S J Glatt

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. doi request reprint Blood-based gene-expression predictors of PTSD risk and resilience among deployed marines: a pilot study
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory PsychGENe Lab, Departments of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 162:313-26. 2013
  2. pmc Blood-based gene expression signatures of infants and toddlers with autism
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory, Medical Genetics Research Center, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Am Acad Child Adolesc Psychiatry 51:934-44.e2. 2012
  3. pmc The genetic validation of heterogeneity in schizophrenia
    Atsushi Tsutsumi
    Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan
    Behav Brain Funct 7:43. 2011
  4. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
  5. pmc Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis
    Stephen J Glatt
    Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Alcohol Depend 90:159-65. 2007
  6. pmc Genome-wide linkage analysis of heroin dependence in Han Chinese: results from Wave Two of a multi-stage study
    Stephen J Glatt
    Department of Psychiatry and Behavioral Sciences, and Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Alcohol Depend 98:30-4. 2008
  7. pmc Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan
    S J Glatt
    Department of Psychiatry and Behavioral Sciences, and Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Mol Psychiatry 14:885-93. 2009
  8. pmc Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory, Medical Genetics Research Center, Department of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 156:869-87. 2011
  9. pmc Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 156:382-92. 2011
  10. doi request reprint A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Clin Psychiatry 71:754-63. 2010

