Ying Huang

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. pmc Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer
    H Sun
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 32:234-41. 2013
  2. doi request reprint Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation
    Lingyan Jiang
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 East Adams St, Syracuse, NY 13210
    Mol Cancer Res 12:119-29. 2014
  3. ncbi request reprint Lappaol F, a novel anticancer agent isolated from plant arctium Lappa L
    Qing Sun
    Corresponding Authors Ying Huang, Department of Pharmacology, State University of New York, Upstate Medical University 750 East Adams Street, Syracuse, NY 13210
    Mol Cancer Ther 13:49-59. 2014
  4. ncbi request reprint TRAIL death receptors and cancer therapeutics
    Ying Huang
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Toxicol Appl Pharmacol 224:284-9. 2007
  5. ncbi request reprint DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies
    Hong Sun
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Mol Cancer Res 8:57-66. 2010
  6. pmc Negative regulation of p53 by Ras superfamily protein RBEL1A
    Ki Lui
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Cell Sci 126:2436-45. 2013
  7. ncbi request reprint Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York, NY 13210, USA
    Oncogene 21:6032-40. 2002
  8. ncbi request reprint Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 22:2674-9. 2003
  9. pmc Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains
    Chad A Corcoran
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 284:21955-70. 2009
  10. ncbi request reprint Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers
    Xiuquan Luo
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Cancer Res 65:10725-33. 2005

Collaborators

Detail Information

Publications85

  1. pmc Potential tumor-suppressive role of monoglyceride lipase in human colorectal cancer
    H Sun
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 32:234-41. 2013
    ..Taken together, our results suggest that MGL plays a negative regulatory role in phosphatidylinositol-3 kinase/Akt signaling and tumor cell growth...
  2. doi request reprint Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation
    Lingyan Jiang
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 East Adams St, Syracuse, NY 13210
    Mol Cancer Res 12:119-29. 2014
    ....
  3. ncbi request reprint Lappaol F, a novel anticancer agent isolated from plant arctium Lappa L
    Qing Sun
    Corresponding Authors Ying Huang, Department of Pharmacology, State University of New York, Upstate Medical University 750 East Adams Street, Syracuse, NY 13210
    Mol Cancer Ther 13:49-59. 2014
    ..Taken together, our results, for the first time, demonstrate that Lappaol F exhibits antitumor activity in vitro and in vivo and has strong potential to be developed as an anticancer therapeutic...
  4. ncbi request reprint TRAIL death receptors and cancer therapeutics
    Ying Huang
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Toxicol Appl Pharmacol 224:284-9. 2007
    ..It is therefore, evident that the future of TRAIL-based therapeutic approaches looks brighter...
  5. ncbi request reprint DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies
    Hong Sun
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Mol Cancer Res 8:57-66. 2010
    ..Collectively, our results indicate that DOC45 is a novel ATPase that is linked to cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker...
  6. pmc Negative regulation of p53 by Ras superfamily protein RBEL1A
    Ki Lui
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Cell Sci 126:2436-45. 2013
    ....
  7. ncbi request reprint Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York, NY 13210, USA
    Oncogene 21:6032-40. 2002
    ..In conclusion, the data presented herein form the basis of future in-depth studies to further explore the utility of Apo2L/TRAIL and NSAIDs, in combination, as a novel cancer preventive/therapeutic strategy...
  8. ncbi request reprint Effect of Bax deficiency on death receptor 5 and mitochondrial pathways during endoplasmic reticulum calcium pool depletion-induced apoptosis
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 22:2674-9. 2003
    ..Our results thus suggest that the combination of Apo2L/TRAIL and TG appears to bypass the Bax deficiency-induced defects in the mitochondrial (intrinsic) pathway by engaging the DR5-dependent apoptotic signals (extrinsic pathway)...
  9. pmc Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains
    Chad A Corcoran
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 284:21955-70. 2009
    ..It is therefore possible that Pirh2A and the novel Pirh2 isoforms identified in this study may also modulate p53 function by engaging MDM2...
