Robert A Levine

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. ncbi request reprint Assessment of fibrosis progression in untreated irish women with chronic hepatitis C contracted from immunoglobulin anti-D
    Robert A Levine
    State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Clin Gastroenterol Hepatol 4:1271-7. 2006
  2. doi request reprint Digital quantification is more precise than traditional semiquantitation of hepatic steatosis: correlation with fibrosis in 220 treatment-naïve patients with chronic hepatitis C
    Sekou R Rawlins
    Department of Medicine, Division of Gastroenterology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Dig Dis Sci 55:2049-57. 2010
  3. doi request reprint Diagnostic accuracy of serum hyaluronic acid, FIBROSpect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C
    Preeti Mehta
    Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Am J Gastroenterol 103:928-36. 2008
  4. doi request reprint TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Mol Cell Biochem 336:17-24. 2010
  5. doi request reprint Gastric acid is the key modulator in the pathogenesis of non-steroidal anti-inflammatory drug-induced ulceration in rats
    J Michael Zinkievich
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Clin Exp Pharmacol Physiol 37:654-61. 2010
  6. doi request reprint Cyclo-oxygenase-1 inhibition increases acid secretion by modulating H+,K+-ATPase expression and activation in rabbit parietal cells
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Clin Exp Pharmacol Physiol 36:127-34. 2009
  7. ncbi request reprint Advances in digital quantification technique enhance discrimination between mild and advanced liver fibrosis in chronic hepatitis C
    Amy L Lazzarini
    Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Liver Int 25:1142-9. 2005
  8. ncbi request reprint Regression of fibrosis in chronic hepatitis C after therapy with interferon and ribavirin
    Asma Arif
    Department of Medicine, Division of Gastroenterology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Dig Dis Sci 48:1425-30. 2003
  9. ncbi request reprint 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Dig Dis Sci 53:123-32. 2008
  10. doi request reprint Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexes
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02115 2696, USA
    Am J Physiol Heart Circ Physiol 294:H2106-11. 2008

Collaborators

  • Jyotirmoy Nandi
  • Raimund Erbel
  • Toshinori Yuasa
  • Ashok Shah
  • Hao Jiang
  • Ronen Beeri
  • Emmanuel Messas
  • Alba I Rodriguez
  • David Koubi
  • J Michael Zinkievich
  • Sekou R Rawlins
  • Chaim Yosefy
  • Judy Hung
  • Mark D Handschumacher
  • Gus J Vlahakes
  • Schuyler O Sanderson
  • Jarret Kuo
  • Lijie Zhang
  • Tangella Jackson Hunter
  • Thomas Buck
  • Roger J Hajjar
  • Federica Del Monte
  • Preeti Mehta
  • Tomas G Neilan
  • Michael H Picard
  • Francesca Nesta
  • Mariana Angoa-Perez
  • J Luis Guerrero
  • Fang Zhu
  • Igal A Sebag
  • Shinichi Minagoe
  • Bo Yu
  • George B Corcoran
  • Subhash C Gautam
  • Shuichi Hamasaki
  • Akira Kisanuki
  • Amy L Lazzarini
  • Chuwa Tei
  • Takeshi Uemura
  • Yutaka Otsuji
  • Sadatoshi Biro
  • Michael D Seidman
  • Michel Desnos
  • Philippe Menasche
  • Laurent Groc
  • Jane A Foster
  • Asma Arif
  • Lisa A Freed
  • Li Li
  • Sunil George
  • Nancy Newman
  • Ola El-Zammar
  • Shalinee Jha
  • Ronald A Mucci
  • Ryuichi Yoneyama
  • Robert Stroud
  • Miguel Chaput
  • Björn Plicht
  • Thanh Thao Ton-Nu
  • Suzan Abedat
  • Thea Pugatsch
  • Robert Ploutz-Snyder
  • Suzanne Sullivan
  • Dan Gilon
  • Shawn M Hwang
  • Yoshiaki Kawase
  • Francis G Spinale
  • Kozo Hoshino
  • Peter Hunold
  • Cary W Akins
  • Eric M Isselbacher
  • Jorge Solis
  • Scott C Streckenbach
  • Mordehay Vaturi
  • Mark S Adams
  • Marc D Handschumacher
  • Albert A Hagege
  • Alain Bel
  • Jean Thomas Vilquin
  • Patrice Bruneval
  • Selva Rivas-Arancibia
  • Severine Peyrard
  • Alain Carpentier
  • Cristina Lemini
  • Claire Carrion
  • Miguel Cortes Morichetti
  • Wenxue Tang
  • Robert J Ploutz-Snyder
  • Kelly Kuo
  • Takayuki Ueno

Detail Information

Publications28

  1. ncbi request reprint Assessment of fibrosis progression in untreated irish women with chronic hepatitis C contracted from immunoglobulin anti-D
    Robert A Levine
    State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Clin Gastroenterol Hepatol 4:1271-7. 2006
    ..To provide insight into the natural history of HCV, we determined liver fibrosis outcomes and any predictors of such...
