TODD SACKTORSummaryAffiliation: State University of New York Country: USA Publications
Research Grants
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Publications
PKM zeta maintains late long-term potentiation by N-ethylmaleimide-sensitive factor/GluR2-dependent trafficking of postsynaptic AMPA receptorsYudong Yao
The Robert F Furchgott Center for Neural and Behavioral Science, Department of Physiology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, USA
J Neurosci 28:7820-7. 2008..Thus, PKMzeta maintains late-LTP by persistently modifying NSF/GluR2-dependent AMPAR trafficking to favor receptor insertion into postsynaptic sites...
Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiationPeter Serrano
Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
J Neurosci 25:1979-84. 2005..An inactive scrambled version of the peptide had no effect on LTP. Thus, persistent, increased phosphorylation by PKMzeta specifically maintains the late phase of LTP...- Memory maintenance by PKMζ--an evolutionary perspectiveTodd Charlton Sacktor
The Robert F Furchgott Center for Neural and Behavioral Science, Department of Physiology, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 10705, USA
Mol Brain 5:31. 2012..Thus, PKMζ, the "working end" of LTP, is a component of an evolutionarily conserved molecular mechanism for the persistent, yet flexible storage of long-term memory... 
JAK/STAT: the enigma within the mystery of NMDAR-LTDTodd C Sacktor
Departments of Physiology, Pharmacology, and Neurology, State University of New York Downstate Medical Center, The Robert F Furchgott Center for Neural and Behavioral Science, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Neuron 73:211-3. 2012..In this issue of Neuron, Nicolas et al. (2012) show that JAK2/STAT3 signaling, a canonical pathway for transmitting information from the cell membrane to the nucleus, is critical for NMDAR-LTD, even in the absence of new DNA transcription...- How does PKMζ maintain long-term memory?Todd C Sacktor
The Robert F Furchgott Center of Neural and Behavioural Science, Department of Physiology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203, USA
Nat Rev Neurosci 12:9-15. 2011..Recent research shows how PKMζ might perpetuate information both at synapses and during long-term memory... - PINing for things pastTodd Charlton Sacktor
Departments of Physiology, Pharmacology, and Neurology, Robert F Furchgott Center for Neural and Behavioral Science, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, USA
Sci Signal 3:pe9. 2010..PKMzeta, once translated, in turn inhibits Pin1, permitting persistent PKMzeta synthesis. In this way, PKMzeta may be up-regulated to the appropriate amounts for maintaining LTP and perpetuating our mental representations of the past... - PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storageTodd Charlton Sacktor
The Robert F Furchgott Center for Neural and Behavioral Science, Departments of Physiology, Pharmacology, and Neurology, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Prog Brain Res 169:27-40. 2008..Similar results are found for conditioned taste aversion when the inhibitor is injected in the insular neocortex. Thus PKMzeta is the first molecule found to be a component of the long-term memory trace... - Storage of spatial information by the maintenance mechanism of LTPEva Pastalkova
Departments of Physiology, Pharmacology, and Neurology, Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Science 313:1141-4. 2006..Thus, the mechanism maintaining LTP sustains spatial memory... - Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiationMatthew Taylor Kelly
Department of Physiology, The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
J Neurosci 27:3439-44. 2007.... - Actin polymerization regulates the synthesis of PKMzeta in LTPMatthew Taylor Kelly
Department of Physiology, The Robert F Furchgott Center for Neural and Behavioral Science, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
Neuropharmacology 52:41-5. 2007..Thus actin filaments formed by tetanization enhance the efficiency of the synthesis of PKMzeta that maintains LTP... - Dendritic transport and localization of protein kinase Mzeta mRNA: implications for molecular memory consolidationIlham Aliagaevich Muslimov
Department of Physiology and Pharmacology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
J Biol Chem 279:52613-22. 2004..Dendritic localization of PKMzeta mRNA provides a molecular basis for the functional integration of synaptic signal transduction and translational control pathways... - Protein kinase M zeta synthesis from a brain mRNA encoding an independent protein kinase C zeta catalytic domain. Implications for the molecular mechanism of memoryA Ivan Hernandez
Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, 11203, USA
J Biol Chem 278:40305-16. 2003..Because PKM zeta is a kinase synthesized in an autonomously active form and is necessary and sufficient for maintaining LTP, it serves as an example of a link coupling gene expression directly to synaptic plasticity... - Magnesium blocks the loss of protein kinase C, leads to a transient translocation of PKC(alpha) and PKC(epsilon), and improves recovery after anoxia in rat hippocampal slicesJenny Libien
Department of Physiology and Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
Brain Res Mol Brain Res 136:104-11. 2005..The mechanisms of magnesium neuroprotection may include altering the PKC response to an anoxic insult... - Protein synthesis-dependent LTP in isolated dendrites of CA1 pyramidal cellsJoan B Cracco
Department of Physiology, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
Hippocampus 15:551-6. 2005..These results show that increased dendritic translation of proteins is a critical molecular mechanism for hippocampal LTP... - Erasing sensorimotor memories via PKMzeta inhibitionLee Michael von Kraus
Graduate Program in Neural and Behavioral Science, State University of New York Downstate Medical Center, Brooklyn, New York, United States of America
PLoS ONE 5:e11125. 2010..These results indicate a shared molecular mechanism of storage for declarative and procedural forms of memory... - Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zetaReut Shema
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel
Science 317:951-3. 2007.... - Synaptic tagging and cross-tagging: the role of protein kinase Mzeta in maintaining long-term potentiation but not long-term depressionSreedharan Sajikumar
Department of Neurophysiology, Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
J Neurosci 25:5750-6. 2005..Thus, PKMzeta is the first LTP-specific PRP and is critical for the transformation of early into late LTP during both synaptic tagging and cross-tagging... - Memory enhancement and formation by atypical PKM activity in Drosophila melanogasterEric A Drier
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
Nat Neurosci 5:316-24. 2002..Finally, induction of DaPKM after training also enhanced memory. These results show that atypical PKM is sufficient to enhance memory in Drosophila and suggest that it is necessary for normal memory maintenance...
Research Grants
- PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYTODD SACKTOR; Fiscal Year: 2007..These 3 goals aim to understand in mechanistic detail the physiological increase of PKMzeta function in LTP maintenance, which might help provide a unifying framework for the complex signaling pathways of memory. ..
- Regulation of Neural Function of Atypical PKCTODD SACKTOR; Fiscal Year: 2007..These mechanisms may be important for both normal memory storage and memory dysfunction in amnestic disorders. ..
- PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYTODD SACKTOR; Fiscal Year: 2009..These 3 goals aim to understand in mechanistic detail the physiological increase of PKMzeta function in LTP maintenance, which might help provide a unifying framework for the complex signaling pathways of memory. ..
- Regulation of Neural Function of Atypical PKCTODD SACKTOR; Fiscal Year: 2009..These mechanisms may be important for both normal memory storage and memory dysfunction in amnestic disorders. ..
- PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYTodd C Sacktor; Fiscal Year: 2010....
- Regulation of Neural Function of Atypical PKCTodd C Sacktor; Fiscal Year: 2010..These mechanisms may be important for both normal memory storage and memory dysfunction in amnestic disorders. ..
- Regulation and Neural Function of Atypical PKCTODD SACKTOR; Fiscal Year: 2005..These 3 aims will provide fundamental knowledge on the role of atypical PKCs in neuronal signaling, and may lead to unifying, evolutionarily conserved molecular mechanisms for synaptic plasticity and behavioral memory. ..
- PROTEOLYTIC REGULATION & NEURAL FUNCTION OF ATYPICAL PKCTODD SACKTOR; Fiscal Year: 2000....
- PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYTODD SACKTOR; Fiscal Year: 2004..These three specific aims will generate fundamental information about the role of PKMz in protein synthesis dependent forms of synaptic plasticity and may provide concrete molecular mechanisms responsible for the persistence of memory. ..
- PROTEIN KINASE C ISOZYMES IN HIPPOCAMPAL PLASTICITYTodd C Sacktor; Fiscal Year: 2011....