W E Van Nostrand

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity
    W E Van Nostrand
    Department of Medicine, Health Sciences Center, State University of New York, Stony Brook 11794 8153, USA
    Biochemistry 38:11570-6. 1999
  2. ncbi request reprint Cerebrovascular smooth muscle cell surface fibrillar A beta. Alteration of the proteolytic environment in the cerebral vessel wall
    W E Van Nostrand
    Department of Medicine, State University of New York, Stony Brook 11794 8153, USA
    Ann N Y Acad Sci 903:89-96. 2000
  3. ncbi request reprint Pathogenic effects of D23N Iowa mutant amyloid beta -protein
    W E Van Nostrand
    Departments of Medicine and Pathology, Health Sciences Center, State University of New York, Stony Brook, NY 11794 8153, USA
    J Biol Chem 276:32860-6. 2001
  4. ncbi request reprint Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells
    W E Van Nostrand
    Department of Medicine, Health Sciences Center, State University of New York, Stony Brook 11794 8153, USA
    Amyloid 8:20-7. 2001
  5. pmc Clearance of amyloid-β protein deposits in transgenic mice following focal cerebral ischemia
    W E Van Nostrand
    Department of Neurosurgery and Medicine, Stony Brook University, Stony Brook, NY 11794 8122, USA
    Neurodegener Dis 10:108-11. 2012
  6. pmc Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice
    F Xu
    Department of Medicine, Health Sciences Center T 15 083, Stony Brook University, Stony Brook, NY 11794 8153, USA
    Neuroscience 146:98-107. 2007

Detail Information

Publications6

  1. ncbi request reprint Plasmin cleavage of the amyloid beta-protein: alteration of secondary structure and stimulation of tissue plasminogen activator activity
    W E Van Nostrand
    Department of Medicine, Health Sciences Center, State University of New York, Stony Brook 11794 8153, USA
    Biochemistry 38:11570-6. 1999
    ..These findings suggest that pathologic interactions between A beta, tPA, and plasmin in the cerebral vessel wall could result in excessive proteolysis contributing to intracerebral hemorrhages...
  2. ncbi request reprint Cerebrovascular smooth muscle cell surface fibrillar A beta. Alteration of the proteolytic environment in the cerebral vessel wall
    W E Van Nostrand
    Department of Medicine, State University of New York, Stony Brook 11794 8153, USA
    Ann N Y Acad Sci 903:89-96. 2000
    ..Together, these altered proteolytic events could create a setting that is conducive to loss of vessel wall integrity and hemorrhagic stroke...
  3. ncbi request reprint Pathogenic effects of D23N Iowa mutant amyloid beta -protein
    W E Van Nostrand
    Departments of Medicine and Pathology, Health Sciences Center, State University of New York, Stony Brook, NY 11794 8153, USA
    J Biol Chem 276:32860-6. 2001
    ..Whereas the A21G Flemish mutation appears to enhance Abeta production, the E22Q Dutch and D23N Iowa mutations enhance fibrillogenesis and the pathogenicity of Abeta toward HCSM cells...
  4. ncbi request reprint Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells
    W E Van Nostrand
    Department of Medicine, Health Sciences Center, State University of New York, Stony Brook 11794 8153, USA
    Amyloid 8:20-7. 2001
    ..This emphasizes the likely requirement of therapeutic compounds that are effective in disrupting cell surface-driven Abeta fibril assembly in the treatment of CAA...
  5. pmc Clearance of amyloid-β protein deposits in transgenic mice following focal cerebral ischemia
    W E Van Nostrand
    Department of Neurosurgery and Medicine, Stony Brook University, Stony Brook, NY 11794 8122, USA
    Neurodegener Dis 10:108-11. 2012
    ..On the other hand, it remains unclear how cerebral ischemia affects preexisting Aβ deposits in the brain. Here we determine the consequences of focal ischemic stroke on existing Aβ pathology in Tg-SwDI transgenic mice...
  6. pmc Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid beta-protein precursor transgenic mice
    F Xu
    Department of Medicine, Health Sciences Center T 15 083, Stony Brook University, Stony Brook, NY 11794 8153, USA
    Neuroscience 146:98-107. 2007
    ..These findings indicate that early-onset accumulation of subicular microvascular amyloid and accompanying neuroinflammation correlates with impaired performance in the learning and memory task in Tg-SwDI mice...