C E Turner

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region
    C E Turner
    Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse 13210
    J Cell Sci 107:1583-91. 1994
  2. pmc Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin
    S L Bellis
    Department of Anatomy and Cell Biology, State University of New York Health Science Center, 750 E Adams Street, Syracuse, NY 13210, USA
    Biochem J 325:375-81. 1997
  3. ncbi request reprint Paxillin interactions
    C E Turner
    Dept of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY13210, USA
    J Cell Sci 113:4139-40. 2000
  4. ncbi request reprint Paxillin and focal adhesion signalling
    C E Turner
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Nat Cell Biol 2:E231-6. 2000
  5. ncbi request reprint Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions
    S N Nikolopoulos
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 276:23499-505. 2001
  6. ncbi request reprint Paxillin
    C E Turner
    Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse 13210, USA
    Int J Biochem Cell Biol 30:955-9. 1998
  7. pmc Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
    C E Turner
    Department of Anatomy and Cell Biology, State University of New York, Health Science Center, Syracuse, New York 13210, USA
    J Cell Biol 145:851-63. 1999
  8. pmc The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)
    K A West
    Department of Cell and Developmental Biology, State University of New York, Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Cell Biol 154:161-76. 2001
  9. pmc Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
    M C Brown
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Syracuse, 13210, USA
    J Cell Biol 135:1109-23. 1996
  10. pmc Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin
    M C Brown
    Department of Anatomy and Cell Biology, Program in Cell and Molecular Biology, State University of New York Health Science Center at Syracuse, Syracuse, New York 13210, USA
    Mol Biol Cell 9:1803-16. 1998

Collaborators

  • M C Brown
  • M C Riedy
  • S Thomas
  • H Zhang
  • - Zhang Hong
  • S N Nikolopoulos
  • S L Bellis
  • K A West
  • L Herreros
  • J F Cote
  • A F Horwitz
  • P Sanchez-Mateos
  • C Cabanas
  • J L Alonso-Lebrero
  • J L Rodriguez-Fernandez
  • N Longo
  • F Sanchez-Madrid
  • M L Tremblay
  • C A Francomano
  • J A Perrotta
  • M S Curtis
  • J T Miller
  • R I Ortiz de Luna
  • E Taylor
  • G A Bellus
  • T W Hefferon
  • S H Blanton
  • I McIntosh
  • D A Meyers
  • J C Murray

