Dennis L Stevens

Summary

Country: USA

Publications

  1. ncbi request reprint Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections
    Dennis L Stevens
    Infectious Diseases Section, Veterans Administration Medical Center, Boise, ID, 83702, USA
    Clin Infect Dis 34:1481-90. 2002
  2. ncbi request reprint Practice guidelines for the diagnosis and management of skin and soft-tissue infections
    Dennis L Stevens
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    Clin Infect Dis 41:1373-406. 2005
  3. ncbi request reprint The role of vancomycin in the treatment paradigm
    Dennis L Stevens
    Infectious Disease Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    Clin Infect Dis 42:S51-7. 2006
  4. ncbi request reprint A review of linezolid: the first oxazolidinone antibiotic
    Dennis L Stevens
    University of Washington, School of Medicine, Boise Veterans Affairs Medical Center, Boise VA Medical Center, 500 W Fort St Boise, ID 83702, USA
    Expert Rev Anti Infect Ther 2:51-9. 2004
  5. ncbi request reprint Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens
    Dennis L Stevens
    Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    J Infect Dis 190:767-73. 2004
  6. ncbi request reprint Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus
    Dennis L Stevens
    Veterans Affairs Medical Center, Boise, ID 83702, USA
    J Infect Dis 195:202-11. 2007
  7. doi request reprint Treatments for skin and soft-tissue and surgical site infections due to MDR Gram-positive bacteria
    Dennis L Stevens
    Infectious Diseases Section, Veterans Administration Medical Center, Boise, Idaho, USA
    J Infect 59:S32-9. 2009
  8. ncbi request reprint The role of clostridial toxins in the pathogenesis of gas gangrene
    Dennis L Stevens
    Veterans Affairs Medical Center, Boise, ID, USA and University of Washington School of Medicine, Seattle, WA, USA
    Clin Infect Dis 35:S93-S100. 2002
  9. pmc Fatal S. aureus hemorrhagic pneumonia: genetic analysis of a unique clinical isolate producing both PVL and TSST-1
    Zhi Li
    Veterans Affairs Medical Center, Boise, Idaho, United States of America
    PLoS ONE 6:e27246. 2011
  10. ncbi request reprint Vascular dysfunction and ischemic destruction of tissue in Streptococcus pyogenes infection: the role of streptolysin O-induced platelet/neutrophil complexes
    Amy E Bryant
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, ID 83702, USA
    J Infect Dis 192:1014-22. 2005

