Bianca Weinstock-Guttmam

Summary

Affiliation: State University of New York at Buffalo
Country: USA

Publications

  1. ncbi request reprint Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Baird Multiple Sclerosis Center for MS Treatment and Research, Jacobs Neurological Institute, State University of New York, Buffalo General Hospital E2, 14203, USA
    Prostaglandins Leukot Essent Fatty Acids 73:397-404. 2005
  2. ncbi request reprint Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis
    Brett A Parmenter
    Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    J Clin Exp Neuropsychol 29:215-23. 2007
  3. ncbi request reprint Impact of diagnosis and early treatment on the course of multiple sclerosis
    Katia Noyes
    Am J Manag Care 19:s321-31. 2013
  4. doi request reprint Natalizumab for multiple sclerosis: appraising risk versus benefit, a seemingly demanding tango
    Sahil Gupta
    SUNY University of Buffalo, Jacobs Neurological Institute, 100 High Street, Buffalo NY 14051, USA
    Expert Opin Biol Ther 14:115-26. 2014
  5. pmc Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    BMC Neurol 12:26. 2012
  6. doi request reprint Vitamin D and multiple sclerosis
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Neurologist 18:179-83. 2012
  7. pmc Decreased brain venous vasculature visibility on susceptibility-weighted imaging venography in patients with multiple sclerosis is related to chronic cerebrospinal venous insufficiency
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurol 11:128. 2011
  8. pmc Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara Bellaria Neurosciences, Ferrara and Bologna, Italy
    BMC Med 9:22. 2011
  9. ncbi request reprint What is new in the treatment of multiple sclerosis?
    B Weinstock-Guttman
    Buffalo General Hospital and Baird Center for Multiple Sclerosis at SUNY University, New York 14203, USA
    Drugs 59:401-10. 2000
  10. ncbi request reprint Pattern reversal visual evoked potentials as a measure of visual pathway pathology in multiple sclerosis
    B Weinstock-Guttman
    Baird MS Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Mult Scler 9:529-34. 2003

Detail Information

Publications96

  1. ncbi request reprint Low fat dietary intervention with omega-3 fatty acid supplementation in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Baird Multiple Sclerosis Center for MS Treatment and Research, Jacobs Neurological Institute, State University of New York, Buffalo General Hospital E2, 14203, USA
    Prostaglandins Leukot Essent Fatty Acids 73:397-404. 2005
    ..The primary outcome measure was the Physical Components Summary Scale (PCS) of the Short Health Status Questionnaire (SF-36). Additional measures using MS specific QOL questionnaires, neurological status and relapse rate were obtained...
  2. ncbi request reprint Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis
    Brett A Parmenter
    Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    J Clin Exp Neuropsychol 29:215-23. 2007
    ..While both tests appear to have good validity in the MS population, the availability of alternative forms makes the DKEFS an attractive alternative to the WCST, as was suggested by a consensus panel...
  3. ncbi request reprint Impact of diagnosis and early treatment on the course of multiple sclerosis
    Katia Noyes
    Am J Manag Care 19:s321-31. 2013
    ..The objectives of this review are to highlight the importance of early diagnosis and treatment of CIS or RRMS and discuss the favorable outcomes associated with early initiation of DMT. ..
  4. doi request reprint Natalizumab for multiple sclerosis: appraising risk versus benefit, a seemingly demanding tango
    Sahil Gupta
    SUNY University of Buffalo, Jacobs Neurological Institute, 100 High Street, Buffalo NY 14051, USA
    Expert Opin Biol Ther 14:115-26. 2014
    ..However, treatment with natalizumab is associated with progressive multifocal leukoencephalopathy (PML), a severe opportunistic brain infection with John Cunningham virus...
  5. pmc Clinical correlates of chronic cerebrospinal venous insufficiency in multiple sclerosis
    Bianca Weinstock-Guttman
    Department of Neurology, State University of New York, Buffalo, NY, USA
    BMC Neurol 12:26. 2012
    ..healthy controls (HC) (56.1% vs. 22.7%, p < 0.001).The objective was to evaluate the clinical correlates of venous anomalies indicative of CCSVI in patients with MS...
