREEMPT 1 trialS K Aurora
Swedish Neuroscience Institute, USA
Cephalalgia 30:793-803. 2010..This is the first of a pair of studies designed to assess efficacy, safety and tolerability of onabotulinumtoxinA (BOTOX) as headache prophylaxis in adults with chronic migraine...
Topiramate modulates excitability of the occipital cortex when measured by transcranial magnetic stimulationS K Aurora
Swedish Headache Center, Seattle, WA 98104, USA
Cephalalgia 30:648-54. 2010....
Mechanism of chronic migraineSheena K Aurora
Swedish Headache Center, Swedish Neurosciences Institute, 1221 Madison Street, Seattle, WA 98116, USA
Curr Pain Headache Rep 15:57-63. 2011..This model also implies that prevention of chronic migraine is an important goal in the management of episodic migraine, particularly in individuals who exhibit risk factors for chronic transformation...
Is chronic migraine one end of a spectrum of migraine or a separate entity?S K Aurora
Swedish Headache Center, Swedish Neurosciences Institute, 1221 Madison, Suite 1026, Seattle, WA 98116, USA
Cephalalgia 29:597-605. 2009..From current research and migraine models, a conceptualization of chronic migraine is emerging in which relatively permanent and pervasive central changes have occurred that warrant novel and tolerable treatments...
Spectrum of illness: understanding biological patterns and relationships in chronic migraineSheena K Aurora
Swedish Pain and Headache Center, 1101 Madison Street, Suite 200, Seattle, WA 98104, USA
Neurology 72:S8-13. 2009..This model also implies that prevention of CM is an important goal in the management of EM, particularly for individuals who exhibit risk factors for chronic transformation...
Implications of current clinical trials focused on medication overuse and therapeutic prophylaxisSheena K Aurora
Swedish Headache Center, Seattle, WA 98104, USA
Headache 51:93-100. 2011..In this program, we will analyze and discuss recent clinical trials investigating topiramate and onabotulinumtoxinA for CM...
Botulinum toxin type A for the treatment of migraineSheena Aurora
Swedish Headache Center, University of Washington, Seattle, WA 98104, USA
Expert Opin Pharmacother 7:1085-95. 2006....
New insights into brain dysfunction in migraineSheena K Aurora
Swedish Headache Center, Seattle, WA, USA
Expert Rev Neurother 6:307-12. 2006..These are usually evident on neuroimaging or laboratory testing. This review will focus mainly on mechanisms of primary headache (i.e., migraine and cluster)...
OnabotulinumtoxinA for treatment of chronic migraine: pooled analyses of the 56-week PREEMPT clinical programSheena K Aurora
Swedish Neuroscience Institute, Seattle, WA, USA
Headache 51:1358-73. 2011..To evaluate safety and efficacy of onabotulinumtoxinA (BOTOX(®) ) as headache prophylaxis in adults with chronic migraine...
Imaging chronic daily headacheSheena K Aurora
Swedish Headache Center, Swedish Neurosciences Institute, 1221 Madison, Suite 1026, Seattle, WA 98116, USA
Curr Pain Headache Rep 7:209-11. 2003..A systematic review was performed using key words "chronic daily headache" and "imaging." This paper reviews the literature on imaging studies performed on daily headache with emphasis on the new imaging technology...
The threshold for phosphenes is lower in migraineS K Aurora
Headache Research Center, Henry Ford Health Sciences Center, Detroit, MI, USA
Cephalalgia 23:258-63. 2003..This is a direct neurophysiological correlate for clinical observations, which have inferred hyperexicitability of the occipital cortex in migraineurs...
Etiology and pathogenesis of cluster headacheSheena K Aurora
Swedish Headache Clinic, Swedish Neurosciences Center, 1221 Madison, Suite 1026, Seattle, WA 98104, USA
Curr Pain Headache Rep 6:71-5. 2002..There is now an increasing body of evidence that the brain is involved primarily in cluster and migraine and that vessel dilatation is an epiphenomenon...
Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illnessSheena K Aurora
Swedish Headache Center, Seattle, WA 98104, and University of Hawaii at Manoa, Department of Psychology, Honolulu, USA
Headache 45:546-52. 2005..This may contribute to their greatly increased attack frequency. TMS-based methods will be important for future research examining the evolution of chronic migraine from episodic migraine over time...
Botulinum toxin type a prophylactic treatment of episodic migraine: a randomized, double-blind, placebo-controlled exploratory studySheena K Aurora
Swedish Pain Center, Seattle, WA 98104, USA
Headache 47:486-99. 2007..This exploratory trial evaluated the safety and efficacy of multiple treatments of botulinum toxin type A (BoNTA; BOTOX, Allergan, Inc., Irvine, CA, USA) as prophylactic treatment of episodic migraine headaches...
Revisiting the efficacy of sumatriptan therapy during the aura phase of migraineSheena K Aurora
The Swedish Medical Center, Seattle, WA, USA
Headache 49:1001-4. 2009..Background.- Although the antimigraine action of triptans is most effective soon after onset of the headache, treatment during the aura phase has been found to be ineffective...
A randomized, double blind, placebo-controlled study of MAP0004 in adult patients with migraineSheena K Aurora
Swedish Pain and Headache Center, Seattle, WA, USA
Headache 49:826-37. 2009..A new formulation of DHE delivered through the lungs by the novel Tempo inhaler is being developed and is designed to offer fast onset, consistent dosing, and sustained response...
Brainstem dysfunction in chronic migraine as evidenced by neurophysiological and positron emission tomography studiesSheena K Aurora
Swedish Headache Center, 1101 Madison 200, Seattle, WA 98104, USA
Headache 47:996-1003; discussion 1004-7. 2007..We aimed to examine transcranial magnetic stimulation (TMS) indices of cortical excitability in patients with CM and also performed PET studies to ascertain if there were any areas of activation and inhibition for possible correlation...
Gastric stasis in migraineurs: Etiology, characteristics, and clinical and therapeutic implicationsSheena K Aurora
Swedish Neuroscience Institute, USA
Cephalalgia 33:408-15. 2013..The association between migraine and gastric stasis has received very little attention in the literature, but the existing evidence suggests that they may share a common etiology...
Trimester-specific blood pressure levels and hypertensive disorders among pregnant migraineursMichelle A Williams
Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA
Headache 51:1468-82. 2011..We evaluated the influence of physician-diagnosed migraine on blood pressure levels and the risk of hypertensive disorders of pregnancy in a clinic-based prospective cohort study of 3373 healthy pregnant women...
MAP0004, orally inhaled DHE: a randomized, controlled study in the acute treatment of migraineSheena K Aurora
Swedish Headache Center, Seattle, WA, USA
Headache 51:507-17. 2011..To evaluate the efficacy and tolerability of MAP0004 compared with placebo for a single migraine in adult migraineurs: The FREEDOM-301 Study...
Migraine's magnetic attractionSheena K Aurora
Swedish Neuroscience Institute, Seattle, WA, USA
Lancet Neurol 1:211. 2002
