Research Topics
Species | Wendy KatesSummaryAffiliation: SUNY Upstate Medical University Country: USA Publications
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Publications
Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblingsPetya D Radoeva
Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY, USA
Behav Brain Funct 8:38. 2012....
Temporal lobe anatomy and psychiatric symptoms in velocardiofacial syndrome (22q11.2 deletion syndrome)Wendy R Kates
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, 13210, USA
J Am Acad Child Adolesc Psychiatry 45:587-95. 2006..To investigate the association between mesial temporal lobe morphology, ratios of prefrontal cortex to amygdala and hippocampus volumes, and psychiatric symptomatology in children and adolescents with velocardiofacial syndrome (VCFS)...- A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome)Wendy R Kates
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Med Genet B Neuropsychiatr Genet 141:274-80. 2006..Longitudinal evaluation of these children is essential in order to identify potential clinical implications of this allele by gender interaction... - The neural correlates of non-spatial working memory in velocardiofacial syndrome (22q11.2 deletion syndrome)Wendy R Kates
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, New York, USA
Neuropsychologia 45:2863-73. 2007.... - Comparing phenotypes in patients with idiopathic autism to patients with velocardiofacial syndrome (22q11 DS) with and without autismWendy R Kates
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Med Genet A 143:2642-50. 2007..These findings carry implications for clinicians who diagnose and treat VCFS or autism, and for researchers who study genotype-phenotype associations in autism... - Gender-moderated dorsolateral prefrontal reductions in 22q11.2 Deletion Syndrome: implications for risk for schizophreniaWendy R Kates
Department of Psychiatry, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
Child Neuropsychol 11:73-85. 2005..2 DS are at a disproportionately high risk... - Introduction: advances in research on velo-cardio-facial syndrome/22q11.2 deletion syndromeWendy R Kates
Department of Psychiatry, State University of New York at Upstate Medical University, Syracuse, NY 13210, USA
Dev Disabil Res Rev 14:1-2. 2008 
Neuroanatomic alterations and social and communication deficits in monozygotic twins discordant for autism disorderShanti R Mitchell
Department of Psychiatry, SUNY Upstate Medical University, 750 E Adams St, Syracuse, NY 13210, USA
Am J Psychiatry 166:917-25. 2009..The authors used magnetic resonance imaging (MRI) to investigate several brain regions of interest in monozygotic twins who varied in degree of phenotypic discordance for narrowly defined autism...- Frontal and caudate alterations in velocardiofacial syndrome (deletion at chromosome 22q11.2)Wendy R Kates
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
J Child Neurol 19:337-42. 2004.... - Gyrification patterns in monozygotic twin pairs varying in discordance for autismWendy R Kates
Department of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, New York 13210, USA
Autism Res 2:267-78. 2009.... - Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autismWendy R Kates
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Psychiatry 161:539-46. 2004..The authors examined the relationship of twin pair differences in clinical phenotype to differences in neuroanatomic phenotype... - Neuroanatomic predictors to prodromal psychosis in velocardiofacial syndrome (22q11.2 deletion syndrome): a longitudinal studyWendy R Kates
Department of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, New York 13210, USA
Biol Psychiatry 69:945-52. 2011..2 deletion syndrome) develop schizophrenia or psychosis. Identifying the neuroanatomic trajectories that increase risk for psychosis in youth with this genetic disorder is of great interest... - MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndromeWendy R Kates
Division of Psychiatric Neuroimaging, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Psychiatry Res 116:63-81. 2002.... - Mapping cortical morphology in youth with velocardiofacial (22q11.2 deletion) syndromeWendy R Kates
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
