Bianca Weinstock-Guttman

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. doi Inter-dependence of vitamin D levels with serum lipid profiles in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY 14203, USA
    J Neurol Sci 311:86-91. 2011
  2. doi Additional efficacy endpoints from pivotal natalizumab trials in relapsing-remitting MS
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo, NY 14203 1126, USA
    J Neurol 259:898-905. 2012
  3. doi Neuromyelitis optica immunoglobulins as a marker of disease activity and response to therapy in patients with neuromyelitis optica
    B Weinstock-Guttman
    Baird Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, NY Department of Neurology, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Mult Scler 14:1061-7. 2008
  4. ncbi Study of mitoxantrone for the treatment of recurrent neuromyelitis optica (Devic disease)
    Bianca Weinstock-Guttman
    The William C Baird Multiple Sclerosis Center, Jacobs Neurological Institute, State University of New York, Buffalo, NY 14203, USA
    Arch Neurol 63:957-63. 2006
  5. ncbi Interferon-beta treatment for relapsing multiple sclerosis
    Bianca Weinstock-Guttman
    The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Expert Opin Biol Ther 8:1435-47. 2008
  6. pmc Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    J Neuroinflammation 8:127. 2011
  7. pmc Diagnostic potential of plasma carboxymethyllysine and carboxyethyllysine in multiple sclerosis
    Zohara Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, 100 High St, Buffalo, NY 14203, USA
    J Neuroinflammation 7:72. 2010
  8. ncbi Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006
  9. doi Genomic effects of once-weekly, intramuscular interferon-beta1a treatment after the first dose and on chronic dosing: Relationships to 5-year clinical outcomes in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 205:113-25. 2008
  10. doi Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, New York, USA
    J Neurol Neurosurg Psychiatry 84:1186-91. 2013

Detail Information

Publications87

  1. doi Inter-dependence of vitamin D levels with serum lipid profiles in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY 14203, USA
    J Neurol Sci 311:86-91. 2011
    ....
  2. doi Additional efficacy endpoints from pivotal natalizumab trials in relapsing-remitting MS
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo, NY 14203 1126, USA
    J Neurol 259:898-905. 2012
    ..001). These analyses underline beneficial effects of natalizumab therapy in relapsing MS patients...
  3. doi Neuromyelitis optica immunoglobulins as a marker of disease activity and response to therapy in patients with neuromyelitis optica
    B Weinstock-Guttman
    Baird Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, NY Department of Neurology, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Mult Scler 14:1061-7. 2008
    ..To determine whether neuromyelitis optica (NMO) immunoglobulin (IgG) antibody status in NMO/Devic's disease patients followed prospectively is persistent or can change relative to the clinical status and/or response to therapy...
  4. ncbi Study of mitoxantrone for the treatment of recurrent neuromyelitis optica (Devic disease)
    Bianca Weinstock-Guttman
    The William C Baird Multiple Sclerosis Center, Jacobs Neurological Institute, State University of New York, Buffalo, NY 14203, USA
    Arch Neurol 63:957-63. 2006
    ..Mitoxantrone hydrochloride, a synthetic anthracenedione approved for worsening relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis, has been shown to primarily suppress the humoral response...
  5. ncbi Interferon-beta treatment for relapsing multiple sclerosis
    Bianca Weinstock-Guttman
    The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Expert Opin Biol Ther 8:1435-47. 2008
    ..Recombinant forms of IFN-beta were the first therapeutic intervention found to be effective at interfering with the course of multiple sclerosis (MS), a chronic and debilitating disease affecting the CNS in young adults...
  6. pmc Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    J Neuroinflammation 8:127. 2011
    ..Vascular co-morbidities are associated with increased risk of progression. Dyslipidemia, elevated LDL and reduced HDL may increase progression by activating inflammatory processes at the vascular endothelium...
  7. pmc Diagnostic potential of plasma carboxymethyllysine and carboxyethyllysine in multiple sclerosis
    Zohara Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, 100 High St, Buffalo, NY 14203, USA
    J Neuroinflammation 7:72. 2010
    ....
  8. ncbi Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006
    ..Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results...
  9. doi Genomic effects of once-weekly, intramuscular interferon-beta1a treatment after the first dose and on chronic dosing: Relationships to 5-year clinical outcomes in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 205:113-25. 2008
    ....