Detail Information

Publications20

  1. ncbi request reprint Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region
    C E Turner
    Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse 13210
    J Cell Sci 107:1583-91. 1994
    ..abstract truncated at 250 words)..
  2. pmc Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin
    S L Bellis
    Department of Anatomy and Cell Biology, State University of New York Health Science Center, 750 E Adams Street, Syracuse, NY 13210, USA
    Biochem J 325:375-81. 1997
    ..These findings support a role for both tyrosine and serine kinases in the signal transduction pathway linking integrin activation to paxillin phosphorylation...
  3. ncbi request reprint Paxillin interactions
    C E Turner
    Dept of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY13210, USA
    J Cell Sci 113:4139-40. 2000
    ....
  4. ncbi request reprint Paxillin and focal adhesion signalling
    C E Turner
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Nat Cell Biol 2:E231-6. 2000
    ..Paxillin is a multi-domain adaptor found at the interface between the plasma membrane and the actin cytoskeleton. Here it provides a platform for the integration and processing of adhesion- and growth factor-related signals...
  5. ncbi request reprint Integrin-linked kinase (ILK) binding to paxillin LD1 motif regulates ILK localization to focal adhesions
    S N Nikolopoulos
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Biol Chem 276:23499-505. 2001
    ..Thus, paxillin binding is necessary for efficient focal adhesion targeting of ILK and may therefore impact the role of ILK in integrin-mediated signal transduction events...
  6. ncbi request reprint Paxillin
    C E Turner
    Department of Anatomy and Cell Biology, SUNY Health Science Center, Syracuse 13210, USA
    Int J Biochem Cell Biol 30:955-9. 1998
    ..Since paxillin interacts with several proteins known to cause cell transformation, the binding sites for these proteins on paxillin represent potential targets for therapeutic agents...
  7. pmc Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
    C E Turner
    Department of Anatomy and Cell Biology, State University of New York, Health Science Center, Syracuse, New York 13210, USA
    J Cell Biol 145:851-63. 1999
    ..These data implicate paxillin as a mediator of p21 GTPase-regulated actin cytoskeletal reorganization through the recruitment to nascent focal adhesion structures of an active PAK/PIX complex potentially via interactions with p95PKL...
  8. pmc The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)
    K A West
    Department of Cell and Developmental Biology, State University of New York, Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
    J Cell Biol 154:161-76. 2001
    ..These data suggest that the paxillin association with PKL is essential for normal integrin-mediated cell spreading, and locomotion and that this interaction is necessary for the regulation of Rac activity during these events...
  9. pmc Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding
    M C Brown
    Department of Anatomy and Cell Biology, State University of New York Health Science Center at Syracuse, 13210, USA
    J Cell Biol 135:1109-23. 1996
    ....
  10. pmc Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin
    M C Brown
    Department of Anatomy and Cell Biology, Program in Cell and Molecular Biology, State University of New York Health Science Center at Syracuse, Syracuse, New York 13210, USA
    Mol Biol Cell 9:1803-16. 1998
    ..Additionally, these results provide the first evidence that paxillin contributes to "inside-out" integrin-mediated signal transduction...
  11. pmc Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion
    S N Nikolopoulos
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York 13210, USA
    J Cell Biol 151:1435-48. 2000
    ..Together, these results suggest an important role for actopaxin in integrin-dependent remodeling of the actin cytoskeleton during cell motility and cell adhesion...
  12. ncbi request reprint Paxillin-ARF GAP signaling and the cytoskeleton
    C E Turner
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Curr Opin Cell Biol 13:593-9. 2001
    ..Evidence suggests an important role for ARF GAPs in mediating changes in the cell's actin cytoskeleton in response to adhesion and growth factor stimulation...
  13. ncbi request reprint Characterization of paxillin LIM domain-associated serine threonine kinases: activation by angiotensin II in vascular smooth muscle cells
    M C Brown
    Department of Anatomy and Cell Biology, Program in Cell and Molecular Biology, State University of New York Health Science Center at Syracuse, Syracuse, New York 13210, USA
    J Cell Biochem 76:99-108. 1999
    ....
  14. ncbi request reprint Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase
    S L Bellis
    Department of Anatomy and Cell Biology, State University of New York Health Science Center, Syracuse 13210, USA
    J Biol Chem 270:17437-41. 1995
    ..Similar to wild type paxillin, mutated paxillin localized to focal adhesions, indicating that the phosphorylation of paxillin on Tyr-118 is not essential for the recruitment of paxillin to sites of cell adhesion...
  15. ncbi request reprint Cell motility: ARNOand ARF6 at the cutting edge
    C E Turner
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Curr Biol 11:R875-7. 2001
    ..Recent studies have shown that ARNO and ARF6 play significant roles in coordinating this transition, providing new insight into the interplay between the Rho and ARF families of GTPases...
  16. ncbi request reprint Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton
    L Herreros
    Servicio de Inmunologia, Hospital General Universitario Gregorio Maranon, 28007 Madrid, Spain
    J Biol Chem 275:26436-40. 2000
    ....
  17. ncbi request reprint Intact LIM 3 and LIM 4 domains of paxillin are required for the association to a novel polyproline region (Pro 2) of protein-tyrosine phosphatase-PEST
    J F Cote
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 274:20550-60. 1999
    ..Thus, we propose that PTP-PEST, by a competition with the ligand of paxillin in the focal adhesion complex, could contribute to the removal of paxillin from the adhesion sites and consequently promote focal adhesion turnover...
  18. ncbi request reprint Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin
    S M Thomas
    Department of Medicine, Cancer Biology Program, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 112:181-90. 1999
    ....
  19. ncbi request reprint Detection of metavinculin in human platelets using a modified talin overlay assay
    C E Turner
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599 7090
    Eur J Cell Biol 49:202-6. 1989
    ..Using conventional immunoblot analysis we have confirmed that this protein is metavinculin, a protein previously believed to be confined to cardiac and smooth muscle tissue...
  20. ncbi request reprint Localization of the achondroplasia gene to the distal 2.5 Mb of human chromosome 4p
    C A Francomano
    Center for Medical Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21287
    Hum Mol Genet 3:787-92. 1994
    ..The establishment of closely linked markers will facilitate positional cloning of the achondroplasia gene and permit prenatal diagnosis of homozygous achondroplasia for at risk couples...