  10. ncbi request reprint Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers
    Xiuquan Luo
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Cancer Res 65:10725-33. 2005
    ....
  11. pmc PDRG1, a novel tumor marker for multiple malignancies that is selectively regulated by genotoxic stress
    Lingyan Jiang
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, USA
    Cancer Biol Ther 11:567-73. 2011
    ..Taken together, our results indicate that PDRG1 expression is increased in multiple human malignancies suggesting it to be a high-value novel tumor marker that could play a role in cancer development and/or progression...
  12. pmc Identification and characterization of RBEL1 subfamily of GTPases in the Ras superfamily involved in cell growth regulation
    Joanne Montalbano
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 284:18129-42. 2009
    ....
  13. ncbi request reprint Prediction of anticancer drug potency from expression of genes involved in growth factor signaling
    Zunyan Dai
    Program of Pharmacogenomics, Department of Pharmacology, The Ohio State University, 5078 Graves Hall, 333 West 10th Avenue, Columbus, 43210, USA
    Pharm Res 23:336-49. 2006
    ..This study develops and evaluates a systematic approach to finding biomarker genes for predicting potency of anticancer drugs against tumor cells, focusing on gene families related to growth factor signaling...
  14. ncbi request reprint Genotoxic and endoplasmic reticulum stresses differentially regulate TRB3 expression
    Chad A Corcoran
    Department of Pharmacology, State University of New York, Upstate Medical, Syracuse, New York 13210, USA
    Cancer Biol Ther 4:1063-7. 2005
    ..Collectively, these findings highlight the importance of stress-specific signaling cascades as well as point out the seemingly divergent roles that TRB3 may play in the cellular stress response...
  15. ncbi request reprint Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation
    Rong Rong
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Oncogene 24:4867-72. 2005
    ..Thus, oncogenic Ras-mediated cellular transformation also involves downmodulation of important molecules such as Gadd153 that negatively regulate cell growth and survival...
  16. pmc CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology
    Jie An
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 287:7411-26. 2012
    ....
  17. ncbi request reprint Proteasome inhibitor MG132 upregulates death receptor 5 and cooperates with Apo2L/TRAIL to induce apoptosis in Bax-proficient and -deficient cells
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 23:2554-8. 2004
    ..Our results have important clinical implications in that the use of Apo2L/TRAIL and proteasome inhibitors in combination could prove to be a novel therapeutic strategy to manage the Apo2L/TRAIL-resistant tumors...
  18. ncbi request reprint Bax deficiency affects caspase-2 activation during ultraviolet radiation-induced apoptosis
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Oncogene 23:1321-5. 2004
    ..Based on our results, we propose that activation of caspases is not a linear cascade of events, but is rather connected via complex feedback loops...
  19. ncbi request reprint RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer
    Joanne Montalbano
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    J Biol Chem 282:37640-9. 2007
    ..Thus, RBEL1A and RBEL1B are novel Rab-like proteins that localize in the nucleus and cytosol and may play an important role in breast tumorigenesis...
  20. pmc Cullin-4A·DNA damage-binding protein 1 E3 ligase complex targets tumor suppressor RASSF1A for degradation during mitosis
    Lingyan Jiang
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 286:6971-8. 2011
    ..Thus, our present study demonstrates that the CUL4A·DDB1 E3 complex is important for regulation of RASSF1A during mitosis, and it may contribute to inactivation of RASSF1A and promoting cell cycle progression...
  21. pmc Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies
    Chad A Corcoran
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Mol Cancer Res 6:795-807. 2008
    ..Collectively, our results have identified nSMase3 to be an important molecule that is linked to tumorigenesis and cellular stress response...
  22. ncbi request reprint Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY, USA
    Cancer Biol Ther 9:819-24. 2010
    ..Based on these results, we propose a novel idea of developing DHA alone and/or in combination with TRAIL for the treatment of prostate cancer...
