Gary S Goldberg

Summary

Affiliation: Stony Brook University
Country: USA

Publications

  1. ncbi Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes
    Gary S Goldberg
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Med Chem 1:57-64. 2005
  2. ncbi Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells
    Gary S Goldberg
    Department of Physiology and Biophysics, School of Medicine, Basic Science Tower T6, Health Science Complex, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    J Biol Chem 278:46533-40. 2003
  3. ncbi Selective permeability of gap junction channels
    Gary S Goldberg
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Health Science Complex, Stony Brook, NY 11794 8661, USA
    Biochim Biophys Acta 1662:96-101. 2004
  4. ncbi SRC utilizes Cas to block gap junctional communication mediated by connexin43
    Yongquan Shen
    Department of Molecular Biology, Science Center, University of Medicine and Dentistry, Stratford, New Jersey 08084, USA
    J Biol Chem 282:18914-21. 2007
  5. ncbi Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity
    David B Alexander
    Department of Physiology and Biophysics, School of Medicine, Health Sciences Complex, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA
    Cancer Res 64:1347-58. 2004
  6. ncbi Nontransformed cells can normalize gap junctional communication with transformed cells
    Virginijus Valiunas
    Department of Physiology and Biophysics, School of Medicine, Basic Science Tower L6, Health Science Complex, State University of New York at Stony Brook, 11794 8661, USA
    Biochem Biophys Res Commun 333:174-9. 2005
  7. ncbi SRC induces podoplanin expression to promote cell migration
    Yongquan Shen
    Molecular Biology Department, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
    J Biol Chem 285:9649-56. 2010
  8. ncbi Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate
    Xun Li
    Molecular Biology Department, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    Cancer Sci 99:1326-33. 2008
  9. ncbi Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth
    Parag Patwardhan
    Department of Physiology and Biophysics, School of Medicine, State University of New York, Stony Brook, 11794, USA
    J Biol Chem 281:20689-97. 2006
  10. ncbi SRC uses Cas to suppress Fhl1 in order to promote nonanchored growth and migration of tumor cells
    Yongquan Shen
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, Science Center, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Cancer Res 66:1543-52. 2006

