Ira S Cohen
Affiliation: Stony Brook University
Ballou L, Lin R, Cohen I. Control of cardiac repolarization by phosphoinositide 3-kinase signaling to ion channels. Circ Res. 2015;116:127-37 pubmed publisher
..Drug development and safety could be improved with a better understanding of the mechanisms by which PI3K regulates cardiac ion channels and the extent to which PI3K inhibition contributes to arrhythmogenic susceptibility. ..
Chauveau S, Anyukhovsky E, Ben Ari M, Naor S, Jiang Y, Danilo P, et al
. Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function. Circ Arrhythm Electrophysiol. 2017;10:e004508 pubmed publisher
..iPSC-CMs can integrate into host myocardium and create a biological pacemaker. Although this is a promising development, rate and rhythm of the iPSC-CMs pacemakers remain to be optimized. ..
Chauveau S, Brink P, Cohen I. Stem cell-based biological pacemakers from proof of principle to therapy: a review. Cytotherapy. 2014;16:873-80 pubmed publisher
Qiu X, Chauveau S, Anyukhovsky E, Rahim T, Jiang Y, Harleton E, et al
. Increased Late Sodium Current Contributes to the Electrophysiological Effects of Chronic, but Not Acute, Dofetilide Administration. Circ Arrhythm Electrophysiol. 2016;9:e003655 pubmed publisher
Cohen I, Lin R, Ballou L. Acquired long QT syndrome and phosphoinositide 3-kinase. Trends Cardiovasc Med. 2017;27:451-459 pubmed publisher
..Reduced PI3K signaling may also play a role in aLQTS associated with diabetes. Drug safety testing to identify aLQTS risk may be improved by examining PI3K-dependent effects that develop over time. ..