Collaborators

Detail Information

Publications38

  1. doi request reprint Blood-based gene-expression predictors of PTSD risk and resilience among deployed marines: a pilot study
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory PsychGENe Lab, Departments of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 162:313-26. 2013
    ..If the observed profiles of pre-deployment mRNA-expression in eventual PTSD cases can be further refined and replicated, they could suggest avenues for early intervention and prevention among individuals at high risk for trauma exposure...
  2. pmc Blood-based gene expression signatures of infants and toddlers with autism
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory, Medical Genetics Research Center, State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Am Acad Child Adolesc Psychiatry 51:934-44.e2. 2012
    ..ASD risk biomarkers expressed early in life could significantly impact diagnosis and treatment, but no transcriptome-wide biomarker classifiers derived from fresh blood samples from children with autism have yet emerged...
  3. pmc The genetic validation of heterogeneity in schizophrenia
    Atsushi Tsutsumi
    Department of Neuropsychiatry, Osaka Medical College, Osaka, Japan
    Behav Brain Funct 7:43. 2011
    ..In addition, by employing the additive model for aggregating the effect of seven variants, we aimed to verify the genetic heterogeneity of schizophrenia diagnosed by an operative diagnostic manual, the DSM-IV...
  4. pmc Evidence for genetic association of RORB with bipolar disorder
    Casey L McGrath
    Department of Psychiatry, Laboratory of Neurophenomics, Indiana University School of Medicine, Indianapolis, IN, USA
    BMC Psychiatry 9:70. 2009
    ..Here we report association studies between bipolar disorder and single-nucleotide polymorphisms (SNPs) in RORA and RORB...
  5. pmc Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis
    Stephen J Glatt
    Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Alcohol Depend 90:159-65. 2007
    ....
  6. pmc Genome-wide linkage analysis of heroin dependence in Han Chinese: results from Wave Two of a multi-stage study
    Stephen J Glatt
    Department of Psychiatry and Behavioral Sciences, and Medical Genetics Research Center, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Drug Alcohol Depend 98:30-4. 2008
    ....
  7. pmc Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan
    S J Glatt
    Department of Psychiatry and Behavioral Sciences, and Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Mol Psychiatry 14:885-93. 2009
    ....
  8. pmc Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory, Medical Genetics Research Center, Department of Psychiatry and Behavioral Sciences and Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Am J Med Genet B Neuropsychiatr Genet 156:869-87. 2011
    ..This study, while exploratory, illustrated the potential utility and increased informativeness of including unaffected first-degree relatives in research in pursuit of peripheral biomarkers for schizophrenia...
  9. pmc Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders
    Stephen J Glatt
    Psychiatric Genetic Epidemiology and Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Medical Genetics Research Center, SUNY Upstate Medical University, Syracuse, New York, USA
    Am J Med Genet B Neuropsychiatr Genet 156:382-92. 2011
    ..Lastly, we suggest potentially fruitful lines for future research that should illuminate the nature, extent, causes, and consequences of alternative splicing abnormalities in neuropsychiatric disorders...
  10. doi request reprint A comparison of the efficacy of medications for adult attention-deficit/hyperactivity disorder using meta-analysis of effect sizes
    Stephen V Faraone
    Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Clin Psychiatry 71:754-63. 2010
    ....
  11. ncbi request reprint Effects of lisdexamfetamine dimesylate treatment for ADHD on growth
    Stephen V Faraone
    State University of New York Upstate Medical University, Syracuse, NY 13210, USA
    J Am Acad Child Adolesc Psychiatry 49:24-32. 2010
    ..To complete an exploratory uncontrolled study of the effects of lisdexamfetamine dimesylate (LDX) on growth of children treated for attention-deficit/hyperactivity disorder (ADHD)...
  12. doi request reprint Effects of extended-release guanfacine on ADHD symptoms and sedation-related adverse events in children with ADHD
    Stephen V Faraone
    SUNY Upstate Medical University, Department of Psychiatry and Behavioral Sciences, 750 East AdamsStreet, Syracuse, NY, USA
    J Atten Disord 13:532-8. 2010
    ..This report documents the time course and predictors of symptom efficacy and sedation-related adverse events (AEs) that emerge during GXR treatment throughout 3 randomized, placebo-controlled, double-blind trials of the drug...
  13. ncbi request reprint Early onset bipolar disorder: possible linkage to chromosome 9q34
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
    Bipolar Disord 8:144-51. 2006
    ..We hypothesized that using age at onset to look at subsets of BD families in a genetic linkage analysis would prove useful in separating etiologically homogeneous BD sub-groups and subsequently identifying genetic susceptibility regions...
  14. doi request reprint Effects of once-daily oral and transdermal methylphenidate on sleep behavior of children with ADHD
    Stephen V Faraone
    SUNY Upstate Medical University, Department of Psychiatry and Behavioral Sciences, Syracuse, NY 13210, USA
    J Atten Disord 12:308-15. 2009
    ..There are few studies on the effects of recently developed longer-acting methylphenidate treatments, such as once-daily oral or transdermal formulations, on sleep...
  15. ncbi request reprint The reliability and validity of self- and investigator ratings of ADHD in adults
    Lenard A Adler
    New York University School of Medicine, New York, NY 10016, USA
    J Atten Disord 11:711-9. 2008
    ....
  16. ncbi request reprint Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior
    Brett M Kia-Keating
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, California, USA
    Am J Med Genet B Neuropsychiatr Genet 144:1048-53. 2007
    ..Given that in the United States a higher proportion of females attempt suicide, and the higher proportion of males successfully commit suicide, it is possible that COMT is related to the lethality of suicide attempts...
  17. pmc The Cys allele of the DRD2 Ser311Cys polymorphism has a dominant effect on risk for schizophrenia: evidence from fixed- and random-effects meta-analyses
    Stephen J Glatt
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, California 92093, USA
    Am J Med Genet B Neuropsychiatr Genet 141:149-54. 2006
    ....
  18. ncbi request reprint Meta-analysis shows schizophrenia is not associated with the 40-base-pair repeat polymorphism of the dopamine transporter gene
    F Gamma
    Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Res 73:55-8. 2005
    ..The results of these studies have been equivocal due to small sample size and low power. This meta-analysis has the aim to evaluate the collective evidence for an association between the VTNR polymorphism and schizophrenia...
  19. ncbi request reprint Three potential susceptibility loci shown by a genome-wide scan for regions influencing the age at onset of mania
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Boston, USA
    Am J Psychiatry 161:625-30. 2004
    ..Because age at onset may have utility in resolving the complexity and heterogeneity of the disorder, the authors sought to identify chromosomal loci that harbor the genes influencing this trait...
  20. ncbi request reprint Meta-analysis of association between the T102C polymorphism of the 5HT2a receptor gene and schizophrenia