  6. doi request reprint Vitamin D and multiple sclerosis
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Neurologist 18:179-83. 2012
    ..In vitro studies have expanded the potential role of vitamin D and its receptor beyond calcium modulation, regulation, and maintenance of bone mineralization, to include immune modulation...
  7. pmc Decreased brain venous vasculature visibility on susceptibility-weighted imaging venography in patients with multiple sclerosis is related to chronic cerebrospinal venous insufficiency
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    BMC Neurol 11:128. 2011
    ....
  8. pmc Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report
    Paolo Zamboni
    Vascular Diseases Center, University of Ferrara Bellaria Neurosciences, Ferrara and Bologna, Italy
    BMC Med 9:22. 2011
    ..We hypothesized a possible relationship between abnormal perfusion in MS and hampered venous outflow at the extracranial level, a condition possibly associated with MS and known as chronic cerebrospinal venous insufficiency (CCSVI)...
  9. ncbi request reprint What is new in the treatment of multiple sclerosis?
    B Weinstock-Guttman
    Buffalo General Hospital and Baird Center for Multiple Sclerosis at SUNY University, New York 14203, USA
    Drugs 59:401-10. 2000
    ..Therefore, standardised methods for evaluating individual patients receiving disease-modifying therapies and development of effective therapeutic algorithms are needed...
  10. ncbi request reprint Pattern reversal visual evoked potentials as a measure of visual pathway pathology in multiple sclerosis
    B Weinstock-Guttman
    Baird MS Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Mult Scler 9:529-34. 2003
    ..Pattern reversal visual evoked potentials (PRVEPs) have a well-documented role in diagnosis of multiple sclerosis (MS), but their value as a visual function surrogate remains controversial...
  11. ncbi request reprint Risk of bone loss in men with multiple sclerosis
    Bianca Weinstock-Guttman
    Baird MS Center, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    Mult Scler 10:170-5. 2004
    ..Emerging data suggest a significantly increased prevalence of osteoporosis in men and women with multiple sclerosis (MS) compared to age-matched controls, but no specific clinical testing recommendations are available for men...
  12. ncbi request reprint Combination therapy for multiple sclerosis: the treatment strategy of the future?
    Bianca Weinstock-Guttman
    Baird MS Research Center of The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    CNS Drugs 18:777-92. 2004
    ..Ultimately, the optimal therapies will likely include strategies that promote repair and limit tissue destruction in combination with anti-inflammatory interventions...
  13. ncbi request reprint Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium
    B Weinstock-Guttman
    William C Baird Multiple Sclerosis Research Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Mult Scler 9:293-8. 2003
    ..Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility...
  14. doi request reprint Increased tissue damage and lesion volumes in African Americans with multiple sclerosis
    B Weinstock-Guttman
    The Jacobs Neurological Institute, Baird Multiple Sclerosis Center, Department of Neurology, State University of New York, E2 Buffalo General Hospital, Buffalo, NY 14203, USA
    Neurology 74:538-44. 2010
    ..African American (AA) patients with multiple sclerosis (MS) have more rapid disease progression and poorer responses to disease-modifying therapies than white American (WA) patients with MS...
  15. doi request reprint Psychometrics and normative data for the Multiple Sclerosis Functional Composite: replacing the PASAT with the Symbol Digit Modalities Test
    A S Drake
    Department of Neurology, State University of New York SUNY at Buffalo School of Medicine, Buffalo, NY, USA
    Mult Scler 16:228-37. 2010
    ....
  16. ncbi request reprint Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
    Int Angiol 29:158-75. 2010
    ....
  17. doi request reprint No association between conventional brain MR imaging and chronic cerebrospinal venous insufficiency in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 33:1913-7. 2012
    ..Therefore, this study determined the associations of CCSVI and conventional MR imaging outcomes in patients with MS and in HCs...
  18. doi request reprint Regression-based norms improve the sensitivity of the National MS Society Consensus Neuropsychological Battery for Pediatric Multiple Sclerosis (NBPMS)
    A M Smerbeck
    Department of Neurology, State University of New York at Buffalo, NY, USA
    Clin Neuropsychol 26:985-1002. 2012
    ..As in the case of adult MS, these results indicate that regression-based norms offer interpretive benefits over their manual-based counterparts...
