S I Said

Summary

Affiliation: Stony Brook University
Country: USA

Publications

  1. ncbi request reprint Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
    Sami I Said
    Departments of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA
    Circulation 115:1260-8. 2007
  2. pmc Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis?
    S I Said
    Pulmonary and Critical Care Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Eur Respir J 35:730-4. 2010
  3. pmc VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension
    Sayyed A Hamidi
    Department of Medicine, State University of New York at Stony Brook, NY, USA
    Respir Res 12:141. 2011
  4. pmc 17β-estradiol protects the lung against acute injury: possible mediation by vasoactive intestinal polypeptide
    Sayyed A Hamidi
    Department of Medicine, State University of New York, Stony Brook, New York 11794 8172, USA
    Endocrinology 152:4729-37. 2011
  5. doi request reprint The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation
    Sami I Said
    Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794 8172, USA
    Ann N Y Acad Sci 1144:148-53. 2008
  6. doi request reprint Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion
    S A Hamidi
    Pulmonary and Critical Care Medicine, State University of New York Health Sciences Center, Stony Brook, NY 11784 8172, USA
    Eur Respir J 31:135-9. 2008
  7. ncbi request reprint Clues to VIP function from knockout mice
    S A Hamidi
    Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794 8172, USA
    Ann N Y Acad Sci 1070:5-9. 2006
  8. ncbi request reprint Mediators and modulators of pulmonary arterial hypertension
    Sami I Said
    Department of Medicine, State University of New York at Stony Brook, and Northport Veterans Affairs Medical Center, Stony Brook, NY 11794 8172, USA
    Am J Physiol Lung Cell Mol Physiol 291:L547-58. 2006
  9. ncbi request reprint The multiple mediators of neurogenic smooth muscle relaxation
    Sami I Said
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Trends Endocrinol Metab 15:189-91. 2004
  10. ncbi request reprint Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP
    Anthony M Szema
    Department of Medicine, State University of New York at Stony Brook, NY 11794 8172, USA
    Am J Physiol Lung Cell Mol Physiol 291:L880-6. 2006

