Frank A Middleton

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. ncbi request reprint Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia
    Frank A Middleton
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:2718-29. 2002
  2. ncbi request reprint Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms
    Yanli Zhang
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 137:5-16. 2005
  3. pmc Genomic investigation of alpha-synuclein multiplication and parkinsonism
    Owen A Ross
    Division of Neurogenetics, Department of Neuroscience, College of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 63:743-50. 2008
  4. pmc Behavioral and genetic evidence for a novel animal model of Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype
    T Sagvolden
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Behav Brain Funct 4:56. 2008
  5. pmc Intrinsic response of thoracic propriospinal neurons to axotomy
    Justin R Siebert
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse New York, USA
    BMC Neurosci 11:69. 2010
  6. ncbi request reprint Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches
    Frank A Middleton
    Center for Neuropsychiatric Genetics, Upstate Medical University, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 136:12-25. 2005
  7. ncbi request reprint Application of genomic technologies: DNA microarrays and metabolic profiling of obesity in the hypothalamus and in subcutaneous fat
    Frank A Middleton
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Nutrition 20:14-25. 2004
  8. ncbi request reprint Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation
    Yan Wang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, Syracuse, NY 13202, USA
    Cells Tissues Organs 186:192-203. 2007
  9. pmc Microarray cluster analysis of irradiated growth plate zones following laser microdissection
    Timothy A Damron
    SUNY Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 74:949-56. 2009
  10. pmc Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways
    Mingliang Zhang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Syracuse, New York, 13210, USA
    Bone 43:511-20. 2008

Research Grants

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia
    Frank A Middleton
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:2718-29. 2002
    ....
  2. ncbi request reprint Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms
    Yanli Zhang
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 137:5-16. 2005
    ..Several novel gene and gene group findings were also obtained that offer new insight into the pathogenesis and potential treatment of PD...
  3. pmc Genomic investigation of alpha-synuclein multiplication and parkinsonism
    Owen A Ross
    Division of Neurogenetics, Department of Neuroscience, College of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 63:743-50. 2008
    ..Herein we characterize five families with parkinsonism that have been identified to harbor multiplication of the chromosomal 4q21 locus containing the alpha-synuclein gene (SNCA)...
  4. pmc Behavioral and genetic evidence for a novel animal model of Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype
    T Sagvolden
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Behav Brain Funct 4:56. 2008
    ..abstract:..
  5. pmc Intrinsic response of thoracic propriospinal neurons to axotomy
    Justin R Siebert
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse New York, USA
    BMC Neurosci 11:69. 2010
    ..On the other hand, propriospinal (PS) neurons, with axons intrinsic to the spinal cord, have shown a greater regenerative response than their supraspinal counterparts, but remain relatively understudied in regards to spinal cord injury...
  6. ncbi request reprint Gene expression analysis of peripheral blood leukocytes from discordant sib-pairs with schizophrenia and bipolar disorder reveals points of convergence between genetic and functional genomic approaches
    Frank A Middleton
    Center for Neuropsychiatric Genetics, Upstate Medical University, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 136:12-25. 2005
    ..Verification of selected changes in expression was performed using quantitative real-time RT-PCR. Our results provide compelling evidence for the utility of analyzing PBL RNA for changes in expression in neuropsychiatric disorders...
  7. ncbi request reprint Application of genomic technologies: DNA microarrays and metabolic profiling of obesity in the hypothalamus and in subcutaneous fat
    Frank A Middleton
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Nutrition 20:14-25. 2004
  8. ncbi request reprint Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation
    Yan Wang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, Syracuse, NY 13202, USA
    Cells Tissues Organs 186:192-203. 2007
    ..The hypothesis was that a limited number of growth factors and cytokines play a role in growth plate proliferative and hypertrophic chondrocyte radio-recovery...
  9. pmc Microarray cluster analysis of irradiated growth plate zones following laser microdissection
    Timothy A Damron
    SUNY Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 74:949-56. 2009
    ..Genes and pathways involved in early growth plate chondrocyte recovery after fractionated irradiation were sought as potential targets for selective radiorecovery modulation...
  10. pmc Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways
    Mingliang Zhang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Syracuse, New York, 13210, USA
    Bone 43:511-20. 2008
    ..We conclude that differential gene expression exists between the RZ and PC chondrocytes and these differentially expressed genes have unique roles to play corresponding to the function of their respective zones...
  11. ncbi request reprint Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family
    Marina Myles-Worsley
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 162:87-95. 2013
    ....
  12. pmc Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations
    STEVEN D HICKS
    Department of Neuroscience, Upstate Medical University, Syracuse, NY 13210, USA
    BMC Neurosci 13:128. 2012
    ....
