D L Sparks

Summary

Affiliation: Sun Health Research Institute
Country: USA

Publications

  1. ncbi request reprint Anatomy of a new paired tract of the pineal gland in humans
    D L Sparks
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Neurosci Lett 248:179-82. 1998
  2. ncbi request reprint Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations
    D L Sparks
    Sun Health Research Institute, Sun City, Arizona, USA
    Ann N Y Acad Sci 903:335-44. 2000
  3. ncbi request reprint Link between heart disease, cholesterol, and Alzheimer's disease: a review
    D L Sparks
    Haldeman Laboratory for Alzheimer s Disease Research, Sun Health Research Institute, Sun City, Arizona, USA
    Microsc Res Tech 50:287-90. 2000
  4. ncbi request reprint Neural tract tracing using Di-I: a review and a new method to make fast Di-I faster in human brain
    D L Sparks
    Haldeman Laboratory for Alzheimers Disease, Roberts Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AZ 85372, USA
    J Neurosci Methods 103:3-10. 2000
  5. ncbi request reprint Cholesterol and cognition: rationale for the AD cholesterol-lowering treatment trial and sex-related Differences in beta-amyloid accumulation in the brains of spontaneously hypercholesterolemic Watanabe rabbits
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Ann N Y Acad Sci 977:356-66. 2002
  6. ncbi request reprint Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs
    D L Sparks
    Haldeman Laboratory for Alzheimer s Disease Research, Sun Health Research Institute, 10510 W Santa Fe Drive, Sun City, AZ 85351, USA
    Neurobiol Aging 21:363-72. 2000
  7. ncbi request reprint Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology
    D L Sparks
    Roberts aboratory for NeurodegenerativeDisease Research, Sun Health Research Institute, Sun City, AZ, USA
    J Nutr Health Aging 10:247-54. 2006
  8. ncbi request reprint Statin therapy in Alzheimer's disease
    D L Sparks
    Robert Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:78-86. 2006
  9. ncbi request reprint HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier
    D L Sparks
    D Larry Sparks, Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA E mail
    J Nutr Health Aging 6:324-31. 2002
  10. ncbi request reprint Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
    D L Sparks
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:3-7. 2006

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Anatomy of a new paired tract of the pineal gland in humans
    D L Sparks
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Neurosci Lett 248:179-82. 1998
    ..Fibers from these tracts invade the pineal gland, and can be traced a short distance into the lateral pre-tectal area. The precise point of origin and termination for this paired tract is unknown...
  2. ncbi request reprint Alterations of Alzheimer's disease in the cholesterol-fed rabbit, including vascular inflammation. Preliminary observations
    D L Sparks
    Sun Health Research Institute, Sun City, Arizona, USA
    Ann N Y Acad Sci 903:335-44. 2000
    ..The data suggest that vascular inflammation can lead to breach of the blood-brain barrier, which may produce biochemical derangements in surrounding brain tissue that are conducive to production of beta-amyloid...
  3. ncbi request reprint Link between heart disease, cholesterol, and Alzheimer's disease: a review
    D L Sparks
    Haldeman Laboratory for Alzheimer s Disease Research, Sun Health Research Institute, Sun City, Arizona, USA
    Microsc Res Tech 50:287-90. 2000
    ..Clinical trials testing the benefit of HMG Co-A reductase inhibitors in the treatment of Alzheimer's disease are underway...
  4. ncbi request reprint Neural tract tracing using Di-I: a review and a new method to make fast Di-I faster in human brain
    D L Sparks
    Haldeman Laboratory for Alzheimers Disease, Roberts Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AZ 85372, USA
    J Neurosci Methods 103:3-10. 2000
    ..Using these methods, for example, we have confirmed the presence of an ipsilateral olivocerebellar climbing fiber projection in the human...
  5. ncbi request reprint Cholesterol and cognition: rationale for the AD cholesterol-lowering treatment trial and sex-related Differences in beta-amyloid accumulation in the brains of spontaneously hypercholesterolemic Watanabe rabbits
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Ann N Y Acad Sci 977:356-66. 2002
    ..This may, in part, explain the epidemiological evidence for "protective" effects of estrogen in AD...
