Karin Sauer

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. pmc The genomics and proteomics of biofilm formation
    Karin Sauer
    State University of New York at Binghamton, 104 Science III, Vestal Parkway East, Binghamton, NY 13902, USA
    Genome Biol 4:219. 2003
  2. pmc Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm
    K Sauer
    Department of Biological Sciences, SUNY at Binghamton, Binghamton, NY 13902, USA
    J Bacteriol 186:7312-26. 2004
  3. pmc Characterization of temporal protein production in Pseudomonas aeruginosa biofilms
    Christopher J Southey-Pillig
    Department of Biological Sciences, Binghamton University, NY 13902, USA
    J Bacteriol 187:8114-26. 2005
  4. pmc Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner
    Lisa A Morici
    Tulane University Health Sciences Center, Department of Microbiology and Immunology, New Orleans, LA 70112, USA
    J Bacteriol 189:7752-64. 2007
  5. pmc Formation of Streptococcus pneumoniae non-phase-variable colony variants is due to increased mutation frequency present under biofilm growth conditions
    Magee Allegrucci
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    J Bacteriol 190:6330-9. 2008
  6. pmc A novel signaling network essential for regulating Pseudomonas aeruginosa biofilm development
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, NY, USA
    PLoS Pathog 5:e1000668. 2009
  7. doi request reprint Neutral super-oxidised solutions are effective in killing P. aeruginosa biofilms
    Karin Sauer
    Department of Biological Sciences, Binghamton University, SUNY at Binghamton, Binghamton, NY, USA
    Biofouling 25:45-54. 2009
  8. pmc The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms
    Julie Liao
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 195:3352-63. 2013
  9. pmc Microcolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    Mol Microbiol 86:819-35. 2012
  10. pmc SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation
    Olga E Petrova
    Binghamton University, State University of New York at Binghamton, Department of Biological Sciences, 85 Murray Hill Road, Binghamton, NY 13902, USA
    J Bacteriol 193:6614-28. 2011