  13. ncbi request reprint Transcriptional profiling of depolarization-dependent phenotypic alterations in primary cultures of developing granule neurons
    Cuong J Bui
    Department of Neurosurgery, SUNY, Upstate Medical University, Syracuse, NY 13210, USA
    Brain Res 1119:13-25. 2006
    ..Altogether, these data indicate that growth in 5 mM KCl more closely mimics survival and maturation of granule neurons in vivo and should therefore be adopted in future studies...
  14. pmc Differential expression of SLC9A9 and interacting molecules in the hippocampus of rat models for attention deficit/hyperactivity disorder
    Yanli Zhang-James
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Dev Neurosci 34:218-27. 2012
    ..Our results suggest that abnormalities in SLC9A9-mediated signaling pathways could contribute to the ADHD phenotype of two rat models (WKY/NCrl and SHR/NCrl), and that the perturbation of the SLC9A9 network is age-dependent...
  15. pmc Regulating the availability of transforming growth factor ß1 in B104 neuroblastoma cells
    Amanda L Lindke
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse NY 13210, USA
    Exp Neurol 225:123-32. 2010
    ..These activities appear to be key for the role of TGFbeta1 in the proliferation and migration of young neurons...
  16. pmc Activation of mammalian target of rapamycin controls the loss of TCRzeta in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation
    David R Fernandez
    Division of Rheumatology, Department of Medicine, State University of New York, Syracuse, NY 13210, USA
    J Immunol 182:2063-73. 2009
    ..The results suggest that activation of mTOR causes the loss of TCRzeta in lupus T cells through HRES-1/Rab4-dependent lysosomal degradation...
  17. doi request reprint Thrombospondin-1: a proatherosclerotic protein augmented by hyperglycemia
    Kristopher G Maier
    Division of Vascular Surgery and Endovascular Services, SUNY Upstate Medical University, Syracuse, NY, USA
    J Vasc Surg 51:1238-47. 2010
    ..This study tested the hypothesis that hyperglycemia amplifies the expression of genes induced by TSP-1 in VSMCs...
  18. pmc Hierarchical clustering of gene expression patterns in the Eomes + lineage of excitatory neurons during early neocortical development
    David A Cameron
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    BMC Neurosci 13:90. 2012
    ..To identify genes selectively expressed by the Eomes + (Tbr2) lineage of excitatory cortical neurons, GFP-expressing cells from Tg(Eomes::eGFP) Gsat embryos were isolated to > 99% purity and profiled...
  19. doi request reprint Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing
    Yueming Qian
    Department of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Biochem J 415:123-34. 2008
    ..The present study identified the TAL deficiency as a modulator of mitochondrial homoeostasis, Ca(2+) fluxing and apoptosis...
  20. pmc Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine
    Robert Hanczko
    Department of Medicine, College of Medicine, State University of New York, Syracuse, New York 13210, USA
    J Clin Invest 119:1546-57. 2009
    ..These data reveal a protective role for the TAL-mediated branch of the PPP against hepatocarcinogenesis and identify NAC as a promising treatment for liver disease in TAL deficiency...
  21. ncbi request reprint Complete maternal uniparental isodisomy of chromosome 4 in a subject with major depressive disorder detected by high density SNP genotyping arrays
    Frank A Middleton
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA
    Am J Med Genet B Neuropsychiatr Genet 141:28-32. 2006
    ..However, since there is no reported case of paternal chromosome 4 UPD, paternal gene imprinting on chromosome 4 cannot be excluded...
  22. pmc Genetic architecture of Wistar-Kyoto rat and spontaneously hypertensive rat substrains from different sources
    Yanli Zhang-James
    Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, New York, USA
    Physiol Genomics 45:528-38. 2013
    ..Moreover, we found two closely related, yet distinct WKY substrains that may provide novel opportunities in modeling psychiatric disorders. ..
  23. ncbi request reprint Weight regain after Roux-en-Y: a significant 20% complication related to PYY
    Michael M Meguid
    Surgical Metabolism and Nutrition Laboratory, Department Surgery, Neuroscience and Physiology Program, SUNY Upstate Medical University, Syracuse, New York, USA
    Nutrition 24:832-42. 2008
    ..Roux-en-Y gastric bypass (RYGB) produces rapid and dramatic weight loss in very heavy obese patients. Up to 20% cannot sustain their weight loss beyond 2 to 3 y after surgery...
  24. ncbi request reprint Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats
    Ana Guijarro
    Dept of Surgery, University Hospital, 750 East Adams St, Syracuse, NY 13210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1474-89. 2007
    ..These events override the compensatory response to the drop in leptin levels aimed at conserving energy...