  2. doi request reprint Digital quantification is more precise than traditional semiquantitation of hepatic steatosis: correlation with fibrosis in 220 treatment-naïve patients with chronic hepatitis C
    Sekou R Rawlins
    Department of Medicine, Division of Gastroenterology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Dig Dis Sci 55:2049-57. 2010
    ..Steatosis, as associated with chronic hepatitis C (CHC) and non-alcoholic fatty liver disease (NAFLD), has been considered a risk factor for development of fibrosis...
  3. doi request reprint Diagnostic accuracy of serum hyaluronic acid, FIBROSpect II, and YKL-40 for discriminating fibrosis stages in chronic hepatitis C
    Preeti Mehta
    Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Am J Gastroenterol 103:928-36. 2008
    ....
  4. doi request reprint TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Mol Cell Biochem 336:17-24. 2010
    ..Our data show TNF-alpha plays an early pro-inflammatory role in indomethacin-induced jejunoileitis. Additionally, down-regulation of NOx by PDE inhibitors, TNF-Ab, or HBO(2) suggests that TNF-alpha modulates iNOS expression...
  5. doi request reprint Gastric acid is the key modulator in the pathogenesis of non-steroidal anti-inflammatory drug-induced ulceration in rats
    J Michael Zinkievich
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Clin Exp Pharmacol Physiol 37:654-61. 2010
    ..4. The data suggest that NSAID-induced ulcerogenesis is dependent on the amount of GA secretion derived from increased proton pump expression and requires inhibition of both COX-1 and COX-2...
  6. doi request reprint Cyclo-oxygenase-1 inhibition increases acid secretion by modulating H+,K+-ATPase expression and activation in rabbit parietal cells
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Clin Exp Pharmacol Physiol 36:127-34. 2009
    ....
  7. ncbi request reprint Advances in digital quantification technique enhance discrimination between mild and advanced liver fibrosis in chronic hepatitis C
    Amy L Lazzarini
    Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Liver Int 25:1142-9. 2005
    ..Our aims were to correlate all Ishak stages of fibrosis (0-6) with fibrosis percentage (%) using computerized digital image analysis, and thereby seek to improve discrimination between varying levels of liver fibrosis...
  8. ncbi request reprint Regression of fibrosis in chronic hepatitis C after therapy with interferon and ribavirin
    Asma Arif
    Department of Medicine, Division of Gastroenterology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Dig Dis Sci 48:1425-30. 2003
    ..Treatment strategies in virological nonresponders who show fibrosis regression should include consideration of maintenance therapy, if such treatment eventually proves to benefit histological outcomes...
  9. ncbi request reprint 5-aminosalicylic acid improves indomethacin-induced enteropathy by inhibiting iNOS transcription in rats
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Dig Dis Sci 53:123-32. 2008
    ..In conclusion, inhibition of iNOS expression by 5-ASA appears to be associated with diminished intestinal ulceration in indomethacin-induced enteropathy...
