Research Topics
| Michael MeguidSummaryAffiliation: SUNY Upstate Medical University Country: USA Publications
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Detail Information
Publications
Hypothalamic dopamine and serotonin in the regulation of food intakeM M Meguid
Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Nutrition 16:843-57. 2000..Data concerning the role of sex-related hormones on dopamine and serotonin with regard to the LHA and VMN in relation to the modulation of food intake are also presented...- Introduction: nutritional supplements and the quest to improve human performance-the need for the strictest standards and rigor when reporting clinical trialsMichael M Meguid
Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Nutrition 19:955-6. 2003 - Tumor anorexia: effects on neuropeptide Y and monoamines in paraventricular nucleusMichael M Meguid
Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Peptides 25:261-6. 2004..We conclude that the increased 5-HT and the decreased DA and NPY concentrations in PVN are associated with cancer anorexia and that the NPY food stimulatory effect is linked to serotoninergic and dopaminergic systems in hypothalamus... - A surgical rat model of human Roux-en-Y gastric bypassMichael M Meguid
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, and the Department of Animal Care, Upstate Medical University, Syracuse, New York 13210, USA
J Gastrointest Surg 8:621-30. 2004..We developed a reproducible rat model of Roux-en-Y gastric bypass. The existence of this model opens a new field of research in which to study the metabolic sequelae of obesity and the mechanisms of weight loss... 
Weight regain after Roux-en-Y: a significant 20% complication related to PYYMichael M Meguid
Surgical Metabolism and Nutrition Laboratory, Department Surgery, Neuroscience and Physiology Program, SUNY Upstate Medical University, Syracuse, New York, USA
Nutrition 24:832-42. 2008..Roux-en-Y gastric bypass (RYGB) produces rapid and dramatic weight loss in very heavy obese patients. Up to 20% cannot sustain their weight loss beyond 2 to 3 y after surgery...- Application of genomic technologies: DNA microarrays and metabolic profiling of obesity in the hypothalamus and in subcutaneous fatFrank A Middleton
Department of Neuroscience and Physiology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Nutrition 20:14-25. 2004 - Omega-3 fatty acids improve appetite in cancer anorexia, but tumor resecting restores itCarolina G Goncalves
From the Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery
Surgery 139:202-8. 2006..Tumor resection in anorexic rats on chow diet restored hypothalamic NPY, alpha-MSH, and food intake quantitatively more than in rats fed omega3FA diet... 
Sustained weight loss after Roux-en-Y gastric bypass is characterized by down regulation of endocannabinoids and mitochondrial functionAna Guijarro
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Ann Surg 247:779-90. 2008..To determine the physiologic importance of endocannabinoids and mitochondrial function in the long-term outcome using a rat model of Roux-en-Y gastric bypass (RYGB) surgery...- Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in ratsAna Guijarro
Dept of Surgery, University Hospital, 750 East Adams St, Syracuse, NY 13210, USA
Am J Physiol Regul Integr Comp Physiol 293:R1474-89. 2007..These events override the compensatory response to the drop in leptin levels aimed at conserving energy... - Is a model useful in exploring the catabolic mechanisms of weight loss after gastric bypass in humans?Henriette Kirchner
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, Neuroscience and Physiology Program, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Curr Opin Clin Nutr Metab Care 10:463-74. 2007..We compare recent human data with the findings in our rats to validate the versatility of using a Roux-en-Y gastric bypass rat model to explore the multifactorial molecular and physiological dimensions of weight loss and weight regain... - Gene expression profiles post Roux-en-Y gastric bypassYuan Xu
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Surgery 136:246-52. 2004..CONCLUSIONS: RYGB-induced weight loss is associated with changes in gene profile expressions that could influence metabolic changes, contributing to weight loss... - Changes in hypothalamic neuropeptide Y and monoaminergic system in tumor-bearing rats: pre- and post-tumor resection and at deathEduardo J B Ramos
