R Zivadinov

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Clinical-magnetic resonance imaging correlations in multiple sclerosis
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, NY 14203, USA
    J Neuroimaging 15:10S-21S. 2005
  2. doi request reprint Advanced magnetic resonance imaging metrics: implications for multiple sclerosis clinical trials
    Robert Zivadinov
    University of Buffalo Department of Neurology, School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    Methods Find Exp Clin Pharmacol 31:29-40. 2009
  3. ncbi request reprint Central nervous system atrophy and clinical status in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, University at Buffalo, SUNY School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 14:27S-35S. 2004
  4. doi request reprint Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    Neurology 71:136-44. 2008
  5. ncbi request reprint Short-term brain atrophy changes in relapsing-remitting multiple sclerosis
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    J Neurol Sci 223:185-93. 2004
  6. ncbi request reprint Reproducibility and accuracy of quantitative magnetic resonance imaging techniques of whole-brain atrophy measurement in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    J Neuroimaging 15:27-36. 2005
  7. doi request reprint The place of conventional MRI and newly emerging MRI techniques in monitoring different aspects of treatment outcome
    Robert Zivadinov
    Dept of Neurology, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
    J Neurol 255:61-74. 2008
  8. ncbi request reprint Steroids and brain atrophy in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical, Sciences, Buffalo, NY, USA
    J Neurol Sci 233:73-81. 2005
  9. ncbi request reprint Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, SUNY Buffalo, Buffalo, NY 14203, USA
    Neurology 68:S72-82; discussion S91-6. 2007
  10. ncbi request reprint Interferon beta-1a slows progression of brain atrophy in relapsing-remitting multiple sclerosis predominantly by reducing gray matter atrophy
    R Zivadinov
    Department of Neurology, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, University at Buffalo, State University of New York, Buffalo, NY, USA
    Mult Scler 13:490-501. 2007

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Clinical-magnetic resonance imaging correlations in multiple sclerosis
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, NY 14203, USA
    J Neuroimaging 15:10S-21S. 2005
    ..Therefore, the short and long-term studies that aim to measure the degree and severity of the neurodegenerative MS disease process should incorporate these MRI metrics as part of their standard routine MRI protocols...
  2. doi request reprint Advanced magnetic resonance imaging metrics: implications for multiple sclerosis clinical trials
    Robert Zivadinov
    University of Buffalo Department of Neurology, School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    Methods Find Exp Clin Pharmacol 31:29-40. 2009
    ..The objective of this review is to provide a brief description of these advanced MRI measures and to discuss preliminary clinical studies that employ these techniques in order to evaluate the efficacy of DMTs...
  3. ncbi request reprint Central nervous system atrophy and clinical status in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, University at Buffalo, SUNY School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 14:27S-35S. 2004
    ..The authors conclude that measurement of atrophy of the CNS is emerging as a clinically relevant biomarker of the MS disease process...
  4. doi request reprint Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    Neurology 71:136-44. 2008
    ..The effects of corticosteroid therapy on changes in BV in patients with MS help clarify the mechanisms through which potent anti-inflammatory treatments may prevent, stabilize, or induce BV loss...
  5. ncbi request reprint Short-term brain atrophy changes in relapsing-remitting multiple sclerosis
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    J Neurol Sci 223:185-93. 2004
    ....
  6. ncbi request reprint Reproducibility and accuracy of quantitative magnetic resonance imaging techniques of whole-brain atrophy measurement in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    J Neuroimaging 15:27-36. 2005
    ..Whole-brain atrophy is of growing interest as an outcome measure in multiple sclerosis (MS) clinical trials. The authors compared the reproducibility and accuracy of 3 quantitative techniques of measurement in patients with MS...
  7. doi request reprint The place of conventional MRI and newly emerging MRI techniques in monitoring different aspects of treatment outcome
    Robert Zivadinov
    Dept of Neurology, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
    J Neurol 255:61-74. 2008
    ..Although detecting the status of neuronal integrity using MRI techniques continues to improve, a "gold standard" model remains to be established...
  8. ncbi request reprint Steroids and brain atrophy in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical, Sciences, Buffalo, NY, USA
    J Neurol Sci 233:73-81. 2005
    ..Further longitudinal studies are needed to elucidate pathogenetic mechanisms contributing to brain volume fluctuations in autoimmune diseases and multiple sclerosis...