  19. pmc Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with multiple sclerosis
    K Dolic
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
    Funct Neurol 26:205-14. 2011
    ..This study suggests that a multimodal non-invasive approach (DS and MRV) increases the specificity for a diagnosis of CCSVI in patients with MS...
  20. doi request reprint Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis
    E A Yeh
    Paediatric Multiple Sclerosis Centre, State University of New York at Buffalo, Buffalo, NY 14260 1200, USA
    Brain 132:3392-400. 2009
    ..Despite this, disability is slower to accrue in paediatric onset multiple sclerosis than adult onset multiple sclerosis...
  21. pmc Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
    Neurology 73:504-10. 2009
    ..Cigarette smoking has been linked to higher susceptibility and increased risk of progressive multiple sclerosis (MS). The effects of smoking on MRI characteristics of patients with MS have not been evaluated...
  22. doi request reprint Value of MR venography for detection of internal jugular vein anomalies in multiple sclerosis: a pilot longitudinal study
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA
    AJNR Am J Neuroradiol 32:938-46. 2011
    ..We assessed the role of conventional MRV for the detection of IJV anomalies in patients with MS diagnosed with CCSVI and in healthy controls who underwent MRV and Doppler sonography examinations during 6 months...
  23. ncbi request reprint Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy
    J Hagemeier
    Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 33:1596-601. 2012
    ..We also examined the association of abnormal phase with conventional MR imaging outcomes at first clinical onset...
  24. doi request reprint Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS
    R Zivadinov
    Department of Neurology, School of Medicine and Biomedical Sciences Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
    Neurology 77:138-44. 2011
    ..Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). A subject is considered CCSVI positive if ≥ 2 venous hemodynamic (VH) criteria are fulfilled...
  25. doi request reprint Subjective fatigue is not associated with cognitive impairment in multiple sclerosis: cross-sectional and longitudinal analysis
    S A Morrow
    School of Medicine, The Jacobs Neurological Institute, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Mult Scler 15:998-1005. 2009
    ..Studies in multiple sclerosis (MS) report conflicting conclusions regarding fatigue and cognition, which may partly be due to the use of small sample sizes and frequent reliance on a cross-sectional approach...
  26. ncbi request reprint Thalamic atrophy and cognition in multiple sclerosis
    M K Houtchens
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
    Neurology 69:1213-23. 2007
    ..In this study, we tested the hypothesis that thalamic volume is lower in MS than in normal subjects, and that thalamic atrophy in MS correlates with cognitive function...
  27. ncbi request reprint Use of the Multiple Sclerosis Functional Composite to predict disability in relapsing MS
    R A Rudick
    Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Cleveland Clinic Foundation, OH 44195, USA
    Neurology 56:1324-30. 2001
    ..To determine whether the MS Functional Composite (MSFC) can predict future disease progression in patients with relapsing remitting MS (RR-MS)...
  28. doi request reprint Voxel-wise magnetization transfer imaging study of effects of natalizumab and IFNβ-1a in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
    Mult Scler 18:1125-34. 2012
    ....
  29. ncbi request reprint Gender-related differences in MS: a study of conventional and nonconventional MRI measures
    R Antulov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, New York 14203, USA
    Mult Scler 15:345-54. 2009
    ..Studies showed gender-associated differences in multiple sclerosis (MS) disease evolution and in the evolution of conventional magnetic resonance imaging (MRI) findings...
  30. doi request reprint Intramuscular interferon beta-1a therapy in patients with relapsing-remitting multiple sclerosis: a 15-year follow-up study
    R A Bermel
    Department of Neurology, Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH 44195, USA
    Mult Scler 16:588-96. 2010
    ....
  31. doi request reprint Soluble receptor for advanced glycation end products in multiple sclerosis: a potential marker of disease severity
    Z Sternberg
    Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Mult Scler 14:759-63. 2008
    ....
  32. doi request reprint Repeated assessment of neuropsychological deficits in multiple sclerosis using the Symbol Digit Modalities Test and the MS Neuropsychological Screening Questionnaire
    R H B Benedict
    School of Medicine, State University of New York at Buffalo, Buffalo, New York, USA
    Mult Scler 14:940-6. 2008
    ....