Collaborators

Detail Information

Publications17

  1. ncbi Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes
    Gary S Goldberg
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Med Chem 1:57-64. 2005
    ..Moreover, both forms of lactoferrin failed to substantially modulate the expression of other genes. Thus, lactoferrin does not seem to directly control gene expression or inhibit tumor cell growth...
  2. ncbi Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cells
    Gary S Goldberg
    Department of Physiology and Biophysics, School of Medicine, Basic Science Tower T6, Health Science Complex, State University of New York at Stony Brook, Stony Brook, NY 11794 8661, USA
    J Biol Chem 278:46533-40. 2003
    ..Thus, a single phosphorylation site on this focal adhesion adaptor protein can effectively separate cell migration from other transformed growth characteristics...
  3. ncbi Selective permeability of gap junction channels
    Gary S Goldberg
    Department of Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook, Health Science Complex, Stony Brook, NY 11794 8661, USA
    Biochim Biophys Acta 1662:96-101. 2004
    ..This review presents some data and interpretations pertaining to mechanisms that govern the differential transfer of signals through gap junction channels...
  4. ncbi SRC utilizes Cas to block gap junctional communication mediated by connexin43
    Yongquan Shen
    Department of Molecular Biology, Science Center, University of Medicine and Dentistry, Stratford, New Jersey 08084, USA
    J Biol Chem 282:18914-21. 2007
    ..This finding introduces a novel role of the Cas focal adhesion linker protein in the gap junction complex. This observation may help explain how gap junctional communication can be suppressed between malignant and metastatic tumor cells...
  5. ncbi Normal cells control the growth of neighboring transformed cells independent of gap junctional communication and SRC activity
    David B Alexander
    Department of Physiology and Biophysics, School of Medicine, Health Sciences Complex, State University of New York at Stony Brook, Stony Brook, NY 11794-8661, USA
    Cancer Res 64:1347-58. 2004
    ..In addition, these results suggest mechanisms by which normal cells may block Wnt signaling, inhibit insulin-like growth factor activity, and promote host recognition of neighboring tumor cells...
  6. ncbi Nontransformed cells can normalize gap junctional communication with transformed cells
    Virginijus Valiunas
    Department of Physiology and Biophysics, School of Medicine, Basic Science Tower L6, Health Science Complex, State University of New York at Stony Brook, 11794 8661, USA
    Biochem Biophys Res Commun 333:174-9. 2005
    ..Thus, nontransformed cells can effectively "normalize" the conductance of gap junction channels expressed by adjacent tumor cells...
  7. ncbi SRC induces podoplanin expression to promote cell migration
    Yongquan Shen
    Molecular Biology Department, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey 08084, USA
    J Biol Chem 285:9649-56. 2010
    ..These genes encode growth factor receptors, adaptor proteins, and products that have not yet been annotated and may play important roles in tumor cell growth and migration...
  8. ncbi Coordinate suppression of Sdpr and Fhl1 expression in tumors of the breast, kidney, and prostate
    Xun Li
    Molecular Biology Department, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    Cancer Sci 99:1326-33. 2008
    ....
  9. ncbi Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth
    Parag Patwardhan
    Department of Physiology and Biophysics, School of Medicine, State University of New York, Stony Brook, 11794, USA
    J Biol Chem 281:20689-97. 2006
    ..Mutants lacking some or all YXXP sites augment the ability of Src to promote anchorage-independent growth. On the other hand, deletion of YXXP sites compromises the ability of Cas to promote tumor cell migration...
  10. ncbi SRC uses Cas to suppress Fhl1 in order to promote nonanchored growth and migration of tumor cells
    Yongquan Shen
    Department of Molecular Biology, University of Medicine and Dentistry of New Jersey, Science Center, 2 Medical Center Drive, Stratford, NJ 08084, USA
    Cancer Res 66:1543-52. 2006
    ....
  11. ncbi Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration
    Jhon Alberto Ochoa-Alvarez
    Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey, Stratford, New Jersey, United States of America
    PLoS ONE 7:e41845. 2012
    ..These studies demonstrate how lectins may be used to help develop dietary agents that target specific receptors to combat malignant cell growth...
  12. ncbi Phosphorylation of connexin43 induced by Src: regulation of gap junctional communication between transformed cells
    Madhuri Pahujaa
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey, Science Center, 2 Medical Center Dr, Stratford, NJ 08084, USA
    Exp Cell Res 313:4083-90. 2007
    ..It has become clear that Src can affect Cx43 activity by multiple mechanisms. Here, we review how Src may orchestrate events that regulate intercellular communication mediated by Cx43...
  13. ncbi Transfer of biologically important molecules between cells through gap junction channels
    David B Alexander
    Dept. of Physiology and Biophsyics, School of Medicine, Basic Science Tower L6, Health Science Complex, State University of New York at Stoneybrook, NY 11796-8661, USA
    Curr Med Chem 10:2045-58. 2003
    ..Indeed, the study of the intercellular transfer of endogenous molecules presents formidable challenges. Here we review developments in identifying biologically relevant molecules that pass between cells through gap junction channels...
  14. ncbi Src activates Abl to augment Robo1 expression in order to promote tumor cell migration
    P Raaj Khusial
    Molecular Biology Department, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    Oncotarget 1:198-209. 2010
    ..Therefore, inhibitors of Src, Abl, Robo1 and small GTPases may target a coordinated pathway required for tumor cell migration...
  15. ncbi Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP
    Gary S Goldberg
    Department of Physiology and Biophysics, State University of New York, Stony Brook, New York 11794 8661, USA
    J Biol Chem 277:36725-30. 2002
    ..This suggests functional consequence because the energy status of a cell could be controlled via connexin expression and channel formation...
  16. ncbi SRC points the way to biomarkers and chemotherapeutic targets
    Harini Krishnan
    University of Medicine and Dentistry of New Jersey, Graduate School of Biomedical Sciences, School of Osteopathic Medicine, Stratford, NJ, USA
    Genes Cancer 3:426-35. 2012
    ..This paradigm illuminates several chemotherapeutic targets and may lead to the identification of new biomarkers and the development of effective anticancer treatments...
  17. ncbi Maternal diet, C-reactive protein, and the outcome of pregnancy
    Theresa O Scholl
    Department of Obstetrics and Gynecology, University of Medicine and Dentistry of New Jersey, Stratford, NJ 08084, USA
    J Am Coll Nutr 30:233-40. 2011
    ....