Research Topics
Species | Jason A HortonSummaryAffiliation: SUNY Upstate Medical University Country: USA Publications
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Publications
Precision and accuracy of DXA and pQCT for densitometry of the rat femurJason A Horton
Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA
J Clin Densitom 6:381-90. 2003..Further, our assessment of the precision and accuracy observed between methods of scanning excised rat femurs validates our data acquisition method and serves as a foundation for future densitometry studies...- Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectantTimothy A Damron
Departments of Orthopedics and Pathology, SUNY Upstate Medical University, Syracuse, New York, USA
J Histochem Cytochem 52:157-67. 2004..These findings underscore the importance of PTHrP in response to growth plate irradiation and show the novel finding of a decrease in Bax expression with amifostine pretreatment... - Radioprotectant combinations spare radiation-induced damage to the physis more than fractionation aloneJoseph A Spadaro
Musculoskeletal Research Laboratory of Department of Orthopedic Surgery, Institute for Human Performance at SUNY Upstate Medical University, Syracuse, New York 13210, USA
Int J Radiat Biol 81:759-65. 2005..CONCLUSIONS: Radioprotectants may be beneficial in growth plate radioprotection, alone or in combination... - Combination radioprotectors maintain proliferation better than single agents by decreasing early parathyroid hormone-related protein changes after growth plate irradiationTimothy A Damron
Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Radiat Res 165:350-8. 2006.... - Restoration of growth plate function following radiotherapy is driven by increased proliferative and synthetic activity of expansions of chondrocytic clonesJason A Horton
Musculoskeletal Sciences Research Center, Department of Orthopaedic Surgery, 3120 Institute for Human Performance, SUNY Upstate Medical University, 505 Irving Avenue, Syracuse, New York 13210, USA
J Orthop Res 24:1945-56. 2006.... 
Ontogeny of skeletal maturation in the juvenile ratJason A Horton
SUNY Upstate Medical University, Department of Orthopedic Surgery, 3120 Institute for Human Performance, Musculoskeletal Sciences Research Center, Syracuse, NY 13210, USA
Anat Rec (Hoboken) 291:283-92. 2008..Taken together, these data provide insight to the temporal coordination of postnatal endochondral growth processes...
Microarray cluster analysis of irradiated growth plate zones following laser microdissectionTimothy A Damron
SUNY Upstate Medical University, Syracuse, NY, USA
Int J Radiat Oncol Biol Phys 74:949-56. 2009..Genes and pathways involved in early growth plate chondrocyte recovery after fractionated irradiation were sought as potential targets for selective radiorecovery modulation...- Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiationYan Wang
Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, Syracuse, NY 13202, USA
Cells Tissues Organs 186:192-203. 2007..The hypothesis was that a limited number of growth factors and cytokines play a role in growth plate proliferative and hypertrophic chondrocyte radio-recovery... - Microarray analysis of irradiated growth plate zones following laser microdissection shows later importance of differentially expressed genes during radiorecoveryMeredith R Pritchard
Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY 13057, USA
Cells Tissues Organs 192:240-9. 2010..Potential targets for selective radiorecovery modulation were investigated via the identification of late upregulated genes and pathways during growth plate chondrocyte recovery... - Histomorphometric evidence of growth plate recovery potential after fractionated radiotherapy: an in vivo modelTimothy A Damron
Musculoskeletal Science Research Center, Department of Orthopedic Surgery, Upstate Medical University, Syracuse, New York, USA
Radiat Res 170:284-91. 2008.... - Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathwaysMingliang Zhang
Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Syracuse, New York, 13210, USA
Bone 43:511-20. 2008..We conclude that differential gene expression exists between the RZ and PC chondrocytes and these differentially expressed genes have unique roles to play corresponding to the function of their respective zones... - Decreased proliferation precedes growth factor changes after physeal irradiationTimothy A Damron
Departments of Orthopedics and Pathology, SUNY Upstate Medical University, Syracuse, NY, USA
Clin Orthop Relat Res . 2004..The current study suggests that decreased proliferation and apoptosis precede any change in histomorphometric features of the growth plate after irradiation and that decreased growth factor expression occurs later... - Growth plate zonal microarray analysis shows upregulation of extracellular matrix genes and downregulation of metalloproteinases and cathepsins following irradiationMingliang Zhang
Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Suite 130, 550 Harrison Street, Syracuse, NY 13210, USA
Calcif Tissue Int 81:26-38. 2007..Upregulation of genes not normally highly expressed in the noninjured growth plate suggests their importance in the injury and repair response... - Metastatic osteosarcoma gene expression differs in vitro and in vivoJennifer W Lisle
Department of Orthopedic Surgery, Musculoskeletal Sciences Research Center, SUNY Upstate Medical University, Suite 130, 550 Harrison Street, Syracuse, NY 13202, USA
Clin Orthop Relat Res 466:2071-80. 2008..Our orthotopic injection model allowed in vivo study of differential gene expression between these two cell lines but did not show radiographic evidence of an established primary lesion... - Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathwaysYan Wang
Department of Orthopedic Surgery, Musculoskeletal Sciences Research Center, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
Bone 35:1273-93. 2004..It is likely that these differentially expressed genes are involved in regulation of the transition from proliferation to differentiation functions in the growth plate... - Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft modelJason A Horton
Department of Orthopaedic Surgery, Musculoskeletal Sciences Research Center, Institute for Human Performance, SUNY Upstate Medical University, 505 Irving Avenue, Syracuse, NY 13210, USA
Sarcoma 2011:815190. 2011..1% decrease in limb length but did not extend survival. This new model provides a clinically relevant means to test the efficacy and safety of novel radioprotectant and radiorecovery strategies for use in this context...