  10. doi Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, New York, USA
    J Neurol Neurosurg Psychiatry 84:1186-91. 2013
    ..To investigate the associations of serum lipid profile with disease progression in high-risk clinically isolated syndromes (CIS) after the first demyelinating event...
  11. ncbi Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 188:167-74. 2007
    ..To investigate the relationship between immune cell secretion of brain-derived neurotrophic factor (BDNF) with clinical and MRI variables in multiple sclerosis (MS) patients...
  12. pmc Decreased brain venous vasculature visibility on susceptibility-weighted imaging venography in patients with multiple sclerosis is related to chronic cerebrospinal venous insufficiency
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurol 11:128. 2011
    ....
  13. ncbi Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden
    Ralph H B Benedict
    Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
    Arch Neurol 61:226-30. 2004
    ..Furthermore, few studies accounted for the influence of age, premorbid intelligence, or depression...
  14. ncbi Gray matter SWI-filtered phase and atrophy are linked to disability in MS
    Jesper Hagemeier
    Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, 100 High Street, Buffalo, NY 14203, USA
    Front Biosci (Elite Ed) 5:525-32. 2013
    ..Our findings suggest that disability in MS patients is associated better with SDGM pathology, as indicated by increased iron content and atrophy, than with lesion burden or white matter and cortical volumes...
  15. doi Anti-phospholipid antibodies are associated with response to interferon-beta1a treatment in MS: results from a 3-year longitudinal study
    Robert Zivadinov
    Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, 100 High St, Buffalo, NY 14203, USA
    Neurol Res 34:761-9. 2012
    ..To prospectively investigate the associations of baseline serum anti-phospholipid antibody (APLA) status on evolution of clinical and MRI measures in a multiple sclerosis (MS) patient cohort treated with interferon-beta (IFN-beta)...
  16. ncbi Interferon inhibitory activity in patients with multiple sclerosis
    Kailash Chadha
    Department of Cell and Molecular Biology, Roswell Park Cancer Institute, Jacobs Neurological Institute, Buffalo, New York 14263, USA
    Arch Neurol 63:1579-84. 2006
    ..Interferon inhibitory activity (IIA) is a logical candidate for explaining neutralizing antibody-negative partial responsiveness to interferon beta in multiple sclerosis (MS), but its role has not been evaluated...
  17. ncbi Pharmacogenetics of MXA SNPs in interferon-beta treated multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 182:236-9. 2007
    ..No significant association was found between the MXA genotype at these two SNPs and clinical, MRI and MXA gene expression in MS patients treated with IFN-beta therapy...
  18. ncbi Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis
    Ayda Tekok-Kilic
    Department of Neurology, University at Buffalo, State University of New York, USA
    Neuroimage 36:1294-300. 2007
    ..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy...
  19. doi Heart disease, overweight, and cigarette smoking are associated with increased prevalence of extra-cranial venous abnormalities
    Kresimir Dolic
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
    Neurol Res 34:819-27. 2012
    ....
  20. doi Predicting loss of employment over three years in multiple sclerosis: clinically meaningful cognitive decline
    Sarah A Morrow
    The Jacobs Neurological Institute, State University of New York at Buffalo, NY 14203, USA
    Clin Neuropsychol 24:1131-45. 2010
    ..8), accounting for 86.7% of the area under the ROC curve. We conclude that decline on NP testing over time is predictive of deterioration in vocational status, establishing a magnitude of decline on NP tests that is clinically meaningful...
  21. doi Plasma pentosidine: a potential biomarker in the management of multiple sclerosis
    Zohara Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY, USA
    Mult Scler 17:157-63. 2011
    ..The chronic inflammation associated with multiple sclerosis (MS) may lead to the upregulation of pentosidine...
  22. ncbi Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Department of Neurology, Division of Departmental and Behavioral Neurosciences, Buffalo, New York, USA
    J Int Neuropsychol Soc 12:549-58. 2006
    ..We conclude that the MACFIMS is a valid approach to routine NP assessment of MS patients. Future work is planned to determine its psychometric properties in a longitudinal study...