  25. pmc SLC9A9 mutations, gene expression, and protein-protein interactions in rat models of attention-deficit/hyperactivity disorder
    Yanli Zhang-James
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 156:835-43. 2011
    ..Our data suggest a novel mechanism whereby SLC9A9 sequence variants and abnormalities in gene expression could contribute to the ADHD-like symptoms of rat models and possibly the pathophysiology of ADHD in humans...
  26. doi request reprint Ethanol-induced methylation of cell cycle genes in neural stem cells
    STEVEN D HICKS
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Neurochem 114:1767-80. 2010
    ..Thus, ethanol disrupts growth factor-related cell cycle progression by inducing checkpoint restriction at the G1/S transition through a feed-forward system involving the methylation of G2/M regulators...
  27. pmc Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats
    Frank A Middleton
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Brain Res 1252:105-16. 2009
    ..Further, they provide insight into an important relationship between fetal exposure to ethanol, adolescent odor responsiveness to the drug and potential underlying molecular mechanisms for the odor-guided behavioral response...
  28. doi request reprint Cyclosporine inhibition of angiogenesis involves the transcription factor HESR1
    Gaurang Shah
    Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Surg Res 149:171-6. 2008
    ..To determine which nuclear factor, if any, may be involved in the antiangiogenic effects of CyA, we performed a microarray analysis of human aortic endothelial cells (HAEC) subjected to CyA and another calcineurin inhibitor, FK 506...
  29. ncbi request reprint Transforming growth factor beta1 and ethanol affect transcription and translation of genes and proteins for cell adhesion molecules in B104 neuroblastoma cells
    Michael W Miller
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Neurochem 97:1182-90. 2006
    ..Thus, the effects of TGFbeta1 and ethanol on CAPs parallel changes described in vivo and likely underlie changes associated with ethanol-induced alterations in neuronal migration...
  30. pmc Molecular substrates of social avoidance seen following prenatal ethanol exposure and its reversal by social enrichment
    Frank A Middleton
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, N Y, USA
    Dev Neurosci 34:115-28. 2012
    ....
  31. doi request reprint Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus
    Rudolf Pullmann
    State University of New York, Syracuse, NY 13210, USA
    Arthritis Rheum 58:532-40. 2008
    ..We therefore undertook the present study to determine the haplotypes of the HRES-1 locus and their linkage to SLE...
  32. ncbi request reprint Gene expression profiles of intact and regenerating zebrafish retina
    David A Cameron
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Mol Vis 11:775-91. 2005
    ..Investigate the molecular determinants of retinal regeneration in adult vertebrates by analyzing the gene expression of control and post-lesion retina of adult zebrafish, a system that regenerates following injury...
  33. pmc Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa
    Andras Perl
    Department of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, USA
    Proc Natl Acad Sci U S A 103:14813-8. 2006
    ..Collectively, these data reveal an essential role of TAL in sperm-cell mitochondrial function and, thus, male fertility...
  34. ncbi request reprint Growth plate zonal microarray analysis shows upregulation of extracellular matrix genes and downregulation of metalloproteinases and cathepsins following irradiation
    Mingliang Zhang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Suite 130, 550 Harrison Street, Syracuse, NY 13210, USA
    Calcif Tissue Int 81:26-38. 2007
    ..Upregulation of genes not normally highly expressed in the noninjured growth plate suggests their importance in the injury and repair response...
  35. pmc A comparison of molecular alterations in environmental and genetic rat models of ADHD: a pilot study
    Tania DasBanerjee
    Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1554-63. 2008
    ..The data provide strong evidence that genes and environment can affect different set of genes in two different models of ADHD and yet result in the similar disease-like symptoms...
  36. doi request reprint Familial transmission of schizophrenia in Palau: A 20-year genetic epidemiological study in three generations
    Marina Myles-Worsley
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 156:247-54. 2011
    ..As they evolve, these HD families can help to elucidate the genetic mechanisms that predict intergenerational transmission of SCZ...
  37. ncbi request reprint Effects of omega-3 fatty acid supplementation on tumor-bearing rats
    Eduardo J B Ramos
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medical University, University Hospital, Syracuse, NY 13210, USA
    J Am Coll Surg 199:716-23. 2004
    ..We hypothesized that dietary fish oil reverses the feeding pattern of tumor anorexia, increasing food intake and retarding tumor growth...
  38. pmc Autism-related behavioral phenotypes in an inbred rat substrain
    Yanli Zhang-James
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, United States Electronic address
    Behav Brain Res 269:103-14. 2014
    ....
  39. pmc Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia
    Ori S Cohen
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory PsychGENe Lab, USA
    Schizophr Res 142:188-99. 2012
    ..These results, if further replicated, clearly illustrate the importance of Identifying transcriptomic variants in expression studies, and implicate novel candidate genes in the disorder...
