Research Topics
Genomes and Genes | Alex E RoherSummaryAffiliation: Sun Health Research Institute Country: USA Publications
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Publications
Atherosclerosis of cerebral arteries in Alzheimer diseaseAlex E Roher
Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, Ariz 85351, USA
Stroke 35:2623-7. 2004..Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia...- Interaction of cardiovascular disease and neurodegeneration: transcranial Doppler ultrasonography and Alzheimer's diseaseAlex E Roher
Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City AZ 85351, USA
Neurol Res 28:672-8. 2006..In this study, we examine the arteries of the circle of Willis by transcranial Doppler (TCD) ultrasonography... - Of mice and men: The relevance of transgenic mice Abeta immunizations to Alzheimer's diseaseAlex E Roher
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
J Alzheimers Dis 4:431-4. 2002 
Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's diseaseAlex E Roher
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
Mol Med 9:112-22. 2003..This failure of fluid drainage has implications for therapeutic strategies to treat Alzheimer's disease...- Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's diseaseAlex E Roher
Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
Arterioscler Thromb Vasc Biol 23:2055-62. 2003..We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer's disease (AD)... - The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregatesAlex E Roher
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
J Biol Chem 279:5829-36. 2004.... - Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementiaAlex E Roher
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
Alzheimers Dement 7:436-44. 2011..To assess this hypothesis, it is vital to rigorously establish the measures of AVD that are most strongly associated with an AD diagnosis... - Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathyGregory D Van Vickle
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
Am J Pathol 173:483-93. 2008.... - Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's diseaseAlex E Roher
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
Biomarkers 14:493-501. 2009..For the discrimination of AD from NADD subjects, measurement of Abeta1-42 alone was superior... - Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's diseaseGregory D Van Vickle
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
Mol Med 14:184-94. 2008.... - Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's diseaseAlex E Roher
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
Alzheimers Dement 5:18-29. 2009..We evaluated the amounts of amyloid beta (Abeta)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Abeta plasma levels and Alzheimer's disease (AD) pathology... - Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysisR Lyle Patton
The Longtine Center for Molecular Biology and Genetics, W.H. Civin Laboratory for Neuropathology, M.D. Sun Health Research Institute, 10515 W. Santa Fe Dr, Sun City, AZ 85351, USA
Am J Pathol 169:1048-63. 2006..This may allow Abeta mobilization under conditions in which drainage and degradation of these toxic peptides is efficient... - TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulationGregory D Van Vickle
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
Biochemistry 46:10317-27. 2007..However, given the phylogenetic distance and the differences in APP processing and Abeta chemistry between Tg mice and AD, caution should be applied in projecting mouse therapeutic interventions onto human subjects... - Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and plateletsTyler A Kokjohn
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
Biochim Biophys Acta 1812:1508-14. 2011.... - APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaquesWalter Kalback
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
Biochemistry 41:922-8. 2002..Thus, differences in disease evolution and biochemistry must be considered when using transgenic animals to evaluate drugs or therapeutic interventions intended to reduce the Abeta burden in Alzheimer's disease... - Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's diseaseJesse M Hunter
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
J Alzheimers Dis 27:361-76. 2011..Understanding the strengths and limitations of Tg mouse AD models through rigorous biochemical, pathological, and functional analyses will facilitate the derivation of models that better approximate human sporadic AD... - Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's diseaseWalter Kalback
Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
Neurol Res 26:525-39. 2004..Our data strongly suggest that severe hemodynamic disturbances contribute to sporadic AD and support the numerous observations indicating cardiovascular system participation in the pathogenesis of these dementias... - Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's diseaseAlex E Roher
The Longtine Center for Molecular Biology and Genetics and Harold Civin Laboratory of Neuropathology, Sun Health Research Institute, Sun City, Arizona 85351, USA
Biochemistry 41:11080-90. 2002..To accurately assess the success of future therapeutic interventions, it is necessary to have a complete appreciation of the full scope and extent of AD pathology... - Transcranial doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's diseaseAlex E Roher
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
Alzheimers Dement 7:445-55. 2011..Multiple lines of evidence suggest that cardiovascular co-morbidities hasten the onset of Alzheimer's disease (AD) or accelerate its course... - Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's DiseaseThomas G Beach
Banner Sun Health Research Institute, Sun City, AZ, USA
BMC Geriatr 11:3. 2011..Autopsy studies of cardiac disease in AD have been few and inconclusive. In this report, clinical and gross anatomic measures of cardiac disease were compared in deceased human subjects with and without AD... - Neuropathology and amyloid-β spectrum in a bapineuzumab immunotherapy recipientAlex E Roher
Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
