Rena Li

Summary

Affiliation: Sun Health Research Institute
Country: USA

Publications

  1. ncbi request reprint Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes
    Joseph Rogers
    L J Roberts Center for Alzheimer s Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P O Box 1278, Sun City, AZ 85372, USA
    Neurobiol Aging 27:1733-9. 2006
  2. ncbi request reprint Estrogen and brain: synthesis, function and diseases
    Rena Li
    L J Roberts Alzheimer Disease s Research Center, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Front Biosci 10:257-67. 2005
  3. pmc Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients
    Rena Li
    Haldeman Laboratory of Molecular and Cellular Neurobiology, L J Roberts Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Proc Natl Acad Sci U S A 101:3632-7. 2004
  4. ncbi request reprint Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death
    Rena Li
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurosci 24:1760-71. 2004
  5. pmc Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment
    Carrie McAllister
    Banner Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurosci 30:7326-34. 2010
  6. pmc Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice
    Ping He
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Cell Biol 178:829-41. 2007
  7. pmc Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model
    Xu Yue
    L J Roberts Center for Alzheimer s Research and Haldeman Laboratory for Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA
    Proc Natl Acad Sci U S A 102:19198-203. 2005
  8. ncbi request reprint CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease
    Rena Li
    Roberts Center for Alzheimer s Research, Sun Health Research Institute, P O Box 1278, Sun City, AZ 85372, USA
    Neurobiol Aging 25:991-9. 2004
  9. pmc Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients
    Xin Cheng
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 19:621-30. 2010
  10. pmc Isolation of living neurons from human elderly brains using the immunomagnetic sorting DNA-linker system
    Yoshihiro Konishi
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA
    Am J Pathol 161:1567-76. 2002

