Linheng Li

Summary

Affiliation: Stowers Institute for Medical Research
Country: USA

Publications

  1. ncbi request reprint Differential gene expression profiling of adult murine hematopoietic stem cells
    In Kyung Park
    University of Michigan, Department of Internal Medicine, Ann Arbor, USA
    Blood 99:488-98. 2002
  2. ncbi request reprint Normal stem cells and cancer stem cells: the niche matters
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, Missouri, USA
    Cancer Res 66:4553-7. 2006
  3. doi request reprint Abnormal Wnt signaling and stem cell activation in reactive lymphoid tissue and low-grade marginal zone lymphoma
    Da Zhang
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Leuk Lymphoma 51:906-10. 2010
  4. ncbi request reprint Stem cell niche: structure and function
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Annu Rev Cell Dev Biol 21:605-31. 2005
  5. ncbi request reprint Does 'immortal DNA strand' exist in 'immortal' stem cells?
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell Res 17:834-5. 2007
  6. ncbi request reprint Unraveling the molecular components and genetic blueprints of stem cells
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, MO, USA
    Biotechniques 35:1233-9. 2003
  7. pmc FGF signaling facilitates postinjury recovery of mouse hematopoietic system
    Meng Zhao
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Blood 120:1831-42. 2012
  8. doi request reprint N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
    Jeffrey S Haug
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Cell Stem Cell 2:367-79. 2008
  9. pmc Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion
    John M Perry
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genes Dev 25:1928-42. 2011
  10. ncbi request reprint PTEN-deficient intestinal stem cells initiate intestinal polyposis
    Xi C He
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nat Genet 39:189-98. 2007

