Nancy C Reich

Summary

Affiliation: Stony Brook University
Country: USA

Publications

  1. pmc Activation of interferon regulatory factor 5 by site specific phosphorylation
    Hui Chen Chang Foreman
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e33098. 2012
  2. doi request reprint STAT3 revs up the powerhouse
    Nancy C Reich
    Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Sci Signal 2:pe61. 2009
  3. ncbi request reprint Tracking STAT nuclear traffic
    Nancy C Reich
    Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11777, USA
    Nat Rev Immunol 6:602-12. 2006
  4. ncbi request reprint STAT2 nuclear trafficking
    Gregg Banninger
    Graduate Program in Genetics, Stony Brook University, New York 11794 8691, USA
    J Biol Chem 279:39199-206. 2004
  5. pmc STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3
    Ling Liu
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 8691, USA
    Proc Natl Acad Sci U S A 102:8150-5. 2005
  6. pmc Live cell imaging reveals continuous STAT6 nuclear trafficking
    Hui Chen Chen
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    J Immunol 185:64-70. 2010
  7. ncbi request reprint Differential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection
    Tsu Fan Cheng
    Department of Molecular Genetics and Microbiology, Stony Brook University, NY 11794, USA
    J Immunol 176:7462-70. 2006
  8. pmc Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3
    Yiwei Gao
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 287:20904-12. 2012
  9. ncbi request reprint Induction of genes involved in cell cycle progression by interleukin-4
    Christine McDonald
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    J Interferon Cytokine Res 24:729-38. 2004
  10. pmc A death-promoting role for ISG54/IFIT2
    Nancy C Reich
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    J Interferon Cytokine Res 33:199-205. 2013

Collaborators

  • Velasco Cimica
  • Ling Liu
  • J Peter Gergen
  • Noriko Yokoyama
  • Nandini Sen
  • M Melissa Gilbert
  • Sarah Van Scoy
  • Kevin M McBride
  • Tsu Fan Cheng
  • Ha Youn Shin
  • Hui Chen Chang Foreman
  • Yiwei Gao
  • Sabrina Brzostek-Racine
  • Marcin Stawowczyk
  • Hui Chen Chen
  • Gregg Banninger
  • Christine McDonald
  • K Prasanna Kumar
  • Janaki Iyer
  • Amanda J Ullman
  • Peter J Alff
  • Patrick Hearing
  • Dolores Gomez
  • Mark T Brown
  • Chris Gordon
  • Irina N Gavrilovskaya
  • Karen Endriss
  • Erika Geimonen
  • Yuson Chong
  • Elena Gorbunova
  • Sabrina Brzostek
  • Osamu Ando
  • Erich R Mackow
  • Sarah Vanscoy
  • Gerard Marriott
  • Walter F Mangel
  • Mary Lynn Baniecki

