Patricia M Whitaker-Azmitia

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism?
    Patricia M Whitaker-Azmitia
    Program in Biopsychology, Department of Psychology, SUNY, Stony Brook, New York, NY 11794 2500, USA
    Int J Dev Neurosci 23:75-83. 2005
  2. ncbi Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome
    Lee A Shapiro
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    Brain Res 1010:17-21. 2004
  3. ncbi Characterization of social behaviors and oxytocinergic neurons in the S-100 beta overexpressing mouse model of Down Syndrome
    Alice Borella
    Program in Biopsychology, Department of Psychology, State University of New York, Stony Brook, NY 11791 2500, USA
    Behav Brain Res 141:229-36. 2003
  4. ncbi Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: role of serotonin and relevance to Down syndrome
    Kimberly Bell
    Program in Biopsychology, Department of Psychology, State University of New York, Stony Brook, NY 11794-2500, USA
    Neuropsychopharmacology 28:1810-6. 2003
  5. ncbi Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: an immunohistochemical study of MAP-2, drebrin and GAP-43
    Lee A Shapiro
    Program in Biopsychology, Department of Psychology, State University of New York, Stony Brook, NY 11794 2500, USA
    Brain Res 1019:39-46. 2004
  6. ncbi Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing mouse model of pathological aging
    Lynn A Bialowas-McGoey
    Department of Psychology, Stony Brook University, Stony Brook, New York, USA
    Glia 56:1780-90. 2008
  7. ncbi Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism
    David Kahne
    Department of Psychology, SUNY at Stony Brook, 11794-2500, USA
    Physiol Behav 75:403-10. 2002
  8. ncbi Transient expression of S-100beta immunostaining in developing thalamus and somatosensory cortex of rat
    Katsumasa T Muneoka
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    Brain Res Dev Brain Res 142:101-4. 2003
  9. ncbi Sexual differentiation and the neuroendocrine hypothesis of autism
    Timothy P Aiello
    Department of Psychology, Stony Brook University, New York, USA
    Anat Rec (Hoboken) 294:1663-70. 2011
  10. ncbi Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors
    Efrain C Azmitia
    Dept of Biology, New York University, 100 Washington Sq East, New York, NY 11791, USA
    Neuropharmacology 60:1347-54. 2011

Research Grants

  1. CONTRIBUTION OF S-100BETA TO DOWNS SYNDROME
    Patricia Whitaker Azmitia; Fiscal Year: 2004
  2. Chlorpyrifos, serotonin and S100B
    Patricia Whitaker Azmitia; Fiscal Year: 2007

Collaborators

Detail Information

Publications11

  1. ncbi Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism?
    Patricia M Whitaker-Azmitia
    Program in Biopsychology, Department of Psychology, SUNY, Stony Brook, New York, NY 11794 2500, USA
    Int J Dev Neurosci 23:75-83. 2005
    ..Thus, increased serotonergic activity during development could damage neurocircuitry involved in emotional responding to social stressors and may have relevance to the symptoms of autism...
  2. ncbi Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome
    Lee A Shapiro
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    Brain Res 1010:17-21. 2004
    ..Our findings show increased clusterin expression in the aged S100B mice compared to their CD-1 controls, a finding we have interpreted as further evidence of pathological brain aging...
  3. ncbi Characterization of social behaviors and oxytocinergic neurons in the S-100 beta overexpressing mouse model of Down Syndrome
    Alice Borella
    Program in Biopsychology, Department of Psychology, State University of New York, Stony Brook, NY 11791 2500, USA
    Behav Brain Res 141:229-36. 2003
    ..These results are discussed in terms of oxytocin contributions to socialization and fear responding and the significance of these findings to DS...
  4. ncbi Harm avoidance, anxiety, and response to novelty in the adolescent S-100beta transgenic mouse: role of serotonin and relevance to Down syndrome
    Kimberly Bell
    Program in Biopsychology, Department of Psychology, State University of New York, Stony Brook, NY 11794-2500, USA
    Neuropsychopharmacology 28:1810-6. 2003
    ..These results are discussed in reference to the known lack of serotonin in the animals, and to the behavioral phenotype of DS...
  5. ncbi Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: an immunohistochemical study of MAP-2, drebrin and GAP-43
    Lee A Shapiro
    Program in Biopsychology, Department of Psychology, State University of New York, Stony Brook, NY 11794 2500, USA
    Brain Res 1019:39-46. 2004
    ..Overall, the data suggest that S100B overexpression leads to changes in cytoskeletal markers. The longitudinal effects of S100B overexpression are discussed with relevance to aging and pathology...
  6. ncbi Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing mouse model of pathological aging
    Lynn A Bialowas-McGoey
    Department of Psychology, Stony Brook University, Stony Brook, New York, USA
    Glia 56:1780-90. 2008
    ..Our findings suggest further investigation into the potential role of vitamin E in reducing the oxidation state of the S100B protein and its influence on neuroinflammatory processes marked by microglial activation in vivo...
  7. ncbi Behavioral and magnetic resonance spectroscopic studies in the rat hyperserotonemic model of autism
    David Kahne
    Department of Psychology, SUNY at Stony Brook, 11794-2500, USA
    Physiol Behav 75:403-10. 2002
    ..In summary, the model we are proposing shows some of the behavioral and metabolic features of autism, as well as being produced through alteration of a neurochemical system known to be altered in autism...
  8. ncbi Transient expression of S-100beta immunostaining in developing thalamus and somatosensory cortex of rat
    Katsumasa T Muneoka
    Department of Psychology, State University of New York at Stony Brook, Stony Brook, NY 11794 2500, USA
    Brain Res Dev Brain Res 142:101-4. 2003
    ..Our findings suggest that S-100beta could indeed be the mediator of serotonin's effects on barrel field formation...
  9. ncbi Sexual differentiation and the neuroendocrine hypothesis of autism
    Timothy P Aiello
    Department of Psychology, Stony Brook University, New York, USA
    Anat Rec (Hoboken) 294:1663-70. 2011
    ..Further studies should be undertaken to confirm the role of extremes of normal sexual differentiation in producing the neuroendocrine changes associated with autism...
  10. ncbi Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors
    Efrain C Azmitia
    Dept of Biology, New York University, 100 Washington Sq East, New York, NY 11791, USA
    Neuropharmacology 60:1347-54. 2011
    ..g. SSRIs and receptor agonist) to treat autistic children. This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  11. ncbi Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes
    Ilan M McNamara
    State University of New York at Stony Brook, New York 11794 2500, USA
    Brain Res 1189:203-14. 2008
    ....

Research Grants5

  1. CONTRIBUTION OF S-100BETA TO DOWNS SYNDROME
    Patricia Whitaker Azmitia; Fiscal Year: 2004
    ..3 Study any behavioral consequences in the animals, by using age appropriate behaviors. The results of these studies may lead to a clearer understanding of the role of S-100beta in DS. ..
  2. Chlorpyrifos, serotonin and S100B
    Patricia Whitaker Azmitia; Fiscal Year: 2007
    ..Any changes observed will be confirmed with electronmicroscopy. Specific Aim 4: Animals will be tested for changes in learning and memory at PND 35, 60 and 365. ..