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Surgery 136:270-6. 2004..After tumor resection, these alterations normalized, providing evidence that the levels of these substances change with anorexia in tumor-bearing rats... - Effects of omega-3 fatty acid supplementation on tumor-bearing ratsEduardo J B Ramos
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medical University, University Hospital, Syracuse, NY 13210, USA
J Am Coll Surg 199:716-23. 2004..Supplementation of omega-3 fatty acids has therapeutic potential in cancer anorexia... - Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypassIrina V Romanova
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, NY, USA
J Am Coll Surg 199:887-95. 2004..05). CONCLUSIONS: Obese rats that undergo weight loss after RYGB demonstrate changes in hypothalamic down regulation of NPY and up regulation of alpha-MSH and serotonin... - Neuropeptide Y, alpha-melanocyte-stimulating hormone, and monoamines in food intake regulationEduardo J B Ramos
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, Upstate Medical University, Syracuse, New York, USA
Nutrition 21:269-79. 2005..A better understanding of the detailed mechanisms underlying the pathogenesis of hyperphagia and hypophagia is needed to develop new therapeutic approaches to obesity... - Oxidative stress and wasting in cancerAlessandro Laviano
Department of Clinical Medicine, University La Sapienza, Rome, Italy
Curr Opin Clin Nutr Metab Care 10:449-56. 2007..Reported findings indicate that increased production of reactive oxygen species and reduced activity of antioxidant enzymes contribute to development of anorexia and cachexia in cancer... - Normalization of hypothalamic serotonin (5-HT 1B) receptor and NPY in cancer anorexia after tumor resection: an immunocytochemical studyIrina G Makarenko
Department of Surgery, Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Neurosci Lett 383:322-7. 2005..These data, discussed in context with our previous studies, support the hypothesis that tumor resection results not only in normalization of food intake but also in reversible changes of anorectic and orexigenic hypothalamic modulators... - Changes in GI hormones and their effect on gastric emptying and transit times after Roux-en-Y gastric bypass in rat modelSusumu Suzuki
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse 13210, USA
Surgery 138:283-90. 2005..Longitudinal studies can be performed with the use of our RYGB model, providing insight into weight loss mechanisms by generating long-term follow-up data currently not available in human studies... - Effects of omega-3 fatty acids on orexigenic and anorexigenic modulators at the onset of anorexiaEduardo J B Ramos
Department of Surgery, Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, University Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Brain Res 1046:157-64. 2005..omega-3FA modified hypothalamic peptides and 5-HT-(1B)-receptor immunoreactivity at anorexia, concomitant with an increase in FI, were probably mediated by omega-3FA inhibition of tumor-induced cytokines... - Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organAkio Inui
Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
FASEB J 18:439-56. 2004..Defective ghrelin signaling from the stomach could contribute to abnormalities in energy balance, growth, and associated gastrointestinal and neuroendocrine functions... - Energy expenditure and treating obesityAlessandro Laviano
Science 298:539-41; author reply 539-41. 2002 - Decreased NPY innervation of the hypothalamic nuclei in rats with cancer anorexiaIrina G Makarenko
Surgical Metabolism and Nutrition Laboratory, Neuroscience Physiology Program, Department of Surgery, University Hospital, Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA
Brain Res 961:100-8. 2003..The data support the hypothesis of an altered hypothalamic NPY system at the onset of anorexia in TB rats and also reveal the hypothalamic nuclei through which NPY influences food intake... - Characterization of the effects of pancreatic polypeptide in the regulation of energy balanceAkihiro Asakawa
Department of Clinical Molecular Medicine, Kobe University Graduate School of Meidicine, Japan
Gastroenterology 124:1325-36. 2003..Pancreatic polypeptide (PP) belongs to a family of peptides including neuropeptide Y and peptide YY. We examined the role of PP in the regulation of body weight as well as the therapeutic potential of PP... - Anorexia in space and possible etiologies: an overviewMonica S Da Silva
