Thomas Gerald Beach

Summary

Affiliation: Sun Health Research Institute
Country: USA

Publications

  1. ncbi request reprint Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 113:13-21. 2007
  2. pmc Evaluation of alpha-synuclein immunohistochemical methods used by invited experts
    Thomas G Beach
    Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 116:277-88. 2008
  3. pmc The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007
    Thomas G Beach
    Sun Health Research Institute, Sun City, 85351, USA
    Cell Tissue Bank 9:229-45. 2008
  4. ncbi request reprint Hippocampal sclerosis dementia with tauopathy
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, Sun City, Ariz 85372, USA
    Brain Pathol 13:263-78. 2003
  5. doi request reprint Physiologic origins of age-related beta-amyloid deposition
    Thomas G Beach
    Sun Health Research Institute, Sun City, Ariz 85351, USA
    Neurodegener Dis 5:143-5. 2008
  6. pmc Reduced striatal tyrosine hydroxylase in incidental Lewy body disease
    Thomas Gerald Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 115:445-51. 2008
  7. ncbi request reprint Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers
    Thomas G Beach
    Sun Health Research Institute, Sun City, Arizona 85372, USA
    J Neuropathol Exp Neurol 63:329-37. 2004
  8. ncbi request reprint Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 114:419-24. 2007
  9. pmc Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    Thomas G Beach
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neuropathol 117:613-34. 2009
  10. pmc Correlation of clinical features with argyrophilic grains at autopsy
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Alzheimer Dis Assoc Disord 23:229-33. 2009