  9. ncbi request reprint Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, SUNY Buffalo, Buffalo, NY 14203, USA
    Neurology 68:S72-82; discussion S91-6. 2007
    ..Although detecting the status of neuronal integrity using MRI techniques continues to improve, a "gold standard" model remains to be established...
  10. ncbi request reprint Interferon beta-1a slows progression of brain atrophy in relapsing-remitting multiple sclerosis predominantly by reducing gray matter atrophy
    R Zivadinov
    Department of Neurology, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, University at Buffalo, State University of New York, Buffalo, NY, USA
    Mult Scler 13:490-501. 2007
    ..Although neurological deficiencies in MS are primarily due to loss of WM, the clinical significance of GM atrophy has not been fully explored in MS...
  11. ncbi request reprint Positivity of cytomegalovirus antibodies predicts a better clinical and radiological outcome in multiple sclerosis patients
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, The Jacobs Neurological Institute, University at Buffalo, State University of New York, 14203, USA
    Neurol Res 28:262-9. 2006
    ....
  12. ncbi request reprint Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    Int Angiol 29:158-75. 2010
    ....
  13. ncbi request reprint Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS
    R Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Italy
    Neurology 57:1239-47. 2001
    ..Furthermore, there are no data on the impact of IVMP on T1 black holes or whole-brain atrophy...
  14. doi request reprint No association between conventional brain MR imaging and chronic cerebrospinal venous insufficiency in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 33:1913-7. 2012
    ..Therefore, this study determined the associations of CCSVI and conventional MR imaging outcomes in patients with MS and in HCs...
  15. doi request reprint Increased tissue damage and lesion volumes in African Americans with multiple sclerosis
    B Weinstock-Guttman
    The Jacobs Neurological Institute, Baird Multiple Sclerosis Center, Department of Neurology, State University of New York, E2 Buffalo General Hospital, Buffalo, NY 14203, USA
    Neurology 74:538-44. 2010
    ..African American (AA) patients with multiple sclerosis (MS) have more rapid disease progression and poorer responses to disease-modifying therapies than white American (WA) patients with MS...
  16. pmc Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with multiple sclerosis
    K Dolic
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
    Funct Neurol 26:205-14. 2011
    ..This study suggests that a multimodal non-invasive approach (DS and MRV) increases the specificity for a diagnosis of CCSVI in patients with MS...
  17. doi request reprint Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, New York 14260, USA
    J Neurol Neurosurg Psychiatry 80:620-5. 2009
    ..The aim of the study was to determine whether the presence of anti-Epstein-Barr virus (EBV) antibodies is associated with MRI measures of brain injury and neurodegeneration in patients with multiple sclerosis (MS)...
  18. ncbi request reprint Risk factors of multiple sclerosis: a case-control study
    M Zorzon
    Department of Clinical Medicine and Neurology, Clinical Neurology Unit, Cattinara Hospital, University of Trieste, Strada di Fiume 447, I 34149 Trieste, Italy
    Neurol Sci 24:242-7. 2003
    ..However, the relatively small number of cases and controls prevents firm conclusions...
  19. doi request reprint Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis
    E A Yeh
    Paediatric Multiple Sclerosis Centre, State University of New York at Buffalo, Buffalo, NY 14260 1200, USA
    Brain 132:3392-400. 2009
    ..Despite this, disability is slower to accrue in paediatric onset multiple sclerosis than adult onset multiple sclerosis...
  20. doi request reprint Value of MR venography for detection of internal jugular vein anomalies in multiple sclerosis: a pilot longitudinal study
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA
    AJNR Am J Neuroradiol 32:938-46. 2011
    ..We assessed the role of conventional MRV for the detection of IJV anomalies in patients with MS diagnosed with CCSVI and in healthy controls who underwent MRV and Doppler sonography examinations during 6 months...
  21. doi request reprint Multimodal imaging in systemic lupus erythematosus patients with diffuse neuropsychiatric involvement
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, NY 14203, USA
    Lupus 22:675-83. 2013
    ....
  22. ncbi request reprint Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy
    J Hagemeier
    Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 33:1596-601. 2012
    ..We also examined the association of abnormal phase with conventional MR imaging outcomes at first clinical onset...