  33. ncbi request reprint Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis
    B A C Cree
    Multiple Sclerosis Center, Department of Neurology, University of California San Francisco, 350 Parnassus Ave, Suite 908, San Francisco, CA 94117, USA
    Neurology 63:2039-45. 2004
    ..African American (AA) individuals are thought to develop multiple sclerosis (MS) less frequently than Caucasian American (CA) individuals...
  34. ncbi request reprint Estimating long-term effects of disease-modifying drug therapy in multiple sclerosis patients
    R A Rudick
    Department of Neurology, Mellen Center for Multiple Sclerosis Treatment and Research, The Cleveland Clinic Foundation, OH 44195, USA
    Mult Scler 11:626-34. 2005
    ..The paucity of data on the long-term treatment of patients with MS may be aided by applying these or similar methods to vigorously followed cohorts of patients...
  35. doi request reprint Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy
    R H B Benedict
    Jacobs Neurological Institute, Buffalo Neuroimaging Analysis Center, and Department of Neurology, State University of New York at Buffalo, New York 14203, USA
    J Neurol Neurosurg Psychiatry 80:201-6. 2009
    ..However, the importance of mesial temporal lobe (MTL) atrophy in MS is largely untested and poorly understood. New structural imaging techniques permit volumetric measures of multiple regions within the MTL lobe and DGM...
  36. pmc Chronic cerebrospinal venous insufficiency is not associated with cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, 100 High St, Buffalo, NY 14203, USA
    BMC Med 11:167. 2013
    ..This study measured the association between the presence and severity of CCSVI and cognitive impairment in patients with MS...
  37. ncbi request reprint Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls
    D Hojnacki
    The Jacobs Neurological Institute, State University of New York, Buffalo, NY, USA
    Int Angiol 29:127-39. 2010
    ..The aim of this paper was to investigate the value of neck magnetic resonance venography (MRV) for the diagnosis of CCSVI compared to DS and SV in patients with MS and in healthy controls (HC)...
  38. doi request reprint Intra- and extraluminal structural and functional venous anomalies in multiple sclerosis, as evidenced by 2 noninvasive imaging techniques
    K Dolic
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA
    AJNR Am J Neuroradiol 33:16-23. 2012
    ..Our aim was to investigate the prevalence and number of intra- and extraluminal structural and functional extracranial venous abnormalities by using DS and MRV, in patients with MS and HCs...
  39. doi request reprint Neuromyelitis optica immunoglobulins as a marker of disease activity and response to therapy in patients with neuromyelitis optica
    B Weinstock-Guttman
    Baird Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, NY Department of Neurology, State University of New York at Buffalo, Buffalo, NY 14203, USA
    Mult Scler 14:1061-7. 2008
    ..To determine whether neuromyelitis optica (NMO) immunoglobulin (IgG) antibody status in NMO/Devic's disease patients followed prospectively is persistent or can change relative to the clinical status and/or response to therapy...
  40. ncbi request reprint Rapid disease course in African Americans with multiple sclerosis
    I Kister
    Department of Neurology, NYU School of Medicine, Multiple Sclerosis Care Center, New York, NY 10003 3804, USA
    Neurology 75:217-23. 2010
    ..MSSS is a frequency-rank algorithm relating MS disability to disease duration in a large, untreated reference population. Design/..
  41. doi request reprint Regression-based pediatric norms for the brief visuospatial memory test: revised and the symbol digit modalities test
    A M Smerbeck
    Department of Neurology, State University of New York SUNY at Buffalo, Buffalo, NY, USA
    Clin Neuropsychol 25:402-12. 2011
    ..As the tests are validated in adult multiple sclerosis, they are likely to be useful in monitoring pediatric onset multiple sclerosis patients as they transition into adulthood...
  42. ncbi request reprint Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
    S D Brass
    Department of Neurology, Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mult Scler 12:437-44. 2006
    ..These data implicate a role for basal ganglia iron deposition in neuropsychological dysfunction...
  43. doi request reprint Visual-cognitive processing deficits in pediatric multiple sclerosis
    A M Smerbeck
    Department of Neurology, State University of New York, Buffalo, NY, USA
    Mult Scler 17:449-56. 2011
    ..This study investigates the sensitivity and validity in pediatric MS of two visual processing tests borrowed from the adult literature, the Brief Visuospatial Memory Test-Revised (BVMTR) and the Symbol Digit Modalities Test (SDMT)...