  23. ncbi request reprint Calcium-sensing receptor ubiquitination and degradation mediated by the E3 ubiquitin ligase dorfin
    Ying Huang
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    J Biol Chem 281:11610-7. 2006
    ..Because endogenous CaR in Madin-Darby canine kidney cells is also subject to degradation from the endoplasmic reticulum, dorfin-mediated ubiquitination may contribute to a general mechanism for CaR quality control during biosynthesis...
  24. ncbi request reprint Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in rats
    Han Ting Zhang
    Department of Pharmacology, The University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 182:104-15. 2005
    ..However, it is not known if PDE4 is associated with beta adrenergic receptors in the mediation of antidepressant-like effects...
  25. ncbi request reprint Cyclooxygenase-2 interacts with p53 and interferes with p53-dependent transcription and apoptosis
    Chad A Corcoran
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Oncogene 24:1634-40. 2005
    ..Based on our results, we propose that p53-dependent upregulation and activation of COX-2 appear to be yet another novel mechanism by which p53 could abate its own growth-inhibitory and apoptotic effects...
  26. ncbi request reprint Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats
    Han Ting Zhang
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Avenue, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 179:613-9. 2005
    ..Inhibition of cyclic AMP (cAMP)-specific phosphodiesterase (PDE4) enhances memory in rodents. MEM1018 and MEM1091 are newly developed PDE4 inhibitors that had not been evaluated as yet for their effects on working and reference memory...
  27. ncbi request reprint Death receptors as targets of cancer therapeutics
    M Saeed Sheikh
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Curr Cancer Drug Targets 4:97-104. 2004
    ..This review discusses the pros and cons of targeting death receptors in the development of novel cancer therapeutic agents...
  28. ncbi request reprint Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance
    Ying Huang
    Program of Pharmacogenomics, Department of Pharmacology, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210 1239, USA
    Cancer Res 65:7446-54. 2005
    ..SLC7A11 expression could serve as a predictor of cellular response to L-alanosine and glutathione-mediated resistance to geldanamycin, yielding a potential target for increasing chemosensitivity to multiple drugs...
  29. ncbi request reprint Tumor suppressor RASSF1A is a microtubule-binding protein that stabilizes microtubules and induces G2/M arrest
    Rong Rong
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 E Adams Street Syracuse, NY 13210, USA
    Oncogene 23:8216-30. 2004
    ..Together, these results provide important new insights into the molecular mechanisms by which this novel tumor suppressor mediates its biological effects...
  30. ncbi request reprint The p53 paddy wagon: COP1, Pirh2 and MDM2 are found resisting apoptosis and growth arrest
    Chad A Corcoran
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Cancer Biol Ther 3:721-5. 2004
    ..Future studies in this field will now face the challenge of elucidating the physiological significance of three molecules all apparently able to independently facilitate p53 degradation and abrogate its function...
  31. ncbi request reprint Rescue of calcium-sensing receptor mutants by allosteric modulators reveals a conformational checkpoint in receptor biogenesis
    Ying Huang
    Department of Biology, Syracuse University, Syracuse, New York 13244, USA
    J Biol Chem 282:9517-25. 2007
    ..e. a protein folding disorder. The allosteric modulators NPS R-568 and NPS 2143 not only alter CaR sensitivity to calcium and hence signaling but also modulate receptor expression...
  32. ncbi request reprint The regulation of energy generating metabolic pathways by p53
    Chad A Corcoran
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA
    Cancer Biol Ther 5:1610-3. 2006
    ..With this discovery, yet another novel means by which p53 carries out its tumor suppressor function is brought into light...
  33. ncbi request reprint Growth factor signaling and resistance to cancer chemotherapy
    Zunyan Dai
    Program of Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, 5168 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA
    Curr Top Med Chem 4:1347-56. 2004
    ..Monitoring expression profiles and activating mutations in growth factor receptors holds promise for the design of individualized therapy with a combination of drugs...
  34. ncbi request reprint Endoplasmic reticulum calcium pool depletion-induced apoptosis is coupled with activation of the death receptor 5 pathway
    Qin He
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, New York, NY 13210, USA
    Oncogene 21:2623-33. 2002
    ....