  23. doi request reprint Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS
    R Zivadinov
    Department of Neurology, School of Medicine and Biomedical Sciences Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
    Neurology 77:138-44. 2011
    ..Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). A subject is considered CCSVI positive if ≥ 2 venous hemodynamic (VH) criteria are fulfilled...
  24. ncbi request reprint Correlation of sexual dysfunction and brain magnetic resonance imaging in multiple sclerosis
    M Zorzon
    Department of Clinical Medicine and Neurology, University of Trieste, Cattinara Hospital, Strada di Fiume, 447 34149 Trieste, Italy
    Mult Scler 9:108-10. 2003
    ..The findings showed a relationship between SD and pontine atrophy, confirmed the correlation of SD with bladder dysfunction and highlighted the role of psychological factors in determining SD...
  25. ncbi request reprint Neuromyelitis optica immunoglobulins as a marker of disease activity and response to therapy in patients with neuromyelitis optica
    B Weinstock-Guttman
    Baird Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, NY Department of Neurology, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Mult Scler 14:1061-7. 2008
    ..To determine whether neuromyelitis optica (NMO) immunoglobulin (IgG) antibody status in NMO/Devic's disease patients followed prospectively is persistent or can change relative to the clinical status and/or response to therapy...
  26. pmc A longitudinal study of brain atrophy and cognitive disturbances in the early phase of relapsing-remitting multiple sclerosis
    R Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    J Neurol Neurosurg Psychiatry 70:773-80. 2001
    ....
  27. doi request reprint Voxel-wise magnetization transfer imaging study of effects of natalizumab and IFNβ-1a in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
    Mult Scler 18:1125-34. 2012
    ....
  28. ncbi request reprint Depression and anxiety in multiple sclerosis. A clinical and MRI study in 95 subjects
    M Zorzon
    Department of Radiology, University of Trieste, Italy
    J Neurol 248:416-21. 2001
    ..The lack of any significant association between symptoms of anxiety and either MRI abnormalities or clinical variables led us to the opinion that anxiety is a reactive response to the psychosocial pressure put on the patients...
  29. pmc Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
    Neurology 73:504-10. 2009
    ..Cigarette smoking has been linked to higher susceptibility and increased risk of progressive multiple sclerosis (MS). The effects of smoking on MRI characteristics of patients with MS have not been evaluated...
  30. ncbi request reprint Effect of age on MRI phase behavior in the subcortical deep gray matter of healthy individuals
    J Hagemeier
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, Buffalo, New York
    AJNR Am J Neuroradiol 34:2144-51. 2013
    ..In this study we investigated the nature of the association between age and SWI-filtered phase values, indicative of iron content, in the subcortical deep gray matter of healthy individuals...
  31. ncbi request reprint Long-term effects of intravenous high dose methylprednisolone pulses on bone mineral density in patients with multiple sclerosis
    M Zorzon
    Department of Clinical Medicine and Neurology, University of Trieste, Cattinara Hospital, Trieste, Italy
    Eur J Neurol 12:550-6. 2005
    ..BMD should be monitored in patients with MS, regardless of the use of methylprednisolone...
  32. ncbi request reprint Gender-related differences in MS: a study of conventional and nonconventional MRI measures
    R Antulov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Mult Scler 15:345-54. 2009
    ..Studies showed gender-associated differences in multiple sclerosis (MS) disease evolution and in the evolution of conventional magnetic resonance imaging (MRI) findings...
  33. ncbi request reprint Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS
    D A Carone
    Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
    Neuroimage 29:505-14. 2006
    ..5%), and superior parietal (-6.1%) regions, with SP patients having lower volumes. Overall, atrophy in MS is diffuse and mostly related to GM loss particularly in deep GM and superior frontal-parietal regions...
  34. ncbi request reprint Rapid disease course in African Americans with multiple sclerosis
    I Kister
    Department of Neurology, NYU School of Medicine, Multiple Sclerosis Care Center, New York, NY 10003 3804, USA
    Neurology 75:217-23. 2010
    ..MSSS is a frequency-rank algorithm relating MS disability to disease duration in a large, untreated reference population. Design/..
  35. ncbi request reprint Sexual dysfunction in multiple sclerosis: a 2-year follow-up study
    M Zorzon
    Department of Neurology, Cattinara Hospital, Strada di Fiume, 447 34149 Trieste, Italy
    J Neurol Sci 187:1-5. 2001
    ..We performed a study on a group of patients with multiple sclerosis to evaluate the change in sexual function and to examine the relationship between sexual dysfunction and other clinical variables over time...