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes
    Joseph Rogers
    L J Roberts Center for Alzheimer s Research, Sun Health Research Institute, 10515 West Santa Fe Drive, P O Box 1278, Sun City, AZ 85372, USA
    Neurobiol Aging 27:1733-9. 2006
    ..Levels of Abeta42 targeted by this pathway differ significantly in AD compared to mild cognitive impairment and nondemented elderly controls...
  2. ncbi request reprint Estrogen and brain: synthesis, function and diseases
    Rena Li
    L J Roberts Alzheimer Disease s Research Center, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Front Biosci 10:257-67. 2005
    ..The conflicting findings suggest that several variables, including age, estrogen dose and formulation, the length of treatment, may determine whether the potential benefits of estrogen treatment would outweigh the associated risks...
  3. pmc Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients
    Rena Li
    Haldeman Laboratory of Molecular and Cellular Neurobiology, L J Roberts Center for Alzheimer s Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Proc Natl Acad Sci U S A 101:3632-7. 2004
    ....
  4. ncbi request reprint Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death
    Rena Li
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurosci 24:1760-71. 2004
    ..Our studies suggest a novel neuronal response of Abeta, which occurs through a TNF receptor signaling cascade and a caspase-dependent death pathway...
  5. pmc Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment
    Carrie McAllister
    Banner Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurosci 30:7326-34. 2010
    ....
  6. pmc Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice
    Ping He
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA
    J Cell Biol 178:829-41. 2007
    ..These findings suggest that TNFR1 not only contributes to neurodegeneration but also that it is involved in APP processing and Abeta plaque formation. Thus, TNFR1 is a novel therapeutic target for AD...
  7. pmc Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model
    Xu Yue
    L J Roberts Center for Alzheimer s Research and Haldeman Laboratory for Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA
    Proc Natl Acad Sci U S A 102:19198-203. 2005
    ..Our results indicate that estrogen depletion in the brain may be a significant risk factor for developing AD neuropathology...
  8. ncbi request reprint CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease
    Rena Li
    Roberts Center for Alzheimer s Research, Sun Health Research Institute, P O Box 1278, Sun City, AZ 85372, USA
    Neurobiol Aging 25:991-9. 2004
    ....
  9. pmc Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer's disease and non-demented patients
    Xin Cheng
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 19:621-30. 2010
    ..01). These studies reveal a novel observation of abnormal TNF receptor activation in AD brains. Differential TNF receptor protein levels and binding affinities suggest distinct pathogenic mechanisms of neurodegeneration in the AD brain...
  10. pmc Isolation of living neurons from human elderly brains using the immunomagnetic sorting DNA-linker system
    Yoshihiro Konishi
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, AZ 85351, USA
    Am J Pathol 161:1567-76. 2002
    ..Our study has opened an opportunity to apply such neurons to dynamic pharmacological studies of neurological disorders at the single-cell level...
  11. pmc Bid signal pathway components are identified in the temporal cortex with Parkinson disease
    Hong Jiang
    Sun Health Research Institute, Sun City, AZ, USA
    Neurology 79:1767-73. 2012
    ....
  12. pmc New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-β
    Jiangang Long
    Laboratory of Molecular Endocrinology, Sun Health Research Institute, Sun City, AZ, USA
    J Alzheimers Dis 30:545-58. 2012
    ..These results indicate that ERβ depletion impairs mitochondrial function in mice, and reduction of brain mtERβ may significantly contribute to the mitochondrial dysfunction involved in AD pathogenesis in women...
  13. pmc Occludin deficiency with BACE1 elevation in cerebral amyloid angiopathy
    Xin Cheng
    From the Department of Neurology X C, Q D, Y S, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China Haldeman Laboratory of Molecular and Cellular Neurobiology X C, P H, Y S, Sun Health Research Institute, Sun City, AZ Center for Hormone Advanced Science and Education P H, R L and Center for Advanced Therapeutic Strategies for Brain Disorders P H, Y S, Roskamp Institute, Sarasota, FL and Department of Neurology Y S, University of Florida College of Medicine, Gainesville
    Neurology 82:1707-15. 2014
    ..A significant cause of spontaneous hemorrhages in the elderly is cerebral amyloid angiopathy (CAA), which causes degeneration of cerebral vessels, but the mechanisms are unclear...
  14. pmc High activities of BACE1 in brains with mild cognitive impairment
    Xin Cheng
    Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, Arizona
    Am J Pathol 184:141-7. 2014
    ..These findings suggest that BACE1 increase occurs early in MCI and is possibly induced by TNF-α and that BACE1 enzymatic activity may be important for conversion of MCI to AD. ..
  15. ncbi request reprint Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
    Joseph Rogers
    Sun Health Research Institute, Sun City, Arisona 85372, USA
    Glia 40:260-9. 2002
    ..These properties make Abeta an excellent target for microglial phagocytosis, a view supported by multiple reports, through well established mechanisms of phagocyte clearance...
  16. ncbi request reprint Effects of estrogen treatment on glutamate uptake in cultured human astrocytes derived from cortex of Alzheimer's disease patients
    Zhe Liang
    Roberts Alzheimer s Research Center, Sun Health Research Institute, Sun City, Arizona, USA
    J Neurochem 80:807-14. 2002
    ..Our data suggest that the action of estrogen on glutamate uptake by astrocytes might contribute to its potential neuroprotective role in AD...
  17. ncbi request reprint Target depletion of distinct tumor necrosis factor receptor subtypes reveals hippocampal neuron death and survival through different signal transduction pathways
    Libang Yang
    Haldeman Laboratory of Molecular and Cellular Neurobiology, Sun Health Research Institute, Sun City, Arizona 85351, USA
    J Neurosci 22:3025-32. 2002
    ..Subsequent neuronal death or survival may ultimately depend on a particular subtype of TNF receptor that is predominately expressed in neurons of the brain during neural development or with neurological diseases...
  18. ncbi request reprint Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease
    Li Bang Yang
    Nat Med 9:3-4. 2003
  19. ncbi request reprint Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains
    Elizabeth Jacobsen
    Molecular and Cellular Biology Program, School of Life Science, Arizona Biodesign Institute, Arizona State University, Tempe, AZ 85287 4501, USA
    Brain Res Mol Brain Res 128:1-7. 2004
    ..These proteins were found substantially reduced in the neurons of AD cortex. Our finding suggests that the loss of the Mre11 complex may be associated with the pathogenesis of AD...