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Differential gene expression profiling of adult murine hematopoietic stem cells
    In Kyung Park
    University of Michigan, Department of Internal Medicine, Ann Arbor, USA
    Blood 99:488-98. 2002
    ..A large number of genes that were differentially expressed by enriched populations of HSCs and MPP cells were identified. These included transcription factors, signaling molecules, and previously unknown genes...
  2. ncbi request reprint Normal stem cells and cancer stem cells: the niche matters
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, Missouri, USA
    Cancer Res 66:4553-7. 2006
    ..We hope this examination of the interaction between stem cells and their niche will enhance understanding of the process of cancer development, invasiveness, and metastasis and reveal possible targets for cancer treatment...
  3. doi request reprint Abnormal Wnt signaling and stem cell activation in reactive lymphoid tissue and low-grade marginal zone lymphoma
    Da Zhang
    Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Leuk Lymphoma 51:906-10. 2010
    ..We show that the anti-pbeta-catenin-S552 antibody may be useful in diagnosing and monitoring the progression of or response to therapy of MALT lymphoma...
  4. ncbi request reprint Stem cell niche: structure and function
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Annu Rev Cell Dev Biol 21:605-31. 2005
    ..We hope this comparative summary defines the basic elements of the stem cell niche, providing guiding principles for identification of the niche in other systems and pointing to areas for future studies...
  5. ncbi request reprint Does 'immortal DNA strand' exist in 'immortal' stem cells?
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Cell Res 17:834-5. 2007
  6. ncbi request reprint Unraveling the molecular components and genetic blueprints of stem cells
    Linheng Li
    Stowers Institute for Medical Research, Kansas City, MO, USA
    Biotechniques 35:1233-9. 2003
    ....
  7. pmc FGF signaling facilitates postinjury recovery of mouse hematopoietic system
    Meng Zhao
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Blood 120:1831-42. 2012
    ..This study provides the first in vivo evidence that FGF signaling facilitates postinjury recovery of the mouse hematopoietic system by promoting proliferation and facilitating mobilization of HSPCs...
  8. doi request reprint N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
    Jeffrey S Haug
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Cell Stem Cell 2:367-79. 2008
    ..Their expression profile and lower cell-cycle entry rate suggest N-cadherin(int) cells are being held in reserve. Thus, differential N-cadherin expression reflects functional distinctions between two HSC subpopulations...
  9. pmc Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion
    John M Perry
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genes Dev 25:1928-42. 2011
    ..We show for the first time that activation of either single pathway is insufficient to expand primitive HSCs, but in combination, both pathways drive self-renewal and expansion of HSCs with long-term functional capacity...
  10. ncbi request reprint PTEN-deficient intestinal stem cells initiate intestinal polyposis
    Xi C He
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nat Genet 39:189-98. 2007
    ..Our observations show that intestinal polyposis is initiated by PTEN-deficient ISCs that undergo excessive proliferation driven by Akt activation and nuclear localization of beta-catenin...
  11. ncbi request reprint Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion
    Jiwang Zhang
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Stem Cells 24:2826-39. 2006
    ..Subsequently, PTEN, through phosphatidyl inositol 3-kinase-Akt, inhibits the activity of beta-catenin, the convergence point of the BMP and Wnt signaling pathways...
  12. doi request reprint Detection of functional haematopoietic stem cell niche using real-time imaging
    Yucai Xie
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nature 457:97-101. 2009
    ..Thus, in contrast to central marrow, the endosteum formed a special zone, which normally maintains HSCs but promotes their expansion in response to bone marrow damage...
  13. doi request reprint Current view: intestinal stem cells and signaling
    David H Scoville
    Stowers Institute for Medical Research, Kansas City, Missouri, USA
    Gastroenterology 134:849-64. 2008
    ..Finally, we review current findings regarding the roles of Wnt, bone morphogenic protein, PtdIns(3,4,5) kinase, and Notch pathways within the intestine...
  14. doi request reprint Inducible expression of Runx2 results in multiorgan abnormalities in mice
    Nan He
    The Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    J Cell Biochem 112:653-65. 2011
    ..Use of tissue specific Cre mice will allow this model to be used to conditionally and inducibly overexpress Runx2 in different tissues and provide a means to study the post-natal tissue- and cell context-dependent functions of Runx2...
  15. doi request reprint Coexistence of quiescent and active adult stem cells in mammals
    Linheng Li
    Stowers Institute for Medical Research SIMR, Kansas City, MO 64110, USA
    Science 327:542-5. 2010
    ..Here, we summarize these findings and propose that quiescent and active stem cell populations have separate but cooperative functional roles...
  16. ncbi request reprint Understanding hematopoietic stem-cell microenvironments
    Zhixing Li
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Trends Biochem Sci 31:589-95. 2006
    ..Knowledge of the basic features of the HSC niches, including physical location, cell type and various signaling pathways, should provide insights into other stem-cell systems and benefit clinical applications...
  17. doi request reprint Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence
    Aparna Venkatraman
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 500:345-9. 2013
    ..Similarly, genetic inactivation of Igf1r partly rescues the H19-DMR deletion phenotype. Our work establishes a new role for this unique form of epigenetic control at the H19-Igf2 locus in maintaining adult stem cells. ..
  18. doi request reprint Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche
    Ryohichi Sugimura
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Cell 150:351-65. 2012
    ..Taken together, our findings demonstrate that noncanonical Wnt signaling maintains quiescent long-term HSCs through Fmi and Fz8 interaction in the niche...
  19. doi request reprint Functional assays for hematopoietic stem cell self-renewal
    John M Perry
    Stowers Institute for Medical Research, Kansas City, MO, USA
    Methods Mol Biol 636:45-54. 2010
    ..Finally, we provide a basic protocol for the serial-dilution assay, a quantitative assay for HSCs, from which individual researchers can construct their own customized protocols utilizing the guidelines discussed...
