JAMES DILGER

Summary

Affiliation: Stony Brook University
Country: USA

Publications

  1. ncbi From individual to population: the minimum alveolar concentration curve
    James P Dilger
    Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794 8480, USA
    Curr Opin Anaesthesiol 19:390-6. 2006
  2. ncbi Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists
    James P Dilger
    Department of Anesthesiology, Stony Brook University, NY 11794 8480, USA, and Department of Anesthesiology, Surugadai Nihon University Hospital, Kanda, Tokyo, Japan
    Anesthesiology 106:1186-95. 2007
  3. ncbi Monte Carlo simulation of buffered diffusion into and out of a model synapse
    James P Dilger
    Department of Anesthesiology, Stony Brook University, Stony Brook, New York, USA
    Biophys J 98:959-67. 2010
  4. ncbi Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor
    Man Liu
    Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11790 8480, USA
    Mol Pharmacol 75:166-73. 2009
  5. ncbi Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors
    Man Liu
    Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11790, USA
    Anesth Analg 107:525-33. 2008
  6. ncbi The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature
    Deeptankar Demazumder
    Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    J Physiol 586:951-63. 2008

Research Grants

  1. Kinetics of Ligand Binding to Synaptic Ion Channels
    JAMES DILGER; Fiscal Year: 2006

Collaborators

Detail Information

Publications6

  1. ncbi From individual to population: the minimum alveolar concentration curve
    James P Dilger
    Department of Anesthesiology, Stony Brook University, Stony Brook, New York 11794 8480, USA
    Curr Opin Anaesthesiol 19:390-6. 2006
    ..This review examines hypotheses about the shape of the minimum alveolar concentration curve, and recent theoretical and experimental approaches to the question...
  2. ncbi Roles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists
    James P Dilger
    Department of Anesthesiology, Stony Brook University, NY 11794 8480, USA, and Department of Anesthesiology, Surugadai Nihon University Hospital, Kanda, Tokyo, Japan
    Anesthesiology 106:1186-95. 2007
    ..To test the generality of this observation, the authors measured current inhibition by five competitive antagonists on wild-type and mutant acetylcholine receptors...
  3. ncbi Monte Carlo simulation of buffered diffusion into and out of a model synapse
    James P Dilger
    Department of Anesthesiology, Stony Brook University, Stony Brook, New York, USA
    Biophys J 98:959-67. 2010
    ..These simulations identify characteristics that can be used to test whether a synaptic process is governed by buffered diffusion. They also indicate that fundamental differences in synapse function may occur with irreversible ligands...
  4. ncbi Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor
    Man Liu
    Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11790 8480, USA
    Mol Pharmacol 75:166-73. 2009
    ....
  5. ncbi Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors
    Man Liu
    Department of Anesthesiology, Stony Brook University, Stony Brook, NY 11790, USA
    Anesth Analg 107:525-33. 2008
    ..The mechanism for synergy has not been elucidated. We tested the hypothesis that synergy arises from a differential selectivity of antagonists for the two ligand binding sites on adult human nAChR...
  6. ncbi The kinetics of competitive antagonism of nicotinic acetylcholine receptors at physiological temperature
    Deeptankar Demazumder
    Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA
    J Physiol 586:951-63. 2008
    ..Differences in ligand desolvation and ligand conformation are not likely to be important...

Research Grants4

  1. Kinetics of Ligand Binding to Synaptic Ion Channels
    JAMES DILGER; Fiscal Year: 2006
    ..4. Use isothermal titration calorimetry to measure the thermodynamics of ligand binding to acetylcholine binding protein - a water soluble protein whose structure is being used as a template for the acetylcholine receptor. ..