Detail Information

Publications43

  1. ncbi request reprint Linezolid versus vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections
    Dennis L Stevens
    Infectious Diseases Section, Veterans Administration Medical Center, Boise, ID, 83702, USA
    Clin Infect Dis 34:1481-90. 2002
    ..1% in the vancomycin group) or microbiological success rates (58.9% in the linezolid group and 63.2% in the vancomycin group). Both regimens were well tolerated, with similar rates of adverse events...
  2. ncbi request reprint Practice guidelines for the diagnosis and management of skin and soft-tissue infections
    Dennis L Stevens
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    Clin Infect Dis 41:1373-406. 2005
  3. ncbi request reprint The role of vancomycin in the treatment paradigm
    Dennis L Stevens
    Infectious Disease Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    Clin Infect Dis 42:S51-7. 2006
    ....
  4. ncbi request reprint A review of linezolid: the first oxazolidinone antibiotic
    Dennis L Stevens
    University of Washington, School of Medicine, Boise Veterans Affairs Medical Center, Boise VA Medical Center, 500 W Fort St Boise, ID 83702, USA
    Expert Rev Anti Infect Ther 2:51-9. 2004
    ..aureus. Linezolid is an excellent and promising new antibiotic for the treatment of resistant Gram-positive pathogens...
  5. ncbi request reprint Immunization with the C-Domain of alpha -Toxin prevents lethal infection, localizes tissue injury, and promotes host response to challenge with Clostridium perfringens
    Dennis L Stevens
    Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    J Infect Dis 190:767-73. 2004
    ..We conclude that immunization with the C-domain of phospholipase C is a viable strategy for the prevention of morbidity and mortality associated with C. perfringens gas gangrene...
  6. ncbi request reprint Impact of antibiotics on expression of virulence-associated exotoxin genes in methicillin-sensitive and methicillin-resistant Staphylococcus aureus
    Dennis L Stevens
    Veterans Affairs Medical Center, Boise, ID 83702, USA
    J Infect Dis 195:202-11. 2007
    ..aureus infections may contribute to worse outcomes...
  7. doi request reprint Treatments for skin and soft-tissue and surgical site infections due to MDR Gram-positive bacteria
    Dennis L Stevens
    Infectious Diseases Section, Veterans Administration Medical Center, Boise, Idaho, USA
    J Infect 59:S32-9. 2009
    ..Several agents are currently under clinical investigation or are being considered for approval by the US Food and Drug Administration, including ceftobiprole, dalbavancin, iclaprim, oritavancin, and telavancin...
  8. ncbi request reprint The role of clostridial toxins in the pathogenesis of gas gangrene
    Dennis L Stevens
    Veterans Affairs Medical Center, Boise, ID, USA and University of Washington School of Medicine, Seattle, WA, USA
    Clin Infect Dis 35:S93-S100. 2002
    ..Over the past century, much has been learned about the pathogenesis of this disease, and novel therapies are on the horizon for patients with this devastating infection...
  9. pmc Fatal S. aureus hemorrhagic pneumonia: genetic analysis of a unique clinical isolate producing both PVL and TSST-1
    Zhi Li
    Veterans Affairs Medical Center, Boise, Idaho, United States of America
    PLoS ONE 6:e27246. 2011
    ..Both ФPVLv68111 and SaPI68111 are fully mobilizable and therefore transmissible to other strains. Taken together, these findings suggest that hypervirulent S. aureus have the potential to emerge worldwide...
  10. ncbi request reprint Vascular dysfunction and ischemic destruction of tissue in Streptococcus pyogenes infection: the role of streptolysin O-induced platelet/neutrophil complexes
    Amy E Bryant
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, ID 83702, USA
    J Infect Dis 192:1014-22. 2005
    ..Strategies that target platelet adherence molecules may prevent vascular occlusion, maintain tissue viability, and reduce the need for amputation in necrotizing GAS infections...
  11. pmc vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes
    Yongsheng Ma
    Research and Development Service, Veterans Affairs Medical Center, 500 West Fort St Bldg 45, Boise, ID 83702, USA
    J Bacteriol 191:3189-94. 2009
    ..Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections...
  12. doi request reprint In vitro production of panton-valentine leukocidin among strains of methicillin-resistant Staphylococcus aureus causing diverse infections
    Stephanie M Hamilton
    Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    Clin Infect Dis 45:1550-8. 2007
    ..Greater than 75% of these strains carry the genes for Panton-Valentine leukocidin (PVL), suggesting that this toxin may mediate these severe infections. However, to date, studies have not provided evidence of toxin production...
  13. doi request reprint Muscle injury, vimentin expression, and nonsteroidal anti-inflammatory drugs predispose to cryptic group A streptococcal necrotizing infection
    Stephanie M Hamilton
    Infectious Diseases Section, Veterans Affairs Medical Center, 500 W Fort Street, Boise, ID 83702, USA
    J Infect Dis 198:1692-8. 2008
    ..The present study investigated whether vimentin up-regulation in injured muscles in vivo is associated with homing of circulating GAS to the injured site and whether NSAIDs facilitate this process...
  14. pmc Identification and characterization of bicistronic speB and prsA gene expression in the group A Streptococcus
