Lesa L Aylward

Summary

Affiliation: Summit Toxicology
Country: USA

Publications

  1. ncbi Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels
    Lesa L Aylward
    Exponent, Inc, Alexandria, Virginia 22314, USA
    J Expo Anal Environ Epidemiol 12:319-28. 2002
  2. ncbi Biomonitoring Equivalents (BE) dossier for trihalomethanes
    Lesa L Aylward
    Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 51:S68-77. 2008
  3. ncbi Guidelines for the communication of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop
    Judy S LaKind
    LaKind Associates, LLC, 106 Oakdale Avenue, Catonsville, MD 21228, USA
    Regul Toxicol Pharmacol 51:S16-26. 2008
  4. ncbi Derivation of biomonitoring equivalent (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia 22044, USA
    J Toxicol Environ Health A 71:1499-508. 2008
  5. ncbi Evaluation of biomonitoring data from the CDC National Exposure Report in a risk assessment context: perspectives across chemicals
    Lesa L Aylward
    Summit Toxicology LLP, Falls Church, Virginia 22044, USA
    Environ Health Perspect 121:287-94. 2013
  6. ncbi Elimination rates of dioxin congeners in former chlorophenol workers from Midland, Michigan
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia, USA 2The Dow Chemical Company, Midland, Michigan, USA
    Environ Health Perspect 121:39-45. 2013
  7. ncbi Interpreting variability in population biomonitoring data: role of elimination kinetics
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA 22044, USA
    J Expo Sci Environ Epidemiol 22:398-408. 2012
  8. ncbi Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans
    Jeremy N Moore
    Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Arch Environ Contam Toxicol 57:416-25. 2009
  9. ncbi A margin-of-exposure approach to assessment of noncancer risks of dioxins based on human exposure and response data
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia 22044, USA
    Environ Health Perspect 116:1344-51. 2008
  10. ncbi TCDD exposure estimation for workers at a New Zealand 2,4,5-T manufacturing facility based on serum sampling data
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA, USA
    J Expo Sci Environ Epidemiol 20:417-26. 2010