  23. pmc Immunomodulatory responses of peripheral blood mononuclear cells from multiple sclerosis patients upon in vitro incubation with the flavonoid luteolin: additive effects of IFN-beta
    Zohara Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY, USA
    J Neuroinflammation 6:28. 2009
    ..Luteolin reduced the MMP-9/TIMP-1 ratio via lowering MMP-9 production. In the majority of cases, luteolin, when combined with IFN-beta, had additive effects in modulating cell proliferation, IL-1beta, TNF-alpha, MMP-9 and TIMP-1...
  24. ncbi Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
    J Neurol Sci 231:29-34. 2005
    ..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment...
  25. doi Vitamin D metabolites are associated with clinical and MRI outcomes in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY 14260, USA
    J Neurol Neurosurg Psychiatry 82:189-95. 2011
    ..This research evaluates the significance of vitamin D and its active metabolites in brain tissue injury and clinical disability in MS patients...
  26. doi Interdependence and contributions of sun exposure and vitamin D to MRI measures in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
    J Neurol Neurosurg Psychiatry 84:1075-81. 2013
    ..To assess the relationships of sun exposure history, supplementation and environmental factors to vitamin D levels in multiple sclerosis (MS) patients and to evaluate the associations between sun exposure and MRI measures...
  27. doi Cortical atrophy and personality in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, School of Medicine, New York, USA
    Neuropsychology 22:432-41. 2008
    ..These findings suggest that cortical atrophy in MS is associated with adverse impact on personality, although longitudinal research is needed to test this hypothesis...
  28. ncbi Quantitative diffusion weighted imaging measures in patients with multiple sclerosis
    Eleonora Tavazzi
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    Neuroimage 36:746-54. 2007
    ..ENT is a sensitive marker of overall brain damage that is strongly related to clinical impairment in patients with SP MS...
  29. doi Arterial, venous and other vascular risk factors in multiple sclerosis
    Yuval Karmon
    The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    Neurol Res 34:754-60. 2012
    ..This article reviews vascular risk factors with specific emphasis on lipid abnormalities reported to be associated with multiple sclerosis (MS)...
  30. pmc Risk factors for chronic cerebrospinal venous insufficiency (CCSVI) in a large cohort of volunteers
    Kresimir Dolic
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, New York, United States of America
    PLoS ONE 6:e28062. 2011
    ....
  31. ncbi Factors that predict health-related quality of life in patients with relapsing-remitting multiple sclerosis
    Deborah M Miller
    Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mult Scler 9:1-5. 2003
    ....
  32. ncbi Genomic effects of IFN-beta in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    J Immunol 171:2694-702. 2003
    ..The findings demonstrate that IFN-beta treatment induces specific and time-dependent changes in multiple mRNAs in lymphocytes of multiple sclerosis patients that could provide a framework for rapid monitoring of the response to therapy...
  33. doi Changes of cine cerebrospinal fluid dynamics in patients with multiple sclerosis treated with percutaneous transluminal angioplasty: a case-control study
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY 14203, USA
    J Vasc Interv Radiol 24:829-38. 2013
    ....
  34. ncbi Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis
    Brett A Parmenter
    Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    J Clin Exp Neuropsychol 29:215-23. 2007
    ..While both tests appear to have good validity in the MS population, the availability of alternative forms makes the DKEFS an attractive alternative to the WCST, as was suggested by a consensus panel...
  35. doi Influence of personality on the relationship between gray matter volume and neuropsychiatric symptoms in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo General Hospital, Buffalo, NY 14203, USA
    Psychosom Med 75:253-61. 2013
    ..We examined the general hypothesis that personality influences the relationship between gray matter volume (GMV) and cognitive/neuropsychiatric MS features...
  36. doi Influence of cognitive function on speech and articulation rate in multiple sclerosis
    Jonathan D Rodgers
    Jacobs Neurological Institute, Buffalo, NY, USA
    J Int Neuropsychol Soc 19:173-80. 2013
    ..Self-generated speech, in this study, was not found to relate more strongly to cognitive tests than simple reading. Implications for further research are discussed...
  37. pmc Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    BMC Neurol 12:26. 2012
    ..healthy controls (HC) (56.1% vs. 22.7%, p < 0.001).The objective was to evaluate the clinical correlates of venous anomalies indicative of CCSVI in patients with MS...