  36. doi request reprint Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy
    R H B Benedict
    Jacobs Neurological Institute, Buffalo Neuroimaging Analysis Center, and Department of Neurology, State University of New York at Buffalo, New York 14203, USA
    J Neurol Neurosurg Psychiatry 80:201-6. 2009
    ..However, the importance of mesial temporal lobe (MTL) atrophy in MS is largely untested and poorly understood. New structural imaging techniques permit volumetric measures of multiple regions within the MTL lobe and DGM...
  37. ncbi request reprint Prevalence of migraine in Croatia: a population-based survey
    R Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Italy
    Headache 41:805-12. 2001
    ..Further studies are needed to estimate the prevalence rates of migraine in the total Croatian population...
  38. ncbi request reprint Comparison of a 1.5T standard vs. 3T optimized protocols in multiple sclerosis patients
    I Livshits
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
    Minerva Med 103:97-102. 2012
    ..This study investigated the superiority of the 3T optimized vs. the 1.5T standardized protocols in detecting gadolinium enhancing (GD-E) lesions in patients with MS...
  39. doi request reprint Intra- and extraluminal structural and functional venous anomalies in multiple sclerosis, as evidenced by 2 noninvasive imaging techniques
    K Dolic
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA
    AJNR Am J Neuroradiol 33:16-23. 2012
    ..Our aim was to investigate the prevalence and number of intra- and extraluminal structural and functional extracranial venous abnormalities by using DS and MRV, in patients with MS and HCs...
  40. ncbi request reprint Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls
    D Hojnacki
    The Jacobs Neurological Institute, State University of New York, Buffalo, NY, USA
    Int Angiol 29:127-39. 2010
    ..The aim of this paper was to investigate the value of neck magnetic resonance venography (MRV) for the diagnosis of CCSVI compared to DS and SV in patients with MS and in healthy controls (HC)...
  41. ncbi request reprint Depressive symptoms and MRI changes in multiple sclerosis
    M Zorzon
    Department of Clinical Medicine and Neurology, University of Trieste, Italy
    Eur J Neurol 9:491-6. 2002
    ..Destructive lesions in the right temporal lobe can contribute to the severity of depression in patients with MS but the influence of the severity of neurological impairment should be taken into account...
  42. ncbi request reprint A longitudinal study of quality of life and side effects in patients with multiple sclerosis treated with interferon beta-1a
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, Cattinara Hospital, University of Trieste, Strada di Fiume, 447 34149, Trieste, Italy
    J Neurol Sci 216:113-8. 2003
    ..Disability progression correlated with patient's QOL. Side effects, which were mild, did not diminish over time, did not induce treatment discontinuation and did not interfere with QOL...
  43. ncbi request reprint Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis
    N Bergsland
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 33:1573-8. 2012
    ....
  44. ncbi request reprint Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis
    R Zivadinov
    Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 29:319-25. 2008
    ..We also wanted to evaluate the relationship between cervical cord atrophy and clinical disability in the presence of other conventional and nonconventional brain MR imaging metrics by using a unique additive variance regression model...
  45. doi request reprint Longitudinal correlates of fatigue in multiple sclerosis
    E Patrick
    Department of Neurology, State University of New York at Stony Brook, New York 11794 8121, USA
    Mult Scler 15:258-61. 2009
    ..To determine the predictors of longitudinal changes in fatigue based on pain, mood, and neurological impairment across multiple sclerosis (MS) subtypes...
  46. doi request reprint Soluble receptor for advanced glycation end products in multiple sclerosis: a potential marker of disease severity
    Z Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Mult Scler 14:759-63. 2008
    ....
  47. ncbi request reprint Is gadolinium enhancement predictive of the development of brain atrophy in multiple sclerosis? A review of the literature
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy
    J Neuroimaging 12:302-9. 2002
    ..Reviewing the published data, the authors highlight some hypothetical pathological mechanisms proposed as determinants of brain atrophy...
  48. ncbi request reprint Regional lobar atrophy predicts memory impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 26:1824-31. 2005
    ..The relationship between regional lobar atrophy and cognitive impairment is yet to be examined. We endeavored to assess the clinical significance of regional lobar atrophy in multiple sclerosis...