Collaborators

Detail Information

Publications48

  1. ncbi Temporal trends in human TCDD body burden: decreases over three decades and implications for exposure levels
    Lesa L Aylward
    Exponent, Inc, Alexandria, Virginia 22314, USA
    J Expo Anal Environ Epidemiol 12:319-28. 2002
    ..Food sampling data are limited, but support these trends...
  2. ncbi Biomonitoring Equivalents (BE) dossier for trihalomethanes
    Lesa L Aylward
    Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 51:S68-77. 2008
    ..The BE values derived in this exercise can be used as one component of a screening-level assessment of future population biomonitoring THM data...
  3. ncbi Guidelines for the communication of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop
    Judy S LaKind
    LaKind Associates, LLC, 106 Oakdale Avenue, Catonsville, MD 21228, USA
    Regul Toxicol Pharmacol 51:S16-26. 2008
    ..Communication of BEs will require outreach, education, and development of communication materials specific to several audiences including the lay public and health care providers...
  4. ncbi Derivation of biomonitoring equivalent (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia 22044, USA
    J Toxicol Environ Health A 71:1499-508. 2008
    ..These values may be used as screening tools for evaluation of biomonitoring data for dioxins in the context of existing risk assessments and for prioritization of the potential need for additional risk assessment efforts for dioxins...
  5. ncbi Evaluation of biomonitoring data from the CDC National Exposure Report in a risk assessment context: perspectives across chemicals
    Lesa L Aylward
    Summit Toxicology LLP, Falls Church, Virginia 22044, USA
    Environ Health Perspect 121:287-94. 2013
    ..Biomonitoring Equivalents (BEs) and other risk assessment-based values now allow interpretation of these biomonitoring data in a public health risk context...
  6. ncbi Elimination rates of dioxin congeners in former chlorophenol workers from Midland, Michigan
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia, USA 2The Dow Chemical Company, Midland, Michigan, USA
    Environ Health Perspect 121:39-45. 2013
    ..Exposure reconstructions and risk assessments for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other dioxins rely on estimates of elimination rates. Limited data are available on elimination rates for congeners other than TCDD...
  7. ncbi Interpreting variability in population biomonitoring data: role of elimination kinetics
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA 22044, USA
    J Expo Sci Environ Epidemiol 22:398-408. 2012
    ..The modeling and data sets presented here provide tools that can assist in interpretation of variability in cross-sectional biomonitoring studies and in design of studies utilizing biomonitoring data as markers for exposure...
  8. ncbi Hepatic P450 enzyme activity, tissue morphology and histology of mink (Mustela vison) exposed to polychlorinated dibenzofurans
    Jeremy N Moore
    Department of Zoology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Arch Environ Contam Toxicol 57:416-25. 2009
    ....
  9. ncbi A margin-of-exposure approach to assessment of noncancer risks of dioxins based on human exposure and response data
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia 22044, USA
    Environ Health Perspect 116:1344-51. 2008
    ....
  10. ncbi TCDD exposure estimation for workers at a New Zealand 2,4,5-T manufacturing facility based on serum sampling data
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA, USA
    J Expo Sci Environ Epidemiol 20:417-26. 2010
    ..The modeled exposures will be used in an evaluation of mortality patterns of workers at this facility...
  11. ncbi Derivation of Biomonitoring Equivalents for di-n-butyl phthalate (DBP), benzylbutyl phthalate (BzBP), and diethyl phthalate (DEP)
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 55:259-67. 2009
    ....
  12. ncbi Derivation of Biomonitoring Equivalents for di(2-ethylhexyl)phthalate (CAS No. 117-81-7)
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 55:249-58. 2009
    ....
  13. ncbi Chemical-specific screening criteria for interpretation of biomonitoring data for volatile organic compounds (VOCs)--application of steady-state PBPK model solutions
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA, USA
    Regul Toxicol Pharmacol 58:33-44. 2010
    ..The screening blood concentrations presented here provide a tool for risk assessment-based evaluation of population biomonitoring data for VOCs and are most appropriately applied to central tendency estimates for such datasets...
  14. ncbi Consideration of dosimetry in evaluation of ToxCast™ data
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA, USA
    J Appl Toxicol 31:741-51. 2011
    ....
  15. ncbi Biomonitoring equivalents for deltamethrin
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 60:189-99. 2011
    ..These values can be used to screen biomonitoring data in the context of current risk assessments for detlamethrin...
  16. ncbi Assessment of margin of exposure based on biomarkers in blood: an exploratory analysis