  38. doi Iron deposition in multiple sclerosis lesions measured by susceptibility-weighted imaging filtered phase: a case control study
    Jesper Hagemeier
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, New York, USA
    J Magn Reson Imaging 36:73-83. 2012
    ..To relate phase lesion characteristics to other clinical and MRI outcomes...
  39. doi Associations of moderate alcohol consumption with clinical and MRI measures in multiple sclerosis
    Mathew Foster
    Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY, USA
    J Neuroimmunol 243:61-8. 2012
    ..To examine the associations of alcohol consumption patterns with disability and brain injury in multiple sclerosis (MS) patients...
  40. ncbi Interferon-beta modulates bone-associated cytokines and osteoclast precursor activity in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    Mult Scler 12:541-50. 2006
    ....
  41. ncbi Health-related quality of life in multiple sclerosis: effects of natalizumab
    Richard A Rudick
    Department of Neurology, Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Neurol 62:335-46. 2007
    ..To report the relationship between disease activity and health-related quality of life (HRQoL) in relapsing multiple sclerosis, and the impact of natalizumab...
  42. ncbi Upper and lower extremity motor function and cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY, USA
    J Int Neuropsychol Soc 17:643-53. 2011
    ..The findings may have implications for risk assessment and treatment of mobility dysfunction in MS...
  43. ncbi Regional lobar atrophy predicts memory impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 26:1824-31. 2005
    ..The relationship between regional lobar atrophy and cognitive impairment is yet to be examined. We endeavored to assess the clinical significance of regional lobar atrophy in multiple sclerosis...
  44. pmc Chronic cerebrospinal vascular insufficiency is not associated with HLA DRB1*1501 status in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, New York, United States of America
    PLoS ONE 6:e16802. 2011
    ..The objective was to assess the associations between HLA DRB1*1501 status and the occurrence of CCSVI in MS patients...
  45. doi Validity of the California Verbal Learning Test-II in multiple sclerosis
    Shane Stegen
    Department of Neurology, State University of New York SUNY at Buffalo, Buffalo, NY, USA
    Clin Neuropsychol 24:189-202. 2010
    ..We conclude that the CVLT-II is a valid test in MS and provides a rich constellation of verbal memory measures...
  46. ncbi Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis
    Erica Grazioli
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    J Neurol Sci 268:12-7. 2008
    ..067). There was negative correlation between average RNFL thickness (average of both eyes) and disability as assessed by EDSS (p=0.02). The results support potential usefulness of OCT for MS patient monitoring and research applications...
  47. doi MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosis
    Milena Stosic
    Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14203, USA
    J Neurol 257:63-71. 2010
    ..MRI reveals more profound injury in patients with MS versus PAPLS. APLA mediates heterogeneous cerebral pathology that remains to be further investigated...
  48. pmc Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity
    Robert A Bermel
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, USA
    Arch Neurol 62:1371-6. 2005
    ..Treatment with intramuscular interferon beta-1a limits brain atrophy in the second year of treatment...
  49. doi Multimodal noninvasive and invasive imaging of extracranial venous abnormalities indicative of CCSVI: results of the PREMiSe pilot study
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    BMC Neurol 13:151. 2013
    ..2 noninvasive imaging techniques for the detection of extracranial venous anomalies in the internal jugular veins (IJVs) and azygos vein/vertebral veins (VVs) in patients with multiple sclerosis (MS)...
  50. doi Comparison of intravascular ultrasound with conventional venography for detection of extracranial venous abnormalities indicative of chronic cerebrospinal venous insufficiency
    Yuval Karmon
    Department of Neurosurgery and Radiology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High Street, Suite B4, Buffalo, NY 14203 Department of Neurology, The Jacobs Neurological Institute, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High Street, Suite B4, Buffalo, NY 14203
    J Vasc Interv Radiol 24:1487-98.e1. 2013
    ....
  51. ncbi Risk of bone loss in men with multiple sclerosis
    Bianca Weinstock-Guttman
    Baird MS Center, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    Mult Scler 10:170-5. 2004
    ..Emerging data suggest a significantly increased prevalence of osteoporosis in men and women with multiple sclerosis (MS) compared to age-matched controls, but no specific clinical testing recommendations are available for men...