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 113:13-21. 2007
    ..The results suggest that the statistical association between intracranial atherosclerosis and AD is not an artifact of diagnostic misclassification or of unequal distribution of the apolipoprotein E-epsilon4 allele...
  2. pmc Evaluation of alpha-synuclein immunohistochemical methods used by invited experts
    Thomas G Beach
    Civin Laboratory for Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 116:277-88. 2008
    ..Some methods, however, achieved relatively high sensitivities with optimized formic acid protocols combined with a hydrolytic step. One method was developed that allows high sensitivity with commercially available reagents...
  3. pmc The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007
    Thomas G Beach
    Sun Health Research Institute, Sun City, 85351, USA
    Cell Tissue Bank 9:229-45. 2008
    ....
  4. ncbi request reprint Hippocampal sclerosis dementia with tauopathy
    Thomas G Beach
    W H Civin Laboratory for Neuropathology, Sun Health Research Institute, Sun City, Ariz 85372, USA
    Brain Pathol 13:263-78. 2003
    ..The results suggest that most cases of HS dementia are sporadic multisystem tauopathies; we suggest the term "hippocampal sclerosis dementia with tauopathy" (HSDT) for these...
  5. doi request reprint Physiologic origins of age-related beta-amyloid deposition
    Thomas G Beach
    Sun Health Research Institute, Sun City, Ariz 85351, USA
    Neurodegener Dis 5:143-5. 2008
    ..Brain beta-amyloid (Abeta) deposition is an extremely common accompaniment of aging in humans and many other mammalian species. We hypothesized that normal physiological changes of aging cause Abeta deposition...
  6. pmc Reduced striatal tyrosine hydroxylase in incidental Lewy body disease
    Thomas Gerald Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 115:445-51. 2008
    ..8% (P = 0.01) reduction in ILBD cases, as compared with control cases. The finding suggests that ILBD is not a benign condition but is likely a precursor to PD and/or DLB...
  7. ncbi request reprint Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers
    Thomas G Beach
    Sun Health Research Institute, Sun City, Arizona 85372, USA
    J Neuropathol Exp Neurol 63:329-37. 2004
    ..Further studies are needed to ascertain the molecular basis of Marinesco body formation; preliminary studies indicate that proteasome dysfunction can lead to similar abnormalities in cultured cells...
  8. ncbi request reprint Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 114:419-24. 2007
    ....
  9. pmc Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
    Thomas G Beach
    Sun Health Research Institute, Sun City, AZ 85351, USA
    Acta Neuropathol 117:613-34. 2009
    ..It is suggested that the proposed staging system would improve on its predecessors by allowing classification of a much greater proportion of cases...
  10. pmc Correlation of clinical features with argyrophilic grains at autopsy
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Alzheimer Dis Assoc Disord 23:229-33. 2009
    ..AGs can occur with or without neurodegenerative conditions and can occur in the absence of significant cognitive decline. AGs are not clearly associated with any single comorbid health condition...
  11. pmc Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Mol Med 9:112-22. 2003
    ..This failure of fluid drainage has implications for therapeutic strategies to treat Alzheimer's disease...
  12. ncbi request reprint Circle of willis atherosclerosis is a risk factor for sporadic Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Arterioscler Thromb Vasc Biol 23:2055-62. 2003
    ..We conducted a quantitative investigation of brain arterial atherosclerotic damage and its relationship to sporadic Alzheimer's disease (AD)...
  13. ncbi request reprint Muscarinic agonists as preventative therapy for Alzheimer's disease
    Thomas G Beach
    Sun Health Research Institute, 10515 Santa Fe Drive, Sun City, AZ 85372, USA
    Curr Opin Investig Drugs 3:1633-6. 2002
    ..Muscarinic agonists, particularly M1-selective agents, have been shown to decrease the production of Abeta in vitro and in vivo; these compounds may be uniquely suited to a preventative role in AD therapy...
  14. ncbi request reprint Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid
    Amanda J Newell
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Neurosci Lett 350:178-80. 2003
    ..Results for Abeta42 showed a similar trend. The results indicate that age-related decreases of neprilysin could lead to increased brain concentrations of Abeta, plaque formation, and AD...
  15. pmc Parkinson disease with dementia: comparing patients with and without Alzheimer pathology
    Marwan N Sabbagh
    The Cleo Roberts Center for Clinical Research, Harold Civin Laboratory of Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Alzheimer Dis Assoc Disord 23:295-7. 2009
    ..PDD-AD and PDD+AD have similar degrees of dementia and approximately half of PDD subjects have enough AD pathology to attain a neuropathologic diagnosis of AD. PDD can develop in the absence of significant Alzheimer pathology...
  16. pmc Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 117:169-74. 2009
    ..It is concluded that olfactory bulb LTS accurately predicts the presence of LTS in other brain regions. It is suggested that olfactory bulb biopsy be considered to confirm the diagnosis in PD subjects being assessed for surgical therapy...
  17. ncbi request reprint Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging
    Marwan N Sabbagh
    Cleo Roberts Center for Clinical Research, Sun Health Research Institute, Sun City, AZ 85351, USA
    Arch Neurol 63:1771-6. 2006
    ..Decreased neocortical nicotinic receptor binding is characteristic of AD but has not been investigated in subjects with MCI...
  18. ncbi request reprint Atherosclerosis of cerebral arteries in Alzheimer disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, Ariz 85351, USA
    Stroke 35:2623-7. 2004
    ..Confirmation of a central role for vascular pathology in AD will suggest important treatment options and directions for additional interventions to stave off this dementia...
  19. ncbi request reprint Interaction of cardiovascular disease and neurodegeneration: transcranial Doppler ultrasonography and Alzheimer's disease
    Alex E Roher
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City AZ 85351, USA
    Neurol Res 28:672-8. 2006
    ..In this study, we examine the arteries of the circle of Willis by transcranial Doppler (TCD) ultrasonography...
  20. pmc Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ 85351, USA
    Am J Pathol 173:483-93. 2008
    ....
  21. pmc Proteomics-derived cerebrospinal fluid markers of autopsy-confirmed Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Biomarkers 14:493-501. 2009
    ..For the discrimination of AD from NADD subjects, measurement of Abeta1-42 alone was superior...
  22. ncbi request reprint Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease
    Walter Kalback
    Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Neurol Res 26:525-39. 2004
    ..Our data strongly suggest that severe hemodynamic disturbances contribute to sporadic AD and support the numerous observations indicating cardiovascular system participation in the pathogenesis of these dementias...
  23. ncbi request reprint Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains
    Douglas G Walker
    Civin Laboratory of Neuropathology, Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Brain Res 926:69-79. 2002
    ..These results provide a connection between the induction of oxidative stress in AD and microglial activation, and establish a possible involvement of uPAR in AD pathogenesis...
  24. pmc Presenilin-1 280Glu-->Ala mutation alters C-terminal APP processing yielding longer abeta peptides: implications for Alzheimer's disease
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Mol Med 14:184-94. 2008
    ....
  25. pmc Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders
    Thomas G Beach
    Sun Health Research Institute, 10515 West Santa Fe Drive, Sun City, AZ 85351, USA
    Acta Neuropathol 119:689-702. 2010
    ..Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest...
  26. pmc Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis
    R Lyle Patton
    The Longtine Center for Molecular Biology and Genetics, W H Civin Laboratory for Neuropathology, M D Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351, USA
    Am J Pathol 169:1048-63. 2006
    ..This may allow Abeta mobilization under conditions in which drainage and degradation of these toxic peptides is efficient...
  27. pmc Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease
    Alex E Roher
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, AZ, USA
    Alzheimers Dement 5:18-29. 2009
    ..We evaluated the amounts of amyloid beta (Abeta)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Abeta plasma levels and Alzheimer's disease (AD) pathology...
  28. pmc Proteomic analysis of Alzheimer's disease cerebrospinal fluid from neuropathologically diagnosed subjects
    Chera L Maarouf
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Curr Alzheimer Res 6:399-406. 2009
    ..The 2D DIGE system identified a set of 21 different protein biomarkers. This panel of proteins probably reflects fundamental pathological changes that are divergent from both normal aging and non-AD dementias...
  29. ncbi request reprint TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation
    Gregory D Van Vickle
    The Longtine Center for Molecular Biology and Genetics, Sun Health Research Institute, Sun City, Arizona 85351, USA
    Biochemistry 46:10317-27. 2007
    ..However, given the phylogenetic distance and the differences in APP processing and Abeta chemistry between Tg mice and AD, caution should be applied in projecting mouse therapeutic interventions onto human subjects...

Research Grants3

  1. AMYLOIDOGENIC EFFECTS OF CHOLINERGIC DENERVATION
    Thomas Beach; Fiscal Year: 2002
    ..This could lead to impaired cerebral vasoregulation and increased susceptibility to ischemia, further compromising cortical function in AD. ..