J Craig Cohen

Summary

Affiliation: Stony Brook University
Country: USA

Publications

  1. pmc CFTR and Wnt/beta-catenin signaling in lung development
    J Craig Cohen
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University, School of Medicine, Stony Brook, New York, USA
    BMC Dev Biol 8:70. 2008
  2. pmc The Peter Pan paradigm
    J Craig Cohen
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    Theor Biol Med Model 5:1. 2008
  3. pmc Small interfering peptide (siP) for in vivo examination of the developing lung interactonome
    J Craig Cohen
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University, School of Medicine, Stony Brook, New York 11794, USA
    Dev Dyn 238:386-93. 2009
  4. ncbi Cystic fibrosis transmembrane conductance regulator (CFTR) dependent cytoskeletal tension during lung organogenesis
    J Craig Cohen
    Section of Neonatology, Department of Pediatrics, Stony Brook Health Sciences Center, Stony Brook, New York, USA
    Dev Dyn 235:2736-48. 2006
  5. pmc Adult onset lung disease following transient disruption of fetal stretch-induced differentiation
    Joseph J Hudak
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University, School of Medicine, Stony Brook, New York, 11794, USA
    Respir Res 10:34. 2009
  6. pmc Transient in utero disruption of cystic fibrosis transmembrane conductance regulator causes phenotypic changes in alveolar type II cells in adult rats
    Ashraf Gad
    The Brady Laboratory, Department of Pediatrics, Division of Neonatology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    BMC Cell Biol 10:24. 2009
  7. pmc Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby
    Damon Love
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 5:e13600. 2010
  8. doi Transient in utero nicotine exposure stimulates mechanosensory-dependent lung development
    Shruti Gupta
    Department of Pediatrics, Stonybrook University, Stonybrook, NY 11794, USA
    Exp Lung Res 36:491-8. 2010
  9. ncbi Simulated transport alters surfactant homeostasis and causes dose-dependent changes in respiratory function in neonatal Sprague-Dawley rats
    Shetal Shah
    Division of Neonatology, Department of Pediatrics, State University of New York at Stony Brook, Stony Brook, New York, NY, USA
    J Perinat Med 38:535-43. 2010
  10. ncbi Improvement of pulmonary hypoplasia associated with congenital diaphragmatic hernia by in utero CFTR gene therapy
    Janet E Larson
    Div of Neonatology, Dept of Pediatrics, T11 060, Stony Brook Univ Health Sciences Center, Stony Brook, NY 11794 8111, USA
    Am J Physiol Lung Cell Mol Physiol 291:L4-10. 2006