  35. ncbi request reprint Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance
    Ying Huang
    Program of Pharmacogenomics, Department of Pharmacology, College of Medicine and Public Health, The Ohio State University, Columbus, 43210, USA
    Cancer Res 64:4294-301. 2004
    ..Measurement of transporter gene expression may prove useful in predicting anticancer drug response...
  36. ncbi request reprint Thimerosal induces apoptosis in a neuroblastoma model via the cJun N-terminal kinase pathway
    Michelle L Herdman
    Department of Pharmacology, Joan C Edwards School of Medicine, Marshall University, 1542 Spring Valley Drive, Huntington, WV 25704, USA
    Toxicol Sci 92:246-53. 2006
    ..Taken together, these results indicate that thimerosal-induced neurotoxicity occurs through the JNK-signaling pathway, independent of cJun activation, leading ultimately to apoptotic cell death...
  37. ncbi request reprint Death receptor activation complexes: it takes two to activate TNF receptor 1
    M Saeed Sheikh
    Department of Pharmacology, SUNY, Upstate Medical University, Syracuse, New York 13210, USA
    Cell Cycle 2:550-2. 2003
    ..These findings highlighting the complexities of TNF-R1-mediated signaling events are likely to further the progress in the constantly evolving area of death receptor-dependent signaling pathways...
  38. ncbi request reprint The FADD is going nuclear
    M Saeed Sheikh
    Department of Pharmacology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Cell Cycle 2:346-7. 2003
    ..In addition to its well-established role in transduction of apoptotic signals, FADD may also play a role in regulating genome surveillance and perhaps in other as yet unidentified cellular processes...
  39. ncbi request reprint Cloning and characterization of a novel gene PDRG that is differentially regulated by p53 and ultraviolet radiation
    Xiuquan Luo
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 12310, USA
    Oncogene 22:7247-57. 2003
    ..Furthermore, stable expression of exogenous PDRG was found to decrease the clonogenic survival after UV irradiation, which highlights the significance of PDRG in facilitating UV-induced killing...
  40. ncbi request reprint Inhibition of the phosphodiesterase 4 (PDE4) enzyme reverses memory deficits produced by infusion of the MEK inhibitor U0126 into the CA1 subregion of the rat hippocampus
    Han Ting Zhang
    Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Neuropsychopharmacology 29:1432-9. 2004
    ..PDE4 is likely to be an important link between the cAMP/PKA and MEK/ERK signaling pathways in the mediation of memory...
  41. ncbi request reprint TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway
    Rong Rong
    Department of Pharmacology, State University of New York, Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Oncogene 21:1062-70. 2002
    ..In conclusion, we have identified PI3-K as an effector of TC21 and demonstrated that the PI3-K/Akt signaling pathway plays important roles in TC21-mediated transformation and cell survival...
  42. ncbi request reprint Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells
    Qin He
    Department of Pharmacology SUNY Upstate Medical University Syracuse, New York 13210 USA
    Cancer Biol Ther 1:287-90. 2002
    ..Thus, our results suggest that DR5 is specifically regulated by selenium and its activation may play an important role in selenium-mediated chemoprevention...
  43. ncbi request reprint Chromic-P32 phosphate treatment of implanted pancreatic carcinoma: mechanism involved
    Lu Liu
    Institute of Nuclear Medicine Technology of Southeast University, 87 Dingjiaqiaolu, Nanjing 210009, Jiangsu Province, China
    World J Gastroenterol 11:2101-8. 2005
    ..To study the effects of chromic-P32 phosphate (32P colloids) interstitial administration in Pc-3 implanted pancreatic carcinoma, and investigate its anticancer mechanism...
  44. ncbi request reprint Pharmacogenomics of sex difference in chemotherapeutic toxicity
    Jeffrey Wang
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Curr Drug Discov Technol 4:59-68. 2007
    ....