Collaborators

Detail Information

Publications30

  1. pmc The genomics and proteomics of biofilm formation
    Karin Sauer
    State University of New York at Binghamton, 104 Science III, Vestal Parkway East, Binghamton, NY 13902, USA
    Genome Biol 4:219. 2003
    ..Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during biofilm formation, revealing the complexity of this developmental process...
  2. pmc Characterization of nutrient-induced dispersion in Pseudomonas aeruginosa PAO1 biofilm
    K Sauer
    Department of Biological Sciences, SUNY at Binghamton, Binghamton, NY 13902, USA
    J Bacteriol 186:7312-26. 2004
    ..aeruginosa from biofilms can be induced by the addition of simple carbon sources. This study is also the first to demonstrate that dispersal of P. aeruginosa correlates with a specific dispersal phenotype...
  3. pmc Characterization of temporal protein production in Pseudomonas aeruginosa biofilms
    Christopher J Southey-Pillig
    Department of Biological Sciences, Binghamton University, NY 13902, USA
    J Bacteriol 187:8114-26. 2005
    ..Reverse transcription-PCR analysis confirmed the detectable change in expression of the respective genes ccoO, PA4101, and PA4208. We propose a possible mechanism for the role of these biofilm-specific proteins in biofilm formation...
  4. pmc Pseudomonas aeruginosa AlgR represses the Rhl quorum-sensing system in a biofilm-specific manner
    Lisa A Morici
    Tulane University Health Sciences Center, Department of Microbiology and Immunology, New Orleans, LA 70112, USA
    J Bacteriol 189:7752-64. 2007
    ..These data also suggest that AlgR may control transcription in a contact-dependent or biofilm-specific manner...
  5. pmc Formation of Streptococcus pneumoniae non-phase-variable colony variants is due to increased mutation frequency present under biofilm growth conditions
    Magee Allegrucci
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    J Bacteriol 190:6330-9. 2008
    ..The results suggest that hydrogen peroxide and environmental conditions specific to biofilms are responsible for the development of non-phase-variable colony variants...
  6. pmc A novel signaling network essential for regulating Pseudomonas aeruginosa biofilm development
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, NY, USA
    PLoS Pathog 5:e1000668. 2009
    ..aeruginosa biofilm development in response to environmental cues...
  7. doi request reprint Neutral super-oxidised solutions are effective in killing P. aeruginosa biofilms
    Karin Sauer
    Department of Biological Sciences, Binghamton University, SUNY at Binghamton, Binghamton, NY, USA
    Biofouling 25:45-54. 2009
    ..Because OIS-125 and OIS-200 enhance the disaggregation of biofilms, their use in the treatment of surface-related biofilm infections deserves further investigation...
  8. pmc The MerR-like regulator BrlR confers biofilm tolerance by activating multidrug efflux pumps in Pseudomonas aeruginosa biofilms
    Julie Liao
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 195:3352-63. 2013
    ..Our results indicate that BrlR acts as an activator of multidrug efflux pumps to confer tolerance to P. aeruginosa biofilms and to resist the action of antimicrobial agents. ..
  9. pmc Microcolony formation by the opportunistic pathogen Pseudomonas aeruginosa requires pyruvate and pyruvate fermentation
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    Mol Microbiol 86:819-35. 2012
    ..Our findings indicate the fermentative utilization of pyruvate to be a microcolony-specific adaptation of the P. aeruginosa biofilm environment...
  10. pmc SagS contributes to the motile-sessile switch and acts in concert with BfiSR to enable Pseudomonas aeruginosa biofilm formation
    Olga E Petrova
    Binghamton University, State University of New York at Binghamton, Department of Biological Sciences, 85 Murray Hill Road, Binghamton, NY 13902, USA
    J Bacteriol 193:6614-28. 2011
    ..aeruginosa biofilms, in a sequential and stage-specific manner...
  11. pmc PAS domain residues and prosthetic group involved in BdlA-dependent dispersion response by Pseudomonas aeruginosa biofilms
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 194:5817-28. 2012
    ..The findings suggest that BdlA plays a role in intracellular sensing of dispersion-inducing conditions and together with DipA forms a regulatory network that modulates an intracellular cyclic d-GMP (c-di-GMP) pool to enable dispersion...
  12. pmc Dispersion by Pseudomonas aeruginosa requires an unusual posttranslational modification of BdlA
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    Proc Natl Acad Sci U S A 109:16690-5. 2012
    ..Insights into the mechanism of BdlA function have implications for the control of biofilm-related infections...
  13. pmc The MerR-like regulator BrlR impairs Pseudomonas aeruginosa biofilm tolerance to colistin by repressing PhoPQ
    Jacob R Chambers
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 195:4678-88. 2013
    ..Our findings establish BrlR as an unusual member of the MerR family, as it not only functions as a multidrug transport activator, but also acts as a repressor of phoPQ expression, thus suppressing colistin resistance. ..
  14. pmc Antimicrobial tolerance of Pseudomonas aeruginosa biofilms is activated during an early developmental stage and requires the two-component hybrid SagS
    Kajal Gupta
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 195:4975-87. 2013
    ..Our findings demonstrate that biofilm tolerance is linked to early biofilm development and SagS, with SagS contributing indirectly to BrlR activation. ..
  15. pmc The MerR-like transcriptional regulator BrlR contributes to Pseudomonas aeruginosa biofilm tolerance
    Julie Liao
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 194:4823-36. 2012
    ....
  16. pmc The novel two-component regulatory system BfiSR regulates biofilm development by controlling the small RNA rsmZ through CafA
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, New York 13902, USA
    J Bacteriol 192:5275-88. 2010
    ....
  17. pmc The novel Pseudomonas aeruginosa two-component regulator BfmR controls bacteriophage-mediated lysis and DNA release during biofilm development through PhdA
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    Mol Microbiol 81:767-83. 2011
    ..Therefore, we propose that BfmR regulates biofilm development by limiting bacteriophage-mediated lysis and thus, eDNA release, via PhdA...
  18. pmc NO-induced biofilm dispersion in Pseudomonas aeruginosa is mediated by an MHYT domain-coupled phosphodiesterase
    Yi Li