  49. ncbi request reprint Interferon-beta treatment for relapsing multiple sclerosis
    Bianca Weinstock-Guttman
    The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Expert Opin Biol Ther 8:1435-47. 2008
    ..Recombinant forms of IFN-beta were the first therapeutic intervention found to be effective at interfering with the course of multiple sclerosis (MS), a chronic and debilitating disease affecting the CNS in young adults...
  50. doi request reprint Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis
    A Kardys
    Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY 14260, USA
    Eur J Neurol 20:1264-71. 2013
    ..To evaluate the associations between retinal nerve fiber layer (RNFL) thickness and lipid profiles in multiple sclerosis (MS)...
  51. ncbi request reprint Glatiramer acetate recovers microscopic tissue damage in patients with multiple sclerosis. A case-control diffusion imaging study
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University of Buffalo, Buffalo, NY, United States The Jacobs Neurological Institute, Department of Neurology, University of Buffalo, Buffalo, NY, United States
    Pathophysiology 18:61-8. 2011
    ..Patients on GA and HC did not develop significant global or regional atrophy over 2 years. GA significantly improved microscopic tissue damage in the brain, as measured by DWI over the 1- and 2-year follow-up...
  52. doi request reprint Retinal architecture predicts pupillary reflex metrics in MS
    A R Salter
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Texas, USA
    Mult Scler 15:479-86. 2009
    ..To study the relation of retinal nerve fiber layer thinning to clinical and physiologic measures of visual function in patients with MS or neuromyelitis optica and unilateral optic neuropathy...
  53. doi request reprint Cortical atrophy and personality in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, School of Medicine, New York, USA
    Neuropsychology 22:432-41. 2008
    ..These findings suggest that cortical atrophy in MS is associated with adverse impact on personality, although longitudinal research is needed to test this hypothesis...
  54. ncbi request reprint Effect of intravenous methylprednisolone on the number, size and confluence of plaques in relapsing-remitting multiple sclerosis
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    J Neurol Sci 267:28-35. 2008
    ..However, pulsed IVMP treatment did not significantly slow down accumulation of overall T2-LV and there were more smaller T2 lesions in the IVMP pulsed arm at the end of the study...
  55. ncbi request reprint Pharmacogenetics of MXA SNPs in interferon-beta treated multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 182:236-9. 2007
    ..No significant association was found between the MXA genotype at these two SNPs and clinical, MRI and MXA gene expression in MS patients treated with IFN-beta therapy...
  56. doi request reprint Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study
    Deepa Preeti Ramasamy
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
    J Neurol Sci 282:47-54. 2009
    ..This study confirmed selective deep gray matter atrophy (mostly thalamic), revealed cerebellum WM atrophy from the earliest clinical stages, and showed that cortical thinning advances with disease progression...
  57. ncbi request reprint Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
    J Neurol Sci 231:29-34. 2005
    ..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment...
  58. ncbi request reprint Sexual dysfunction in multiple sclerosis: a MRI, neurophysiological and urodynamic study
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Cattinara Hospital, Strada di Fiume, 447 34149 Trieste, Italy
    J Neurol Sci 210:73-6. 2003
    ....
  59. ncbi request reprint Effect of MRI coregistration on serial short-term brain volume changes in multiple sclerosis
    David A Fritz
    Buffalo Neuroimaging Analysis Center, Department of Neurology, The Jacobs Neurological Institute, University at Buffalo, State University of New York, 14203, USA
    Neurol Res 28:275-9. 2006
    ..However, the effect of coregistration on measurement of whole brain volume changes from serial scans in the short term has not been tested in MS patients...
  60. ncbi request reprint Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006
    ..Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results...
  61. ncbi request reprint Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis
    Ayda Tekok-Kilic
    Department of Neurology, University at Buffalo, State University of New York, USA
    Neuroimage 36:1294-300. 2007
    ..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy...
  62. ncbi request reprint Interferon inhibitory activity in patients with multiple sclerosis
    Kailash Chadha
    Department of Cell and Molecular Biology, Roswell Park Cancer Institute, Jacobs Neurological Institute, Buffalo, New York 14263, USA
    Arch Neurol 63:1579-84. 2006
    ..Interferon inhibitory activity (IIA) is a logical candidate for explaining neutralizing antibody-negative partial responsiveness to interferon beta in multiple sclerosis (MS), but its role has not been evaluated...
