Jason A Horton

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. ncbi request reprint Precision and accuracy of DXA and pQCT for densitometry of the rat femur
    Jason A Horton
    Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Clin Densitom 6:381-90. 2003
  2. ncbi request reprint Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant
    Timothy A Damron
    Departments of Orthopedics and Pathology, SUNY Upstate Medical University, Syracuse, New York, USA
    J Histochem Cytochem 52:157-67. 2004
  3. ncbi request reprint Radioprotectant combinations spare radiation-induced damage to the physis more than fractionation alone
    Joseph A Spadaro
    Musculoskeletal Research Laboratory of Department of Orthopedic Surgery, Institute for Human Performance at SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Int J Radiat Biol 81:759-65. 2005
  4. ncbi request reprint Combination radioprotectors maintain proliferation better than single agents by decreasing early parathyroid hormone-related protein changes after growth plate irradiation
    Timothy A Damron
    Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Radiat Res 165:350-8. 2006
  5. ncbi request reprint Restoration of growth plate function following radiotherapy is driven by increased proliferative and synthetic activity of expansions of chondrocytic clones
    Jason A Horton
    Musculoskeletal Sciences Research Center, Department of Orthopaedic Surgery, 3120 Institute for Human Performance, SUNY Upstate Medical University, 505 Irving Avenue, Syracuse, New York 13210, USA
    J Orthop Res 24:1945-56. 2006
  6. doi request reprint Ontogeny of skeletal maturation in the juvenile rat
    Jason A Horton
    SUNY Upstate Medical University, Department of Orthopedic Surgery, 3120 Institute for Human Performance, Musculoskeletal Sciences Research Center, Syracuse, NY 13210, USA
    Anat Rec (Hoboken) 291:283-92. 2008
  7. pmc Microarray cluster analysis of irradiated growth plate zones following laser microdissection
    Timothy A Damron
    SUNY Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 74:949-56. 2009
  8. ncbi request reprint Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation
    Yan Wang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, Syracuse, NY 13202, USA
    Cells Tissues Organs 186:192-203. 2007
  9. pmc Microarray analysis of irradiated growth plate zones following laser microdissection shows later importance of differentially expressed genes during radiorecovery
    Meredith R Pritchard
    Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY 13057, USA
    Cells Tissues Organs 192:240-9. 2010
  10. pmc Histomorphometric evidence of growth plate recovery potential after fractionated radiotherapy: an in vivo model
    Timothy A Damron
    Musculoskeletal Science Research Center, Department of Orthopedic Surgery, Upstate Medical University, Syracuse, New York, USA
    Radiat Res 170:284-91. 2008

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Precision and accuracy of DXA and pQCT for densitometry of the rat femur
    Jason A Horton
    Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Clin Densitom 6:381-90. 2003
    ..Further, our assessment of the precision and accuracy observed between methods of scanning excised rat femurs validates our data acquisition method and serves as a foundation for future densitometry studies...
  2. ncbi request reprint Temporal changes in PTHrP, Bcl-2, Bax, caspase, TGF-beta, and FGF-2 expression following growth plate irradiation with or without radioprotectant
    Timothy A Damron
    Departments of Orthopedics and Pathology, SUNY Upstate Medical University, Syracuse, New York, USA
    J Histochem Cytochem 52:157-67. 2004
    ..These findings underscore the importance of PTHrP in response to growth plate irradiation and show the novel finding of a decrease in Bax expression with amifostine pretreatment...
  3. ncbi request reprint Radioprotectant combinations spare radiation-induced damage to the physis more than fractionation alone
    Joseph A Spadaro
    Musculoskeletal Research Laboratory of Department of Orthopedic Surgery, Institute for Human Performance at SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Int J Radiat Biol 81:759-65. 2005
    ..The aim of this study was to determine if fractionation and individual or combinations of radioprotectants could minimize damage to physeal longitudinal growth in an animal model to any greater extent than fractionation alone...
  4. ncbi request reprint Combination radioprotectors maintain proliferation better than single agents by decreasing early parathyroid hormone-related protein changes after growth plate irradiation
    Timothy A Damron
    Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Radiat Res 165:350-8. 2006
    ....
  5. ncbi request reprint Restoration of growth plate function following radiotherapy is driven by increased proliferative and synthetic activity of expansions of chondrocytic clones
    Jason A Horton
    Musculoskeletal Sciences Research Center, Department of Orthopaedic Surgery, 3120 Institute for Human Performance, SUNY Upstate Medical University, 505 Irving Avenue, Syracuse, New York 13210, USA
    J Orthop Res 24:1945-56. 2006
    ....