    Yongsheng Ma
    Research and Development Service, Veterans Affairs Medical Center, 500 West Fort St, Bldg 45, Boise, ID 83702, USA
    J Bacteriol 188:7626-34. 2006
    ..Taken together, these results demonstrate that prsA is required for production of fully mature, enzymatically active SpeB...
  15. pmc Do cardiomyocytes mount an immune response to Group A Streptococcus?
    Zhi Li
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, ID 83702, USA
    Cytokine 54:258-65. 2011
    ..These locally produced, cardiomyocyte-derived cytokines may mediate cardiac contractile dysfunction observed in patients with StrepTSS-associated cardiomyopathy and may hold the key to our ability to attenuate this severe complication...
  16. ncbi request reprint Group A streptococcal myonecrosis: increased vimentin expression after skeletal-muscle injury mediates the binding of Streptococcus pyogenes
    Amy E Bryant
    Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    J Infect Dis 193:1685-92. 2006
    ..This understanding may provide a basis for novel preventive strategies or therapies for patients with this devastating infection...
  17. doi request reprint Cardiac dysfunction in StrepTSS: group A streptococcus disrupts the directional cardiomyocyte-to-macrophage crosstalk that maintains macrophage quiescence
    Zhi Li
    Veterans Affairs Medical Center, Boise, ID 83702, USA
    Cytokine 59:191-4. 2012
    ..Understanding the role of these cardiomyocyte-derived effectors of macrophage function (herein termed "cardiokines") in sepsis-associated cardiomyopathy may suggest new targets for therapeutic intervention...
  18. ncbi request reprint The pathogenesis of clostridial myonecrosis
    D L Stevens
    Veterans Affairs Medical Center, Infectious Diseases Section, Boise, ID 83702, USA
    Int J Med Microbiol 290:497-502. 2000
    ..When toxins reach arterial circulation, systemic shock and multiorgan failure rapidly ensue, and death is common...
  19. pmc Staphylococcus aureus α-Hemolysin Promotes Platelet-Neutrophil Aggregate Formation
    Tanyalak Parimon
    Research and Development Service, Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho
    J Infect Dis 208:761-70. 2013
    ..These findings suggest a role for S. aureus α-hemolysin-induced PNA formation in alveolar capillary destruction in hemorrhagic/necrotizing pneumonia caused by CA-MRSA and offer novel targets for intervention. ..
  20. doi request reprint Iclaprim: a novel dihydrofolate reductase inhibitor for skin and soft tissue infections
    Andrew Morgan
    Veterans Affairs Medical Center, Boise, Idaho, USA and, Idaho State University School of Pharmacy, Pocatello, Idaho 83702, USA
    Future Microbiol 4:131-44. 2009
    ....
  21. ncbi request reprint Activation of platelet gpIIbIIIa by phospholipase C from Clostridium perfringens involves store-operated calcium entry
    Amy E Bryant
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, Idaho 83702, USA
    J Infect Dis 187:408-17. 2003
    ..These findings suggest that calcium-channel blockade and strategies targeting gpIIbIIIa may prevent vascular occlusion, maintain tissue viability, and provide an alternative to radical amputation for patients with gas gangrene...
  22. ncbi request reprint Spontaneous postoperative cerebrospinal fluid leaks following application of anti-adhesion barrier gel: case report and review of the literature
    L D Hieb
    Spine (Phila Pa 1976) 26:748-51. 2001
    ..This report documents cerebrospinal fluid leakage after application of anti-adhesion barrier gel in a single-surgeon clinical series of 27 patients treated with ADCON-L (Gliatech, Cleveland, OH) during surgery...
  23. pmc M type 1 and 3 group A streptococci stimulate tissue factor-mediated procoagulant activity in human monocytes and endothelial cells
    A E Bryant
    Veterans Affairs Medical Center, 500 West Fort Street, Building 45, Boise, Idaho 83702, USA
    Infect Immun 71:1903-10. 2003
    ..In total, these findings suggest that a novel interaction between GAS and host cells contributes to the observed coagulopathy in StrepTSS...
  24. ncbi request reprint Clostridium perfringens phospholipase C-induced platelet/leukocyte interactions impede neutrophil diapedesis
    A E Bryant
    Infectious Diseases Section, Veterans Affairs Medical Center, Boise, ID 83702, USA
    J Med Microbiol 55:495-504. 2006
    ....
  25. ncbi request reprint Clostridial gas gangrene. I. Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens
    A E Bryant
    VA Medical Center, Infectious Diseases Section, Boise, ID 83702, USA
    J Infect Dis 182:799-807. 2000
    ..It is concluded that tissue destruction in gas gangrene is related to profound attenuation of blood flow initiated by activation of platelet responses by PLC...
  26. doi request reprint Life-threatening clostridial infections
    Dennis L Stevens
    Research and Development, Veterans Affairs Medical Center, Boise, ID 83702, USA
    Anaerobe 18:254-9. 2012
    ..Recent studies have elucidated novel targets that may hold promise for newer therapeutic modalities...
  27. ncbi request reprint Evaluation of an intervention designed to decrease the rate of nosocomial methicillin-resistant Staphylococcus aureus infection by encouraging decreased fluoroquinolone use
    Karl J Madaras-Kelly
    Clinical Pharmacy Service, Boise VA Medical Center, Boise, ID 83702, USA
    Infect Control Hosp Epidemiol 27:155-69. 2006
    ....
  28. pmc Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment
    D L Stevens