J Am Acad Child Adolesc Psychiatry 50:272-282.e2. 2011..Insofar as up to 30% of individuals with this genetic disorder develop schizophrenia, VCFS constitutes a unique, etiologically homogeneous model for understanding the pathogenesis of schizophrenia... - Comparing ADHD in velocardiofacial syndrome to idiopathic ADHD: a preliminary studyKevin M Antshel
SUNY Upstate Medical University, NY, USA
J Atten Disord 11:64-73. 2007..Children with velocardiofacial syndrome (VCFS), a contiguous deletion syndrome, have an increased prevalence of attention deficit/hyperactivity disorder (ADHD)... - Velo-cardio-facial syndromeRobert J Shprintzen
Center for the Diagnosis, Treatment and Study of Velo Cardio Facial Syndrome, Department of Otolaryngology and Communication Sciences, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
Curr Opin Pediatr 17:725-30. 2005..In this review, we cover multiple areas of research during the past year, including psychiatric disorders, neuroimaging, and the delineation of clinical features... - Manic symptoms and behavioral dysregulation in youth with velocardiofacial syndrome (22q11.2 deletion syndrome)Alka Aneja
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York 13210, USA
J Child Adolesc Psychopharmacol 17:105-14. 2007..Accordingly, our findings of severe behavioral impairment in youth with VCFS and manic symptoms suggest that these children may warrant more intensive monitoring and treatment relative to youth with VCFS and ADHD only... - Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion)Kevin M Antshel
State University of New York Upstate Medical University, Syracuse, NY, USA
J Autism Dev Disord 37:1776-86. 2007..Children with VCFS + ASD had larger right amygdala volumes. All other neuroanatomic regions of interest were statistically similar between the two groups... - Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: a 3-year follow-up studyKevin M Antshel
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
J Am Acad Child Adolesc Psychiatry 49:333-44. 2010..To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS)... - Associations between performance on the Rey-Osterrieth Complex Figure and regional brain volumes in children with and without velocardiofacial syndromeKevin M Antshel
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Dev Neuropsychol 33:601-22. 2008..Assumptions about the organization of and the localization of the brain structures that subserve specific cognitive functions in the typically developing brain may not apply in the abnormally developing brain... - The neurocognitive phenotype in velo-cardio-facial syndrome: a developmental perspectiveKevin M Antshel
Department of Psychiatry and Behavioral Sciences, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
Dev Disabil Res Rev 14:43-51. 2008..We propose several considerations that could advance our knowledge of developmental changes in the VCFS cognitive phenotype. The most salient of these is the need for more longitudinal designs with carefully matched control participants... - 22q11.2 deletion syndrome: genetics, neuroanatomy and cognitive/behavioral features keywordsKevin M Antshel
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Child Neuropsychol 11:5-19. 2005..2 Deletion Syndrome is also explored, including variables that are thought to affect symptom expression. The history of the deletion syndrome is described, and future directions for continued research are discussed... - Behavior and corpus callosum morphology relationships in velocardiofacial syndrome (22q11.2 deletion syndrome)Kevin M Antshel
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
Psychiatry Res 138:235-45. 2005..In addition to other anatomic anomalies, corpus callosal abnormalities appear to be another variable to consider when analyzing brain/behavior relations in this population... - Sex differences in cognitive functioning in velocardiofacial syndrome (VCFS)Kevin M Antshel
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
Dev Neuropsychol 28:849-69. 2005.... - ADHD, major depressive disorder, and simple phobias are prevalent psychiatric conditions in youth with velocardiofacial syndromeKevin M Antshel
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, Syracuse, 13210, USA
J Am Acad Child Adolesc Psychiatry 45:596-603. 2006..To examine prevalence rates of psychopathology in children with velocardiofacial syndrome (VCFS)... - The effects of gender and catechol O-methyltransferase (COMT) Val108/158Met polymorphism on emotion regulation in velo-cardio-facial syndrome (22q11.2 deletion syndrome): An fMRI studyIoana L Coman