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Moderate pulmonary arterial hypertension in male mice lacking the vasoactive intestinal peptide gene
    Sami I Said
    Departments of Medicine, State University of New York at Stony Brook, Stony Brook, NY, USA
    Circulation 115:1260-8. 2007
    ..We have tested the hypothesis that targeted deletion of the VIP gene may lead to PAH with pulmonary vascular remodeling...
  2. pmc Asthma and pulmonary arterial hypertension: do they share a key mechanism of pathogenesis?
    S I Said
    Pulmonary and Critical Care Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    Eur Respir J 35:730-4. 2010
    ..Enough evidence exists to support the views that asthma and PAH share important pathological features, probably related to NFAT activation, and that VIP may be a physiological modulator of this mechanism...
  3. pmc VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension
    Sayyed A Hamidi
    Department of Medicine, State University of New York at Stony Brook, NY, USA
    Respir Res 12:141. 2011
    ..The objectives of this investigation were to answer the questions: 1) Can VIP protect against PH in other experimental models? and 2) Does combining VIP with an endothelin (ET) receptor antagonist bosentan enhance its efficacy?..
  4. pmc 17β-estradiol protects the lung against acute injury: possible mediation by vasoactive intestinal polypeptide
    Sayyed A Hamidi
    Department of Medicine, State University of New York, Stony Brook, New York 11794 8172, USA
    Endocrinology 152:4729-37. 2011
    ..Estradiol attenuated acute lung injury in three experimental models while stimulating VIP gene expression, a known mechanism of lung protection. The up-regulated VIP expression could have partially mediated the protection by estrogen...
  5. doi request reprint The vasoactive intestinal peptide gene is a key modulator of pulmonary vascular remodeling and inflammation
    Sami I Said
    Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794 8172, USA
    Ann N Y Acad Sci 1144:148-53. 2008
    ..If this hypothesis is validated, VIP would emerge as an endogenous modulator of pulmonary vascular remodeling and inflammation, through its suppression of NFAT activation...
  6. doi request reprint Enhancement of pulmonary vascular remodelling and inflammatory genes with VIP gene deletion
    S A Hamidi
    Pulmonary and Critical Care Medicine, State University of New York Health Sciences Center, Stony Brook, NY 11784 8172, USA
    Eur Respir J 31:135-9. 2008
    ..The present findings shed more light on the molecular mechanisms of pulmonary arterial hypertension, and could lead to better understanding of the pathogenesis of human pulmonary arterial hypertension, and hence to improved therapy...
  7. ncbi request reprint Clues to VIP function from knockout mice
    S A Hamidi
    Pulmonary and Critical Care Medicine, SUNY Health Sciences Center, Stony Brook, NY 11794 8172, USA
    Ann N Y Acad Sci 1070:5-9. 2006
    ....
  8. ncbi request reprint Mediators and modulators of pulmonary arterial hypertension
    Sami I Said
    Department of Medicine, State University of New York at Stony Brook, and Northport Veterans Affairs Medical Center, Stony Brook, NY 11794 8172, USA
    Am J Physiol Lung Cell Mol Physiol 291:L547-58. 2006
    ..This classification, now widely accepted, was first proposed at a meeting in Evian, France, in 1998, and modified in Venice, Italy, in 2003 (124)...
  9. ncbi request reprint The multiple mediators of neurogenic smooth muscle relaxation
    Sami I Said
    Department of Medicine, Division of Gastroenterology and Hepatology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
    Trends Endocrinol Metab 15:189-91. 2004
    ..A recent paper highlights the complex but coordinated control of the internal anal sphincter by three neurotransmitters...
  10. ncbi request reprint Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP
    Anthony M Szema
    Department of Medicine, State University of New York at Stony Brook, NY 11794 8172, USA
    Am J Physiol Lung Cell Mol Physiol 291:L880-6. 2006
    ....
  11. ncbi request reprint Pathways of inflammation and cell death in the lung: modulation by vasoactive intestinal peptide
    S I Said
    University Medical Center at Stony Brook, and Northport VA Medical Center, New York, NY, USA
    Regul Pept 93:21-9. 2000
    ..Finally, a hypothesis is presented for survival-promoting pathways that can be augmented by VIP and the related pituitary adenylyl cyclase-activating peptide...
  12. ncbi request reprint New evidence for transmitter role of VIP in the airways: impaired relaxation by a catalytic antibody
    H I Berisha
    State University of New York at Stony Brook, N Y 11794 8172, Medical Center, Northport, NY 11768, USA
    Pulm Pharmacol Ther 15:121-7. 2002
    ..The findings support a role for VIP as a major mediator of neurogenic relaxation of guinea pig tracheal smooth muscle. Lack of complete abrogation of relaxation is consistent with a co-transmitter role for NO...
  13. ncbi request reprint The discovery of VIP: initially looked for in the lung, isolated from intestine, and identified as a neuropeptide
    Sami I Said
    Pulmonary and Critical Care Medicine State University of New York, SUNY at Stony Brook, Stony Brook, NY, USA
    Peptides 28:1620-1. 2007
  14. ncbi request reprint Nitric oxide and vasoactive intestinal peptide as co-transmitters of airway smooth-muscle relaxation: analysis in neuronal nitric oxide synthase knockout mice
    Nadia A Hasaneen
    Medical Service and Research Service, VA Medical Center, Northport, NY, USA
    Chest 124:1067-72. 2003
    ..The availability of neuronal NO synthase (nNOS) knockout mice (nNOS-/-) provides a unique opportunity for evaluating NO...
  15. ncbi request reprint Ionotropic glutamate receptors in lungs and airways: molecular basis for glutamate toxicity
    Kathleen G Dickman
    V A Medical Center, Northport, NY, USA
    Am J Respir Cell Mol Biol 30:139-44. 2004
    ..These findings provide a molecular-biological basis for the excitotoxic actions of glutamate in rat lungs and airways, and raise the question of a possible physiologic role for NMDAR in lung and airway function...
  16. ncbi request reprint Vasoactive intestinal peptide attenuates cytochrome c translocation, and apoptosis, in rat hippocampal stem cells
    Francis J Antonawich
    Department of Neurology, HSC T12 020, S U N Y at Stony Brook, Stony Brook, NY 11794 8121, USA
    Neurosci Lett 325:151-4. 2002
    ..VIP decreased this translocation of cytochrome c in a dose-dependent manner, and reduced apoptosis. This demonstrates that VIP regulates neuronal apoptosis and may contribute to stem cell homeostasis...