  6. ncbi request reprint Neuropathology of mitral valve prolapse in man and cardiopulmonary bypass (CPB) surgery in adolescent Yorkshire pigs
    D L Sparks
    Haldeman Laboratory for Alzheimer s Disease Research, Sun Health Research Institute, 10510 W Santa Fe Drive, Sun City, AZ 85351, USA
    Neurobiol Aging 21:363-72. 2000
    ..It is further coupled with the probability that these forms of cardiovascular surgery exacerbate the extent and progression of AD-like neuropathology...
  7. ncbi request reprint Trace copper levels in the drinking water, but not zinc or aluminum influence CNS Alzheimer-like pathology
    D L Sparks
    Roberts aboratory for NeurodegenerativeDisease Research, Sun Health Research Institute, Sun City, AZ, USA
    J Nutr Health Aging 10:247-54. 2006
    ..Collectively, these data suggest that water quality may have a significant influence on disease progression and Ab neuropathology in AD...
  8. ncbi request reprint Statin therapy in Alzheimer's disease
    D L Sparks
    Robert Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:78-86. 2006
    ..Evidence also suggests that atorvastatin may slow the progression of mild-to-moderate AD, thereby prolonging the quality of an afflicted individual's life...
  9. ncbi request reprint HMG-CoA reductase inhibitors (statins) in the treatment of Alzheimer's disease and why it would be ill-advise to use one that crosses the blood-brain barrier
    D L Sparks
    D Larry Sparks, Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA E mail
    J Nutr Health Aging 6:324-31. 2002
    ....
  10. ncbi request reprint Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial
    D L Sparks
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neurol Scand Suppl 185:3-7. 2006
    ..Recent evidence suggests that treatment of mild-to-moderate Alzheimer's disease (AD) with atorvastatin provides significant benefit on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-cog) after 6 months...
  11. ncbi request reprint Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research Sun Health Research Institute, Sun City, AZ 85351, USA
    Curr Alzheimer Res 3:157-60. 2006
    ..To determine whether Apolipoprotein E4 (Apo E4) gene status or ApoE gene dose affect the lipid profile in AD...
  12. ncbi request reprint Relationship of cognitive measures and gray and white matter in Alzheimer's disease
    Leslie C Baxter
    Barrow Neurological Institute, Phoenix, AZ 85013, USA
    J Alzheimers Dis 9:253-60. 2006
    ..To examine the relationship between commonly used screening cognitive measures with gray and white matter integrity in patients with mild to moderate AD...
  13. ncbi request reprint Change in circulating C-reactive protein is not associated with atorvastatin treatment in Alzheimer's disease
    Goran Stankovic
    Neurol Res 28:621-4. 2006
    ..Here we report that cholesterol lowering with atorvastatin produces no significant change in CRP levels in treating AD patients who participated in ADCLT (AD cholesterol lowering trial)...
  14. ncbi request reprint Cholesterol metabolism and brain amyloidosis: evidence for a role of copper in the clearance of Abeta through the liver
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Curr Alzheimer Res 4:165-9. 2007
    ..12 PPM) are added to the drinking water Abeta accumulates in the brain, while the levels in the liver are greatly reduced...
  15. pmc Cholesterol enhances classical conditioning of the rabbit heart rate response
    Bernard G Schreurs
    Blanchette Rockefeller Neurosciences Institute and Department of Physiology and Pharmacology, West Virginia University, P O Box 9302, Morgantown, WV, United States
    Behav Brain Res 181:52-63. 2007
    ..The data provide additional support for our finding that, in the absence of plaques, dietary cholesterol may facilitate learning and memory...
  16. pmc High dietary cholesterol facilitates classical conditioning of the rabbit's nictitating membrane response
    Bernard G Schreurs
    Department of Physiology and Pharmacology, West Virginia University, Blanchette Rockefeller Neurosciences Institute, Morgantown, WV, USA
    Nutr Neurosci 10:31-43. 2007
    ..The data provide support for the idea that dietary cholesterol may facilitate learning and memory...