  10. doi request reprint Progressive nature of chronic mitral regurgitation and the role of tissue Doppler-derived indexes
    Tomas G Neilan
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02115 2696, USA
    Am J Physiol Heart Circ Physiol 294:H2106-11. 2008
    ..001). Therefore, in a chronic model of MR, serial echocardiography demonstrated that MR begets MR and that those TD-derived indexes that initially increased post-MR decreased to baseline before any changes in LV ejection fraction...
  11. ncbi request reprint Proximal flow convergence region as assessed by real-time 3-dimensional echocardiography: challenging the hemispheric assumption
    Chaim Yosefy
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 2696, USA
    J Am Soc Echocardiogr 20:389-96. 2007
    ..We hypothesized that the PFCR contour is not necessarily hemispheric, but rather hemielliptic, and aimed to apply a hemielliptic calculation, based on the 3D contour of the PFCR for more accurate MR quantification...
  12. ncbi request reprint Molecular genetics of mitral valve prolapse
    Robert A Levine
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Curr Opin Cardiol 22:171-5. 2007
    ..It is associated with important mitral regurgitation requiring surgical repair and other clinical complications. Genetic studies can provide clues to mechanism and therapy...
  13. ncbi request reprint The crossed swords sign: insights into the dilemma of repair in bileaflet mitral valve prolapse
    Ronen Beeri
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Soc Echocardiogr 20:698-702. 2007
    ..Some patients show two crossed jets oppositely directed from the coaptation zone. We hypothesized that these indicate bileaflet lesions requiring complex repair...
  14. doi request reprint Mitral regurgitation augments post-myocardial infarction remodeling failure of hypertrophic compensation
    Ronen Beeri
    Cardiac Ultrasound Laboratory, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Am Coll Cardiol 51:476-86. 2008
    ..We examined whether mitral regurgitation (MR) augments post-myocardial infarction (MI) remodeling...
  15. doi request reprint Automated flow quantification in valvular heart disease based on backscattered Doppler power analysis: implementation on matrix-array ultrasound imaging systems
    Thomas Buck
    West German Heart Center Essen, Department of Cardiology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Int J Cardiovasc Imaging 24:463-77. 2008
    ....
  16. ncbi request reprint Autologous myoblast transplantation for chronic ischemic mitral regurgitation
    Emmanuel Messas
    Universite Rene Descartes Paris 5, Faculté de médecine René Descartes Paris 5, Paris, France
    J Am Coll Cardiol 47:2086-93. 2006
    ..This study was designed to assess whether post-myocardial infarction (MI) in-scar transplantation of skeletal myoblasts (SM) could reduce chronic ischemic mitral regurgitation (MR) by decreasing left ventricular (LV) remodeling...
  17. ncbi request reprint Mitral valve prolapse in the general population: the benign nature of echocardiographic features in the Framingham Heart Study
    Lisa A Freed
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    J Am Coll Cardiol 40:1298-304. 2002
    ..The aim of this study was to examine the echocardiographic features and associations of mitral valve prolapse (MVP) diagnosed by current two-dimensional echocardiographic criteria in an unselected outpatient sample...
  18. ncbi request reprint Stenosis is in the eye of the observer: impact of pressure recovery on assessing aortic valve area
    Robert A Levine
    J Am Coll Cardiol 41:443-5. 2003
  19. ncbi request reprint Kainic acid lesion-induced nigral neuronal death
    Jane A Foster
    William T Gossett Neurology Laboratories, Henry Ford Health System, 1 Ford Place, 4D, Detroit, MI 48202, USA
    J Chem Neuroanat 26:65-73. 2003
    ..This experimental procedure is useful for studying mechanisms underlying protracted death of nigral DA neurons and may provide valuable mechanistic information relevant to understanding the etiology of PD...