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medial University, Syracuse, New York 13210, USA
Nutrition 18:805-13. 2002.... - Cachexia and obesity: two sides of one coin?Akio Inui
Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Curr Opin Clin Nutr Metab Care 6:395-9. 2003..It is not well known, however, how these feeding-regulatory molecules are affected in cachexia associated with cancer and other critical conditions in which cytokines such as interleukin-1 and interleukin-6 may have a key role... - Age and sex influence on appetiteAlessandro Laviano
Clin Nutr 21:186-7; author reply 187. 2002 - Is obesity an inflammatory disease?Eduardo J B Ramos
Department of Surgery, Management Information and Decision, Clinical Molecular Medicine, SUNY Upstate Medical University, Syracuse University, Syracuse, NY, USA
Surgery 134:329-35. 2003..Most obese individuals have elevated concentrations of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), markers of inflammation closely associated with diabetes, hypertension, and stroke... - Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in miceAkihiro Asakawa
Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
Int J Mol Med 10:523-5. 2002..These results suggest that AGRP, orexin and MCH might have different effects on energy expenditure, thereby regulating appetite and body weight... - Catabolic effects of gastric bypass in a diet-induced obese rat modelAna Guijarro
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13021, USA
Curr Opin Clin Nutr Metab Care 9:423-35. 2006.... - Antimyopathic effects of carnitine and nicotineAlessandro Laviano
Department of Clinical Medicine, University La Sapienza, Rome, Italy
Curr Opin Clin Nutr Metab Care 9:442-8. 2006..This anorexia/cachexia syndrome leads to deterioration of quality of life, and increased morbidity and mortality. The clinical efficacy of currently available therapeutic strategies is limited and more effective treatments are needed... - Hypothalamic integration of immune function and metabolismAna Guijarro
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, University Hospital, SUNY Upstate Medical University, 750 Adams St, Syracuse, NY 13210, USA
Prog Brain Res 153:367-405. 2006.... - Does leptin really influence cancer anorexia?Tomoi Sato
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, Upstate Medical University Hospital, Syracuse, New York 13210, USA
Nutrition 18:82-3. 2002 - Expression of dopaminergic receptors in the hypothalamus of lean and obese Zucker rats and food intakeSerguei O Fetissov
Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Physiol Regul Integr Comp Physiol 283:R905-10. 2002..High level of D(1) receptor expression in the VMH and low in the LHA may also contribute to the specific feeding pattern in obese rats represented by large meal size and low meal number... - Neurohormonal pathways regulating food intake and changes after Roux-en-Y gastric bypassFrank A Orlando
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, Neuroscience Program, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Surg Obes Relat Dis 1:486-95. 2005 - Central mechanisms involved with catabolismJyotirmoy Nandi
Department of Medicine, Gastroenterology Division, University Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Curr Opin Clin Nutr Metab Care 5:407-18. 2002..Several studies have demonstrated important progress towards our understanding of the central mechanisms involved in anorexia and weight loss, which we summarize in this review... - Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexiaMark D DeBoer
Center for the Study of Weight Regulation, Oregon Health and Science University, 707 SW Gaines Road, Portland, OR 97239, USA
Endocrinology 148:3004-12. 2007..We conclude that ghrelin and a synthetic ghrelin receptor agonist improve weight gain and lean body mass retention via effects involving orexigenic neuropeptides and antiinflammatory changes... - Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube developmentHideki Yuzuriha
Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
FASEB J 21:2108-12. 2007..The present study is the first linking GI hormones to the leading cause of infant mortality and provides a novel insight for neurogenesis in which materno-fetal communication through GI hormones appears to be important... - Role of leucine in regulating food intakeAlessandro Laviano
Science 313:1236-8; author reply 1236-8. 2006 - Therapy insight: Cancer anorexia-cachexia syndrome--when all you can eat is yourselfAlessandro Laviano