  20. doi request reprint Noncanonical Wnt signaling in vertebrate development, stem cells, and diseases
    Ryohichi Sugimura
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Birth Defects Res C Embryo Today 90:243-56. 2010
    ..In this review, we describe and discuss components of noncanonical Wnt signaling, diseases caused by deregulation of the signaling, regulation of adult stem cells by the signaling, and implications in cancer biology...
  21. ncbi request reprint PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 441:518-22. 2006
    ..Thus, PTEN has essential roles in restricting the activation of HSCs, in lineage fate determination, and in the prevention of leukaemogenesis...
  22. ncbi request reprint Cellular and molecular regulation of hematopoietic and intestinal stem cell behavior
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
    Ann N Y Acad Sci 1049:28-38. 2005
    ..Our work provided more evidence to demonstrate the essential function of the niche in maintenance of stem cells and showed that multiple signals are required to maintain a balanced control of stem cell self-renewal...
  23. ncbi request reprint Disrupting the stem cell niche: good seeds in bad soil
    John M Perry
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Cell 129:1045-7. 2007
    ..2007a, 2007b) demonstrate in mice that alterations in the niche for hematopoietic stem cells lead to the development of myeloproliferative disease...
  24. doi request reprint Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis
    Ryohichi Sugimura
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    J Mol Cell Biol 2:61-2. 2010
    ..However, a recent study (Naveiras et al., 2009. Nature 460, 259-263) shows that adipocytes are microenvironmental components that suppress hematopoiesis under homeostatic and especially stressed conditions...
  25. pmc The stem cell niches in bone
    Tong Yin
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    J Clin Invest 116:1195-201. 2006
    ..Many of the discoveries described herein may contribute to future clinical treatments for hematopoietic and bone-related disorders, including cancer...
  26. pmc Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis
    John M Perry
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genes Dev 22:1107-9. 2008
    ..Matsuoka and colleagues (pp. 986-991) have further illustrated this theme by demonstrating that inactivation of the tumor suppressor Fbxw7 leads to HSC depletion by active cell cycling and the initiation of leukemia...
  27. ncbi request reprint Stem cells and their niche: an inseparable relationship
    Ting Xie
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Development 134:2001-6. 2007
    ..Novel types of stem cells and niches were also reported and new findings that clarify our understanding of the molecular mechanisms that regulate and maintain stem cells were presented...
  28. pmc Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay
    Fengchao Wang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Gastroenterology 145:383-95.e1-21. 2013
    ..We sought to identify reliable surface markers of ISCs and establish a robust functional assay to characterize ISCs from mouse and human tissues...
  29. ncbi request reprint Finding the hematopoietic stem cell niche in the placenta
    Linheng Li
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, Missouri 64110, USA
    Dev Cell 8:297-8. 2005
    ....
  30. ncbi request reprint Sterile and disposable fluidic subsystem suitable for clinical high speed fluorescence-activated cell sorting
    Sachintha M Jayasinghe
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Cytometry B Clin Cytom 70:344-54. 2006
    ..However, modern "off-the shelf" flow cytometers are suboptimally designed for these purposes because nonsterile instrument hardware components directly contact sample-harboring fluids, compromising their sterility...
  31. ncbi request reprint Recent advances in understanding extrinsic control of hematopoietic stem cell fate
    Jason Ross
    Department of Pathology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Curr Opin Hematol 13:237-42. 2006
    ..The purpose of this review is to discuss recent advances and findings in how these different pathways interact to achieve a balanced control of these stem cells...
  32. ncbi request reprint BMP signaling and stem cell regulation
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Dev Biol 284:1-11. 2005
    ....
  33. ncbi request reprint BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    Xi C He
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, Missouri 64110, USA
    Nat Genet 36:1117-21. 2004
    ..Thus, BMP signaling may control the duplication of intestinal stem cells, thereby preventing crypt fission and the subsequent increase in crypt number...
  34. ncbi request reprint Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  35. ncbi request reprint Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
    Koichi Akashi
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 101:383-9. 2003
    ..These data support the hypothesis that stem cells possess a wide-open chromatin structure to maintain their multipotentiality, which is progressively quenched as they go down a particular pathway of differentiation...
  36. ncbi request reprint Hematopoietic stem cells contribute to the regeneration of renal tubules after renal ischemia-reperfusion injury in mice
    Fangming Lin
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Mail Code 9063, Dallas, TX 75390 9063, USA
    J Am Soc Nephrol 14:1188-99. 2003
    ..This is the first report to show that HSC can differentiate into renal tubular cells after I/R injury. Because of their availability, HSC may be useful for cell replacement therapy of acute renal failure...
  37. ncbi request reprint Hypothermic protection of the ischemic heart via alterations in apoptotic pathways as assessed by gene array analysis
    Xue Han Ning
    Division of Cardiology, Department of Pediatrics, University of Washington, Seattle 98195, USA
    J Appl Physiol 92:2200-7. 2002
    ..These data imply that hypothermia modifies signaling pathways for apoptosis and suggest possible mechanisms for hypothermia-induced myocardial protection...
  38. ncbi request reprint Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice
    Sylvia A Bleuming
    Center for Experimental and Molecular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    Cancer Res 67:8149-55. 2007
    ..Our data show that BMP signaling through Bmpr1a suppresses tumorigenesis at gastric epithelial junctional zones that are distinct from the adjacent gastric epithelium in both cellular differentiation and proliferation...
  39. ncbi request reprint Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation
    Michela Noseda
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
    Circ Res 94:910-7. 2004
    ....
  40. ncbi request reprint Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta
    Qiang Tian
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Cell Cycle 4:215-6. 2005
    ....