Alex E Roher

Summary

Affiliation: Sun Health Research Institute
Country: USA

Publications

  1. ncbi request reprint Atherosclerosis of cerebral arteries in Alzheimer disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, Ariz 85351, USA
    Stroke 35:2623-7. 2004
  2. ncbi request reprint The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Biol Chem 279:5829-36. 2004
  3. ncbi request reprint Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Arterioscler Thromb Vasc Biol 23:2055-62. 2003
  4. ncbi request reprint Interaction of cardiovascular disease and neurodegeneration: transcranial Doppler ultrasonography and Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City AZ 85351, USA
    Neurol Res 28:672-8. 2006
  5. pmc Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Mol Med 9:112-22. 2003
  6. ncbi request reprint Of mice and men: The relevance of transgenic mice Abeta immunizations to Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 4:431-4. 2002
  7. pmc Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Am J Pathol 173:483-93. 2008
  8. pmc Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 7:436-44. 2011
  9. ncbi request reprint TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 46:10317-27. 2007
  10. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Atherosclerosis of cerebral arteries in Alzheimer disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, Ariz 85351, USA
    Stroke 35:2623-7. 2004
    ..Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia...
  2. ncbi request reprint The human amyloid-beta precursor protein770 mutation V717F generates peptides longer than amyloid-beta-(40-42) and flocculent amyloid aggregates
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Biol Chem 279:5829-36. 2004
    ....
  3. ncbi request reprint Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Arterioscler Thromb Vasc Biol 23:2055-62. 2003
    ..We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer's disease (AD)...
  4. ncbi request reprint Interaction of cardiovascular disease and neurodegeneration: transcranial Doppler ultrasonography and Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City AZ 85351, USA
    Neurol Res 28:672-8. 2006
    ..In this study, we examine the arteries of the circle of Willis by transcranial Doppler (TCD) ultrasonography...
  5. pmc Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Mol Med 9:112-22. 2003
    ..This failure of fluid drainage has implications for therapeutic strategies to treat Alzheimer's disease...
  6. ncbi request reprint Of mice and men: The relevance of transgenic mice Abeta immunizations to Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 4:431-4. 2002
  7. pmc Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Am J Pathol 173:483-93. 2008
    ....
  8. pmc Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 7:436-44. 2011
    ..To assess this hypothesis, it is vital to rigorously establish the measures of AVD that are most strongly associated with an AD diagnosis...
  9. ncbi request reprint TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 46:10317-27. 2007
    ..However, given the phylogenetic distance and the differences in APP processing and Abeta chemistry between Tg mice and AD, caution should be applied in projecting mouse therapeutic interventions onto human subjects...
  10. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009
    ..For the discrimination of AD from NADD subjects, measurement of Abeta1-42 alone was superior...
  11. pmc Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 5:18-29. 2009
    ..We evaluated the amounts of amyloid beta (Abeta)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Abeta plasma levels and Alzheimer's disease (AD) pathology...
  12. pmc Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Mol Med 14:184-94. 2008
    ....
  13. pmc Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis
    R Lyle Patton
    The Longtine Center for Molecular Biology and Genetics, W H Civin Laboratory for Neuropathology, M D Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Am J Pathol 169:1048-63. 2006
    ..This may allow Abeta mobilization under conditions in which drainage and degradation of these toxic peptides is efficient...
  14. pmc Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets
    Tyler A Kokjohn
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Biochim Biophys Acta 1812:1508-14. 2011
    ....
  15. ncbi request reprint APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques
    Walter Kalback
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 41:922-8. 2002
    ..Thus, differences in disease evolution and biochemistry must be considered when using transgenic animals to evaluate drugs or therapeutic interventions intended to reduce the Abeta burden in Alzheimer's disease...
  16. pmc Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease
    Jesse M Hunter
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 27:361-76. 2011