Department of Clinical Medicine, University La Sapienza, Rome, Italy
Nat Clin Pract Oncol 2:158-65. 2005.... - Interleukin-1beta system in anorectic catabolic tumor-bearing ratsNicolas P Turrin
Molecular Endocrinology and Oncology Research Centre, Laval University Hospital Centre, and Department of Anatomy and Physiology, Laval University, Ste-Foy, , G1V 4G2, Canada
Curr Opin Clin Nutr Metab Care 7:419-26. 2004..In vivo, the characterization of cytokine components in the brain may provide data for potential pharmacological interventions to ameliorate the anorexia of disease... - Cancer anorexia-cachexia syndrome: cytokines and neuropeptidesEduardo J B Ramos
Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, Upstate Medical University, Syracuse, NY 13210, USA
Curr Opin Clin Nutr Metab Care 7:427-34. 2004..Interfering pharmacologically with cytokine expression or neural transduction of cytokine signals can be an effective therapeutic strategy in anorectic patients before they develop cancer anorexia-cachexia syndrome... - Plasma leptin, insulin and free tryptophan contribute to cytokine-induced anorexiaTomoi Sato
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
Adv Exp Med Biol 527:233-9. 2003.... - Improving food intake in anorectic cancer patientsAlessandro Laviano
Department of Clinical Medicine, University La Sapienza, Rome, Italy
Curr Opin Clin Nutr Metab Care 6:421-6. 2003..This article discusses the currently proposed hypothesis of its pathogenesis, and reviews the available and future therapeutic options as they relate to the pathogenic mechanisms... - Metabolic alterations during inflammation and its modulation by central actions of omega-3 fatty acidsUndurti N Das
EFA Sciences LLC, Norwood, Massachusetts 02062, USA
Curr Opin Clin Nutr Metab Care 6:413-9. 2003.... - Nicotine infusion into rat ventromedial nuclei and effects on monoaminergic systemEduardo J B Ramos
Neuroscience Program, Surgical Metabolism and Nutrition Laboratory, Department of Surgery, SUNY Upstate Medical University, University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA
Neuroreport 15:2293-7. 2004..Our data suggest that the nicotine-induced hypophagia correlates with VMN and LHA monoaminergic changes... - Cytokines: the mother of catabolic mediators!Michael M Meguid
Curr Opin Clin Nutr Metab Care 6:383-6. 2003 - Hypothalamic 5-HT1B-receptor changes in anorectic tumor bearing ratsIrina G Makarenko
Department of Surgery, Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, SUNY Upstate Medical University, University Hospital, 750 East Adams Street, Syracuse, NY 13210, USA
Neurosci Lett 376:71-5. 2005..These findings emphasize serotonin's influence on the magnocellular hypothalamic nuclei during developing of cancer anorexia, which is associated with a decrease in food intake... - Omega-3 fatty acids and anorexiaCarolina G Goncalves
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Curr Opin Clin Nutr Metab Care 8:403-7. 2005..SUMMARY: Based on current data, omega-3 fatty acid supplementation has a role in the treatment of anorexia by stimulating the production and release of orexigenic neurotransmitters in food intake regulatory nuclei in the hypothalamus... - Catabolic outcome from non-gastrointestinal malignancy-related malabsorption leading to malnutrition and weight lossSususmu Suzuki
Surgical Metabolism and Nutrition Laboratory, Department of Surgery, University Hospital, Upstate Medical University, Syracuse, New York 13210, USA
Curr Opin Clin Nutr Metab Care 8:419-27. 2005..SUMMARY: The combination of small intestine atrophy and delayed gastrointestinal motility are some of the reasons for malabsorption in cancer patients with non-gastrointestinal malignancies that contribute to the catabolic process... - Nutrition, physical activity, and obesityUndurti N Das
Lancet 360:1249-50. 2002 - Cancer anorexia: clinical implications, pathogenesis, and therapeutic strategiesAlessandro Laviano
Department of Clinical Medicine, University La Sapienza, Rome, Italy
Lancet Oncol 4:686-94. 2003.... - Did it all start with Delilah?Michael M Meguid
Curr Opin Clin Nutr Metab Care 9:386-7. 2006
Research Grants
- SEROTONIN/DOPAMINE MEDIATION OF EARLY CANCER ANOREXIAMichael Meguid; Fiscal Year: 2001..As external perturbations, they will use progressively increasing peripheral infusions of IL-1 and TRP, the serotonin precursor, as would result from a progressively growing tumor. ..