  17. pmc Microglial activation in the hippocampus of hypercholesterolemic rabbits occurs independent of increased amyloid production
    Qing Shan Xue
    Department of Neuroscience, University of Florida College of Medicine and McKnight Brain Institute, 100 Newell Drive, Gainesville FL 32611, USA
    J Neuroinflammation 4:20. 2007
    ..The purpose of this study was to survey microglial activation in rabbits fed cholesterol in the presence or absence of copper or other metal ions, such as zinc and aluminum...
  18. ncbi request reprint Hippocampal volume change in the Alzheimer Disease Cholesterol-Lowering Treatment trial
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Cleve Clin J Med 75:S87-93. 2008
    ....
  19. ncbi request reprint Cholesterol, copper and Abeta in controls, MCI, AD and the AD cholesterol-lowering treatment trial (ADCLT)
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ, USA
    Curr Alzheimer Res 2:527-39. 2005
    ..The clinical benefit of atorvastatin therapy is clearly not associated with decreased circulating Abeta or increased HDL-cholesterol, but a positive influence of reduced copper (ceruloplasmin) levels may be a consideration...
  20. ncbi request reprint Is cholesterol a culprit in Alzheimer's disease?
    D Larry Sparks
    Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Int Psychogeriatr 15:153-9. 2003
    ..Nevertheless, the foregoing suggests that routine monitoring and intervention for elevated cholesterol levels among the elderly could promote more than a healthy heart...
  21. ncbi request reprint Atorvastatin therapy lowers circulating cholesterol but not free radical activity in advance of identifiable clinical benefit in the treatment of mild-to-moderate AD
    D Larry Sparks
    SunHealth Research Institute, USA
    Curr Alzheimer Res 2:343-53. 2005
    ..Accordingly, atorvastatin therapy may be an effective treatment and may slow the progression of AD among mild-to-moderately affected patients...
  22. ncbi request reprint Should the guidelines for monitoring serum cholesterol levels in the elderly be re-evaluated?
    D Larry Sparks
    Laboratory of Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Mol Neurosci 19:209-12. 2002
    ..Based on this observation we suggest that cholesterol levels should be actively monitored in the elderly, as many individuals with AD are over 65 years of age and therefore excluded by currently accepted guidelines...
  23. ncbi request reprint The nicotinic acetylcholine receptor, smoking, and Alzheimer's disease
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 4:317-25. 2002
    ..Thus, while controversies still exist, ongoing research is illuminating how nicotinic receptor changes and functions may be relevant to clinical, pathological and neurochemical changes that occur in AD...
  24. ncbi request reprint Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain
    D Larry Sparks
    Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Alzheimers Dis 4:523-9. 2002
    ..These findings suggest that water quality may impact on human health in the setting of increased circulating cholesterol levels, and could illustrate a truly simple life-style change that could be of benefit in AD...
  25. ncbi request reprint Length of stay in skilled nursing facilities is longer for patients with dementia
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 5:57-63. 2003
    ..It is likely that demented patients enter for non-physical, cognitive related reasons. These results may help families and institutions plan for long-term care...
  26. pmc Trace amounts of copper in water induce beta-amyloid plaques and learning deficits in a rabbit model of Alzheimer's disease
    D Larry Sparks
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Proc Natl Acad Sci U S A 100:11065-9. 2003
    ..Cholesterol-fed rabbits have at least 12 pathological markers seen in AD, suggesting that the cholesterol-fed rabbit is a good animal model for studying AD...
  27. ncbi request reprint A position paper: based on observational data indicating an increased rate of altered blood chemistry requiring withdrawal from the Alzheimer's Disease Cholesterol-Lowering Treatment Trial (ADCLT)
    D Larry Sparks
    Ralph and Murial Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City, AZ 95351, USA
    J Mol Neurosci 20:407-10. 2003
    ....
