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rad52 dna repair and recombination protein
rec a recombinases
Genomes and Genes
Saccharomyces cerevisiae S288c
Xin Jie Chen
SUNY Upstate Medical University
Chen X, Wang X, Butow R. Yeast aconitase binds and provides metabolically coupled protection to mitochondrial DNA. Proc Natl Acad Sci U S A. 2007;104:13738-43
..Therefore, mitochondria are opportunistic organelles that seize proteins, such as metabolic enzymes, for construction of the nucleoid, an mtDNA maintenance/segregation apparatus. ..
Chen X. Mechanism of homologous recombination and implications for aging-related deletions in mitochondrial DNA. Microbiol Mol Biol Rev. 2013;77:476-96
..These findings could have profound implications for understanding the mechanism of mtDNA inheritance and the generation of mtDNA deletions in aging cells. ..
Liu Y, Wang X, Chen X. Misfolding of mutant adenine nucleotide translocase in yeast supports a novel mechanism of Ant1-induced muscle diseases. Mol Biol Cell. 2015;26:1985-94
..This finding could have broad implications for understanding other dominant diseases (e.g., retinitis pigmentosa) caused by missense mutations in membrane proteins. ..
Chen X, Clark Walker G. Unveiling the mystery of mitochondrial DNA replication in yeasts. Mitochondrion. 2018;38:17-22
..Such a replication mode spares the need for conventional replicative components, including those required for origin recognition/remodelling, RNA primer synthesis and lagging-strand processing. ..
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