    University of Washington School of Medicine, Seattle, Washington, USA
    Emerg Infect Dis 1:69-78. 1995
    ..Finally, new concepts in the treatment of streptococcal toxic-shock syndrome are discussed...
  29. ncbi request reprint Clostridial gas gangrene. II. Phospholipase C-induced activation of platelet gpIIbIIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene
    A E Bryant
    VA Medical Center, Infectious Diseases Section, Boise, ID 83702, USA
    J Infect Dis 182:808-15. 2000
    ..Therapeutic strategies that target gpIIbIIIa may prevent vascular occlusion, maintain tissue viability, and provide an alternative to radical amputation for patients with this infection...
  30. doi request reprint Serious group a streptococcal infections
    Christopher J Wong
    Division of General Internal Medicine, Department of Medicine, University of Washington, 4245 Roosevelt Way Northeast, Box 354760, Seattle, WA 98105, USA
    Med Clin North Am 97:721-36, xi-xii. 2013
    ..In this review, the pathophysiology, clinical manifestations, and treatment of invasive GAS infections are discussed. ..
  31. pmc Pregnancy-related group a streptococcal infections: temporal relationships between bacterial acquisition, infection onset, clinical findings, and outcome
    Stephanie M Hamilton
    Veterans Affairs Medical Center, Boise, Idaho
    Clin Infect Dis 57:870-6. 2013
    ..Additional research is needed to further explore the source of GAS, the specific M types involved, and the pathogenesis of these pregnancy-related infections to generate novel preventative and therapeutic strategies. ..
  32. ncbi request reprint Molecular epidemiology of nga and NAD glycohydrolase/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome
    D L Stevens
    Infectious Disease Section, Veterans Affairs Medical Center, Boise, ID 83702, USA
    J Infect Dis 182:1117-28. 2000
    ..In summary, the temporal relationship of NADase expression, alone or with other streptococcal virulence factors, may contribute to the pathogenesis of invasive GAS infections...
  33. ncbi request reprint The flesh-eating bacterium: what's next?
    D L Stevens
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    J Infect Dis 179:S366-74. 1999
    ..Finally, new concepts in the treatment of StrepTSS will be discussed...
  34. ncbi request reprint Clostridial myonecrosis: new insights in pathogenesis and management
    Amy E Bryant
    Infectious Diseases Section, Veterans Affairs Medical Center, 500 West Fort Street Bldg 45, Boise, ID, 83702, USA
    Curr Infect Dis Rep 12:383-91. 2010
    ....
  35. doi request reprint Innate immune recognition of, and response to, Clostridium sordellii
    M J Aldape
    Veterans Affairs Medical Center, Infectious Diseases Section, Boise, ID 83702, USA
    Anaerobe 16:125-30. 2010
    ..sordellii infection is not related to inadequate immune detection of the organism, but rather is attributable to a species-specific immune system dysfunction that remains to be elucidated...
  36. ncbi request reprint Clostridial gas gangrene: evidence that alpha and theta toxins differentially modulate the immune response and induce acute tissue necrosis
    D L Stevens
    Infectious Diseases Section, VA Medical Center, Boise, Idaho 83702, USA
    J Infect Dis 176:189-95. 1997
    ..Histopathologic studies in which recombinant toxins were injected together with killed, washed C. perfringens further substantiated these tissue-destructive and differential antiinflammatory effects...
  37. pmc In vitro antimicrobial effects of various combinations of penicillin and clindamycin against four strains of Streptococcus pyogenes
    D L Stevens
    Infectious Diseases Section, VA Medical Center, Boise, Idaho 83702, USA
    Antimicrob Agents Chemother 42:1266-8. 1998
    ..Timed-kill studies utilizing clinical concentrations suggest that there is no antagonism with the combination of drugs but that the combination does not have a bactericidal advantage over either penicillin or clindamycin alone...
  38. ncbi request reprint Streptococcal pyrogenic exotoxin A and streptolysin O enhance polymorphonuclear leukocyte binding to gelatin matrixes
    A E Bryant
    VA Medical Center, Infectious Diseases Section, Boise, Idaho 83702
    J Infect Dis 166:165-9. 1992
    ..In contrast, SLO-induced PMNL binding was highly dose dependent (maximal binding, 55.1 +/- 1.6% at 0.5 hemolytic units/5.5 x 10(6) PMNL) and was mediated by CD11/CD18 adherence glycoprotein...
  39. ncbi request reprint Streptococcal toxic shock syndrome associated with necrotizing fasciitis
    D L Stevens
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Annu Rev Med 51:271-88. 2000
    ..Emerging treatments for strep TSS include clindamycin and intravenous gamma-globulin...
  40. ncbi request reprint Community-acquired Staphylococcus aureus infections: Increasing virulence and emerging methicillin resistance in the new millennium
    Dennis L Stevens
    Curr Opin Infect Dis 16:189-91. 2003
  41. ncbi request reprint Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics
    Dennis L Stevens
    Clin Infect Dis 42:729-30. 2006
  42. ncbi request reprint Dilemmas in the treatment of invasive Streptococcus pyogenes infections
    Dennis L Stevens
    Clin Infect Dis 37:341-3. 2003
  43. doi request reprint Health care-associated infection (HAI): a critical appraisal of the emerging threat-proceedings of the HAI Summit
    Marin H Kollef
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Infect Dis 47:S55-99; quiz S100-1. 2008
    ....