  45. ncbi request reprint [Therapeutic effect of high-density lipoprotein of human plasma on rat endotoxemia]
    Ying Huang
    Department of Pathophysiology, West China School of Predinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Hua Xi Yi Ke Da Xue Xue Bao 33:65-7. 2002
    ..To investigate the therapeutic effect of high-density lipoprotein (HDL) of human plasma on rat endotoxemia...
  46. ncbi request reprint Genetic polymorphism of UL144 open reading frame of human cytomegalovirus DNA detected in colon samples from infants with Hirschsprung's disease
    Zhi Qin Mao
    Department of Pediatrics, Second Affiliated Hospital, China Medical University, Shenyang 110004, Liaoning Province, China
    World J Gastroenterol 13:4350-4. 2007
    ....
  47. ncbi request reprint Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end
    Ying Huang
    Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:34958-67. 2007
    ..Prolonged nuclear retention, but not reduced intranuclear mobility, mapped to the CT7 domain of Stat3beta...
  48. ncbi request reprint The Chinese medicinal herbal formula ZYD88 inhibits cell growth and promotes cell apoptosis in prostatic tumor cells
    Yuan Shan Zhu
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Oncol Rep 10:1633-9. 2003
    ..These data suggest that ZYD88 is a potential agent for prostate cancer therapy, and deserves further study...
  49. ncbi request reprint Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARalpha, resulting in sequestration and decreased mobility of SMRT
    Ying Huang
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiaotong University School of Medicine SJTU SM, No 280, Chong Qing South Road, Shanghai 200025, China
    Biochem Biophys Res Commun 365:258-65. 2008
    ..These results would shed new insights for the molecular mechanisms of PML-RARalpha-associated leukemogenesis...
  50. ncbi request reprint CD72 polymorphism associated with child-onset of idiopathic thrombocytopenic purpura in Chinese patients
    Jianhui Xu
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, China
    J Clin Immunol 28:214-9. 2008
    ..32-7.25] and 1.98-fold (95% CI, 0.92-4.25) increased risk of appearing ITP manifestation at their childhood respectively. The haplotype CD72*1 is apparently a risk allele, whereas CD72*2 a protective allele for child-onset of ITP disease...
  51. ncbi request reprint Nucleophosmin/B23 negatively regulates GCN5-dependent histone acetylation and transactivation
    Yonglong Zou
    Biosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    J Biol Chem 283:5728-37. 2008
    ..Taken together, our studies suggest a molecular mechanism of B23 in the mitotic inhibition of GCN5-mediated histone acetylation and transactivation...
  52. ncbi request reprint [Diamide and cyclosporin A enhanced arsenic trioxide-induced apoptosis in NB4 cells]
    Yun Yu
    Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Xue Ye Xue Za Zhi 23:254-7. 2002
    ....
  53. ncbi request reprint An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy
    John L Jakubczak
    Genetic Therapy, Inc, Gaithersburg, Maryland 20878, USA
    Cancer Res 63:1490-9. 2003
    ..Our results support the use of oncolytic adenoviruses using tumor-selective promoter(s) that are activated or derepressed in tumor cells by virtue of a particular defective pathway, such as the Rb pathway...
  54. ncbi request reprint Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection by E. coli
    Ying Huang
    Department of Pathophysiology, Huaxi School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 8:1134-7. 2002
    ..To investigate the therapeutic effects of recombinant human growth hormone (rhGH) on rat septic shock with intraabdominal infection by E. coli and its possible mechanism...
  55. ncbi request reprint Genetic variations and gene expression of transporters in drug disposition and response
    Ying Huang
    Western University of Health Sciences, College of Pharmacy, Department of Pharmaceutical Sciences, Pomona, CA 91766, USA
    Expert Opin Drug Metab Toxicol 4:237-54. 2008
    ..The importance of transporters in drug disposition and response has led to increasing interest in genetic variations and expression differences of their genes...