J Alzheimers Dis 24:315-25. 2011..These results suggest that, in this particular case, bapineuzumab immunotherapy neither resulted in detectable clearance of amyloid plaques nor prevented further cognitive impairment... - Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tanglesThomas G Beach
W H Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
Acta Neuropathol 113:13-21. 2007..The results suggest that the statistical association between intracranial atherosclerosis and AD is not an artifact of diagnostic misclassification or of unequal distribution of the apolipoprotein E-epsilon4 allele... - The biochemical aftermath of anti-amyloid immunotherapyChera L Maarouf
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
Mol Neurodegener 5:39. 2010..These patients were compared to 6 non-immunized AD cases and 5 non-demented control (NDC) cases... - Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptidesChera Esh
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
Biochemistry 44:13807-19. 2005..Understanding at the molecular level the nature of these important animal models will permit a better understanding of therapeutic interventions directed to prevent, delay, or reverse the ravages of sporadic AD... - Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjectsChera L Maarouf
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
Curr Alzheimer Res 6:399-406. 2009..The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias... - Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutationsChera L Maarouf
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
Mol Neurodegener 3:20. 2008..In addition, the levels of Abeta40/42 peptides were quantified by ELISA... - Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjectsEduardo M Castano
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
Neurol Res 28:155-63. 2006..A single biomarker offering such diagnostic and prognostic capacities has eluded identification. Therefore, a valuable test for AD is likely to be based on a specific pattern of change in a set of proteins, rather than a single protein... - Antibody responses, amyloid-beta peptide remnants and clinical effects of AN-1792 immunization in patients with AD in an interrupted trialTyler A Kokjohn
Sun Health Research Institute, Sun City, Arizona 85351, USA
CNS Neurol Disord Drug Targets 8:88-97. 2009.... - Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributionsTyler A Kokjohn
The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
Alzheimers Dement 5:340-7. 2009..These observations suggest that the pathogenesis of AD is by far more intricate than can be explained by a straightforward accumulation of Abeta... 
Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson's disease subjectsChera L Maarouf
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
Neurol Res 34:669-76. 2012..We sought to discover potential biomarkers in the cerebrospinal fluid (CSF) of neuropathologically confirmed PD cases...- The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007Thomas G Beach
Sun Health Research Institute, Sun City, 85351, USA
Cell Tissue Bank 9:229-45. 2008.... - Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stressAgata Fernández-Gamba
Fundación Instituto Leloir Instituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, Argentina
J Neurochem 121:985-95. 2012.... - Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?Tyler A Kokjohn
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA Department of Microbiology, Midwestern University, Glendale, AZ, USA
Alzheimers Dement 8:574-83. 2012..Successful application of AD preventative approaches may hinge on an accurate and comprehensive view of comorbidities, including cardiovascular disease, diabetes, and head trauma... - Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic miceLary C Walker
CNS Pharmacology, Pfizer Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
Peptides 23:1241-7. 2002..The AD-seeding model can illuminate the emergence and spread of cerebral beta-amyloidosis and tau hyperphosphorylation, and thus could enhance our understanding of AD and its pathogenic commonalties with other cerebral proteopathies... - Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaquesLeticia Miravalle
Indiana Alzheimer Disease Center, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
Biochemistry 44:10810-21. 2005.... - An association with great implications: vascular pathology and Alzheimer diseaseAlex E Roher
Alzheimer Dis Assoc Disord 20:73-5. 2006 - A beta, aging, and Alzheimer's disease: a tale, models, and hypothesesMichael O Chaney
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY
Neurol Res 25:581-9. 2003..Finally, we speculate about the possibility of a peripheral source of A beta that may, by crossing the BBB, contribute to the vascular and parenchymal deposits of A beta in the AD brain... - RAGE and amyloid beta interactions: atomic force microscopy and molecular modelingMichael O Chaney
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Biochim Biophys Acta 1741:199-205. 2005..Our modeling suggests that a soluble dimeric RAGE assembly creates a positively charged well into which the negative charges of the N-terminal domain of dimeric Abeta dock... - Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's diseaseDesiree Watson
Pfizer, Global Research and Development, Ann Arbor, MI 48106 USA
Neurol Res 27:869-81. 2005.... - The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesisRamiro E Llovera
Fundación Instituto Leloir Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, 435 Av Patricias Argentinas, Ciudad de Buenos Aires C1405BWE, Argentina
J Biol Chem 283:17039-48. 2008..Taken together, these results are suggestive of an unprecedented mechanism of conformation-dependent substrate binding that may perturb Abeta clearance, insulin turnover, and promote AD pathogenesis... - Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)Carlos Opazo
, Departamento de Biologia Celular y Molecular, , , Santiago 114-D, Chile
J Biol Chem 277:40302-8. 2002..Cu. Therefore, microregional catalytic H(2)O(2) production, combined with the exhaustion of reducing agents, may mediate the neurotoxicity of Abeta in Alzheimer's disease, and inhibitors of this novel activity may be of therapeutic value...
Research Grants
- AB and ApoE in animal models of Alzheimer's diseaseAlex Roher; Fiscal Year: 2004..abstract_text> ..
- APP/ABeta chemistry in transgenic, familial and sporadic ADAlex Roher; Fiscal Year: 2007..abstract_text> ..