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 61:44-52. 2011
    ....
  17. ncbi Urinary DEHP metabolites and fasting time in NHANES
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia 22044, USA
    J Expo Sci Environ Epidemiol 21:615-24. 2011
    ..Finally, a previously published pharmacokinetic model for DEHP demonstrates that time since previous urinary void, a parameter not measured in NHANES, is predicted to result in non-random effects on measured urinary concentrations...
  18. ncbi Biomonitoring data for 2,4-dichlorophenoxyacetic acid in the United States and Canada: interpretation in a public health risk assessment context using Biomonitoring Equivalents
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, Virginia 22044, USA
    Environ Health Perspect 118:177-81. 2010
    ..Reference doses (RfDs) exist for 2,4-D, and Biomonitoring Equivalents (BEs; concentrations in urine or plasma that are consistent with those RfDs) for 2,4-D have recently been derived and published...
  19. ncbi Biomonitoring-based risk assessment for hexabromocyclododecane (HBCD)
    Lesa L Aylward
    Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA
    Int J Hyg Environ Health 214:179-87. 2011
    ....
  20. ncbi Biomonitoring equivalents for hexachlorobenzene
    Lesa L Aylward
    Summit Toxicology, LLP, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 58:25-32. 2010
    ....
  21. ncbi Mortality rates among workers exposed to dioxins in the manufacture of pentachlorophenol
    James J Collins
    The Dow Chemical Company, Midland, Michigan 48674, USA
    J Occup Environ Med 51:1212-9. 2009
    ..We sought to determine if workers exposed to dioxins in pentachlorophenol (PCP) manufacturing were at increased risk of death from specific causes...
  22. ncbi Biomonitoring equivalents for inorganic arsenic
    Sean M Hays
    Summit Toxicology, LLP, Lyons, CO 22044, USA
    Regul Toxicol Pharmacol 58:1-9. 2010
    ..The BEs associated with the various cancer risk assessments are significantly lower. These BE values may be used as screening tools for evaluation of biomonitoring data for inorganic arsenic in a public health risk context...
  23. ncbi Biomonitoring equivalents for di-isononyl phthalate (DINP)
    Sean M Hays
    Summit Toxicology, LLP, Lyons, CO, USA
    Regul Toxicol Pharmacol 60:181-8. 2011
    ....
  24. ncbi Derivation of Biomonitoring Equivalents for cyfluthrin
    Sean M Hays
    Summit Toxicology, LLP, Lyons, CO, USA
    Regul Toxicol Pharmacol 55:268-75. 2009
    ....
  25. ncbi Biomonitoring Equivalents for benzene
    Sean M Hays
    Summit Toxicology, L L P, Allenspark, CO, USA
    Regul Toxicol Pharmacol 62:62-73. 2012
    ....
  26. ncbi Biomonitoring equivalents for DDT/DDE
    Christopher R Kirman
    Summit Toxicology, LLP, Orange Village, OH, USA
    Regul Toxicol Pharmacol 60:172-80. 2011
    ....
  27. ncbi Environmental chemicals in people: challenges in interpreting biomonitoring information
    Judy S LaKind
    Summit Toxicology, L L P, Falls Church, VA 22044, USA
    J Environ Health 70:61-4. 2008
    ..This commentary examines issues unique to the use of such databases and the interpretation of biomonitoring-based epidemiological studies...
  28. ncbi Evaluation of NHANES biomonitoring data for volatile organic chemicals in blood: application of chemical-specific screening criteria
    Christopher R Kirman
    Summit Toxicology, Orange Village, Ohio 44022, USA
    J Expo Sci Environ Epidemiol 22:24-34. 2012
    ..Interpretations of measured blood concentrations of VOCs must be made with caution due to the substantial within-individual, within-day fluctuations in levels expected due to the rapid elimination of VOCs...
  29. ncbi Interpreting human biomonitoring data in a public health risk context using Biomonitoring Equivalents
    Sean M Hays
    Summit Toxicology, L L P, P O Box 427, Allenspark, CO 80510, USA
    Int J Hyg Environ Health 215:145-8. 2012
    ..This paper provides an overview of the derivation of BEs and how BEs can be used to interpret human biomonitoring data in a public health risk context...
  30. ncbi Mortality rates among trichlorophenol workers with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    James J Collins
    Epidemiology Department, The Dow Chemical Company, Midland, Michigan 48674, USA
    Am J Epidemiol 170:501-6. 2009
    ..With the exception of soft tissue sarcoma, the authors found little evidence of increased disease risk from exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin...
  31. ncbi Guidelines for the derivation of Biomonitoring Equivalents: report from the Biomonitoring Equivalents Expert Workshop
    Sean M Hays
    Summit Toxicology, LLP, 165 Valley Road, Lyons, CO 80540, USA
    Regul Toxicol Pharmacol 51:S4-15. 2008
    ..The findings from this Expert Panel Workshop on BE derivation are presented and provide a set of guidelines and considerations for use in BE derivation...
  32. ncbi Using Biomonitoring Equivalents to interpret human biomonitoring data in a public health risk context
    Sean M Hays
    Summit Toxicology, LLP, 165 Valley Road, Lyons, CO 80540, USA