  56. ncbi request reprint Drug sensitivity and resistance genes in cancer chemotherapy: a chemogenomics approach
    Ying Huang
    Program of Pharmacogenomics, Dept of Pharmacology, College of Medicine and Public Health, The Ohio State University, 5078 Graves Hall, 333 W 10th Avenue, Columbus, OH 43210, USA
    Drug Discov Today 8:356-63. 2003
    ..Therefore, validated pharmacogenomic biomarkers offer the potential for the selection of optimal treatment regimens for individual patients and for identifying novel therapeutic targets to overcome drug resistance...
  57. ncbi request reprint The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell-cycle arrest in T-cells
    Yafeng Zhang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, People s Republic of China
    Biochem J 413:239-50. 2008
    ..Altogether, our results demonstrate that DnaJB6 is necessary for translocation of Slfn1 into the nucleus, where Slfn1 down-regulates cyclin D1, induces cell-cycle arrest and programmes a quiescent state of T-cells...
  58. ncbi request reprint Glutamine decreases lipopolysaccharide-induced IL-8 production in Caco-2 cells through a non-NF-kappaB p50 mechanism
    Ying Huang
    Children s Hospital of Fudan University, 183 Fenglin Road, Shanghai 200032, People s Republic of China
    Cytokine 22:77-83. 2003
    ..However, the glutamine-mediated decrease in LPS-stimulated IL-8 production is not associated with NF-kappaB p50 nuclear binding...
  59. pmc Identification and characterization of a novel folliculin-interacting protein FNIP2
    Hisashi Hasumi
    Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20894, United States
    Gene 415:60-7. 2008
    ....
  60. ncbi request reprint Retinoic acid-induced AP-1 transcriptional activity regulates B16 mouse melanoma growth inhibition and differentiation
    Ying Huang
    Department of Biochemistry and Molecular Biology, Joan C Edwards School of Medicine, Marshall University, Huntington, West Virginia 25704, USA
    J Cell Physiol 194:162-70. 2003
    ..Our observations suggest that AP-1 transcriptional activity induced by RA likely plays an important role in the biological changes mediated by this retinoid in B16 melanoma cells...
  61. doi request reprint The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo
    Stephen J Kennel
    Graduate School of Medicine, University of TN, Knoxville, TN 37920, USA
    Nucl Med Biol 35:501-14. 2008
    ..We have used a model system of radiolabeled quantum dots to document the competition between efficient vascular targeting and interaction of the NP with the reticuloendothelial (RE) system...
  62. ncbi request reprint Functional characterization of Narc 1, a novel proteinase related to proteinase K
    Saule Naureckiene
    Neuroscience Discovery Research, Wyeth Research, CN 8000, Princeton, NJ 08543 8000, USA
    Arch Biochem Biophys 420:55-67. 2003
    ....
  63. ncbi request reprint The epidermal growth factor receptor intron1 (CA) n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with Gefitinib
    Qiang Nie
    Lung Cancer Research Institute and Cancer Center, Guangdong Provincial People s Hospital, Guangzhou, People s Republic of China
    Eur J Pharmacol 570:175-81. 2007
    ..Overall, our data suggest that the intron1 (CA) n polymorphism of the EGF receptor gene may be associated with the sensitivity to and the prognosis of non-small cell lung cancer after EGF receptor targeted inhibitor treatment...
  64. ncbi request reprint Equilibrium interactions of corepressors and coactivators with agonist and antagonist complexes of glucocorticoid receptors
    Qi Wang
    Steriod Hormones Section, National Institute of Diabetes and Digestive and Kidney Disease Laboratory of Molecular and Cellular Biology, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Endocrinol 18:1376-95. 2004
    ..This modulation provides an attractive mechanism for differential control of gene expression during development, differentiation, homeostasis, and endocrine therapies...
  65. ncbi request reprint TRAIL death receptors, Bcl-2 protein family, and endoplasmic reticulum calcium pool
    M Saeed Sheikh
    Department of Pharmacology State University of New York Upstate Medical University Syracuse, New York 13210, USA
    Vitam Horm 67:169-88. 2004
    ..The recent explosion of information in the fields of cell signaling and apoptosis is likely to facilitate the future investigations aiming to explore these issues...