Detail Information

Publications25

  1. pmc Activation of interferon regulatory factor 5 by site specific phosphorylation
    Hui Chen Chang Foreman
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 7:e33098. 2012
    ..Results indicate polyubiquitination of IRF5 does not play a major role in its transcriptional activity, and that ubiquitination and phosphorylation are independent modifications...
  2. doi request reprint STAT3 revs up the powerhouse
    Nancy C Reich
    Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    Sci Signal 2:pe61. 2009
    ..STAT3 modifed by serine phosphorylation augmented oxidative phosphorylation in mitochondria and supported cellular transformation by oncogenic Ras...
  3. ncbi request reprint Tracking STAT nuclear traffic
    Nancy C Reich
    Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11777, USA
    Nat Rev Immunol 6:602-12. 2006
    ..In either case, the regulation of nuclear trafficking can provide a target for therapeutic intervention...
  4. ncbi request reprint STAT2 nuclear trafficking
    Gregg Banninger
    Graduate Program in Genetics, Stony Brook University, New York 11794 8691, USA
    J Biol Chem 279:39199-206. 2004
    ..The regulation of STAT2 nuclear trafficking is distinct from the previously characterized STAT1 factor...
  5. pmc STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3
    Ling Liu
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 8691, USA
    Proc Natl Acad Sci U S A 102:8150-5. 2005
    ..These results distinguish STAT3 cellular localization from other STAT molecules and identify a feature that may be targeted in the clinical intervention of STAT3-dependent neoplasia...
  6. pmc Live cell imaging reveals continuous STAT6 nuclear trafficking
    Hui Chen Chen
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    J Immunol 185:64-70. 2010
    ..These findings will impact diagnostic approaches and strategies to block the deleterious effects of STAT6 in autoimmunity...
  7. ncbi request reprint Differential activation of IFN regulatory factor (IRF)-3 and IRF-5 transcription factors during viral infection
    Tsu Fan Cheng
    Department of Molecular Genetics and Microbiology, Stony Brook University, NY 11794, USA
    J Immunol 176:7462-70. 2006
    ..These studies support the distinct activation profiles of IRF-3 in comparison to IRF-5, but reveal a potential shared biological effect...
  8. pmc Suppressor of cytokine signaling 3 inhibits breast tumor kinase activation of STAT3
    Yiwei Gao
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794, USA
    J Biol Chem 287:20904-12. 2012
    ..SOCS3 is the only known inhibitor of Brk, and knowledge of the mechanisms by which SOCS3 inhibits Brk may lead to methods that block Brk in cancer progression...
  9. ncbi request reprint Induction of genes involved in cell cycle progression by interleukin-4
    Christine McDonald
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    J Interferon Cytokine Res 24:729-38. 2004
    ..Our results support a role for the Stat6 signal pathway in regulating a subset of E2F-responsive genes. In addition, activation of PI3K may play a complementary role in the induction of cell cycle-regulated genes in response to IL-4...
  10. pmc A death-promoting role for ISG54/IFIT2
    Nancy C Reich
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    J Interferon Cytokine Res 33:199-205. 2013
    ..The apoptotic response to ISG54/IFIT2 may contribute to other functions that have been reported, including translational regulation, inhibition of tumor colonization, and protection against a lethal viral infection...
  11. pmc The interferon stimulated gene 54 promotes apoptosis
    Marcin Stawowczyk
    Department of Molecular Genetics and Microbiology, Stony Brook University Stony Brook, New York 11794, USA
    J Biol Chem 286:7257-66. 2011
    ..The results reveal a previously unidentified role of ISG54 in the induction of apoptosis via a mitochondrial pathway and shed new light on the mechanism by which IFN elicits anti-viral and anti-cancer effects...
  12. ncbi request reprint Stimulation of primary human endothelial cell proliferation by IFN
    Dolores Gomez
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    J Immunol 170:5373-81. 2003
    ..These results reveal changes in the RNA levels of genes in endothelial cells that encode proteins involved in cellular proliferation...
  13. pmc Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha
    Kevin M McBride
    Department of Pathology, Stony Brook University, Stony Brook, NY 11794, USA
    EMBO J 21:1754-63. 2002
    ..This result may play a role in localizing STAT1 to its destination in the nucleus, and in releasing importin-alpha5 from STAT1 for recycling back to the cytoplasm...
  14. pmc Adenovirus E4 ORF3 protein inhibits the interferon-mediated antiviral response
    Amanda J Ullman
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA
    J Virol 81:4744-52. 2007
    ..We propose that the evolutionarily conserved function of the adenovirus E4 ORF3 protein is the inhibition of a host interferon response to viral infection via disruption of the PML oncogenic domain...
  15. pmc Dynamics of the STAT3 transcription factor: nuclear import dependent on Ran and importin-β1
    Velasco Cimica
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 6:e20188. 2011
    ..Expression of the Ran interfering mutant inhibited STAT3 nuclear import. This study defines importin-α/importin-β1/Ran as the molecular mechanism by which STAT3 traffics to the nucleus...
  16. doi request reprint Nuclear trafficking of STAT proteins visualized by live cell imaging
    Velasco Cimica
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY, USA
    Methods Mol Biol 967:189-202. 2013
    ....
  17. pmc The DNA damage response induces IFN
    Sabrina Brzostek-Racine
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794 5200, USA
    J Immunol 187:5336-45. 2011
    ..The significant finding of IFN production as a stress response to DNA damage provides a new perspective on the role of IFN signaling...
  18. ncbi request reprint Constitutive nuclear import of latent and activated STAT5a by its coiled coil domain
    Janaki Iyer
    Dept of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794, USA
    FASEB J 22:391-400. 2008
    ..However, after tyrosine phosphorylation, STAT5a accumulates in the nucleus because of its retention by DNA binding. These findings should provide a foundation for further studies that involve targeting the activity of STAT5a...
  19. ncbi request reprint The ins and outs of STAT1 nuclear transport
    Kevin M McBride
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Sci STKE 2003:RE13. 2003
    ..The nuclear import and subsequent recycling of STAT1 to the cytoplasm are integral to its function as a signal transducer and activator of transcription...
  20. pmc The pathogenic NY-1 hantavirus G1 cytoplasmic tail inhibits RIG-I- and TBK-1-directed interferon responses
    Peter J Alff
    Molecular and Cellular Biology Graduate Program, SUNY at Stony Brook, Stony Brook, NY 11794, USA
    J Virol 80:9676-86. 2006
    ....
  21. pmc Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signal
    Ha Youn Shin
    Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York 11794, USA
    J Cell Sci 126:3333-43. 2013
    ..These findings provide insight into the fundamental mechanisms that regulate STAT5 nuclear trafficking and cooperation with the glucocorticoid receptor and provide a basis for clinical intervention of STAT5 function in disease. ..
  22. ncbi request reprint A novel functional activator of the Drosophila JAK/STAT pathway, unpaired2, is revealed by an in vivo reporter of pathway activation
    M Melissa Gilbert
    Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794 5222, USA
    Mech Dev 122:939-48. 2005
    ..This reporter system will benefit future investigations of JAK/STAT signaling modulators both in whole animals and tissue culture...
  23. ncbi request reprint Determinants for the interaction between Janus kinase 2 and protein phosphatase 2A
    Noriko Yokoyama
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    Arch Biochem Biophys 417:87-95. 2003
    ....
  24. ncbi request reprint Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton
    Mark T Brown
    Department of Pharmacological Sciences, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 277:46298-303. 2002
    ..Cleavage of cytoskeletal proteins weakens the structure of the cell, and therefore, actin as a cofactor may play a role in cell lysis and release of nascent virions...
  25. ncbi request reprint Nuclear/cytoplasmic localization of IRFs in response to viral infection or interferon stimulation
    Nancy C Reich
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Interferon Cytokine Res 22:103-9. 2002
    ..This review compares the activation of IRF-3 and IRF-9 and their respective physiologic impacts...