Affiliation: Stony Brook University
- From individual to population: the minimum alveolar concentration curveJames P Dilger
Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794 8480, USA
Curr Opin Anaesthesiol 19:390-6. 2006..This review examines hypotheses about the shape of the minimum alveolar concentration curve, and recent theoretical and experimental approaches to the question...
- Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonistsJames P Dilger
Department of Anesthesiology, Stony Brook University, NY 11794 8480, USA, and Department of Anesthesiology, Surugadai Nihon University Hospital, Kanda, Tokyo, Japan
Anesthesiology 106:1186-95. 2007..To test the generality of this observation, the authors measured current inhibition by five competitive antagonists on wild-type and mutant acetylcholine receptors...
- Monte Carlo simulation of buffered diffusion into and out of a model synapseJames P Dilger
Department of Anesthesiology, Stony Brook University, Stony Brook, New York, USA
Biophys J 98:959-67. 2010..These simulations identify characteristics that can be used to test whether a synaptic process is governed by buffered diffusion. They also indicate that fundamental differences in synapse function may occur with irreversible ligands...
- Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptorMan Liu
Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11790 8480, USA
Mol Pharmacol 75:166-73. 2009....
- Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptorsMan Liu
Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11790, USA
Anesth Analg 107:525-33. 2008..The mechanism for synergy has not been elucidated. We tested the hypothesis that synergy arises from a differential selectivity of antagonists for the two ligand binding sites on adult human nAChR...
- The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperatureDeeptankar Demazumder
Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
J Physiol 586:951-63. 2008..Differences in ligand desolvation and ligand conformation are not likely to be important...
- Kinetics of Ligand Binding to Synaptic Ion ChannelsJAMES DILGER; Fiscal Year: 2006..4. Use isothermal titration calorimetry to measure the thermodynamics of ligand binding to acetylcholine binding protein - a water soluble protein whose structure is being used as a template for the acetylcholine receptor. ..