  66. ncbi request reprint ATID: a web-oriented database for collection of publicly available alternative translational initiation events
    Jun Cai
    MOE Key Laboratory of Bioinformatics and Department of Automation, Tsinghua University Beijing 100084, China
    Bioinformatics 21:4312-4. 2005
    ..Resources in ATID, including gene information, alternative products of genes and domain structures of isoforms, are provided through a user-friendly web interface...
  67. ncbi request reprint ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
    Natasha Y Frank
    Department of Genetics, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:4320-33. 2005
    ....
  68. ncbi request reprint Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines
    Jim J Xiao
    College of Pharmacy, The Ohio State University, Columbus, OH, USA
    J Pharmacol Exp Ther 314:467-75. 2005
    ..This study reveals a significant role of histone acetylation in MDR1 transcription, which seems to mediate FK228 resistance...
  69. ncbi request reprint [Antitumor efficacy of CD/5-FC suicide gene therapy system mediated by Bifidobacterium infantis against melanoma]
    Cheng Yi
    Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 36:165-8. 2005
    ..To observe the antitumor efficacy of cytosine deaminase/5-fluorocytosine (CD/5-FC) suicide gene therapy system mediated by Bifidobacterium infantis against melanoma in vitro and in vivo...
  70. ncbi request reprint Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer
    Patricia C Ryan
    Genetic Therapy, Inc, Gaithersburg, Maryland 20878, USA
    Cancer Gene Ther 11:555-69. 2004
    ..Furthermore, efficacy was significantly improved when OAS403 treatment was combined with doxorubicin. This virus holds promise for the treatment of a broad range of human cancers including metastatic disease...
  71. ncbi request reprint Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1
    Jim J Xiao
    Division of Pharmaceutics, College of Pharmacy, The Ohio State Univeristy, Columbus, Ohio 43210, USA
    J Pharmacol Exp Ther 313:268-76. 2005
    ..These studies demonstrate that FK228 is a substrate for Pgp and MRP1, and reversible Pgp up-regulation is predominantly involved in FK228 resistance in vitro...
  72. pmc Mutations in the RNA polymerase III subunit Rpc11p that decrease RNA 3' cleavage activity increase 3'-terminal oligo(U) length and La-dependent tRNA processing
    Ying Huang
    Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, NIH, 31 Center Dr, Room 2A25, Bethesda, MD 20892 2426, USA
    Mol Cell Biol 25:621-36. 2005
    ..The data indicate that Rpc11p limits RNA 3'-U length and that this significantly restricts pre-tRNAs to a La-independent pathway of maturation in fission yeast...
  73. ncbi request reprint Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells
    Hua Yan
    Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Rui Jin Hospital, Shanghai Jiao Tong University SJU SM, formerly named Shanghai Second Medical University, Shanghai 200025, China
    Haematologica 90:1607-16. 2005
    ....
  74. ncbi request reprint Alteration of protein subcellular location and domain formation by alternative translational initiation
    Jun Cai
    Institute of Bioinformatics, MOE Key Laboratory of Bioinformatics, Department of Automation, Tsinghua University, Beijing, China
    Proteins 62:793-9. 2006
    ..The peculiar consequence of subcellular relocation as well as change of domain contents reflected the very high level of biological complexity as alternative usage of initiation codons...
  75. ncbi request reprint Mechanistic link between the anti-HCV effect of interferon gamma and control of viral replication by a Ras-MAPK signaling cascade
    Ying Huang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Hepatology 43:81-90. 2006
    ..In conclusion, the direct anti-HCV effect of IFN-gamma in cell culture is, at least in part, mediated through the Ras-MAPK signaling pathway, which possibly involves a direct or indirect modulation of NS5A protein phosphorylation...
  76. ncbi request reprint Structural basis for dimerization of LAP2alpha, a component of the nuclear lamina
    Christina Marchetti Bradley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Structure 15:643-53. 2007
    ..The surface involved in binding lamin A/C is proposed based on results from alanine-scanning mutagenesis and a solid-phase overlay binding assay...