  6. doi request reprint Ontogeny of skeletal maturation in the juvenile rat
    Jason A Horton
    SUNY Upstate Medical University, Department of Orthopedic Surgery, 3120 Institute for Human Performance, Musculoskeletal Sciences Research Center, Syracuse, NY 13210, USA
    Anat Rec (Hoboken) 291:283-92. 2008
    ..Taken together, these data provide insight to the temporal coordination of postnatal endochondral growth processes...
  7. pmc Microarray cluster analysis of irradiated growth plate zones following laser microdissection
    Timothy A Damron
    SUNY Upstate Medical University, Syracuse, NY, USA
    Int J Radiat Oncol Biol Phys 74:949-56. 2009
    ..Genes and pathways involved in early growth plate chondrocyte recovery after fractionated irradiation were sought as potential targets for selective radiorecovery modulation...
  8. ncbi request reprint Connective tissue growth factor and insulin-like growth factor 2 show upregulation in early growth plate radiorecovery response following irradiation
    Yan Wang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, Syracuse, NY 13202, USA
    Cells Tissues Organs 186:192-203. 2007
    ..The hypothesis was that a limited number of growth factors and cytokines play a role in growth plate proliferative and hypertrophic chondrocyte radio-recovery...
  9. pmc Microarray analysis of irradiated growth plate zones following laser microdissection shows later importance of differentially expressed genes during radiorecovery
    Meredith R Pritchard
    Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY 13057, USA
    Cells Tissues Organs 192:240-9. 2010
    ..Potential targets for selective radiorecovery modulation were investigated via the identification of late upregulated genes and pathways during growth plate chondrocyte recovery...
  10. pmc Histomorphometric evidence of growth plate recovery potential after fractionated radiotherapy: an in vivo model
    Timothy A Damron
    Musculoskeletal Science Research Center, Department of Orthopedic Surgery, Upstate Medical University, Syracuse, New York, USA
    Radiat Res 170:284-91. 2008
    ....
  11. pmc Microarray analysis of perichondral and reserve growth plate zones identifies differential gene expressions and signal pathways
    Mingliang Zhang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Syracuse, New York, 13210, USA
    Bone 43:511-20. 2008
    ..We conclude that differential gene expression exists between the RZ and PC chondrocytes and these differentially expressed genes have unique roles to play corresponding to the function of their respective zones...
  12. ncbi request reprint Decreased proliferation precedes growth factor changes after physeal irradiation
    Timothy A Damron
    Departments of Orthopedics and Pathology, SUNY Upstate Medical University, Syracuse, NY, USA
    Clin Orthop Relat Res . 2004
    ..The current study suggests that decreased proliferation and apoptosis precede any change in histomorphometric features of the growth plate after irradiation and that decreased growth factor expression occurs later...
  13. ncbi request reprint Growth plate zonal microarray analysis shows upregulation of extracellular matrix genes and downregulation of metalloproteinases and cathepsins following irradiation
    Mingliang Zhang
    Musculoskeletal Sciences Research Laboratory, Department of Orthopedic Surgery, State University of New York Upstate Medical University, Suite 130, 550 Harrison Street, Syracuse, NY 13210, USA
    Calcif Tissue Int 81:26-38. 2007
    ..Upregulation of genes not normally highly expressed in the noninjured growth plate suggests their importance in the injury and repair response...
  14. pmc Metastatic osteosarcoma gene expression differs in vitro and in vivo
    Jennifer W Lisle
    Department of Orthopedic Surgery, Musculoskeletal Sciences Research Center, SUNY Upstate Medical University, Suite 130, 550 Harrison Street, Syracuse, NY 13202, USA
    Clin Orthop Relat Res 466:2071-80. 2008
    ..Our orthotopic injection model allowed in vivo study of differential gene expression between these two cell lines but did not show radiographic evidence of an established primary lesion...
  15. ncbi request reprint Microarray analysis of proliferative and hypertrophic growth plate zones identifies differentiation markers and signal pathways
    Yan Wang
    Department of Orthopedic Surgery, Musculoskeletal Sciences Research Center, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    Bone 35:1273-93. 2004
    ..It is likely that these differentially expressed genes are involved in regulation of the transition from proliferation to differentiation functions in the growth plate...
  16. pmc Physeal bystander effects in rhabdomyosarcoma radiotherapy: experiments in a new xenograft model
    Jason A Horton
    Department of Orthopaedic Surgery, Musculoskeletal Sciences Research Center, Institute for Human Performance, SUNY Upstate Medical University, 505 Irving Avenue, Syracuse, NY 13210, USA
    Sarcoma 2011:815190. 2011
    ..1% decrease in limb length but did not extend survival. This new model provides a clinically relevant means to test the efficacy and safety of novel radioprotectant and radiorecovery strategies for use in this context...