  52. pmc Comparison of Standard 1.5 T vs. 3 T Optimized Protocols in Patients Treated with Glatiramer Acetate. A Serial MRI Pilot Study
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA E Mails S H N B E C J D M G D C K
    Int J Mol Sci 13:5659-73. 2012
    ..the 1.5 T protocol (p = NS for both time points). This MRI mechanistic study suggests that GA may exert a greater effect on decreasing lesion activity as measured on 3 T optimized compared to 1.5 T standard protocol...
  53. doi Clinical efficacy, effects on MRI and tolerability of weekly intramuscular interferon-beta-1a in patients with MS and CIS
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Drugs Today (Barc) 44:601-13. 2008
    ..Early initiation of disease-modifying therapy after the diagnosis of relapsing-remitting MS or after a single demyelinating event (and evidence of lesions on MRI) allows patients the opportunity to obtain maximal long-term benefits...
  54. ncbi The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction
    Michael P Sanfilipo
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    Neuroimage 26:1068-77. 2005
    ..These findings suggest that gray matter loss is related to other aspects of brain pathology and has more clinical relevance than white matter atrophy in MS...
  55. doi Chronic cerebrospinal venous insufficiency in multiple sclerosis: diagnostic, pathogenetic, clinical and treatment perspectives
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
    Expert Rev Neurother 11:1277-94. 2011
    ..The potential usefulness of endovascular treatment for CCSVI in multiple sclerosis patients is still unknown...
  56. ncbi Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY 14260, USA
    Hum Mol Genet 16:2659-68. 2007
    ..There were no significant associations between Met66 allele status and other neurocognitive measures. The BDNF Met66 allele is associated with lower damage as evidenced by measurement of NGMV and T2-LV in MS patients...
  57. doi Interactions of serum cholesterol with anti-herpesvirus responses affect disease progression in clinically isolated syndromes
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    J Neuroimmunol 263:121-7. 2013
    ..To investigate whether anti-herpesvirus antibodies are associated with serum cholesterol profiles in clinically isolated syndromes (CIS)...
  58. ncbi Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York SUNY at Buffalo, School of Medicine, Buffalo, NY 14203, USA
    Mult Scler 13:722-30. 2007
    ..Given its overall simplicity and moderate correlation with cognition, DWI may offer several logistic advantages over more traditional MRI measures when predicting the presence of NP impairment...
  59. doi Fatigue and depression in children with demyelinating disorders
    Joy B Parrish
    Pediatric MS Center of the JNI, SUNY Buffalo, Buffalo, NY, USA
    J Child Neurol 28:713-8. 2013
    ..Clinical attention to and implementation of effective therapies oriented toward these conditions in children with acquired demyelinating syndromes is needed...
  60. doi Quercetin and interferon-beta modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients
    Zohara Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY 14223, United States
    J Neuroimmunol 205:142-7. 2008
    ..Quercetin, when combined with IFN-beta, had additive effects in modulating TNF-alpha and MMP-9. These immunomodulatory responses to quercetin were similar between MS patients and healthy control (HC) subjects...
  61. doi MRI characteristics of familial and sporadic multiple sclerosis patients
    Anita Tipirneni
    Buffalo Neuroimaging Analysis Center, State University of New York, USA
    Mult Scler 19:1145-52. 2013
    ..To investigate the MRI characteristics in a large cohort of multiple sclerosis (MS) patients with and without a family history of MS...
  62. doi Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis: a case-control study
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY 14203, USA
    Neuroimage 59:331-9. 2012
    ....
  63. ncbi Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis
    Michael P Sanfilipo
    Department of Neurology, SUNY University, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Neurology 66:685-92. 2006
    ..The relationship of gray and white matter atrophy in multiple sclerosis (MS) to neuropsychological and neuropsychiatric impairment has not been examined...
  64. ncbi Effect of Met66 allele of the BDNF rs6265 SNP on regional gray matter volumes in patients with multiple sclerosis: A voxel-based morphometry study
    Deepa P Ramasamy
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY, USA
    Pathophysiology 18:53-60. 2011
    ..Future studies are warranted to investigate longitudinally possible protective role of the Met66 allele of the BDNF rs6265 SNP in relation to specific GM regions...
  65. ncbi Combination therapy for multiple sclerosis: the treatment strategy of the future?
