H A Lewis

Summary

Affiliation: Structural GenomiX
Country: USA

Publications

  1. ncbi request reprint A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs
    H A Lewis
    Structural GenomiX, San Diego, CA 92121, USA
    Structure 9:527-37. 2001
  2. pmc Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator
    Hal A Lewis
    Structural GenomiX Inc, San Diego, CA, USA
    EMBO J 23:282-93. 2004
  3. ncbi request reprint Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure
    Hal A Lewis
    Structural GenomiX, Inc, San Diego, California 92121, USA
    J Biol Chem 280:1346-53. 2005
  4. doi request reprint Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry
    H A Lewis
    SGX Pharmaceuticals, San Diego, CA 92121, USA
    J Mol Biol 396:406-30. 2010
  5. ncbi request reprint Structural analysis of a set of proteins resulting from a bacterial genomics project
    J Badger
    Structural GenomiX Inc, San Diego, California, USA
    Proteins 60:787-96. 2005

Detail Information

Publications5

  1. ncbi request reprint A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs
    H A Lewis
    Structural GenomiX, San Diego, CA 92121, USA
    Structure 9:527-37. 2001
    ..LuxS and AI-2 have been described in both Gram-negative and Gram-positive bacterial species and have been shown to be involved in the expression of virulence genes in several pathogens...
  2. pmc Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator
    Hal A Lewis
    Structural GenomiX Inc, San Diego, CA, USA
    EMBO J 23:282-93. 2004
    ..Our results are consistent with a CFTR mechanism, whereby channel gating occurs through ATP binding in an NBD1-NBD2 nucleotide sandwich that forms upon displacement of NBD1 regulatory segments...
  3. ncbi request reprint Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure
    Hal A Lewis
    Structural GenomiX, Inc, San Diego, California 92121, USA
    J Biol Chem 280:1346-53. 2005
    ....
  4. doi request reprint Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry
    H A Lewis
    SGX Pharmaceuticals, San Diego, CA 92121, USA
    J Mol Biol 396:406-30. 2010
    ..However, they also suggest that increased exposure of the 509-511 loop and increased dynamics in its vicinity could promote aggregation in vitro and aberrant intermolecular interactions that impede trafficking in vivo...
  5. ncbi request reprint Structural analysis of a set of proteins resulting from a bacterial genomics project
    J Badger
    Structural GenomiX Inc, San Diego, California, USA
    Proteins 60:787-96. 2005
    ..More distant sequence-structure relationships between the SGX and PDB structures were investigated using PDB-BLAST and Combinatorial Extension (CE). Only one structure, SufD, has a truly unique topology compared to all folds in the PDB...