  28. ncbi request reprint Cholesterol modifies classical conditioning of the rabbit (Oryctolagus cuniculus) nictitating membrane response
    Bernard G Schreurs
    Blanchette Rockefeller Neurosciences Institute, Morgantown, West Virginia, USA
    Behav Neurosci 117:1220-32. 2003
    ..The cholesterol-fed rabbits had beta amyloid accumulation in the cortex, but little in the hippocampus. The data suggest cholesterol had facilitative effects that outweighed potential amnesic effects of cortical beta amyloid...
  29. ncbi request reprint Reduced risk of incident AD with elective statin use in a clinical trial cohort
    D Larry Sparks
    Roberts Laboratory for Neurodegenerative Disease Research, Sun Health Research Institute, Sun City AZ, USA
    Curr Alzheimer Res 5:416-21. 2008
    ..Cholesterol levels were lower among statin users compared with non-LLA users, but the MMSE scores were equivalent. The data suggest that statin therapy may be of benefit in reducing the risk of AD...
  30. ncbi request reprint Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results
    D Larry Sparks
    Author Affiliations Sun Health Research Institute, Sun City, AZ 85351, USA
    Arch Neurol 62:753-7. 2005
    ....
  31. ncbi request reprint Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study
    Peter P Zandi
    Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Arch Gen Psychiatry 62:217-24. 2005
    ..Prior reports suggest reduced occurrence of dementia and Alzheimer disease (AD) in statin users, but, to our knowledge, no prospective studies relate statin use and dementia incidence...
  32. ncbi request reprint Is there a characteristic lipid profile in Alzheimer's disease?
    Marwan Sabbagh
    The Cleo Roberts Center for Clinical Research, USA
    J Alzheimers Dis 6:585-9; discussion 673-81. 2004
    ..To characterize the lipid profile in Alzheimer's Disease (AD) and to determine whether it differs from the cardiac risk profile...
  33. ncbi request reprint Dystrophic microglia in the aging human brain
    Wolfgang J Streit
    Department of Neuroscience, PO Box 100244, University of Florida College of Medicine, Building 59, 100 Newell Drive, Gainesville, FL 32610, USA
    Glia 45:208-12. 2004
    ..Thus, we conclude that microglial dystrophy is a sign of microglial cell senescence. We hypothesize that microglial senescence could be important for understanding age-related declines in cognitive function...
  34. pmc Classical conditioning of the rabbit's nictitating membrane response is a function of the duration of dietary cholesterol
    Bernard G Schreurs
    Department of Physiology and Pharmacology, Blanchette Rockefeller Neurosciences Institute, West Virginia University, Morgantown, WV, USA
    Nutr Neurosci 10:159-68. 2007
    ..The data provide support for the idea that dietary cholesterol may facilitate learning and memory but there is an eventual trade off with pathophysiological consequences of the diet...
  35. doi request reprint Microglial dystrophy in the aged and Alzheimer's disease brain is associated with ferritin immunoreactivity
    Kryslaine O Lopes
    Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida 32610 0244, USA
    Glia 56:1048-60. 2008
    ..We conclude that ferritin immunohistochemistry may be a useful method for detecting degenerating microglia in the human brain...
  36. ncbi request reprint The serotonin transporter promoter polymorphism and suicide
    Nicole Helbecque
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, 1 rue Calmette, BP 245, 59019 Lille Cedex, France
    Neurosci Lett 400:13-5. 2006
    ..No association could be detected between the 5-HTTLPR polymorphism and suicide. This result is consistent with the proposal that different genes are involved in hopelessness and suicidal behavior or in depressive illness...
  37. ncbi request reprint Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
    Sandip Ray
    Satoris, Inc, 2686 Middlefield Road, Suite E, Redwood City, California 94063, USA
    Nat Med 13:1359-62. 2007
    ..Biological analysis of the 18 proteins points to systemic dysregulation of hematopoiesis, immune responses, apoptosis and neuronal support in presymptomatic Alzheimer's disease...