    ..Understanding the strengths and limitations of Tg mouse AD models through rigorous biochemical, pathological, and functional analyses will facilitate the derivation of models that better approximate human sporadic AD...
  17. pmc Neurochemical profile of dementia pugilistica
    Tyler A Kokjohn
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurotrauma 30:981-97. 2013
    ..Understanding the precise threshold of damage needed for the induction of pathology in DP and TBI is vital...
  18. ncbi request reprint Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 113:13-21. 2007
    ..The results suggest that the statistical association between intracranial atherosclerosis and AD is not an artifact of diagnostic misclassification or of unequal distribution of the apolipoprotein E-epsilon4 allele...
  19. pmc Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson's disease subjects
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Neurol Res 34:669-76. 2012
    ..We sought to discover potential biomarkers in the cerebrospinal fluid (CSF) of neuropathologically confirmed PD cases...
  20. pmc Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's Disease
    Thomas G Beach
    Banner Sun Health Research Institute, Sun City, AZ, USA
    BMC Geriatr 11:3. 2011
    ..Autopsy studies of cardiac disease in AD have been few and inconclusive. In this report, clinical and gross anatomic measures of cardiac disease were compared in deceased human subjects with and without AD...
  21. pmc Transcranial doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 7:445-55. 2011
    ..Multiple lines of evidence suggest that cardiovascular co-morbidities hasten the onset of Alzheimer's disease (AD) or accelerate its course...
  22. ncbi request reprint Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics and Harold Civin Laboratory of Neuropathology, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 41:11080-90. 2002
    ..To accurately assess the success of future therapeutic interventions, it is necessary to have a complete appreciation of the full scope and extent of AD pathology...
  23. ncbi request reprint Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease
    Walter Kalback
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Neurol Res 26:525-39. 2004
    ..Our data strongly suggest that severe hemodynamic disturbances contribute to sporadic AD and support the numerous observations indicating cardiovascular system participation in the pathogenesis of these dementias...
  24. pmc Neuropathology and amyloid-β spectrum in a bapineuzumab immunotherapy recipient
    Alex E Roher
    Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    J Alzheimers Dis 24:315-25. 2011
    ..These results suggest that, in this particular case, bapineuzumab immunotherapy neither resulted in detectable clearance of amyloid plaques nor prevented further cognitive impairment...
  25. ncbi request reprint Altered APP processing in PDAPP (Val717 --> Phe) transgenic mice yields extended-length Abeta peptides
    Chera Esh
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 44:13807-19. 2005
    ..Understanding at the molecular level the nature of these important animal models will permit a better understanding of therapeutic interventions directed to prevent, delay, or reverse the ravages of sporadic AD...
  26. ncbi request reprint Comparative proteomics of cerebrospinal fluid in neuropathologically-confirmed Alzheimer's disease and non-demented elderly subjects
    Eduardo M Castano
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Neurol Res 28:155-63. 2006
    ..A single biomarker offering such diagnostic and prognostic capacities has eluded identification. Therefore, a valuable test for AD is likely to be based on a specific pattern of change in a set of proteins, rather than a single protein...
  27. pmc The biochemical aftermath of anti-amyloid immunotherapy
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Mol Neurodegener 5:39. 2010
    ..These patients were compared to 6 non-immunized AD cases and 5 non-demented control (NDC) cases...
  28. pmc Quantitative appraisal of ventricular cerebrospinal fluid biomarkers in neuropathologically diagnosed Parkinson's disease cases lacking Alzheimer's disease pathology
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Biomark Insights 8:19-28. 2013
    ..Our results suggest coexistent AD CSF biomarkers within the PD group notwithstanding that it was selected to minimize AD neuropathological lesions...
  29. pmc Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
    Chera L Maarouf
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Curr Alzheimer Res 6:399-406. 2009
    ..The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias...
  30. pmc Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations
    Chera L Maarouf
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Mol Neurodegener 3:20. 2008
    ..In addition, the levels of Abeta40/42 peptides were quantified by ELISA...
