L F Lue

Summary

Affiliation: Sun Health Research Institute
Country: USA

Publications

  1. ncbi Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism
    L F Lue
    The Roberts Alzheimer s Disease Center, Sun Health Research Institute, Sun City, Arizona 85372, USA
    Exp Neurol 171:29-45. 2001
  2. ncbi Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease
    L F Lue
    Laboratory of Neurovascular Inflammation, Sun Health Research Institute, Sun City, AZ 85351, USA
    Curr Drug Targets CNS Neurol Disord 4:249-66. 2005
  3. ncbi Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex
    R Li
    Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurochem 75:1447-54. 2000
  4. ncbi Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
    L F Lue
    Sun Health Research Institute, Sun City, Arizona 85372, USA
    Glia 35:72-9. 2001
  5. ncbi Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia
    D G Walker
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Neurobiol Aging 22:957-66. 2001
  6. ncbi Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease
    J Rogers
    L J Roberts Center for Alzheimer s Research, Sun Health Research Institute, P O Box 1278, 10515 West Santa Fe Drive, Sun City, AZ 85372, USA
    Neurochem Int 39:333-40. 2001
  7. ncbi Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures
    L F Lue
    L J Roberts Alzheimer s Center, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Neurobiol Aging 22:945-56. 2001
  8. ncbi Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases
    D G Walker
    Laboratory of Neuroinflammation, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurosci Res 81:412-25. 2005
  9. ncbi Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimer's Disease
    L Arab
    The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, Arizona, USA
    Curr Neuropharmacol 9:693-705. 2011
  10. ncbi Neural tract tracing using Di-I: a review and a new method to make fast Di-I faster in human brain
    D L Sparks
    Haldeman Laboratory for Alzheimers Disease, Roberts Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AZ 85372, USA
    J Neurosci Methods 103:3-10. 2000

Detail Information

Publications10

  1. ncbi Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism
    L F Lue
    The Roberts Alzheimer s Disease Center, Sun Health Research Institute, Sun City, Arizona 85372, USA
    Exp Neurol 171:29-45. 2001
    ..These data suggest a positive feedback loop in which Abeta-RAGE-mediated microglial activation enhances expression of M-CSF and RAGE, possibly initiating an ascending spiral of cellular activation...
  2. ncbi Preventing activation of receptor for advanced glycation endproducts in Alzheimer's disease
    L F Lue
    Laboratory of Neurovascular Inflammation, Sun Health Research Institute, Sun City, AZ 85351, USA
    Curr Drug Targets CNS Neurol Disord 4:249-66. 2005
    ..The potential for targeting RAGE mechanisms as therapeutic strategies for AD will be discussed...
  3. ncbi Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex
    R Li
    Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurochem 75:1447-54. 2000
    ..Thus, stimulation of the ER might contribute to the therapeutic action of estrogen in the treatment of AD...
  4. ncbi Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
    L F Lue
    Sun Health Research Institute, Sun City, Arizona 85372, USA
    Glia 35:72-9. 2001
    ..Taken together with previous in situ hybridization findings, these results demonstrate unequivocally that elderly human microglia provide a brain endogenous source for a wide range of inflammatory mediators...
  5. ncbi Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia
    D G Walker
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Neurobiol Aging 22:957-66. 2001
    ..These results confirm the usefulness of the gene array approach for studying Abeta-mediated inflammatory processes...
  6. ncbi Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease
    J Rogers
    L J Roberts Center for Alzheimer s Research, Sun Health Research Institute, P O Box 1278, 10515 West Santa Fe Drive, Sun City, AZ 85372, USA
    Neurochem Int 39:333-40. 2001
    ..This presents a critical dilemma for strategies to remove A beta by enhancing micoglial activation--a dilemma that warrants substantial further investigation...
  7. ncbi Modeling microglial activation in Alzheimer's disease with human postmortem microglial cultures
    L F Lue
    L J Roberts Alzheimer s Center, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Neurobiol Aging 22:945-56. 2001
    ..Finally, our studies on the use of an Abeta spot paradigm to model microglia interactions with plaques demonstrated that many of the features of AD inflammation can be modeled with postmortem brain derived microglia...
  8. ncbi Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases
    D G Walker
    Laboratory of Neuroinflammation, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurosci Res 81:412-25. 2005
    ..Experimental data produced by our laboratory and others is reviewed to determine the contribution of this unique experimental model to understanding disease mechanisms and possibly discovering new therapeutic targets...
  9. ncbi Consequences of Aberrant Insulin Regulation in the Brain: Can Treating Diabetes be Effective for Alzheimer's Disease
    L Arab
    The Cleo Roberts Center for Clinical Research, Banner Sun Health Research Institute, Sun City, Arizona, USA
    Curr Neuropharmacol 9:693-705. 2011
    ....
  10. ncbi Neural tract tracing using Di-I: a review and a new method to make fast Di-I faster in human brain
    D L Sparks
    Haldeman Laboratory for Alzheimers Disease, Roberts Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AZ 85372, USA
    J Neurosci Methods 103:3-10. 2000
    ..Using these methods, for example, we have confirmed the presence of an ipsilateral olivocerebellar climbing fiber projection in the human...