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York, USA
Neuroimage 53:1043-50. 2010.... - Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorderStewart H Mostofsky
Department of Neurology, Kennedy Krieger Institute, 707 N. Broadway, Baltimore, MD 21205, USA
Biol Psychiatry 52:785-94. 2002..More than one subdivision of the frontal lobes appears to be reduced in volume, suggesting that the clinical picture of ADHD encompasses dysfunctions attributable to anomalous development of both premotor and prefrontal cortices... - 22q11.2 deletion syndrome: are motor deficits more than expected for IQ level?Nancy J Roizen
Department of Psychiatry and Behavioral Sciences, the Center for the Diagnosis, Treatment, and Study of Velo Cardio Facial Syndrome and the Communications Disorder Unit, State University of New York Upstate Medical University, Syracuse, NY, USA
J Pediatr 157:658-61. 2010..To examine motor function in children with 22q11.2 deletion syndrome (22q11.2) and a Full Scale IQ (FSIQ) comparable control group... - Genotype and cardiovascular phenotype correlations with TBX1 in 1,022 velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patientsTingwei Guo
Department of Genetics, Ob Gyn and Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA
Hum Mutat 32:1278-89. 2011..This work demonstrates that common DNA variations in TBX1 do not explain variable cardiovascular expression in 22q11DS patients, implicating existence of modifiers in other genes on 22q11.2 or elsewhere in the genome... - Social behavior profile in young males with fragile X syndrome: characteristics and specificityAlice S M Kau
Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
Am J Med Genet A 126:9-17. 2004..In agreement with recent studies, our data suggest that FraX+Aut, and more generally SBP, is a distinctive subphenotype among boys with FraX, which may share some pathophysiological mechanisms with IA... - Frontal white matter reductions in healthy males with complex stereotypiesWendy R Kates
Department of Psychiatry and Behavioral Sciences, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY 13210, USA
Pediatr Neurol 32:109-12. 2005..These preliminary data suggest a possible dysfunction of cortico-striatal-thalamo-cortical circuitry in children with nonautistic, physiologic motor stereotypies... - Specificity of cerebellar vermian abnormalities in autism: a quantitative magnetic resonance imaging studyWalter E Kaufmann
Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Child Neurol 18:463-70. 2003..The latter results are consistent with MRI studies showing lobules VI-VII hyperplasia in a subset of subjects with idiopathic autism and cerebral and hippocampal enlargements in fragile X syndrome... - Cerebral growth in Fragile X syndrome: review and comparison with Down syndromeWendy R Kates
aMRI Analysis Laboratory, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Microsc Res Tech 57:159-67. 2002..These neuroimaging data are discussed in the context of FraX neurobiology and other developmental disorders... - 22q11.2DS deletion syndrome: developmental milestones in infants and toddlersNancy J Roizen
Department of Developmental and Rehabilitation Pediatrics, Cleveland Clinic, Cleveland, Ohio, USA
J Dev Behav Pediatr 28:119-24. 2007..2DS) have learning disabilities, and a substantial number have mental retardation. Although cognitive data have been reported on several samples of children with 22q11.2DS, data on their early developmental milestones are limited... - Inroads to mechanisms of disease in child psychiatric disordersWendy R Kates
Am J Psychiatry 164:547-51. 2007
Research Grants
- Biomarkers for Psychosis in Velocardiofacial SyndromeWendy Kates; Fiscal Year: 2009....
- Biomarkers for Psychosis in Velocardiofacial SyndromeWendy Kates; Fiscal Year: 2007....
- Biomarkers for Psychosis in Velocardiofacial SyndromeWendy Kates; Fiscal Year: 2006..To address these aims, children and youth will be assessed across multiple domains, including neuropsychological function, sustained attention, eye-tracking performance, brain morphology and clinical symptomatology. ..
- Neuroanatomy and Cognition in Velocardiofacial SyndromeWendy Kates; Fiscal Year: 2005....
- Biomarkers for Psychosis in Velocardiofacial SyndromeWendy Kates; Fiscal Year: 2010....