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry, Harvard Medical School, Massachusetts Mental Health Center, Boston, MA 02115, USA
    Schizophr Res 67:53-62. 2004
    ..The effects of other genes, environmental effects on DNA methylation, or different methods of classification may be the causes for such heterogeneity, but more study in this area is needed...
  21. ncbi request reprint Meta-analysis reveals no association of the Val66Met polymorphism of brain-derived neurotrophic factor with either schizophrenia or bipolar disorder
    Tetsufumi Kanazawa
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, California 92093, USA
    Psychiatr Genet 17:165-70. 2007
    ..Many case-control association studies have been performed to see if BDNF could serve as a useful clinical diagnostic biomarker for schizophrenia or bipolar disorder, but results have been equivocal...
  22. ncbi request reprint Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Am J Med Genet B Neuropsychiatr Genet 144:667-73. 2007
    ....
  23. ncbi request reprint Genome-wide linkage scan of schizophrenia: a cross-isolate study
    Kazima B Bulayeva
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkin Street 3, Moscow 117809, Russia
    Genomics 89:167-77. 2007
    ..A study at higher genotyping density across the regions of interest and fluorescence in situ hybridization analyses are currently underway...
  24. ncbi request reprint The genetics of pediatric-onset bipolar disorder
    Stephen V Faraone
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Biol Psychiatry 53:970-7. 2003
    ....
  25. ncbi request reprint CAG-repeat length in exon 1 of KCNN3 does not influence risk for schizophrenia or bipolar disorder: a meta-analysis of association studies
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 121:14-20. 2003
    ..Further, it remains unknown if this polymorphism, or one in linkage disequilibrium with it, contributes to some distinct feature of the disorder, such as symptom severity or anticipation...
  26. ncbi request reprint Schizophrenia is not associated with DRD4 48-base-pair-repeat length or individual alleles: results of a meta-analysis
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Biol Psychiatry 54:629-35. 2003
    ..The present work sought to determine if this observation reflected the true absence of association or the low power of individual studies...
  27. ncbi request reprint DRD2 -141C insertion/deletion polymorphism is not associated with schizophrenia: results of a meta-analysis
    Stephen J Glatt
    Department of Psychiatry, Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 128:21-3. 2004
    ..Haplotype analysis within this gene would be useful for definitively specifying the role of this gene in the etiology of schizophrenia...
  28. ncbi request reprint Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders
    Jessica A Lasky-Su
    Department of Psychiatry, Harvard Medical School at the Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 133:110-5. 2005
    ..The small but significant effects of the 44-bp insertion/deletion polymorphism for BP is consistent with being one of many genes that contributes to the multi-factorial nature of these psychiatric disorders...
  29. ncbi request reprint Assessing the validity of blood-based gene expression profiles for the classification of schizophrenia and bipolar disorder: a preliminary report
    Ming T Tsuang
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, California 92093 0603, USA
    Am J Med Genet B Neuropsychiatr Genet 133:1-5. 2005
    ..We therefore propose that blood cell-derived RNA may have significant value for performing diagnostic functions and identifying disease biomarkers in schizophrenia and BPD...
  30. ncbi request reprint Five NOTCH4 polymorphisms show weak evidence for association with schizophrenia: evidence from meta-analyses
    Stephen J Glatt
    Department of Psychiatry, Institute of Behavioral Genomics, University of California, San Diego, La Jolla, CA, United States
    Schizophr Res 73:281-90. 2005
    ....
  31. ncbi request reprint Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center, Boston, Massachusetts, USA
    Am J Med Genet B Neuropsychiatr Genet 134:60-6. 2005
    ..Further studies with a larger sample set would be required to validate these preliminary observations...
  32. ncbi request reprint Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity
    Thomas J Spencer
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:415-20. 2006
    ....
  33. ncbi request reprint Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians
    Susan E Luczak
    Department of Psychology, University of Southern California, Los Angeles 90089 1061, and the Veterans Medical Research Foundation, San Diego, CA, USA
    Psychol Bull 132:607-21. 2006
    ..These findings highlight the importance of methodological issues and potential gene-gene and gene-environment interactions that must be considered when examining relationships between genetic polymorphisms and phenotypes...
  34. pmc Genome-wide linkage analysis of heroin dependence in Han Chinese: results from wave one of a multi-stage study
    Stephen J Glatt
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, Gilman Drive, La Jolla, California 92093 0603, USA
    Am J Med Genet B Neuropsychiatr Genet 141:648-52. 2006
    ....
  35. ncbi request reprint Schizophrenia is not associated with the functional candidate gene ERBB3: results from a case-control study
    Tetsufumi Kanazawa
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, La Jolla, California 92093, USA
    Am J Med Genet B Neuropsychiatr Genet 144:113-6. 2007
    ..However, our failure to find genetic association suggests that the differential expression of ERBB3 in schizophrenia may be environmentally driven, or involve cis- or trans-acting genetic factors beyond the boundaries of the gene itself...
  36. pmc Hypomethylation of MB-COMT promoter is a major risk factor for schizophrenia and bipolar disorder
    Hamid Mostafavi Abdolmaleky
    Department of Psychiatry at Massachusetts Mental Health Center and Harvard Institute of Psychiatric Epidemiology and Genetics, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 15:3132-45. 2006
    ....
  37. ncbi request reprint Evaluation of potential gene-gene interactions for attention deficit hyperactivity disorder in the Han Chinese population
    Qiujin Qian
    Institute of Mental Health, Peking University, Beijing, China
    Am J Med Genet B Neuropsychiatr Genet 144:200-6. 2007
    ..We found no evidence for gene-gene interactions among the candidate genes studied. The present study suggests that dopamine candidate genes are associated with increased vulnerability to ADHD in the Han Chinese population...
  38. ncbi request reprint Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: meta-analysis of case-control and family-based studies
    Stephen J Glatt
    Department of Psychiatry, Harvard Medical School at Massachusetts Mental Health Center and Massachusetts General Hospital, Boston 02115, USA
    Am J Psychiatry 160:469-76. 2003
    ..The authors' goal was to evaluate the collective evidence for an association between the Val158/108Met polymorphism of the catechol O-methyltransferase (COMT) gene and schizophrenia...

Research Grants4

  1. 2/2-Expanding Rapid Ascertainment Networks Of Schizophrenia Families In Taiwan
    Stephen Glatt; Fiscal Year: 2009
    ..Also, by capitalizing on an existing clinical infrastructure and an efficient screening and assessment protocol, we will obtain a well-powered sample in a very rapid and cost-effective manner. ..
  2. 2/2-Expanding Rapid Ascertainment Networks Of Schizophrenia Families In Taiwan
    Stephen J Glatt; Fiscal Year: 2010
    ..Also, by capitalizing on an existing clinical infrastructure and an efficient screening and assessment protocol, we will obtain a well-powered sample in a very rapid and cost-effective manner. ..