Collaborators

Detail Information

Publications17

  1. pmc CFTR and Wnt/beta-catenin signaling in lung development
    J Craig Cohen
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University, School of Medicine, Stony Brook, New York, USA
    BMC Dev Biol 8:70. 2008
    ..Adenoviruses containing full-length CFTR, a short anti-sense CFTR gene fragment, or a reporter gene as control were used in an intra-amniotic gene therapy procedure to transiently modify CFTR expression in the fetal lung...
  2. pmc The Peter Pan paradigm
    J Craig Cohen
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    Theor Biol Med Model 5:1. 2008
    ..You may delay, but time will not" Benjamin Franklin, USA Founding Father...
  3. pmc Small interfering peptide (siP) for in vivo examination of the developing lung interactonome
    J Craig Cohen
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University, School of Medicine, Stony Brook, New York 11794, USA
    Dev Dyn 238:386-93. 2009
    ..Physiologically, it was shown that siPs that interfered with the NOX-CFTR-CK2 complex that we call an "interactonome" affected markers of stretch-induced lung organogenesis including Wnt/beta-catenin signaling...
  4. ncbi Cystic fibrosis transmembrane conductance regulator (CFTR) dependent cytoskeletal tension during lung organogenesis
    J Craig Cohen
    Section of Neonatology, Department of Pediatrics, Stony Brook Health Sciences Center, Stony Brook, New York, USA
    Dev Dyn 235:2736-48. 2006
    ..Deficiency of CFTR altering lung development would contribute significantly to the Cystic Fibrosis disease phenotype...
  5. pmc Adult onset lung disease following transient disruption of fetal stretch-induced differentiation
    Joseph J Hudak
    The Brady Laboratory, Section of Neonatology, Department of Pediatrics, Stony Brook University, School of Medicine, Stony Brook, New York, 11794, USA
    Respir Res 10:34. 2009
    ..They illustrate how an adult onset disease can arise from subtle changes in gene expression during fetal development...
  6. pmc Transient in utero disruption of cystic fibrosis transmembrane conductance regulator causes phenotypic changes in alveolar type II cells in adult rats
    Ashraf Gad
    The Brady Laboratory, Department of Pediatrics, Division of Neonatology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
    BMC Cell Biol 10:24. 2009
    ..In this study, we examined adult alveolar type II (ATII) cell phenotype after transient knock down of CFTR by adenovirus-directed in utero expression of ASCFTR in the fetal lung...
  7. pmc Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby
    Damon Love
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 5:e13600. 2010
    ..Moreover, we demonstrate that Cby is a direct downstream target for the master ciliogenesis transcription factor Foxj1. Collectively, our results demonstrate that Cby facilitates proper postnatal lung development and function...
  8. doi Transient in utero nicotine exposure stimulates mechanosensory-dependent lung development
    Shruti Gupta
    Department of Pediatrics, Stonybrook University, Stonybrook, NY 11794, USA
    Exp Lung Res 36:491-8. 2010
    ..The increase in smooth muscle phosphorylation may stimulate stretch-induced lung organogenesis, which affects lung development and accelerates lung maturation in rats...
  9. ncbi Simulated transport alters surfactant homeostasis and causes dose-dependent changes in respiratory function in neonatal Sprague-Dawley rats
    Shetal Shah
    Division of Neonatology, Department of Pediatrics, State University of New York at Stony Brook, Stony Brook, New York, NY, USA
    J Perinat Med 38:535-43. 2010
    ..In this study, we sought to determine the relationship between the duration of transport and respiratory performance in the rat model...
  10. ncbi Improvement of pulmonary hypoplasia associated with congenital diaphragmatic hernia by in utero CFTR gene therapy
    Janet E Larson
    Div of Neonatology, Dept of Pediatrics, T11 060, Stony Brook Univ Health Sciences Center, Stony Brook, NY 11794 8111, USA
    Am J Physiol Lung Cell Mol Physiol 291:L4-10. 2006
    ..Lung development may be significantly delayed in human CDH to allow for successful gene transfer later in gestation, providing a substantial therapeutic window...
  11. pmc Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung
    J Craig Cohen
    Louisiana State University Health Sciences Center, Department of Medicine, School of Medicine, New Orleans, LA 70112, USA
    BMC Dev Biol 5:2. 2005
    ..A previously described transient in utero knockout (TIUKO) technology was used to address the developmental role of CFTR in the rat lung...
  12. ncbi "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease"
    J Craig Cohen
    J Appl Physiol 103:1905-8; author reply 1909-10. 2007
  13. ncbi Developmental paradigm for early features of cystic fibrosis
    Janet E Larson
    Joint Laboratory of Molecular Therapeutics, USA
    Pediatr Pulmonol 40:371-7. 2005
    ..Early changes in the CF lung are examined from a perspective of disrupted fetal development, explaining a number of paradoxes seen with the disease...
  14. pmc The "Goldilocks effect" in cystic fibrosis: identification of a lung phenotype in the cftr knockout and heterozygous mouse
    J Craig Cohen
    Departments of Medicine and Physiology, Louisiana State University, School of Medicine, New Orleans, LA, 70112 USA
    BMC Genet 5:21. 2004
    ..However, knockout in the mouse of cftr, the gene whose mutant alleles are responsible for cystic fibrosis, has previously failed to produce a readily, quantifiable lung phenotype...
  15. pmc Transient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse
    J Craig Cohen
    Department of Medicine, LSU School of Medicine, 533 Bolivar St, New Orleans, USA
    BMC Dev Biol 4:4. 2004
    ..In utero delivery of transgenes was shown previously to result in high efficiency transfer to pulmonary and intestinal epithelial stem cells. Thus, this technology can be used to evaluate late gestation development...
  16. pmc In utero recombinant adeno-associated virus gene transfer in mice, rats, and primates
    Deiadra J Garrett
    Ochsner Children s Research Institute, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    BMC Biotechnol 3:16. 2003
    ..Recombinant adenovirus associated viruses (rAAV) have the advantage of maintaining the viral genome in daughter cells thus providing for long-term expression of transgenes...
  17. ncbi Developmental changes in respiratory mechanics in the neonatal rat
    David Broussard
    Department of Anesthesiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Exp Lung Res 32:263-73. 2006
    ..The respiratory function assessments coincide well with the classically described periods of lung growth. These studies provide a normal baseline for correlating changes in structural with respiratory function...