  44. ncbi request reprint A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon beta
    D R Smith
    Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Mult Scler 11:573-82. 2005
    ..To evaluate the efficacy and safety of combination therapy with pulse cyclophosphamide given with methylprednisolone (MP) and interferon beta (IFNbeta)-Ia in multiple sclerosis (MS) patients with active disease during IFNbeta monotherapy...
  45. ncbi request reprint In vivo gene expression revealed by cDNA arrays: the pattern in relapsing-remitting multiple sclerosis patients compared with normal subjects
    M Ramanathan
    Department of Pharmaceutics, 543 Cooke Hall, State University of New York at Buffalo, 14260 1200, Buffalo, NY, USA
    J Neuroimmunol 116:213-9. 2001
    ..To use DNA arrays to identify differences in gene expression associated with relapsing-remitting (RR) MS...
  46. ncbi request reprint Screening for cognitive impairment in multiple sclerosis using the Symbol digit Modalities Test
    B A Parmenter
    Department of Neurology, Division of Developmental and Behavioral Neurosciences, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Mult Scler 13:52-7. 2007
    ..71, and negative predictive value (NPV) of 0.73. These results suggest that the effectiveness of the SDMT as a screen for cognitive impairment in MS is roughly equal to that of other psychometric and questionnaire methods...
  47. pmc Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis
    L B Krupp
    Department of Neurology, State University of New York at Stony Brook, Stony Brook, NY 11794 8121, USA
    Neurology 76:1500-7. 2011
    ..The goal of this study was to determine if memory would be improved by donepezil as compared to placebo in a multicenter, double-blind, randomized clinical trial (RCT)...
  48. ncbi request reprint Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosis
    R H B Benedict
    Department of Neurology, State University of New York SUNY, Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York 14203, USA
    Mult Scler 9:393-6. 2003
    ..The BDI-FS may be useful in this regard although, to date, its validity in MS patients has not been assessed...
  49. ncbi request reprint An association between autoreactive antibodies and anti-interferon-beta antibodies in multiple sclerosis
    N Garg
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY, USA
    Mult Scler 13:895-9. 2007
    ..No significant correlations were found for other ARAB. The presence of autoreactive antibodies, particularly APLA and ATA is associated with increased risk of occurrence of IFN-beta BAb in MS patients on long-term IFN-beta therapy...
  50. ncbi request reprint Natalizumab reduces visual loss in patients with relapsing multiple sclerosis
    L J Balcer
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurology 68:1299-304. 2007
    ....
  51. doi request reprint Retinal nerve fiber thickness in inflammatory demyelinating diseases of childhood onset
    E A Yeh
    Pediatric Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, New York, USA
    Mult Scler 15:802-10. 2009
    ..To evaluate retinal nerve fiber layer thickness (RNFLT) using optical coherence tomography (OCT) in children with acquired demyelinating diseases...
  52. ncbi request reprint Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis
    R Zivadinov
    Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 29:319-25. 2008
    ..We also wanted to evaluate the relationship between cervical cord atrophy and clinical disability in the presence of other conventional and nonconventional brain MR imaging metrics by using a unique additive variance regression model...
  53. ncbi request reprint Comparison of a 1.5T standard vs. 3T optimized protocols in multiple sclerosis patients
    I Livshits
    Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
    Minerva Med 103:97-102. 2012
    ..This study investigated the superiority of the 3T optimized vs. the 1.5T standardized protocols in detecting gadolinium enhancing (GD-E) lesions in patients with MS...
  54. ncbi request reprint Interpreting patient/informant discrepancies of reported cognitive symptoms in MS
    D A Carone
    SUNY Buffalo School of Medicine and Buffalo General Hospital, Buffalo, New York 14203, USA
    J Int Neuropsychol Soc 11:574-83. 2005
    ..We conclude that patient/informant discrepancy scores on the MSNQ are associated with the aforementioned neuropsychiatric features, and that the MSNQ has potential utility for predicting euphoria and disinhibition syndromes in MS...
  55. doi request reprint Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis
    R Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, New York 14260, USA
    J Neurol Neurosurg Psychiatry 80:620-5. 2009
    ..The aim of the study was to determine whether the presence of anti-Epstein-Barr virus (EBV) antibodies is associated with MRI measures of brain injury and neurodegeneration in patients with multiple sclerosis (MS)...