  63. ncbi request reprint Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis
    Brett A Parmenter
    Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    J Clin Exp Neuropsychol 29:215-23. 2007
    ..While both tests appear to have good validity in the MS population, the availability of alternative forms makes the DKEFS an attractive alternative to the WCST, as was suggested by a consensus panel...
  64. pmc Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosis
    R H B Benedict
    Division of Cognitive and Behavioral Neurosciences, State University of New York at Buffalo, School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    Neuropsychol Rev 18:149-66. 2008
    ..There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research...
  65. ncbi request reprint Migraine and tension-type headache in Croatia: a population-based survey of precipitating factors
    R Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    Cephalalgia 23:336-43. 2003
    ..MA was more frequently associated with precipitating factors than MO. We suggest that some triggering factors may contribute to the higher occurrence of precipitant-dependent headache attacks in susceptible individuals...
  66. ncbi request reprint Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual method
    Michael P Sanfilipo
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical Sciences, NY 14203, USA
    Neuroimage 22:1732-43. 2004
    ..Our findings suggest that head size correction of brain regions with the residual method generally may provide advantages over the proportion method...
  67. ncbi request reprint Predicting neuropsychological abnormalities in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York, SUNY at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, 14203, USA
    J Neurol Sci 245:67-72. 2006
    ..We conclude that the MSNQ is reliable and valid for detecting neuropsychological and neuropsychiatric complications of MS...
  68. ncbi request reprint Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorder
    Dominic A Carone
    Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, and Jacobs Neurological Institute, USA
    J Neuroimaging 16:163-6. 2006
    ..We speculate that temporal lobe atrophy was influenced by the established susceptibility of this region in various neurological diseases...
  69. doi request reprint Use of perfusion- and diffusion-weighted imaging in differential diagnosis of acute and chronic ischemic stroke and multiple sclerosis
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY, USA
    Neurol Res 30:816-26. 2008
    ....
  70. ncbi request reprint Thalamic involvement in multiple sclerosis: a diffusion-weighted magnetic resonance imaging study
    Andrew J Fabiano
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 13:307-14. 2003
    ..Diffusion-weighted magnetic resonance imaging (MRI) can assess tissue damage with greater sensitivity than conventional MRI. The authors' objective was to assess thalamic gray matter damage by diffusion-weighted imaging in MS patients...
  71. doi request reprint Gene-environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Neuroimmunol 209:123-30. 2009
    ....
  72. ncbi request reprint HLA-DRB1*1501, -DQB1*0301, -DQB1*0302, -DQB1*0602, and -DQB1*0603 alleles are associated with more severe disease outcome on MRI in patients with multiple sclerosis
    Robert Zivadinov
    Department of Neurology, State University of New York at Buffalo, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, State University at Buffalo, New York 14203, USA
    Int Rev Neurobiol 79:521-35. 2007
    ..High-resolution HLA genotyping analysis revealed a robust relationship between alleles HLA-DRB1*1501, -DQB1*0301, -DQB1*0302, -DQB1*0602, and -DQB1*0603, and more severe damage on inflammatory and neurodegenerative MRI measures...
  73. doi request reprint Clinical efficacy, effects on MRI and tolerability of weekly intramuscular interferon-beta-1a in patients with MS and CIS
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Drugs Today (Barc) 44:601-13. 2008
    ..Early initiation of disease-modifying therapy after the diagnosis of relapsing-remitting MS or after a single demyelinating event (and evidence of lesions on MRI) allows patients the opportunity to obtain maximal long-term benefits...
  74. ncbi request reprint Quantitative diffusion weighted imaging measures in patients with multiple sclerosis
    Eleonora Tavazzi
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    Neuroimage 36:746-54. 2007
    ..ENT is a sensitive marker of overall brain damage that is strongly related to clinical impairment in patients with SP MS...
  75. ncbi request reprint Role of MRI in multiple sclerosis II: brain and spinal cord atrophy
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Front Biosci 9:647-64. 2004
    ..This should in turn lead to better long term neurologic functioning and a better quality of life for patients with MS...