  20. ncbi request reprint Efficacy of chordal cutting to relieve chronic persistent ischemic mitral regurgitation
    Emmanuel Messas
    Faculte de Medecine Necker Enfants Malades, Inserm EMI 0016, Ecole de Chirurgie, Assistance Publique Hopitaux de Paris, Service de Cardiologie 1 et de Chirurgie Cardio Vasculaire, Hopital Europeen Georges Pompidou, Paris, France
    Circulation 108:II111-5. 2003
    ..3-Dimensional echo quantified MR, LV function, and valve geometry. Five other sheep were followed for a mean of 7.8+/-1.2 months after inferobasal infarction with chordal cutting...
  21. ncbi request reprint Role of Bcl-2 family of proteins in mediating apoptotic death of PC12 cells exposed to oxygen and glucose deprivation
    David Koubi
    William T Gossett Neurology Laboratories, Detroit, MI 48202, USA
    Neurochem Int 46:73-81. 2005
    ..It also reveals the importance of developing therapeutic strategies for maintaining the mitochondrial membrane potential as a possible way of reducing necrotic and apoptotic cell death that occurs following an ischemic insult...
  22. ncbi request reprint Inhibitors of iNOS protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation
    Hao Jiang
    William T Gossett Neurology Laboratories, Henry Ford Health System, One Ford Place, 4D, Detriot, MI 48202, USA
    Neurosci Lett 375:59-63. 2005
    ..These results suggest the critical role of iNOS in mediating apoptosis under ischemic conditions, likely through the induction of caspase-3 activity...
  23. ncbi request reprint Resveratrol-induced apoptotic death in human U251 glioma cells
    Hao Jiang
    William T Gossett Neurology Laboratories, Henry Ford Health System, Detroit, Michigan 48202, USA
    Mol Cancer Ther 4:554-61. 2005
    ..These results suggest that multiple signaling pathways may underlie the apoptotic death of U251 glioma induced by resveratrol, which warrants further exploration as an anticancer agent in human glioma...
  24. ncbi request reprint Papillary muscle dysfunction attenuates ischemic mitral regurgitation in patients with localized basal inferior left ventricular remodeling: insights from tissue Doppler strain imaging
    Takeshi Uemura
    First Department of Internal Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan
    J Am Coll Cardiol 46:113-9. 2005
    ..The purpose of this research was to test whether papillary muscle (PM) dysfunction attenuates ischemic mitral regurgitation (MR) in patients with left ventricular (LV) remodeling of a similar location and extent...
  25. ncbi request reprint Mechanism of persistent ischemic mitral regurgitation after annuloplasty: importance of augmented posterior mitral leaflet tethering
    Fang Zhu
    Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima City, 890 8520, Japan
    Circulation 112:I396-401. 2005
    ..Relationships between leaflet configurations and persistent ischemic MR after the annuloplasty were investigated...
  26. ncbi request reprint Usefulness of three-dimensionally guided assessment of mitral stenosis using matrix-array ultrasound
    Igal A Sebag
    Cardiac Ultrasound Laboratory, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 96:1151-6. 2005
    ..6% to 6.1% (SEE 0.15 to 0.09 cm(2), p <0.02). In conclusion, matrix-array technology provides a feasible and highly reproducible direct 3-D-guided method for measuring the limiting mitral orifice area...
  27. ncbi request reprint Estrogen counteracts ozone-induced oxidative stress and nigral neuronal death
    Mariana Angoa-Perez
    Department of Physiology, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
    Neuroreport 17:629-33. 2006
    ..These results indicate that ozone exposure may be a useful Parkinson's disease model and neuroprotection afforded by 17beta-estradiol is dependent on the high levels achieved after its prolonged administration...
  28. ncbi request reprint Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model
    Li Li
    Department of Periodontology and Oral Biology, School of Dental Medicine, Boston University, Boston, Mass 02118, USA
    Circulation 105:861-7. 2002
    ....