  56. doi request reprint Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis
    A Kardys
    Department of Pharmaceutical Sciences, State University of New York, Buffalo, NY 14260, USA
    Eur J Neurol 20:1264-71. 2013
    ..To evaluate the associations between retinal nerve fiber layer (RNFL) thickness and lipid profiles in multiple sclerosis (MS)...
  57. ncbi request reprint MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis
    C W Tjoa
    Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Neurol Sci 234:17-24. 2005
    ..Ambulatory dysfunction limits quality of life; however correlation with conventional MRI remains poor...
  58. ncbi request reprint Multiple sclerosis gender issues: clinical practices of women neurologists
    P K Coyle
    MS Comprehensive Care Center, SUNY at Stony Brook, New York, NY, USA
    Mult Scler 10:582-8. 2004
    ..The survey results described here provide insight into how neurologists manage reproductive health issues among women with MS...
  59. doi request reprint Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis
    K C O'Connor
    Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    J Neuroimmunol 223:92-9. 2010
    ..Our findings identify an immune mechanism that could contribute to the observed heterogeneity in spectrum of clinical presentations in early-onset MS...
  60. ncbi request reprint Health-related quality of life in multiple sclerosis: effects of natalizumab
    Richard A Rudick
    Department of Neurology, Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Ann Neurol 62:335-46. 2007
    ..To report the relationship between disease activity and health-related quality of life (HRQoL) in relapsing multiple sclerosis, and the impact of natalizumab...
  61. doi request reprint Intense immunosuppression in patients with rapidly worsening multiple sclerosis: treatment guidelines for the clinician
    Aaron Boster
    The Multiple Sclerosis Clinical Research Center, Department of Neurology, Wayne State University School of Medicine, and The Detroit Medical Center, Detroit, MI 48201, USA
    Lancet Neurol 7:173-83. 2008
    ..This Review describes the use of intense immunosuppressant drugs and natalizumab in patients with rapidly worsening MS and provides clinicians with guidelines for the use of these drugs in this patient group...
  62. ncbi request reprint Validity of the minimal assessment of cognitive function in multiple sclerosis (MACFIMS)
    Ralph H B Benedict
    State University of New York at Buffalo School of Medicine, Department of Neurology, Division of Departmental and Behavioral Neurosciences, Buffalo, New York, USA
    J Int Neuropsychol Soc 12:549-58. 2006
    ..We conclude that the MACFIMS is a valid approach to routine NP assessment of MS patients. Future work is planned to determine its psychometric properties in a longitudinal study...
  63. ncbi request reprint Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    Richard A Rudick
    Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 354:911-23. 2006
    ..Despite interferon beta therapy, many patients have relapses. Natalizumab, an alpha4 integrin antagonist, appeared to be safe and effective alone and when added to interferon beta-1a in preliminary studies...
  64. ncbi request reprint Functional imaging during covert auditory attention in multiple sclerosis
    Michael P Santa Maria
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6 Buffalo, 100 High Street, 14203, USA
    J Neurol Sci 218:9-15. 2004
    ..This study demonstrates cingulate hypoactivity and cerebral reorganization during auditory attention in MS...
  65. ncbi request reprint Interferon-beta treatment for relapsing multiple sclerosis
    Bianca Weinstock-Guttman
    The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Expert Opin Biol Ther 8:1435-47. 2008
    ..Recombinant forms of IFN-beta were the first therapeutic intervention found to be effective at interfering with the course of multiple sclerosis (MS), a chronic and debilitating disease affecting the CNS in young adults...
  66. ncbi request reprint Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis
    Michael P Sanfilipo
    Department of Neurology, SUNY University, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Neurology 66:685-92. 2006
    ..The relationship of gray and white matter atrophy in multiple sclerosis (MS) to neuropsychological and neuropsychiatric impairment has not been examined...
  67. pmc Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity
    Robert A Bermel
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, USA
    Arch Neurol 62:1371-6. 2005
    ..Treatment with intramuscular interferon beta-1a limits brain atrophy in the second year of treatment...
