GRANT KELLEY

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. pmc G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner
    Grant G Kelley
    Department of Medicine and Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 281:2639-48. 2006
  2. pmc Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins
    Grant G Kelley
    Department of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Biochem J 378:129-39. 2004
  3. ncbi request reprint Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 38:1397-405. 2006
  4. ncbi request reprint Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
    Gretchen A Murphy
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 277:9966-75. 2002
  5. pmc Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
    Simona Citro
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:15543-8. 2007
  6. ncbi request reprint Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy
    Huan Wang
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Circ Res 97:1305-13. 2005
  7. pmc Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors
    Kamil J Alzayady
    Departments of Pharmacology and Medicine, SUNY Upstate Medical University, Syracuse, New York 13210 2339, USA
    J Biol Chem 280:34530-7. 2005
  8. ncbi request reprint Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis
    Paul M Campbell
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Methods Enzymol 407:195-217. 2006
  9. ncbi request reprint Purification of phospholipase C beta and phospholipase C epsilon from Sf9 cells
    Mousumi Ghosh
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, NY, USA
    Methods Mol Biol 237:55-64. 2004
  10. ncbi request reprint Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes
    Emily A Oestreich
    Department of Pharmacology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 282:5488-95. 2007

Research Grants

  1. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002

Collaborators

  • Alan Smrcka
  • Gretchen A Murphy
  • Richard Wojcikiewicz
  • M Katan
  • Emily A Oestreich
  • Huan Wang
  • Sundeep Malik
  • Simona Citro
  • Paul M Campbell
  • Bernward Hinkes
  • Burns C Blaxall
  • Robert T Dirksen
  • Kamil J Alzayady
  • Mousumi Ghosh
  • Joan Heller Brown
  • Julie Radeff-Huang
  • Katherine A Kaproth-Joslin
  • Alexander Dietrich
  • Rakesh Verma
  • Bryan L Wharram
  • Anurag Singh
  • Friedhelm Hildebrandt
  • Dontscho Kerjaschki
  • Tom D Bunney
  • Channing J Der
  • Alper Soylu
  • Meera Goyal
  • Falina J Williams
  • Christopher N Vlangos
  • Bethan E Hoskins
  • Lawrence B Holzman
  • Roger C Wiggins
  • Jinhong Liu
  • Gudrun Nurnberg
  • Dominik Seelow
  • Roxana Cleper
  • Hans Christian Hennies
  • Karen Frantz
  • Alexey N Tsygin
  • Rasheed Gbadegesin
  • Katrin Hasselbacher
  • Bettina Mucha
  • Peter Nurnberg
  • Asher D Schachter
  • Hassan Chaib
  • JOHN F O'TOOLE
  • Aysin Bakkaloglu
  • Caroline S Sorli
  • Iain Drummond
  • Sudha Mudumana
  • Massimo Attanasio
  • Dominik Muller
  • Edgar A Otto
  • Christian Becker
  • Martin Griebel
  • Lina Basel-Vanagaite
  • Martin Pohl
  • Rudiger Waldherr
  • Andreas Kispert
  • Shazia Ashraf
  • Aylin S Ulku
  • Rannar Airik
  • Fatih Ozaltin
  • Thomas Gudermann
  • Puneet Garg
  • Tara A Bullard
  • Naoya Maekawa
  • Karen L Vikstrom
  • Margaret M Panning

Detail Information

Publications10

  1. pmc G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner
    Grant G Kelley
    Department of Medicine and Pharmacology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 281:2639-48. 2006
    ..Activation of these PLC isoforms displays agonist-specific temporal profiles; however, PLCbeta3 is predominantly involved in acute and PLCepsilon in sustained PI hydrolysis...
  2. pmc Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins
    Grant G Kelley
    Department of Medicine, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Biochem J 378:129-39. 2004
    ..In addition, the stimulation by LPA and S1P is also partly sensitive to pertussis toxin. These studies demonstrate diverse hormonal regulation of PLCepsilon by distinct and overlapping pathways...
  3. ncbi request reprint Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 38:1397-405. 2006
    ..These findings, together with the zebrafish model of human nephrotic syndrome generated by plce1 knockdown, open new inroads into pathophysiology and treatment mechanisms of nephrotic syndrome...
  4. ncbi request reprint Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation
    Gretchen A Murphy
    Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7295, USA
    J Biol Chem 277:9966-75. 2002
    ..Finally, unlike Ras, TC21 did not activate the Rac small GTPase, indicating that Ras may not activate Rac by PI3K. Taken together, these results suggest that PI3K, but not RalGDS, is an important mediator of cell proliferation by TC21...
  5. pmc Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation
    Simona Citro
    Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:15543-8. 2007
    ..Thus, PLCepsilon serves to transduce mitogenic signals through a mechanism distinct from its role in generation of PLC-derived second messengers...
  6. ncbi request reprint Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy
    Huan Wang
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Circ Res 97:1305-13. 2005
    ....
  7. pmc Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors
    Kamil J Alzayady
    Departments of Pharmacology and Medicine, SUNY Upstate Medical University, Syracuse, New York 13210 2339, USA
    J Biol Chem 280:34530-7. 2005
    ..These data also establish that the p97-Ufd1-Npl4 complex mediates endoplasmic reticulum-associated degradation in mammalian cells...
  8. ncbi request reprint Genetic and pharmacologic dissection of Ras effector utilization in oncogenesis
    Paul M Campbell
    Department of Pharmacology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Methods Enzymol 407:195-217. 2006
    ....
  9. ncbi request reprint Purification of phospholipase C beta and phospholipase C epsilon from Sf9 cells
    Mousumi Ghosh
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, NY, USA
    Methods Mol Biol 237:55-64. 2004
    ..6-His-tagged PLC epsilon can be purified in a single step with nickel nitrilotriacetic acid-agarose (Ni-NTA) affinity chromatography...
  10. ncbi request reprint Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes
    Emily A Oestreich
    Department of Pharmacology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 282:5488-95. 2007
    ..These data define a novel endogenous PKA-independent betaAR-signaling pathway through cAMP-dependent Epac activation, Rap, and PLC(epsilon) that enhances intracellular Ca(2+) release in cardiac myocytes...

Research Grants4

  1. PHOSPHOLIPASE C AND ISLET BETA CELLS
    GRANT KELLEY; Fiscal Year: 2002
    ..This novel signaling pathway may play a critical role in glucose and hormone stimulated insulin secretion and beta cell function. ..