  76. doi request reprint Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    J Neurol Sci 282:96-105. 2009
    ..Measurement of retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) is gaining increasing attention...
  77. doi request reprint Regional specificity of magnetization transfer imaging in multiple sclerosis
    Christopher W Tjoa
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York, USA
    J Neuroimaging 18:130-6. 2008
    ..We also studied the topography of MTR changes in multiple sclerosis (MS) and in normal controls (NC), and preliminarily examined the clinical usefulness of this method...
  78. ncbi request reprint Normalized regional brain atrophy measurements in multiple sclerosis
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, Cattinara Hospital, University of Trieste, Strada di Fiume, 447 34149 Trieste, Italy
    Neuroradiology 45:793-8. 2003
    ..These data suggest that normalized regional brain atrophy measurements are preferable to absolute regional measurements in cross-sectional studies...
  79. doi request reprint Brain atrophy and white matter hyperintensities in early Parkinson's disease(a)
    Turi O Dalaker
    Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Mov Disord 24:2233-41. 2009
    ..We conclude that global structural brain changes are not a major feature in patients with incident PD...
  80. ncbi request reprint Familial and environmental risk factors in Parkinson's disease: a case-control study in north-east Italy
    M Zorzon
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    Acta Neurol Scand 105:77-82. 2002
    ..We performed a case-control study to investigate the association of familial and environmental risk factors with Parkinson's disease (PD)...
  81. doi request reprint Evidence for gray matter pathology in multiple sclerosis: a neuroimaging approach
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
    J Neurol Sci 282:1-4. 2009
    ..GM pathology imaging correlates are related to disability progression, as measured both by motor and cognitive functional outcomes...
  82. doi request reprint MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosis
    Milena Stosic
    Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14203, USA
    J Neurol 257:63-71. 2010
    ..MRI reveals more profound injury in patients with MS versus PAPLS. APLA mediates heterogeneous cerebral pathology that remains to be further investigated...
  83. ncbi request reprint HLA genotypes and disease severity assessed by magnetic resonance imaging findings in patients with multiple sclerosis
    Robert Zivadinov
    Dept of Clinical Medicine and Neurology, Cattinara Hospital, University of Trieste, Strada di Fiume, 447, 34149, Trieste, Italy
    J Neurol 250:1099-106. 2003
    ..Since the size of the sample studied is relatively small, further studies are needed to draw any firm conclusion about genotype/phenotype correlation in patients with MS...
  84. doi request reprint A sensitive, noise-resistant method for identifying focal demyelination and remyelination in patients with multiple sclerosis via voxel-wise changes in magnetization transfer ratio
    Michael Dwyer
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
    J Neurol Sci 282:86-95. 2009
    ..It improves on the sensitivity of other approaches, and may increase the statistical power of studies investigating the effects of therapy on MRI outcomes in MS...
  85. ncbi request reprint Signal abnormalities on 1.5 and 3 Tesla brain MRI in multiple sclerosis patients and healthy controls. A morphological and spatial quantitative comparison study
    Carol Di Perri
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, State University of New York, Buffalo, NY 14203, USA
    Neuroimage 47:1352-62. 2009
    ..This study provides important information regarding morphological and spatial differences between data acquired using 1.5 T and 3 T protocols at the two scanner field strengths...
  86. ncbi request reprint Role of MRI in multiple sclerosis I: inflammation and lesions
    Robert Zivadinov
    Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Front Biosci 9:665-83. 2004
    ..In particular, the use of these techniques is promising in elucidating mechanisms underlying the accumulation of tissue damage, repair and functional reorganization of neural pathways in patients with MS...
  87. ncbi request reprint Corticosteroids for multiple sclerosis: II. Application for disease-modifying effects
    Anjali Shah
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Neurotherapeutics 4:627-32. 2007
    ..Nevertheless, we will focus on the rationale and practical schemes that can be considered for using corticosteroids (CS) (and perhaps even ACTH) in an attempt to modify various domains of ongoing disease activity...
  88. ncbi request reprint Detection of cortical lesions is dependent on choice of slice thickness in patients with multiple sclerosis
    Ondrej Dolezal
    Department of Neurology, State University of New York at Buffalo, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    Int Rev Neurobiol 79:475-89. 2007
    ..Cortical and juxtacortical lesions contribute more to disability development than total T2-LV alone...