  68. ncbi request reprint Regional lobar atrophy predicts memory impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 26:1824-31. 2005
    ..The relationship between regional lobar atrophy and cognitive impairment is yet to be examined. We endeavored to assess the clinical significance of regional lobar atrophy in multiple sclerosis...
  69. ncbi request reprint The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction
    Michael P Sanfilipo
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    Neuroimage 26:1068-77. 2005
    ..These findings suggest that gray matter loss is related to other aspects of brain pathology and has more clinical relevance than white matter atrophy in MS...
  70. ncbi request reprint Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
    J Neurol Sci 231:29-34. 2005
    ..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment...
  71. ncbi request reprint Reliable screening for neuropsychological impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, School of Medicine, Buffalo, New York, NY, USA
    Mult Scler 10:675-8. 2004
    ..It is concluded that the MSNQ is useful, although patient self-reports may be exaggerated in depressed patients or reduced in patients with severe cognitive impairment...
  72. ncbi request reprint Construct validity and frequency of euphoria sclerotica in multiple sclerosis
    Inna Fishman
    State University of New York SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York, USA
    J Neuropsychiatry Clin Neurosci 16:350-6. 2004
    ..Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates...
  73. ncbi request reprint Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentation
    Jitendra Sharma
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, NY, USA
    AJNR Am J Neuroradiol 25:985-96. 2004
    ..Semiautomated and automated methods are used to measure whole-brain atrophy in multiple sclerosis (MS), but their comparative reliability, sensitivity, and validity are unknown...
  74. ncbi request reprint Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden
    Ralph H B Benedict
    Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
    Arch Neurol 61:226-30. 2004
    ..Furthermore, few studies accounted for the influence of age, premorbid intelligence, or depression...
  75. ncbi request reprint Thalamic involvement in multiple sclerosis: a diffusion-weighted magnetic resonance imaging study
    Andrew J Fabiano
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 13:307-14. 2003
    ..Diffusion-weighted magnetic resonance imaging (MRI) can assess tissue damage with greater sensitivity than conventional MRI. The authors' objective was to assess thalamic gray matter damage by diffusion-weighted imaging in MS patients...
  76. ncbi request reprint Genomic effects of IFN-beta in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    J Immunol 171:2694-702. 2003
    ..The findings demonstrate that IFN-beta treatment induces specific and time-dependent changes in multiple mRNAs in lymphocytes of multiple sclerosis patients that could provide a framework for rapid monitoring of the response to therapy...
  77. ncbi request reprint Dynamics of immune cell trafficking in interferon-beta treated multiple sclerosis patients
    Laura Hartrich
    Department of Pathology, State University of New York at Buffalo, Buffalo, NY 14260 1200, USA
    J Neuroimmunol 139:84-92. 2003
    ..To investigate the effects of interferon-beta-1a (IFN-beta-1a) on the trafficking of cell populations in peripheral blood cells of multiple sclerosis (MS) patients...
  78. ncbi request reprint Sex differences in in vitro pro-inflammatory cytokine production from peripheral blood of multiple sclerosis patients
    Linh T Nguyen
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, 543 Cooke Hall, Buffalo, NY 14260 1200, USA
    J Neurol Sci 209:93-9. 2003
    ..49, P=0.018). The secretion of the pro-inflammatory cytokines, IFN-gamma and TNF-alpha, is influenced by gender in MS patients and may contribute to the sexual dimorphism of MS...
  79. ncbi request reprint Factors that predict health-related quality of life in patients with relapsing-remitting multiple sclerosis
    Deborah M Miller
    Mellen Center for Multiple Sclerosis Treatment and Research, Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Mult Scler 9:1-5. 2003
    ....
  80. ncbi request reprint Dynamics of interferon-beta modulated mRNA biomarkers in multiple sclerosis patients with anti-interferon-beta neutralizing antibodies
    Roseane Santos
    Department of Pharmaceutical Sciences, State University of New York at Buffalo, and Jacobs Neurological Institute, Buffalo General Hospital, NY 14260 1200, United States
    J Neuroimmunol 176:125-33. 2006
    ..Patients with borderline NAB had average responses that appear to be lower than NAB negative patients on several genes, notably Stat-1, TRAIL and beta2 microglobulin...