    Bianca Weinstock-Guttman
    Baird MS Research Center of The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    CNS Drugs 18:777-92. 2004
    ..Ultimately, the optimal therapies will likely include strategies that promote repair and limit tissue destruction in combination with anti-inflammatory interventions...
  66. doi Phytosterols ameliorate clinical manifestations and inflammation in experimental autoimmune encephalomyelitis
    Michael Valerio
    SUNY at Buffalo, 2 Sherman Hall, Buffalo, NY 14214, USA
    Inflamm Res 60:457-65. 2011
    ..Using experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), the objective of this study was to examine the effect of phytosterol (PS) administration on inflammation-based EAE development...
  67. doi Cine cerebrospinal fluid imaging in multiple sclerosis
    Christopher Magnano
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, New York, USA
    J Magn Reson Imaging 36:825-34. 2012
    ..To investigate cerebrospinal fluid (CSF) dynamics in the aqueduct of Sylvius in multiple sclerosis (MS) patients and healthy controls (HC) using cine phase contrast imaging...
  68. doi The nervous system's potential role in multiple sclerosis associated bone loss
    Sowmya Josyula
    Dept of Neurology, SUNY Buffalo, 100 High Street, Buffalo, NY 14203, USA
    J Neurol Sci 319:8-14. 2012
    ....
  69. doi Vitamin D and multiple sclerosis
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Neurologist 18:179-83. 2012
    ..In vitro studies have expanded the potential role of vitamin D and its receptor beyond calcium modulation, regulation, and maintenance of bone mineralization, to include immune modulation...
  70. doi Patterns of dietary and herbal supplement use by multiple sclerosis patients
    Kerri O'Connor
    Department of Pharmaceutical Sciences, State University of New York, 427 Cooke Hall, Buffalo, NY 14260, USA
    J Neurol 259:637-44. 2012
    ..Dietary supplements are used more frequently by MS patients than controls. Use tends to increase after MS onset compared to before, especially for DS. The use of HS by MS patients is only modestly greater than by controls...
  71. ncbi Dynamics of immune cell trafficking in interferon-beta treated multiple sclerosis patients
    Laura Hartrich
    Department of Pathology, State University of New York at Buffalo, Buffalo, NY 14260 1200, USA
    J Neuroimmunol 139:84-92. 2003
    ..To investigate the effects of interferon-beta-1a (IFN-beta-1a) on the trafficking of cell populations in peripheral blood cells of multiple sclerosis (MS) patients...
  72. doi Gene-environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Neuroimmunol 209:123-30. 2009
    ....
  73. ncbi The rs2030324 SNP of brain-derived neurotrophic factor (BDNF) is associated with visual cognitive processing in multiple sclerosis
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Department of Neurology, Buffalo General Hospital, Buffalo, NY 14203, United States
    Pathophysiology 18:43-52. 2011
    ..Conclusions: The C allele of BDNF rs2030324 is associated with protection against visual cognitive processing deficits via mechanisms that appear associated with the volume of the thalamus...
  74. ncbi Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Baird Multiple Sclerosis Center for MS Treatment and Research, Jacobs Neurological Institute, State University of New York, Buffalo General Hospital E2, 14203, USA
    Prostaglandins Leukot Essent Fatty Acids 73:397-404. 2005
    ..The primary outcome measure was the Physical Components Summary Scale (PCS) of the Short Health Status Questionnaire (SF-36). Additional measures using MS specific QOL questionnaires, neurological status and relapse rate were obtained...
  75. doi Disease progression in pediatric multiple sclerosis: disparities between physical and neurocognitive outcomes
    Eluen Ann Yeh
    Pediatric MS and Demyelinating Disorders Center of the Jacobs Neurological Institute, Women and Children s Hospital of Buffalo, Buffalo, NY 14222, USA
    Expert Rev Neurother 11:433-40. 2011
    ..This article will explore this paradox, taking into account studies that have focused on neuroimaging, cognition and outcomes in pediatric MS...
  76. ncbi Reliable screening for neuropsychological impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, School of Medicine, Buffalo, New York, NY, USA
    Mult Scler 10:675-8. 2004
    ..It is concluded that the MSNQ is useful, although patient self-reports may be exaggerated in depressed patients or reduced in patients with severe cognitive impairment...