  89. ncbi request reprint Neuroimaging in multiple sclerosis
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14203, USA
    Int Rev Neurobiol 79:449-74. 2007
    ..However, evidence is increasing that these nonconventional MRI measures correlate better with both existing and developing neurological impairment and disability when compared to conventional metrics...
  90. ncbi request reprint [Use of magnetic resonance imaging in the diagnosis and prognosis of multiple sclerosis]
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute and Baird MS Research Center, Department of Neurology, School of Medicine and Biomedical Sciences University Buffalo, State University of New York, Buffalo, NY, USA
    Lijec Vjesn 128:295-308. 2006
    ..Additional short- and long-term prospective studies are requested to establish their value in the diagnosis and prognosis of multiple sclerosis...
  91. ncbi request reprint The role of quantitative neuroimaging indices in the differentiation of ischemia from demyelination: an analytical study with case presentation
    Romy Hoque
    Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA
    Int Rev Neurobiol 79:491-519. 2007
    ..Chronic ischemic and demyelinating lesions were evaluated for comparison as well...
  92. ncbi request reprint Frontal parenchymal atrophy measures in multiple sclerosis
    Laura Locatelli
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    Mult Scler 10:562-8. 2004
    ..The normalized measures of whole and regional brain parenchymal atrophy should be preferred to absolute measures in future studies that correlate neuropsychological performances and brain atrophy measures in patients with MS...
  93. doi request reprint Application of hidden Markov random field approach for quantification of perfusion/diffusion mismatch in acute ischemic stroke
    Michael G Dwyer
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY, USA
    Neurol Res 30:827-34. 2008
    ..For the in vivo dataset, the mean absolute error decreased from 564.6% for thresholding to 34.2% for the delay-weighted HMRF approach. The described method represents a significant improvement over thresholding techniques...
  94. ncbi request reprint MMP-9 microsatellite polymorphism and multiple sclerosis
    Nicola Fiotti
    Department of Clinical, Morphological and Technological Sciences, University of Trieste, Strada di Fiume, 447, 34149, Cattinara Trieste, Italy
    J Neuroimmunol 152:147-53. 2004
    ..4, 95% CI: 1.7-6.8, P<0.0001). An earlier age at disease onset was a characteristic of patients with >22 CA repeats (33+/-10 vs. 28+/-10, P=0.027). No differences were found in the main MRI parameters...
  95. ncbi request reprint Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 188:167-74. 2007
    ..To investigate the relationship between immune cell secretion of brain-derived neurotrophic factor (BDNF) with clinical and MRI variables in multiple sclerosis (MS) patients...
  96. ncbi request reprint A magnetization transfer MRI study of deep gray matter involvement in multiple sclerosis
    Jitendra Sharma
    Center for Neurological Imaging, Partners MS Center, Department of Neurology, Brigham Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 16:302-10. 2006
    ..Magnetization transfer imaging (MTI), an advanced MRI technique, is sensitive to disease in normal appearing white matter (NAWM) in patients with MS...
  97. ncbi request reprint Optical coherence tomography in multiple sclerosis
    Elliot Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Lancet Neurol 5:853-63. 2006
    ..In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis...
  98. ncbi request reprint Reliability and validity of neuropsychological screening and assessment strategies in MS
    Ralph H B Benedict
    SUNY Buffalo School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
    J Neurol 254:II22-II25. 2007
    ..Work with new non-conventional brain imaging techniques and finer analysis of reliability during serial testing protocols is underway...
  99. ncbi request reprint Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY 14260, USA
    Hum Mol Genet 16:2659-68. 2007
    ..There were no significant associations between Met66 allele status and other neurocognitive measures. The BDNF Met66 allele is associated with lower damage as evidenced by measurement of NGMV and T2-LV in MS patients...
  100. ncbi request reprint The use of standardized incidence and prevalence rates in epidemiological studies on multiple sclerosis. A meta-analysis study
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Italy
    Neuroepidemiology 22:65-74. 2003
    ....
  101. ncbi request reprint Corticosteroids for multiple sclerosis: I. Application for treating exacerbations
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
    Neurotherapeutics 4:618-26. 2007
    ..This review discusses the pharmacology of these agents, to better understand how they may act to mitigate attacks and to provide some practical formulations for how to use them in the clinic for the benefit of patients...