  40. pmc The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI study
    Ioana L Coman
    Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York, USA
    Neuroimage 53:1043-50. 2010
    ....
  41. ncbi request reprint Isolation and confirmation of a calcium excretion quantitative trait locus on chromosome 1 in genetic hypercalciuric stone-forming congenic rats
    Richard R Hoopes
    Department of Medicine, SUNY Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    J Am Soc Nephrol 17:1292-304. 2006
    ..This is the first QTL for hypercalciuria to be isolated in a congenic animal...
  42. ncbi request reprint Depolarization and Ca(2+) down regulate CB1 receptors and CB1-mediated signaling in cerebellar granule neurons
    Mary Lou Vallano
    Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Neuropharmacology 50:651-60. 2006
    ..Further, they suggest that a depolarization and Ca(2+)-dependent signaling pathway represses CB1 gene transcription...
  43. pmc Accuracy of self-reported medical problems in patients with alcohol dependence and co-occurring schizophrenia or schizoaffective disorder
    Zsuzsa Szombathyne Meszaros
    Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, United States
    Schizophr Res 132:190-3. 2011
    ..Schizophrenia and alcohol dependence (AD) are both major risk factors for a variety of medical problems, yet little is known about the medical status of patients in whom both conditions coexist...
  44. pmc Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjects
    Chiharu Kumagai
    Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Neuroimmunol 246:51-7. 2012
    ....
  45. pmc Long descending cervical propriospinal neurons differ from thoracic propriospinal neurons in response to low thoracic spinal injury
    Justin R Siebert
    Department of Cell and Developmental Biology, SUNY Upstate Medical University 750 East Adams Street Syracuse, New York 13210, USA
    BMC Neurosci 11:148. 2010
    ..These neurons also were axotomized by T9 spinal injury in the same animals used in our previous study...
  46. pmc A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease
    Antony E Shrimpton
    Department of Clinical Pathology, State University of New York, Upstate Medical University, Syracuse, 13210, USA
    Am J Hum Genet 75:92-6. 2004
    ..In the study family, this mutation was fully penetrant and exhibited significant evidence of linkage (LOD 6.33; theta =0), and it very likely accounts for both CVT and CMT in heterozygotes...
  47. ncbi request reprint Heat shock protein 12A shows reduced expression in the prefrontal cortex of subjects with schizophrenia
    Julie L Pongrac
    Department of Psychiatry, E1655 BST, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biol Psychiatry 56:943-50. 2004
    ..001; mean log2 signal difference = -.58) in transcript expression for a gene clone KIAA0417. This database entry has been recently annotated as two highly homologous members of a heat-shock protein family (HSPA12A and HSPA12B)...
  48. ncbi request reprint Genetic linkage of bipolar disorder to chromosome 6q22 is a consistent finding in Portuguese subpopulations and may generalize to broader populations
    Carlos N Pato
    Veterans Affairs Medical Center, Washington, DC 20422, USA
    Am J Med Genet B Neuropsychiatr Genet 134:119-21. 2005
    ..Taken together these observations suggest a shared genetic liability among Portuguese populations for bipolar disorder on chromosome 6q, and that the PIC population is likely representative of Caucasians in general...
  49. ncbi request reprint Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders
    Julie Pongrac
    Neurochem Res 27:1049-63. 2002
    ..Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings...
  50. ncbi request reprint Association and linkage analyses of RGS4 polymorphisms in schizophrenia
    Kodavali V Chowdari
    Department of Psychiatry, University of Pittsburgh, School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, PA 15213, USA
    Hum Mol Genet 11:1373-80. 2002
    ..Our results illustrate the potential power of combining gene expression profiling and genomic analyses to identify susceptibility genes for genetically complex disorders...
  51. ncbi request reprint Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia
    Frank A Middleton
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 30:974-83. 2005
    ....
  52. ncbi request reprint Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function
    Claudia B Zraly
    Cardinal Bernardin Cancer Center, Oncology Institute and Department of Pathology, Loyola University of Chicago, Maywood, Illinois 60153, USA
    J Biol Chem 281:35305-15. 2006
    ..Our results reveal that the Brm complex assists in coordinating hormone-dependent transcription regulation of the Eig genes...

Research Grants5

  1. Pathophysiogenomic markers:ethanol-induced brain damage
    Frank Middleton; Fiscal Year: 2007
    ....
  2. Pathophysiogenomic markers:ethanol-induced brain damage
    Frank Middleton; Fiscal Year: 2006
    ....
  3. Pathophysiogenomic markers:ethanol-induced brain damage
    Frank Middleton; Fiscal Year: 2009
    ....
  4. Pathophysiogenomic markers:ethanol-induced brain damage
    Frank A Middleton; Fiscal Year: 2010
    ....