Research Topics
Species | Bernadette KalmanSummaryAffiliation: SUNY Upstate Medical University Country: USA Publications
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Detail Information
Publications
Studies of mitochondrial DNA in Devic's disease revealed no pathogenic mutations, but polymorphisms also found in association with multiple sclerosisBernadette Kalman
Ann Neurol 51:661-2. 2002- Bcl-2 and its homologues in the brain of patients with multiple sclerosisIleana Banisor
Department of Neurology, SLRHC, Hospital of Columbia University, New York 10019, USA
Mult Scler 10:176-81. 2004..This finding indicates that both pro- and anti-apoptotic mechanisms are activated, not only within but also outside of plaques... - The involvement of mitochondria in the pathogenesis of multiple sclerosisBernadette Kalman
VAMC, SUNY Upstate Medical University, Syracuse, NY 13210, USA
J Neuroimmunol 188:1-12. 2007.... 
Structural chromosomal variations in neurological diseasesBernadette Kalman
VA Medical Center, Syracuse, NY, USA
Neurologist 15:245-53. 2009....- CCL genes in multiple sclerosis and systemic lupus erythematosusTamara Vyshkina
VAMC Research, 800 Irving Avenue, Syracuse, NY 13210, United States
J Neuroimmunol 200:145-52. 2008..In SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype... 
Association of common mitochondrial DNA variants with multiple sclerosis and systemic lupus erythematosusTamara Vyshkina
VAMC Research, 800 Irving Avenue, Syracuse, NY 13210, USA
Clin Immunol 129:31-5. 2008..In addition, we detect the association of common variants of the mitochondrial ND2 and ATP6 genes with both MS and SLE, which raises the possibility of a shared mitochondrial genetic background of these two autoimmune diseases...- Lack of mitochondrial DNA deletions in lesions of multiple sclerosisAndrei Blokhin
VA Medical Center, Research 151, Syracuse, NY, USA
Neuromolecular Med 10:187-94. 2008..To test if mitochondrial (mt)DNA deletions accumulate in brains of patients with multiple sclerosis (MS)... - Increased promoter methylation of the immune regulatory gene SHP-1 in leukocytes of multiple sclerosis subjectsChiharu Kumagai
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
J Neuroimmunol 246:51-7. 2012.... - Variations in mitochondrial DNA copy numbers in MS brainsAndrei Blokhin
VA Medical Center, 800 Irving Avenue, Syracuse, NY 13210, USA
J Mol Neurosci 35:283-7. 2008..The age-related decline in mtDNA copy numbers may explain some features of late-onset MS... - Pathogenesis of multiple sclerosis: what can we learn from the cuprizone modelPeter Acs
Department of Neurology, SUNY Upstate Medical University, VA Medical Center, Syracuse, NY, USA
Methods Mol Biol 900:403-31. 2012..This chapter summarizes the classical and more contemporary concepts of MS, and provides methodologies for employing the cuprizone model for further explorations of the pathogenesis and treatment of the disease... - Autoantibodies and neurodegeneration in multiple sclerosisTamara Vyshkina
Veterans Administration Medical Center, Syracuse, NY 13210, USA
Lab Invest 88:796-807. 2008..A better understanding of molecular pathways leading to immune-mediated neurodegeneration may have key importance in the successful treatment of the disease... - Haplotypes within genes of beta-chemokines in 17q11 are associated with multiple sclerosis: a second phase studyTamara Vyshkina
Department of Neurology, Saint Luke's Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY, 10019, USA
Hum Genet 118:67-75. 2005..Sequencing of the identified chromosomal segments and their flanking regions will be necessary to define specific variants with direct relevance to MS pathogenesis... - Analyses of a MS-associated haplotype encompassing the CCL3 geneTamara Vyshkina
Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432W 58th Street, Room 226, New York, NY 10019, United States
J Neuroimmunol 176:216-8. 2006.... - Role of mitochondria in multiple sclerosisBernadette Kalman
Department of Neurology, Saint Luke s Roosevelt Hospital Center, Columbia University, 432 West 58th Street, Room 226, New York, NY 10019, USA
Curr Neurol Neurosci Rep 6:244-52. 2006.... - Genetic variants of Complex I in multiple sclerosisTamara Vyshkina
Department of Neurology, SLRHC, Columbia University, 432W 58th Street, New York, NY 10019, USA
J Neurol Sci 228:55-64. 2005..A mitochondrial mechanism contributes to neurodegeneration in multiple sclerosis (MS). Genetic variants of Complex I genes may influence the nature of tissue response to inflammation in the central nervous system (CNS)... - Genetics of multiple sclerosis: determinants of autoimmunity and neurodegenerationBernadette Kalman
Department of Neurology, MS423, MCP Hahnemann University, 245N 15th Street, Philadelphia, PA 19102, USA
Autoimmunity 35:225-34. 2002..This approach may yield important insights with utility in clinical practice... - A mitochondrial component of neurodegeneration in multiple sclerosisBernadette Kalman
SLRHC Columbia University, Department of Neurology, Multiple Sclerosis Research Center, New York, NY 10019, USA
Neuromolecular Med 3:147-58. 2003..Considering the need for additional therapeutic strategies, we emphasize the degenerative components, and review a mitochondrial mechanism of tissue loss potentially involved in the process of MS... - An extended genome scan in 442 Canadian multiple sclerosis-affected sibships: a report from the Canadian Collaborative Study GroupDavid A Dyment
The Wellcome Trust Center for Human Genetics, Oxford, UK
Hum Mol Genet 13:1005-15. 2004..This observation is most consistent with a model of genetic heterogeneity between HLA and other genetic loci. These findings offer guidance for future genetic studies including dense SNP linkage disequilibrium analysis... - Familial multiple sclerosis and other inherited disorders of the white matterBernadette Kalman
Department of Neurology, MS Research Center, SLRHC, Columbia University, New York, NY 10019, USA
Neurologist 10:201-15. 2004..Nevertheless, the exclusion of other entities still remains an integral element of the diagnostic process... - Association of haplotypes in the beta-chemokine locus with multiple sclerosisTamara Vyshkina
Department of Neurology, SLRHC, Columbia University, 432W 58th Street, New York, NY 10019, USA
Eur J Hum Genet 13:240-7. 2005.... - CD45 (PTPRC) as a candidate gene in multiple sclerosisTamara Vyshkina
Department of Neurology, SLRHC, Columbia University, New York, NY 10019, USA
Mult Scler 10:614-7. 2004..0342. We conclude that the 77C-->G PTPRC polymorphism is present and preferentially transmitted in a small subgroup (<5%) of MS families, which may only be detected with complementary methods of analysis... - Cognitive impairments in multiple sclerosis: a reviewEduardo Adonias DeSousa
Department of Neurology, MCP Hahnemann University, Philadelphia, Pennsylvania, USA
Am J Alzheimers Dis Other Demen 17:23-9. 2002..Until more powerful neuroprotective agents become available, simple neuropsychological screening and cognitive rehabilitation for memory and language impairments will remain important components in the care of MS patients...