D Larry Sparks

Summary

Affiliation: Sun Health Research Institute
Country: USA

Publications

  1. ncbi request reprint Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results
    D Larry Sparks
    Author Affiliations Sun Health Research Institute, Sun City, AZ 85351, USA
    Arch Neurol 62:753-7. 2005
  2. doi request reprint Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors
    D Larry Sparks
    Sun Health Research Institute, Sun City, Arizona, USA
    Am J Med Genet B Neuropsychiatr Genet 150:290-4. 2009
  3. pmc Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid production
    Qing Shan Xue
    Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, 100 Newell Drive, Gainesville FL 32611, USA
    J Neuroinflammation 4:20. 2007
  4. ncbi request reprint Should the guidelines for monitoring serum cholesterol levels in the elderly be re-evaluated?
    D Larry Sparks
    Laboratory of Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Mol Neurosci 19:209-12. 2002
  5. ncbi request reprint Is cholesterol a culprit in Alzheimer's disease?
    D Larry Sparks
    Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Int Psychogeriatr 15:153-9. 2003
  6. ncbi request reprint Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT)
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Curr Alzheimer Res 2:527-39. 2005
  7. ncbi request reprint Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
    D L Sparks
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:3-7. 2006
  8. ncbi request reprint Statin therapy in Alzheimer's disease
    D L Sparks
    Robert Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:78-86. 2006
  9. ncbi request reprint Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Curr Alzheimer Res 4:165-9. 2007
  10. ncbi request reprint Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Cleve Clin J Med 75:S87-93. 2008