  31. pmc Cerebral blood flow in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ 85351, USA
    Vasc Health Risk Manag 8:599-611. 2012
    ....
  32. pmc Amyloid precursor protein transgenic mouse models and Alzheimer's disease: understanding the paradigms, limitations, and contributions
    Tyler A Kokjohn
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 5:340-7. 2009
    ..These observations suggest that the pathogenesis of AD is by far more intricate than can be explained by a straightforward accumulation of Abeta...
  33. pmc Antibody responses, amyloid-beta peptide remnants and clinical effects of AN-1792 immunization in patients with AD in an interrupted trial
    Tyler A Kokjohn
    Sun Health Research Institute, Sun City, Arizona 85351, USA
    CNS Neurol Disord Drug Targets 8:88-97. 2009
    ....
  34. pmc The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007
    Thomas G Beach
    Sun Health Research Institute, Sun City, 85351, USA
    Cell Tissue Bank 9:229-45. 2008
    ....
  35. doi request reprint Is Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?
    Tyler A Kokjohn
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 8:574-83. 2012
    ..Successful application of AD preventative approaches may hinge on an accurate and comprehensive view of comorbidities, including cardiovascular disease, diabetes, and head trauma...
  36. pmc Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress
    Agata Fernández-Gamba
    Fundación Instituto Leloir Instituto de Investigaciones Bioquímicas de Buenos Aires, CONICET, Buenos Aires, Argentina
    J Neurochem 121:985-95. 2012
    ....
  37. ncbi request reprint Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease
    Desiree Watson
    Pfizer, Global Research and Development, Ann Arbor, MI 48106 USA
    Neurol Res 27:869-81. 2005
    ....
  38. ncbi request reprint RAGE and amyloid beta interactions: atomic force microscopy and molecular modeling
    Michael O Chaney
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Biochim Biophys Acta 1741:199-205. 2005
    ..Our modeling suggests that a soluble dimeric RAGE assembly creates a positively charged well into which the negative charges of the N-terminal domain of dimeric Abeta dock...
  39. ncbi request reprint A beta, aging, and Alzheimer's disease: a tale, models, and hypotheses
    Michael O Chaney
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY
    Neurol Res 25:581-9. 2003
    ..Finally, we speculate about the possibility of a peripheral source of A beta that may, by crossing the BBB, contribute to the vascular and parenchymal deposits of A beta in the AD brain...
  40. ncbi request reprint An association with great implications: vascular pathology and Alzheimer disease
    Alex E Roher
    Alzheimer Dis Assoc Disord 20:73-5. 2006
  41. ncbi request reprint Exogenous induction of cerebral beta-amyloidosis in betaAPP-transgenic mice
    Lary C Walker
    CNS Pharmacology, Pfizer Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Peptides 23:1241-7. 2002
    ..The AD-seeding model can illuminate the emergence and spread of cerebral beta-amyloidosis and tau hyperphosphorylation, and thus could enhance our understanding of AD and its pathogenic commonalties with other cerebral proteopathies...
  42. ncbi request reprint Amino-terminally truncated Abeta peptide species are the main component of cotton wool plaques
    Leticia Miravalle
    Indiana Alzheimer Disease Center, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Biochemistry 44:10810-21. 2005
    ....
  43. ncbi request reprint Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2)
    Carlos Opazo
    Centro de Regulación Celular y Patología, Departamento de Biologia Celular y Molecular, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Santiago 114 D, Chile
    J Biol Chem 277:40302-8. 2002
    ..Cu. Therefore, microregional catalytic H(2)O(2) production, combined with the exhaustion of reducing agents, may mediate the neurotoxicity of Abeta in Alzheimer's disease, and inhibitors of this novel activity may be of therapeutic value...
  44. doi request reprint The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid beta peptide: implications for Alzheimer disease pathogenesis
    Ramiro E Llovera
    Fundación Instituto Leloir Instituto de Investigaciones Bioquímicas de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, 435 Av Patricias Argentinas, Ciudad de Buenos Aires C1405BWE, Argentina
    J Biol Chem 283:17039-48. 2008
    ..Taken together, these results are suggestive of an unprecedented mechanism of conformation-dependent substrate binding that may perturb Abeta clearance, insulin turnover, and promote AD pathogenesis...

Research Grants8

  1. AB and ApoE in animal models of Alzheimer's disease
    Alex Roher; Fiscal Year: 2004
    ..abstract_text> ..
  2. APP/ABeta chemistry in transgenic, familial and sporadic AD
    Alex Roher; Fiscal Year: 2007
    ..abstract_text> ..