Feng Qian Li

Summary

Affiliation: Stony Brook University
Country: USA

Publications

  1. ncbi Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase
    Kathleen F Benson
    Division of Medical Genetics/Department of Medicine, University of Washington School of Medicine, Box 357720, 1705 NE Pacific Street, HSB-K236B, Seattle, Washington 98195, USA
    Nat Genet 35:90-6. 2003
  2. ncbi Generation and characterization of monoclonal antibodies against human Chibby protein
    Benjamin Cyge
    Graduate Program in Molecular and Cellular Pharmacology, Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, USA
    Hybridoma (Larchmt) 30:163-8. 2011
  3. ncbi Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of β-catenin signaling
    Victoria Fischer
    Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University, BST 7 186, Nicolls Rd, Stony Brook, NY, 11794 8651, USA
    J Mol Signal 7:6. 2012
  4. ncbi Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity
    Feng Qian Li
    Department of Pharmacological Sciences and 2Graduate Program in Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 181:1141-54. 2008
  5. ncbi Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling
    Feng Qian Li
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, NY 11794, USA
    Mol Biol Cell 21:311-22. 2010
  6. ncbi Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif
    Adaobi Mofunanya
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    BMC Mol Biol 10:41. 2009
  7. ncbi Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling
    Feng Qian Li
    SUNY at Stony Brook, Department of Pharmacology, Stony Brook, NY 11794 8651, USA
    Mol Cell Biol 27:4347-54. 2007
  8. ncbi Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby
    Damon Love
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 5:e13600. 2010
  9. ncbi Fine-tuning of nuclear-catenin by Chibby and 14-3-3
    Ken Ichi Takemaru
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York 11794 8651, USA
    Cell Cycle 8:210-3. 2009
  10. ncbi Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells
    Amar M Singh
    Department of Pathology, University of Florida College of Medicine, Box 100275, Gainesville, FL 32610, USA
    Circulation 115:617-26. 2007

Collaborators

Detail Information

Publications11

  1. ncbi Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase
    Kathleen F Benson
    Division of Medical Genetics/Department of Medicine, University of Washington School of Medicine, Box 357720, 1705 NE Pacific Street, HSB-K236B, Seattle, Washington 98195, USA
    Nat Genet 35:90-6. 2003
    ..Most mutations in ELA2 that cause human cyclic hematopoiesis prevent membrane localization of neutrophil elastase, whereas most mutations in ELA2 that cause SCN lead to exclusive membrane localization...
  2. ncbi Generation and characterization of monoclonal antibodies against human Chibby protein
    Benjamin Cyge
    Graduate Program in Molecular and Cellular Pharmacology, Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, USA
    Hybridoma (Larchmt) 30:163-8. 2011
    ..These Cby MAbs therefore hold promise as useful tools for the investigation of Wnt signaling and ciliogenesis...
  3. ncbi Chibby suppresses growth of human SW480 colon adenocarcinoma cells through inhibition of β-catenin signaling
    Victoria Fischer
    Graduate Program in Molecular and Cellular Pharmacology, Stony Brook University, BST 7 186, Nicolls Rd, Stony Brook, NY, 11794 8651, USA
    J Mol Signal 7:6. 2012
    ..Our results suggest that Cby, in collaboration with 14-3-3 proteins, can counteract oncogenic β-catenin signaling in colon cancer cells...
  4. ncbi Chibby cooperates with 14-3-3 to regulate beta-catenin subcellular distribution and signaling activity
    Feng Qian Li
    Department of Pharmacological Sciences and 2Graduate Program in Genetics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    J Cell Biol 181:1141-54. 2008
    ..Our results therefore suggest a novel paradigm through which Cby acts in concert with 14-3-3 proteins to facilitate nuclear export of beta-catenin, thereby antagonizing beta-catenin signaling...
  5. ncbi Nuclear-cytoplasmic shuttling of Chibby controls beta-catenin signaling
    Feng Qian Li
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, NY 11794, USA
    Mol Biol Cell 21:311-22. 2010
    ..Taken together, these findings unravel the molecular basis through which a combinatorial action of Cby and 14-3-3 proteins controls the dynamic nuclear-cytoplasmic trafficking of beta-catenin...
  6. ncbi Chibby forms a homodimer through a heptad repeat of leucine residues in its C-terminal coiled-coil motif
    Adaobi Mofunanya
    Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    BMC Mol Biol 10:41. 2009
    ..Although Cby harbors a predicted coiled-coil motif in the C-terminal region, its molecular nature and functional importance remain largely unexplored...
  7. ncbi Chibby promotes adipocyte differentiation through inhibition of beta-catenin signaling
    Feng Qian Li
    SUNY at Stony Brook, Department of Pharmacology, Stony Brook, NY 11794 8651, USA
    Mol Cell Biol 27:4347-54. 2007
    ..Our results therefore establish Cby as a novel proadipogenic factor required for adipocyte differentiation...
  8. ncbi Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby
    Damon Love
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 5:e13600. 2010
    ..Moreover, we demonstrate that Cby is a direct downstream target for the master ciliogenesis transcription factor Foxj1. Collectively, our results demonstrate that Cby facilitates proper postnatal lung development and function...
  9. ncbi Fine-tuning of nuclear-catenin by Chibby and 14-3-3
    Ken Ichi Takemaru
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York 11794 8651, USA
    Cell Cycle 8:210-3. 2009
    ..Here, we review recent literature concerning Cby function and discuss our current understanding of the relationship between Wnt and Akt signaling...
  10. ncbi Chibby, an antagonist of the Wnt/beta-catenin pathway, facilitates cardiomyocyte differentiation of murine embryonic stem cells
    Amar M Singh
    Department of Pathology, University of Florida College of Medicine, Box 100275, Gainesville, FL 32610, USA
    Circulation 115:617-26. 2007
    ..Chibby is a recently identified nuclear protein that directly binds to beta-catenin and antagonizes its transcriptional activity...
  11. ncbi Hereditary neutropenia: dogs explain human neutrophil elastase mutations
    Marshall Horwitz
    Division of Medical Genetics Department of Medicine, University of Washington School of Medicine, 1705 NE Pacific Street, HSB K236B, Box 357720 Seattle, WA 98195, USA
    Trends Mol Med 10:163-70. 2004
    ....