  77. doi Comparison of the immunomodulatory effects of the plant sterol beta-sitosterol to simvastatin in peripheral blood cells from multiple sclerosis patients
    Forum Desai
    Department of Exercise and Nutrition Sciences, State University of New York, Buffalo, NY 14214, USA
    Int Immunopharmacol 9:153-7. 2009
    ..The results show that SIT is effective in modulating the secretion of pro/anti-inflammatory cytokines and suggest a potential beneficial effect of SIT in MS management without the side effects associated with statin therapy...
  78. doi Trend for decreasing Multiple Sclerosis Severity Scores (MSSS) with increasing calendar year of enrollment into the New York State Multiple Sclerosis Consortium
    Ilya Kister
    Multiple Sclerosis Care Center, Department of Neurology, New York University School of Medicine, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003 3804, USA
    Mult Scler 17:725-33. 2011
    ..Although the natural history of multiple sclerosis has been charted extensively, it is still not known whether the trajectory of disability accumulation has changed in the era of disease-modifying therapies (DMTs)...
  79. ncbi Thalamic involvement in multiple sclerosis: a diffusion-weighted magnetic resonance imaging study
    Andrew J Fabiano
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 13:307-14. 2003
    ..Diffusion-weighted magnetic resonance imaging (MRI) can assess tissue damage with greater sensitivity than conventional MRI. The authors' objective was to assess thalamic gray matter damage by diffusion-weighted imaging in MS patients...
  80. ncbi Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentation
    Jitendra Sharma
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, NY, USA
    AJNR Am J Neuroradiol 25:985-96. 2004
    ..Semiautomated and automated methods are used to measure whole-brain atrophy in multiple sclerosis (MS), but their comparative reliability, sensitivity, and validity are unknown...
  81. pmc Iron deposition and inflammation in multiple sclerosis. Which one comes first?
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurosci 12:60. 2011
    ..Creating a representative animal model that can study independently such relationship will be the key factor in this endeavor...
  82. ncbi Construct validity and frequency of euphoria sclerotica in multiple sclerosis
    Inna Fishman
    State University of New York SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York, USA
    J Neuropsychiatry Clin Neurosci 16:350-6. 2004
    ..Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates...
  83. pmc Personality traits in women with multiple sclerosis: discrepancy in patient/partner report and disease course
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Departments of Neurology and Psychiatry, Buffalo, NY, USA
    J Psychosom Res 66:147-54. 2009
    ..We endeavored to examine the extent to which patients' self-perceptions are congruent with how they are perceived by significant others across five trait domains as demarcated by the well known Five-Factor Model (FFM)...
  84. doi Intense immunosuppression in patients with rapidly worsening multiple sclerosis: treatment guidelines for the clinician
    Aaron Boster
    The Multiple Sclerosis Clinical Research Center, Department of Neurology, Wayne State University School of Medicine, and The Detroit Medical Center, Detroit, MI 48201, USA
    Lancet Neurol 7:173-83. 2008
    ..This Review describes the use of intense immunosuppressant drugs and natalizumab in patients with rapidly worsening MS and provides clinicians with guidelines for the use of these drugs in this patient group...
  85. ncbi Functional imaging during covert auditory attention in multiple sclerosis
    Michael P Santa Maria
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6 Buffalo, 100 High Street, 14203, USA
    J Neurol Sci 218:9-15. 2004
    ..This study demonstrates cingulate hypoactivity and cerebral reorganization during auditory attention in MS...
  86. doi A phase 3 trial of extended release oral dalfampridine in multiple sclerosis
    Andrew D Goodman
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Ann Neurol 68:494-502. 2010
    ..The current study was designed to confirm efficacy and further define safety and pharmacodynamics...
  87. ncbi Sex differences in in vitro pro-inflammatory cytokine production from peripheral blood of multiple sclerosis patients
    Linh T Nguyen
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, 543 Cooke Hall, Buffalo, NY 14260 1200, USA
    J Neurol Sci 209:93-9. 2003
    ..49, P=0.018). The secretion of the pro-inflammatory cytokines, IFN-gamma and TNF-alpha, is influenced by gender in MS patients and may contribute to the sexual dimorphism of MS...