  81. ncbi request reprint Study of mitoxantrone for the treatment of recurrent neuromyelitis optica (Devic disease)
    Bianca Weinstock-Guttman
    The William C Baird Multiple Sclerosis Center, Jacobs Neurological Institute, State University of New York, Buffalo, NY 14203, USA
    Arch Neurol 63:957-63. 2006
    ..Mitoxantrone hydrochloride, a synthetic anthracenedione approved for worsening relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis, has been shown to primarily suppress the humoral response...
  82. doi request reprint Cortical atrophy and personality in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo, School of Medicine, New York, USA
    Neuropsychology 22:432-41. 2008
    ..These findings suggest that cortical atrophy in MS is associated with adverse impact on personality, although longitudinal research is needed to test this hypothesis...
  83. ncbi request reprint Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis
    Erica Grazioli
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    J Neurol Sci 268:12-7. 2008
    ..067). There was negative correlation between average RNFL thickness (average of both eyes) and disability as assessed by EDSS (p=0.02). The results support potential usefulness of OCT for MS patient monitoring and research applications...
  84. ncbi request reprint Clinical features and viral serologies in children with multiple sclerosis: a multinational observational study
    Brenda Banwell
    Division of Neurology, The Hospital for Sick Children, University of Toronto, ON, Canada
    Lancet Neurol 6:773-81. 2007
    ..Our aim was to determine some of these characteristics in children with MS...
  85. ncbi request reprint Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY 14260, USA
    Hum Mol Genet 16:2659-68. 2007
    ..There were no significant associations between Met66 allele status and other neurocognitive measures. The BDNF Met66 allele is associated with lower damage as evidenced by measurement of NGMV and T2-LV in MS patients...
  86. ncbi request reprint New MRI criteria in the diagnosis of multiple sclerosis
    Bianca Weinstock-Guttman
    Lancet Neurol 6:664-5. 2007
  87. ncbi request reprint Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York SUNY at Buffalo, School of Medicine, Buffalo, NY 14203, USA
    Mult Scler 13:722-30. 2007
    ..Given its overall simplicity and moderate correlation with cognition, DWI may offer several logistic advantages over more traditional MRI measures when predicting the presence of NP impairment...
  88. ncbi request reprint Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 188:167-74. 2007
    ..To investigate the relationship between immune cell secretion of brain-derived neurotrophic factor (BDNF) with clinical and MRI variables in multiple sclerosis (MS) patients...
  89. ncbi request reprint Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis
    Ayda Tekok-Kilic
    Department of Neurology, University at Buffalo, State University of New York, USA
    Neuroimage 36:1294-300. 2007
    ..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy...
  90. ncbi request reprint Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients
    Neeta Garg
    Multiple Sclerosis Center, UMass Memorial Medical Center, Worcester, MA 01605, USA
    J Neuroimmunol 187:159-65. 2007
    ....
  91. ncbi request reprint Quantitative diffusion weighted imaging measures in patients with multiple sclerosis
    Eleonora Tavazzi
    Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    Neuroimage 36:746-54. 2007
    ..ENT is a sensitive marker of overall brain damage that is strongly related to clinical impairment in patients with SP MS...
  92. ncbi request reprint Pharmacogenetics of MXA SNPs in interferon-beta treated multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 182:236-9. 2007
    ..No significant association was found between the MXA genotype at these two SNPs and clinical, MRI and MXA gene expression in MS patients treated with IFN-beta therapy...
  93. ncbi request reprint Interferon inhibitory activity in patients with multiple sclerosis
    Kailash Chadha
    Department of Cell and Molecular Biology, Roswell Park Cancer Institute, Jacobs Neurological Institute, Buffalo, New York 14263, USA
    Arch Neurol 63:1579-84. 2006
    ..Interferon inhibitory activity (IIA) is a logical candidate for explaining neutralizing antibody-negative partial responsiveness to interferon beta in multiple sclerosis (MS), but its role has not been evaluated...
  94. ncbi request reprint Interferon-beta modulates bone-associated cytokines and osteoclast precursor activity in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    Mult Scler 12:541-50. 2006
    ....
  95. ncbi request reprint Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
    Arch Neurol 63:1301-6. 2006
    ..Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results...
  96. ncbi request reprint Lawrence D. Jacobs, MD (1938-2001)
    Richard Rudick
    Neurology 58:999-1000. 2002