J M Shefner

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy
    J M Shefner
    Department of Neurology, State University of New York Health Science Center at Syracuse, 13210, USA
    Neurology 53:1239-46. 1999
  2. ncbi request reprint Revised statistical motor unit number estimation in the Celecoxib/ALS trial
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Muscle Nerve 35:228-34. 2007
  3. ncbi request reprint Effect of neurophilin ligands on motor units in mice with SOD1 ALS mutations
    J M Shefner
    Department of Neurology, Upstate Medical University, Syracuse, NY 13210, USA
    Neurology 57:1857-61. 2001
  4. ncbi request reprint Motor unit number estimation in human neurological diseases and animal models
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Clin Neurophysiol 112:955-64. 2001
  5. pmc Multipoint incremental motor unit number estimation as an outcome measure in ALS
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Neurology 77:235-41. 2011
  6. ncbi request reprint A clinical trial of creatine in ALS
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13104, USA
    Neurology 63:1656-61. 2004
  7. ncbi request reprint Functional outcome measures as clinical trial endpoints in ALS
    B J Traynor
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 63:1933-5. 2004
  8. ncbi request reprint The use of statistical MUNE in a multicenter clinical trial
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Muscle Nerve 30:463-9. 2004
  9. ncbi request reprint ALS surrogate markers. MUNE
    C L Gooch
    Columbia College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:104-7. 2004

Detail Information

Publications9

  1. ncbi request reprint Mice lacking cytosolic copper/zinc superoxide dismutase display a distinctive motor axonopathy
    J M Shefner
    Department of Neurology, State University of New York Health Science Center at Syracuse, 13210, USA
    Neurology 53:1239-46. 1999
    ..To characterize the motor neuron dysfunction in two models by performing physiologic and morphometric studies...
  2. ncbi request reprint Revised statistical motor unit number estimation in the Celecoxib/ALS trial
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Muscle Nerve 35:228-34. 2007
    ..Thus, we conclude that the statistical method is not an appropriate measure of motor unit number in any disease associated with motor unit instability...
  3. ncbi request reprint Effect of neurophilin ligands on motor units in mice with SOD1 ALS mutations
    J M Shefner
    Department of Neurology, Upstate Medical University, Syracuse, NY 13210, USA
    Neurology 57:1857-61. 2001
    ..Mice with trangenes that express mutations in the gene for cytosolic copper/zinc superoxide dismutase (SOD1) develop motor neuron degeneration resembling human ALS. Neurophilin ligands are small molecules that promote neurite outgrowth...
  4. ncbi request reprint Motor unit number estimation in human neurological diseases and animal models
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Clin Neurophysiol 112:955-64. 2001
    ..Despite the lack of a perfect method for performing MUNE, it has great clinical value in the assessment of progressive motor axon loss. Further refinements in the method will likely increase its utility in the future...
  5. pmc Multipoint incremental motor unit number estimation as an outcome measure in ALS
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Neurology 77:235-41. 2011
    ..Motor unit number estimation (MUNE) is a potentially attractive tool. MUNE methods previously employed in multicenter trials exhibited excessive variability and were prone to artifact...
  6. ncbi request reprint A clinical trial of creatine in ALS
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13104, USA
    Neurology 63:1656-61. 2004
    ..Creatine stabilizes the mitochondrial transition pore, and is important in mitochondrial ATP production. In a transgenic mouse model of ALS, administration of creatine prolongs survival and preserves motor function and motor neurons...
  7. ncbi request reprint Functional outcome measures as clinical trial endpoints in ALS
    B J Traynor
    Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 63:1933-5. 2004
    ..Rates of FVC% and ALFRS decline, but not of MVIC-arm or MVIC-grip, were independent predictors of survival...
  8. ncbi request reprint The use of statistical MUNE in a multicenter clinical trial
    J M Shefner
    Department of Neurology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA
    Muscle Nerve 30:463-9. 2004
    ..Thus, MUNE can be used reliably as an outcome measure in multicenter clinical trials; specific remedies are suggested for the difficulties encountered in this study...
  9. ncbi request reprint ALS surrogate markers. MUNE
    C L Gooch
    Columbia College of Physicians and Surgeons, Columbia Presbyterian Medical Center, New York, NY 10032, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:104-7. 2004
    ..As MUNE methods continue to be refined and disseminated, they are proving to be useful and unique tools for the study of motor neuron disease...