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 195:3531-42. 2013
    ..This is the first description of a PDE specifically involved in NO-induced biofilm dispersion in P. aeruginosa. ..
  19. pmc Characterization of colony morphology variants isolated from Streptococcus pneumoniae biofilms
    Magee Allegrucci
    Department of Biological Sciences, State University of New York at Binghamton, NY 13902, USA
    J Bacteriol 189:2030-8. 2007
    ..Overall, our findings suggest that in vitro biofilm formation of S. pneumoniae serotype 3 coincides with the emergence of colony variants with distinct genotypic and phenotypic characteristics...
  20. pmc BdlA, DipA and Induced Dispersion Contribute to Acute Virulence and Chronic Persistence of Pseudomonas aeruginosa
    Yi Li
    Department of Biological Sciences, Binghamton University, Binghamton, New York, United States of America
    PLoS Pathog 10:e1004168. 2014
    ..In contrast, bdlA inactivation rendered P. aeruginosa more persistent upon chronic colonization of the murine lung, overall indicating that dispersion may contribute to both acute and chronic infections. ..
  21. pmc The phosphodiesterase DipA (PA5017) is essential for Pseudomonas aeruginosa biofilm dispersion
    Ankita Basu Roy
    Department of Biological Sciences, Binghamton University, Binghamton, NY, USA
    J Bacteriol 194:2904-15. 2012
    ..Dispersion was found to require protein synthesis and resulted in increased dipA expression and reduction of c-di-GMP levels. We propose a role of DipA in enabling dispersion in P. aeruginosa biofilms...
  22. pmc Phenotypic characterization of Streptococcus pneumoniae biofilm development
    Magee Allegrucci
    State University of New York at Binghamton, Department of Biological Sciences, 104 Science III, Vestal Parkway East, Binghamton, NY 13902, USA
    J Bacteriol 188:2325-35. 2006
    ..Protein identification revealed that proteins involved in virulence, adhesion, and resistance were more abundant under biofilm growth conditions. A possible role of the identified proteins in biofilm formation is discussed...
  23. pmc BdlA, a chemotaxis regulator essential for biofilm dispersion in Pseudomonas aeruginosa
    Ryan Morgan
    Department of Biological Sciences, Binghamton University, SUNY at Binghamton, 104 Science III, NY 13902, USA
    J Bacteriol 188:7335-43. 2006
    ..Our findings suggest that BdlA may be a link between sensing environmental cues, c-di-GMP levels, and detachment. Based on our findings, a possible involvement of BdlA in a signaling cascade resulting in biofilm dispersion is discussed...
  24. pmc Elevated levels of the second messenger c-di-GMP contribute to antimicrobial resistance of Pseudomonas aeruginosa
    Kajal Gupta
    Department of Biological Sciences, Binghamton University, Binghamton, NY, 13902, USA
    Mol Microbiol 92:488-506. 2014
    ..Our findings suggest that a signalling pathway involving a specific c-di-GMP pool regulated by SagS contributes to the resistance of P. aeruginosa biofilms. ..
  25. pmc BrlR from Pseudomonas aeruginosa is a c-di-GMP-responsive transcription factor
    Jacob R Chambers
    Department of Biological Sciences, Binghamton University, Binghamton, NY, 13902, USA
    Mol Microbiol 92:471-87. 2014
    ..Our findings demonstrate BrlR to be an unusual MerR-family member in that BrlR function and expression require the secondary messenger c-di-GMP. ..
  26. pmc Sticky situations: key components that control bacterial surface attachment
    Olga E Petrova
    Department of Biological Sciences, Binghamton University, Binghamton, New York, USA
    J Bacteriol 194:2413-25. 2012
    ....
  27. doi request reprint Effect of a solution containing citrate/Methylene Blue/parabens on Staphylococcus aureus bacteria and biofilm, and comparison with various heparin solutions
    Karin Sauer
    Department of Biological Sciences, SUNY at Binghamton, NY, USA
    J Antimicrob Chemother 63:937-45. 2009
    ..The degree of eradication of both planktonic and sessile microorganisms was evaluated...
  28. pmc Small RNAs and their role in biofilm formation
    Jacob R Chambers
    Department of Biological Sciences, Binghamton University, Binghamton, NY 13902, USA
    Trends Microbiol 21:39-49. 2013
    ..This review gives an overview of the contribution of sRNAs in regulating the switch from the planktonic to the sessile bacterial lifestyle by highlighting how sRNAs converge with known regulatory systems required for biofilm formation...
  29. pmc Proteomic, microarray, and signature-tagged mutagenesis analyses of anaerobic Pseudomonas aeruginosa at pH 6.5, likely representing chronic, late-stage cystic fibrosis airway conditions
    Mark D Platt
    Department of Chemistry, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    J Bacteriol 190:2739-58. 2008
    ..aeruginosa to limit the growth of this important CF pathogen when it is either limited or completely restricted in its oxygen supply...
  30. pmc Pseudomonas aeruginosa displays multiple phenotypes during development as a biofilm
    Karin Sauer
    Center for Biofilm Engineering, Montana State University Bozeman, Bozeman, Montana, USA
    J Bacteriol 184:1140-54. 2002
    ..These results demonstrate that P. aeruginosa displays multiple phenotypes during biofilm development and that knowledge of stage-specific physiology may be important in detecting and controlling biofilm growth...

Research Grants6

  1. Role of BdlA in biofilm dispersion and virulence properties of P. aeruginosa
    Karin Sauer; Fiscal Year: 2010
    ....
  2. P. Aeruginosa Biofilms and Burn Wound Infections
    Karin Sauer; Fiscal Year: 2006
    ..aeruginosa pathogenesis and by identifying virulence factors that may be targeted for therapeutic intervention. ..
  3. Role of PA4878 in biofilm antimicrobial resistance
    Karin Sauer; Fiscal Year: 2010
    ..aeruginosa biofilms. Findings from this research may lead to novel and innovative treatment strategies to treat and eradicate biofilm infections. ..
  4. P. aeruginosa biofilm specific proteins and regulators
    Karin Sauer; Fiscal Year: 2007
    ..Findings from this research are intended to lead to novel and more effective approaches for the treatment of such biofilm infections. ..
  5. Role of BdlA in biofilm dispersion and virulence properties of P. aeruginosa
    Karin Sauer; Fiscal Year: 2009
    ....
  6. Role of PA4878 in biofilm antimicrobial resistance
    Karin Sauer; Fiscal Year: 2009
    ..aeruginosa biofilms. Findings from this research may lead to novel and innovative treatment strategies to treat and eradicate biofilm infections. ..