Scott D Blystone

Summary

Affiliation: SUNY Upstate Medical University
Country: USA

Publications

  1. ncbi Ligand-dependent activation of integrin alpha vbeta 3
    Boyd Butler
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 278:5264-70. 2003
  2. ncbi Kinetic regulation of beta 3 integrin tyrosine phosphorylation
    Scott D Blystone
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 277:46886-90. 2002
  3. ncbi Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2
    Boyd Butler
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 280:14556-62. 2005
  4. ncbi Integrating an integrin: a direct route to actin
    Scott D Blystone
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Biochim Biophys Acta 1692:47-54. 2004
  5. ncbi Beta3 tyrosine phosphorylation and alphavbeta3-mediated adhesion are required for Vav1 association and Rho activation in leukocytes
    Chunlei Gao
    Department of Cell and Development Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 280:15422-9. 2005
  6. ncbi Integrin alphaIIb-subunit cytoplasmic domain mutations demonstrate a requirement for tyrosine phosphorylation of beta3-subunits in actin cytoskeletal organization
    Innocent H Yamodo
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Cell Commun Adhes 11:121-35. 2004
  7. ncbi A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation
    Chunlei Gao
    Department of Cell and Development Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Biochem J 420:49-56. 2009
  8. ncbi Purified integrin adhesion complexes exhibit actin-polymerization activity
    Boyd Butler
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams St, Syracuse, New York 13210, USA
    Curr Biol 16:242-51. 2006
  9. ncbi Beta 3 integrin phosphorylation is essential for Arp3 organization into leukocyte alpha V beta 3-vitronectin adhesion contacts
    Surjit K Chandhoke
    Department of Cell and Developmental Biology SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Cell Sci 117:1431-41. 2004
  10. ncbi The formin FRL1 (FMNL1) is an essential component of macrophage podosomes
    Akos T Mersich
    Department of Cell and Development Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Cytoskeleton (Hoboken) 67:573-85. 2010

Collaborators

  • Boyd Butler
  • Jason A Horton
  • Errol Wijelath
  • Chunlei Gao
  • Akos T Mersich
  • George P Christophi
  • Erik Schaefer
  • Innocent H Yamodo
  • Surjit K Chandhoke
  • Monica S Da Silva
  • Halina Chkourko
  • Matthew R Miller
  • Chad A Hudson
  • Rebecca L Christophi
  • Burk Jubelt
  • Michael Panos
  • Ross C Gruber
  • Paul T Massa
  • Montaha Lakkis
  • Linda Zorn
  • Matthew Williams
  • Lisa W Blystone
  • Wallace R Fish
  • Jacqui M Wijelath
  • Michael Sobel
  • Kurt Strand

Detail Information

Publications12

  1. ncbi Ligand-dependent activation of integrin alpha vbeta 3
    Boyd Butler
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 278:5264-70. 2003
    ....
  2. ncbi Kinetic regulation of beta 3 integrin tyrosine phosphorylation
    Scott D Blystone
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 277:46886-90. 2002
    ..These data demonstrate that recognition of ligand is sufficient to induce beta(3) tyrosine phosphorylation and suggests that this event is regulated by the alpha subunit pairing of beta(3)...
  3. ncbi Tyrosine phosphorylation of beta3 integrin provides a binding site for Pyk2
    Boyd Butler
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 280:14556-62. 2005
    ..These data identify Pyk2 as a phosphorylated beta(3) binding partner, providing a potential structural and signaling platform to achieve alpha(V)beta(3) -mediated remodeling of the actin cytoskeleton...
  4. ncbi Integrating an integrin: a direct route to actin
    Scott D Blystone
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Biochim Biophys Acta 1692:47-54. 2004
    ....
  5. ncbi Beta3 tyrosine phosphorylation and alphavbeta3-mediated adhesion are required for Vav1 association and Rho activation in leukocytes
    Chunlei Gao
    Department of Cell and Development Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 280:15422-9. 2005
    ..These studies describe a phosphorylation-dependent association between beta(3) integrin and Vav1 which is essential for cell progression to a Rho-dominant phenotype during cell adhesion...
  6. ncbi Integrin alphaIIb-subunit cytoplasmic domain mutations demonstrate a requirement for tyrosine phosphorylation of beta3-subunits in actin cytoskeletal organization
    Innocent H Yamodo
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Cell Commun Adhes 11:121-35. 2004
    ....
  7. ncbi A Pyk2-Vav1 complex is recruited to beta3-adhesion sites to initiate Rho activation
    Chunlei Gao
    Department of Cell and Development Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Biochem J 420:49-56. 2009
    ..These results indicate that Pyk2 is a critical signalling molecule downstream of beta3 integrin tyrosine phosphorylation and mediates Vav1 recruitment to accomplish actin reorganization necessary for adhesion...
  8. ncbi Purified integrin adhesion complexes exhibit actin-polymerization activity
    Boyd Butler
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams St, Syracuse, New York 13210, USA
    Curr Biol 16:242-51. 2006
    ..CONCLUSIONS: These results suggest that adhesion complexes actively promote actin assembly from their cytosolic face in order to establish a mechanical linkage with the extracellular matrix...
  9. ncbi Beta 3 integrin phosphorylation is essential for Arp3 organization into leukocyte alpha V beta 3-vitronectin adhesion contacts
    Surjit K Chandhoke
    Department of Cell and Developmental Biology SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Cell Sci 117:1431-41. 2004
    ....
  10. ncbi The formin FRL1 (FMNL1) is an essential component of macrophage podosomes
    Akos T Mersich
    Department of Cell and Development Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Cytoskeleton (Hoboken) 67:573-85. 2010
    ..Our data suggest that FRL1 is responsible for modifying actin at the macrophage podosome and may be involved in actin cytoskeleton dynamics during adhesion and migration within tissues...
  11. ncbi Heparin modulates integrin-mediated cellular adhesion: specificity of interactions with alpha and beta integrin subunits
    Monica S Da Silva
    Department of Surgery, SUNY Upstate Medical University and Veteran Affairs Medical Center, Syracuse, NY, USA
    Cell Commun Adhes 10:59-67. 2003
    ..The inhibitory or stimulatory effects of heparin depend on the beta subunit type, and the potency is dictated by structural characteristics of the glycosaminoglycan...
  12. ncbi Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype
    George P Christophi
    Department of Neurology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Lab Invest 89:742-59. 2009
    ....