PAUL MASSA

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. ncbi Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus
    Paul T Massa
    Department of Neurology, Upstate Medical University, State University of New York, Syracuse 13210, USA
    J Virol 76:8335-46. 2002
  2. ncbi Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice
    Paul T Massa
    Department of Neurology, Neuroscience Program, SUNY Upstate Medical University, Syracuse, New York 13066, USA
    J Neurosci Res 77:15-25. 2004
  3. ncbi Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1
    George P Christophi
    Department of Neurology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
    Viral Immunol 22:371-87. 2009
  4. ncbi Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia
    Kathryn L Bonaparte
    Department of Neurology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
    Glia 53:827-35. 2006
  5. ncbi Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Virol 83:522-39. 2009
  6. ncbi Induction of IL-33 expression and activity in central nervous system glia
    Chad A Hudson
    Department of Neurology and Interest Group in Neuro Immune Interactions, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Leukoc Biol 84:631-43. 2008
  7. ncbi Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 89:742-59. 2009
  8. ncbi SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 88:243-55. 2008
  9. ncbi NFkappaB in neurons? The uncertainty principle in neurobiology
    Paul T Massa
    Department of Neurology, State University of New York-Upstate Medical University, Syracuse, New York, USA
    J Neurochem 97:607-18. 2006
  10. ncbi Interferon regulatory factor-1 is required for interferon-gamma-induced MHC class I genes in astrocytes
    Keith W Jarosinski
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Neuroimmunol 122:74-84. 2002

Research Grants

  1. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2003
  2. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2007
  3. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
  4. Role of SHP-1 in monocyte-mediated demyelination
    Paul T Massa; Fiscal Year: 2010

Collaborators

  • Keith Jarosinski
  • Cornelia Mihai
  • George P Christophi
  • Chad A Hudson
  • Ross C Gruber
  • Michael Panos
  • Burk Jubelt
  • Kathryn L Bonaparte
  • Akos T Mersich
  • Rebecca L Christophi
  • Scott D Blystone
  • Joel R Wilmore
  • David A Lawrence
  • Luis J Mejico
  • Christoforos P Christophi
  • Charlene Wu

Detail Information

Publications10

  1. ncbi Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus
    Paul T Massa
    Department of Neurology, Upstate Medical University, State University of New York, Syracuse 13210, USA
    J Virol 76:8335-46. 2002
    ..These findings indicate that SHP-1 is a critical factor in controlling virus replication in the CNS glia and virus-induced demyelination...
  2. ncbi Dysmyelination and reduced myelin basic protein gene expression by oligodendrocytes of SHP-1-deficient mice
    Paul T Massa
    Department of Neurology, Neuroscience Program, SUNY Upstate Medical University, Syracuse, New York 13066, USA
    J Neurosci Res 77:15-25. 2004
    ..We propose that SHP-1 is a critical regulator of developmental signals leading to terminal differentiation and myelin sheath formation by oligodendrocytes...
  3. ncbi Central neuroinvasion and demyelination by inflammatory macrophages after peripheral virus infection is controlled by SHP-1
    George P Christophi
    Department of Neurology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
    Viral Immunol 22:371-87. 2009
    ....
  4. ncbi Inverse regulation of inducible nitric oxide synthase (iNOS) and arginase I by the protein tyrosine phosphatase SHP-1 in CNS glia
    Kathryn L Bonaparte
    Department of Neurology, Upstate Medical University, State University of New York, Syracuse, New York 13210, USA
    Glia 53:827-35. 2006
    ..Thus, we propose that SHP-1 is a critical regulator of innate immunity to virus infections in CNS cells...
  5. ncbi Modulation of macrophage infiltration and inflammatory activity by the phosphatase SHP-1 in virus-induced demyelinating disease
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Virol 83:522-39. 2009
    ....
  6. ncbi Induction of IL-33 expression and activity in central nervous system glia
    Chad A Hudson
    Department of Neurology and Interest Group in Neuro Immune Interactions, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Leukoc Biol 84:631-43. 2008
    ..In conclusion, these results implicate IL-33-producing astrocytes as a potentially critical regulator of innate immune responses in the CNS...
  7. ncbi Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 89:742-59. 2009
    ....
  8. ncbi SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 88:243-55. 2008
    ..Thus, PBMCs of MS patients display a stable deficiency of SHP-1 expression, heightened STAT6 phosphorylation, and an enhanced state of activation relevant to the mechanisms of inflammatory demyelination...
  9. ncbi NFkappaB in neurons? The uncertainty principle in neurobiology
    Paul T Massa
    Department of Neurology, State University of New York-Upstate Medical University, Syracuse, New York, USA
    J Neurochem 97:607-18. 2006
    ..Recent research has illuminated the importance of these problems, as well as opportunities to move past them to the nuances manifest through variable activation pathways, subunit complexity and target sequence preferences...
  10. ncbi Interferon regulatory factor-1 is required for interferon-gamma-induced MHC class I genes in astrocytes
    Keith W Jarosinski
    Department of Microbiology and Immunology, State University of New York Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Neuroimmunol 122:74-84. 2002
    ..These studies conclusively demonstrate a major role for IRF-1/MHC-IRF-E interactions in controlling MHC class I gene expression in astrocytes in response to IFN-gamma...

Research Grants9

  1. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2003
    ..It is proposed that SHP-1 plays an essential role in the mediating the actions of the interferons and virus-host interactions in the CNS. ..
  2. REGULATION OF INTERFERON ACTIVITY BY SHP-1 IN THE CNS
    PAUL MASSA; Fiscal Year: 2007
    ..We believe that information gained under these specific aims will elucidate mechanisms whereby SHP-1 controls virus infections in oligodendrocytes and perhaps other cells of the CNS. ..
  3. Deficiency of SHP-1 expression and function in multiple sclerosis
    Paul T Massa; Fiscal Year: 2010
    ..abstract_text> ..
  4. Role of SHP-1 in monocyte-mediated demyelination
    Paul T Massa; Fiscal Year: 2010
    ..The present project is thus focused on defining the essential role of SHP-1 in macrophage-mediated demyelinating disease. ..