    J Appl Toxicol 29:275-88. 2009
    ..Future challenges related to the derivation and use of BE values as tools in risk management are discussed...
  33. ncbi Biomonitoring Equivalents (BE) dossier for 2,4-dichlorophenoxyacetic acid (2,4-D) (CAS No. 94-75-7)
    Lesa L Aylward
    Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 51:S37-48. 2008
    ....
  34. ncbi Biomonitoring Equivalents (BE) dossier for acrylamide (AA) (CAS No. 79-06-1)
    Sean M Hays
    Summit Toxicology, LLP, 165 Valley Road, Lyons, CO 80540, USA
    Regul Toxicol Pharmacol 51:S57-67. 2008
    ....
  35. ncbi Biomonitoring Equivalents (BE) dossier for toluene (CAS No. 108-88-3)
    Lesa L Aylward
    Summit Toxicology, LLP, 6343 Carolyn Drive, Falls Church, VA 22044, USA
    Regul Toxicol Pharmacol 51:S27-36. 2008
    ....
  36. ncbi Biomonitoring Equivalents (BE) dossier for cadmium (Cd) (CAS No. 7440-43-9)
    Sean M Hays
    Summit Toxicology, LLP, 165 Valley Road, Lyons, CO 80540, USA
    Regul Toxicol Pharmacol 51:S49-56. 2008
    ....
  37. ncbi Is age an independent risk factor for chemically induced acute myelogenous leukemia in children?
    David W Pyatt
    Summit Toxicology, LLP, Lafayette, Colorado 80026, USA
    J Toxicol Environ Health B Crit Rev 10:379-400. 2007
    ..Available scientific and medical literature does not support the hypothesis that children necessarily possess an increased risk of developing AML following leukemogenic chemical exposure...
  38. ncbi 2,4-D exposure and risk assessment: comparison of external dose and biomonitoring based approaches
    Sean M Hays
    Summit Toxicology, L L P Allenspark, CO, USA
    Regul Toxicol Pharmacol 64:481-9. 2012
    ..These comparisons support a conclusion that exposure assessments conducted as part of the registration process for 2,4-D incorporate sufficiently conservative assumptions...
  39. ncbi An evaluation of benchmark dose methodology for non-cancer continuous-data health effects in animals due to exposures to dioxin (TCDD)
    David W Gaylor
    Gaylor and Associates, LLC, Eureka Springs, AR 72631, USA
    Regul Toxicol Pharmacol 40:9-17. 2004
    ....
  40. ncbi Nondestructive scat sampling in assessment of mink (Mustela vison) exposed to polychlorinated dibenzofurans (PCDFs)
    Matthew J Zwiernik
    Zoology Department, Center for Integrative Toxicology, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Arch Environ Contam Toxicol 55:529-37. 2008
    ..Overall, concentrations of PCDFs in mink scat can be used as a rapid and inexpensive nondestructive method to predict concentrations of PCDFs in mink when certain assumptions are met...
  41. ncbi Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort
    Lesa L Aylward
    Exponent, Inc, 1800 Diagonal Road, Suite 355, Alexandria, VA 22314, USA
    J Expo Anal Environ Epidemiol 15:51-65. 2005
    ....
  42. ncbi Exposure reconstruction for the TCDD-exposed NIOSH cohort using a concentration- and age-dependent model of elimination
    Lesa L Aylward
    Exponent, Inc, Alexandria, VA 22314, USA
    Risk Anal 25:945-56. 2005
    ....
  43. ncbi Comment on "Chronic disease and early exposure to air-borne mixtures. 2. Exposure assessment"
    Lesa L Aylward
    Environ Sci Technol 42:2201; author reply 2202-3. 2008
  44. ncbi A mechanism-based cancer risk assessment for 1,4-dichlorobenzene
    Byron E Butterworth
    Butterworth Consulting, 4820 Regalwood Dr, Raleigh, NC 27613, USA
    Regul Toxicol Pharmacol 49:138-48. 2007
    ..00004 ppm, some 2500-fold lower than the mechanism-based model and 1,875,000-fold lower than the no observed effect concentration for induced cancer of 75 ppm in the inhalation bioassay...
  45. ncbi Dioxin risks in perspective: past, present, and future
    Sean M Hays
    Exponent, Inc, 4940 Pearl East Circle, Suite 300, Boulder, CO 80301, USA
    Regul Toxicol Pharmacol 37:202-17. 2003
    ....
  46. ncbi Relative cancer potencies of selected dioxin-like compounds on a body-burden basis: comparison to current toxic equivalency factors (TEFs)
    Michael N Gray
    AMEC Earth and Environmental, Inc, Portland, Maine, USA
    J Toxicol Environ Health A 69:907-17. 2006
    ..The current WHO TEF values, which were derived from data on noncancer endpoints evaluated on an administered dose basis, overpredict the carcinogenic potency of these compounds on a body-burden basis compared to TCDD...
  47. ncbi Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR
    Kevin T Connor
    Geomatrix, Inc, Folsom, California, USA
    J Toxicol Environ Health B Crit Rev 9:147-71. 2006
    ..Quantitative risk assessments involving interspecies extrapolation from sensitive laboratory species and strains should take these fundamental differences into account when margins of exposure and safety factors are considered...
  48. ncbi Issues in risk assessment for developmental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds
    Lesa L Aylward
    Exponent, Inc, Alexandria, Virginia 22314, USA
    Toxicol Sci 87:3-10. 2005
    ..Additional research areas that may increase the foundation for interspecies extrapolations are discussed...