Detail Information

Publications27

  1. ncbi request reprint Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results
    D Larry Sparks
    Author Affiliations Sun Health Research Institute, Sun City, AZ 85351, USA
    Arch Neurol 62:753-7. 2005
    ....
  2. doi request reprint Angiotensin I-converting enzyme I/D polymorphism and suicidal behaviors
    D Larry Sparks
    Sun Health Research Institute, Sun City, Arizona, USA
    Am J Med Genet B Neuropsychiatr Genet 150:290-4. 2009
    ..In the two population samples studied a statistically significant risk of suicidal behavior was observed for subjects bearing the DD genotype. These results suggest a possible role of the renin-angiotensin system in suicidal behavior...
  3. pmc Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid production
    Qing Shan Xue
    Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, 100 Newell Drive, Gainesville FL 32611, USA
    J Neuroinflammation 4:20. 2007
    ..The purpose of this study was to survey microglial activation in rabbits fed cholesterol in the presence or absence of copper or other metal ions, such as zinc and aluminum...
  4. ncbi request reprint Should the guidelines for monitoring serum cholesterol levels in the elderly be re-evaluated?
    D Larry Sparks
    Laboratory of Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Mol Neurosci 19:209-12. 2002
    ..Based on this observation we suggest that cholesterol levels should be actively monitored in the elderly, as many individuals with AD are over 65 years of age and therefore excluded by currently accepted guidelines...
  5. ncbi request reprint Is cholesterol a culprit in Alzheimer's disease?
    D Larry Sparks
    Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Int Psychogeriatr 15:153-9. 2003
    ..Nevertheless, the foregoing suggests that routine monitoring and intervention for elevated cholesterol levels among the elderly could promote more than a healthy heart...
  6. ncbi request reprint Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT)
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Curr Alzheimer Res 2:527-39. 2005
    ..The clinical benefit of atorvastatin therapy is clearly not associated with decreased circulating Abeta or increased HDL-cholesterol, but a positive influence of reduced copper (ceruloplasmin) levels may be a consideration...
  7. ncbi request reprint Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
    D L Sparks
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:3-7. 2006
    ..Recent evidence suggests that treatment of mild-to-moderate Alzheimer's disease (AD) with atorvastatin provides significant benefit on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog) after 6 months...
  8. ncbi request reprint Statin therapy in Alzheimer's disease
    D L Sparks
    Robert Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:78-86. 2006
    ..Evidence also suggests that atorvastatin may slow the progression of mild-to-moderate AD, thereby prolonging the quality of an afflicted individual's life...
  9. ncbi request reprint Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Curr Alzheimer Res 4:165-9. 2007
    ..12 PPM) are added to the drinking water Abeta accumulates in the brain, while the levels in the liver are greatly reduced...
  10. ncbi request reprint Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Cleve Clin J Med 75:S87-93. 2008
    ....
  11. ncbi request reprint Reduced risk of incident AD with elective statin use in a clinical trial cohort
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City AZ, USA
    Curr Alzheimer Res 5:416-21. 2008
    ..Cholesterol levels were lower among statin users compared with non-LLA users, but the MMSE scores were equivalent. The data suggest that statin therapy may be of benefit in reducing the risk of AD...
  12. ncbi request reprint The early and ongoing experience with the cholesterol-fed rabbit as a model of Alzheimer's disease: the old, the new and the pilot
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 15:641-56. 2008
    ..Emerging data suggest that low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears Abeta from brain and that excess circulating copper negatively influences this process...
  13. ncbi request reprint Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD
    D Larry Sparks
    SunHealth Research Institute, USA
    Curr Alzheimer Res 2:343-53. 2005
    ..Accordingly, atorvastatin therapy may be an effective treatment and may slow the progression of AD among mild-to-moderately affected patients...
  14. pmc Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
    D Larry Sparks
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Proc Natl Acad Sci U S A 100:11065-9. 2003
    ..Cholesterol-fed rabbits have at least 12 pathological markers seen in AD, suggesting that the cholesterol-fed rabbit is a good animal model for studying AD...
  15. ncbi request reprint A position paper: based on observational data indicating an increased rate of altered blood chemistry requiring withdrawal from the Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT)
    D Larry Sparks
    Ralph and Murial Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 95351, USA
    J Mol Neurosci 20:407-10. 2003
    ....
  16. ncbi request reprint Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain
    D Larry Sparks
    Sun Health Research Institute SHRI, Sun City, AZ 85351, USA
    J Mol Neurosci 24:97-104. 2004
    ..The data suggest that there is an accumulation of fibrillar Abeta induced in the brains of rabbits fed a cholesterol diet and administered trace levels of copper ion in their drinking water...
  17. ncbi request reprint HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier
    D L Sparks
    D Larry Sparks, Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA E mail
    J Nutr Health Aging 6:324-31. 2002
    ....
  18. pmc Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, Ariz, USA
    Neurodegener Dis 7:183-6. 2010
    ....
  19. ncbi request reprint Cholesterol and cognition: rationale for the AD cholesterol-lowering treatment trial and sex-related Differences in beta-amyloid accumulation in the brains of spontaneously hypercholesterolemic Watanabe rabbits
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Ann N Y Acad Sci 977:356-66. 2002
    ..This may, in part, explain the epidemiological evidence for "protective" effects of estrogen in AD...
  20. ncbi request reprint Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain
    D Larry Sparks
    Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Alzheimers Dis 4:523-9. 2002
    ..These findings suggest that water quality may impact on human health in the setting of increased circulating cholesterol levels, and could illustrate a truly simple life-style change that could be of benefit in AD...
  21. ncbi request reprint Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research Sun Health Research Institute, Sun City, AZ 85351, USA
    Curr Alzheimer Res 3:157-60. 2006
    ..To determine whether Apolipoprotein E4 (Apo E4) gene status or ApoE gene dose affect the lipid profile in AD...
  22. ncbi request reprint Is there a characteristic lipid profile in Alzheimer's disease?
    Marwan Sabbagh
    The Cleo Roberts Center for Clinical Research, USA
    J Alzheimers Dis 6:585-9; discussion 673-81. 2004
    ..To characterize the lipid profile in Alzheimer's Disease (AD) and to determine whether it differs from the cardiac risk profile...
  23. ncbi request reprint The nicotinic acetylcholine receptor, smoking, and Alzheimer's disease
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 4:317-25. 2002
    ..Thus, while controversies still exist, ongoing research is illuminating how nicotinic receptor changes and functions may be relevant to clinical, pathological and neurochemical changes that occur in AD...
  24. ncbi request reprint Length of stay in skilled nursing facilities is longer for patients with dementia
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 5:57-63. 2003
    ..It is likely that demented patients enter for non-physical, cognitive related reasons. These results may help families and institutions plan for long-term care...
  25. pmc KIF6 719Arg allele is associated with statin effects on cholesterol levels in amnestic mild cognitive impairment and Alzheimer's disease patients
    Marwan Sabbagh
    Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 33:111-6. 2013
    ..Accounting for 719Arg carrier status may be important in future studies investigating the link between cholesterol and AD and also for AD and aMCI clinical trials using statins as a treatment...
  26. pmc Influence of water quality on cholesterol-induced tau pathology: preliminary data
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Int J Alzheimers Dis 2011:987023. 2011
    ..These studies suggest the possibility that circulating tau could be the source of the tau accumulating in the brain...
  27. ncbi request reprint Statins to treat Alzheimer's disease: an incomplete story
    Marwan N Sabbagh
    Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Expert Rev Neurother 12:27-30. 2012
    ....