  77. ncbi request reprint Human IgG1 Cgamma1 domain is crucial for the bioactivity of the engineered anti-CD20 antibodies
    Shusheng Geng
    College of Life Science, Hebei University, Baoding, China
    Cell Mol Immunol 4:121-5. 2007
    ..Our study highlights some interests and advantages of a methodology based on the homology modeling and analysis of molecular structural properties...
  78. ncbi request reprint Structured to reduce the mitogenicity of anti-CD3 antibody based on computer-guided molecular design
    Ming Lv
    Institute of Basic Medical Sciences, Beijing, PR China
    Int J Biochem Cell Biol 39:1142-55. 2007
    ....
  79. ncbi request reprint Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-
    Zunyan Dai
    Program of Pharmacogenomics, Department of Pharmacology and the Comprehensive Cancer Center, College of Medicine, The Ohio State University, Columbus Ohio 43210, USA
    J Med Chem 50:1896-906. 2007
    ..In cell lines strongly expressing SLC7A11, the potency of selected compounds, was enhanced by inhibition of SLC7A11. This system provides a rapid screen for detecting susceptibility of anticancer drugs to GSH-mediated resistance...
  80. ncbi request reprint Solution NMR structure of the barrier-to-autointegration factor-Emerin complex
    Mengli Cai
    Laboratories of Chemical Physics and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892 0520, USA
    J Biol Chem 282:14525-35. 2007
    ..The relevance of the implications of the structural and biophysical data on the complex in the context of the interaction between the BAF(2) dimer and Em(LEM) at the nuclear envelope is discussed...
  81. ncbi request reprint Pharmacogenetics/genomics of membrane transporters in cancer chemotherapy
    Ying Huang
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
    Cancer Metastasis Rev 26:183-201. 2007
    ....
  82. ncbi request reprint Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
    Xianhua Cao
    Division of Pharmaceutics, School of Pharmacy, The Ohio State University, 500 W 12th Ave, Columbus, OH 43210, USA
    Cancer Chemother Pharmacol 59:495-505. 2007
    ..Inhibition of glucose transporter will preferentially sensitize the anticancer effects of chemotherapeutic drugs to overcome drug resistance in hypoxia...
  83. ncbi request reprint Crystal structure of the HP1-EMSY complex reveals an unusual mode of HP1 binding
    Ying Huang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Structure 14:703-12. 2006
    ..This structural information expands our understanding of HP1 binding specificity and provides insights into interactions between HP1 homodimers that are likely to be important for heterochromatin formation...
  84. ncbi request reprint Regulation of recombinant monoclonal antibody production in chinese hamster ovary cells: a comparative study of gene copy number, mRNA level, and protein expression
    Zhou Jiang
    The Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Biotechnol Prog 22:313-8. 2006
    ..We also observed that the HC to LC gene copy ratio may affect the protein yield in MAb expression systems...
  85. ncbi request reprint [Study on acute pancreatitis-associated lung injury induced by L-arginine in mice]
    Qiu ling Zhao
    Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 35:839-42. 2004
    ..To establish the model of acute pancreatitis (AP)-associated lung injury induced by L-arginine and study the role of TNF-alpha and ICAM-1 in the model mice...

Research Grants8

  1. Characterization of a novel nuclear Rab protein
    Ying Huang; Fiscal Year: 2007
    ....
  2. Characterization of a Novel Lysophospholipase
    Ying Huang; Fiscal Year: 2003
    ..abstract_text> ..
  3. Characterization of a novel ER membrane protein SPOC
    Ying Huang; Fiscal Year: 2005
    ....
  4. Role of a Novel Lysophospholipase in Tumorigenesis
    Ying Huang; Fiscal Year: 2010
    ....
  5. Characterization of a putative GTP-binding protein as a novel tumor marker.
    Ying Huang; Fiscal Year: 2007
    ....
  6. Role of a Novel Lysophospholipase in Tumorigenesis
    Ying Huang; Fiscal Year: 2009
    ....