Clinton T Rubin

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Spine (Phila Pa 1976) 28:2621-7. 2003
  2. ncbi request reprint Anabolism. Low mechanical signals strengthen long bones
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    Nature 412:603-4. 2001
  3. pmc Self-reported adherence with the use of a device in a clinical trial as validated by electronic monitors: the VIBES study
    Brianne A Jeffrey
    Hebrew SeniorLife Institute for Aging Research, Musculoskeletal Research Center, Boston, MA, USA
    BMC Med Res Methodol 12:171. 2012
  4. pmc Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals
    C T Rubin
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 104:17879-84. 2007
  5. ncbi request reprint Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York, Stony Brook, New York, USA
    J Bone Miner Res 19:343-51. 2004
  6. ncbi request reprint Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Bone 30:445-52. 2002
  7. ncbi request reprint Low-level mechanical signals and their potential as a non-pharmacological intervention for osteoporosis
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Age Ageing 35:ii32-ii36. 2006
  8. pmc Biology of bone and how it orchestrates the form and function of the skeleton
    D W Sommerfeldt
    Center for Biotechnology, State University of New York, Stony Brook, USA
    Eur Spine J 10:S86-95. 2001
  9. ncbi request reprint The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580 USA
    FASEB J 15:2225-9. 2001
  10. ncbi request reprint Increased expression of matrix metalloproteinase-1 in osteocytes precedes bone resorption as stimulated by disuse: evidence for autoregulation of the cell's mechanical environment?
    C Rubin
    Musculo Skeletal Research Laboratory, Program in Biomedical Engineering, Health Sciences Center, State University of New York, Stony Brook 11794 8181, USA
    J Orthop Res 17:354-61. 1999

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Spine (Phila Pa 1976) 28:2621-7. 2003
    ..Experiments were undertaken to determine the degree to which high-frequency (15-35 Hz) ground-based, whole-body vibration are transmitted to the proximal femur and lumbar vertebrae of the standing human...
  2. ncbi request reprint Anabolism. Low mechanical signals strengthen long bones
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
    Nature 412:603-4. 2001
    ..As the strain levels generated by this treatment are three orders of magnitude below those that damage bone tissue, this anabolic, non-invasive stimulus may have potential for treating skeletal conditions such as osteoporosis...
  3. pmc Self-reported adherence with the use of a device in a clinical trial as validated by electronic monitors: the VIBES study
    Brianne A Jeffrey
    Hebrew SeniorLife Institute for Aging Research, Musculoskeletal Research Center, Boston, MA, USA
    BMC Med Res Methodol 12:171. 2012
    ..The purpose of this study was to determine whether real time self-reported adherence is an accurate measurement of device usage during a clinical trial by comparing it to electronic recording...
  4. pmc Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signals
    C T Rubin
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 104:17879-84. 2007
    ..Translated to the human, this may represent the basis for the nonpharmacologic prevention of obesity and its sequelae, achieved through developmental, rather than metabolic, pathways...
  5. ncbi request reprint Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York, Stony Brook, New York, USA
    J Bone Miner Res 19:343-51. 2004
    ..2g, 30 Hz) vibration applied during quiet standing can effectively inhibit bone loss in the spine and femur, with efficacy increasing significantly with greater compliance, particularly in those subjects with lower body mass...
  6. ncbi request reprint Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical bone
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Bone 30:445-52. 2002
    ....
  7. ncbi request reprint Low-level mechanical signals and their potential as a non-pharmacological intervention for osteoporosis
    Clinton Rubin
    Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Age Ageing 35:ii32-ii36. 2006
    ..Recent data indicate that extremely low-level mechanical signals are anabolic to bone, and thus may be used, non-invasively, as a form of 'passive' exercise to positively influence skeletal status...
  8. pmc Biology of bone and how it orchestrates the form and function of the skeleton
    D W Sommerfeldt
    Center for Biotechnology, State University of New York, Stony Brook, USA
    Eur Spine J 10:S86-95. 2001
    ..Bone research remains interdisciplinary by nature, and a deeper understanding of bone biology will ultimately lead to advances in the treatment of diseases and injuries to bone itself...
  9. ncbi request reprint The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuli
    C Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580 USA
    FASEB J 15:2225-9. 2001
    ..This work indicates that this noninvasive, extremely low-level stimulus may provide an effective biomechanical intervention for the bone loss that plagues long-term space flight, bed rest, or immobilization caused by paralysis...
  10. ncbi request reprint Increased expression of matrix metalloproteinase-1 in osteocytes precedes bone resorption as stimulated by disuse: evidence for autoregulation of the cell's mechanical environment?
    C Rubin
    Musculo Skeletal Research Laboratory, Program in Biomedical Engineering, Health Sciences Center, State University of New York, Stony Brook 11794 8181, USA
    J Orthop Res 17:354-61. 1999
    ..We believe that such autoregulation of the osteocyte's physical environment will accommodate subtle changes in the bone's functional environment without the need to add or resorb bone tissue...
  11. pmc Bone structure and B-cell populations, crippled by obesity, are partially rescued by brief daily exposure to low-magnitude mechanical signals
    M Ete Chan
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794 5281, USA
    FASEB J 26:4855-63. 2012
    ....
  12. ncbi request reprint Gene expression patterns in bone after 4 days of hind-limb unloading in two inbred strains of mice
    Nan Zhong
    Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
    Aviat Space Environ Med 76:530-5. 2005
    ....
  13. pmc Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancer
    Gabriel M Pagnotti
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    Bone 51:570-7. 2012
    ..Further, these data reflect the numerous system-level benefits of exercise in general, and mechanical signals in particular, in the preservation of bone density and the suppression of cancer progression...
  14. ncbi request reprint Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeleton
    Liqin Xie
    Department of Biomedical Engineering, Psychology A, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Bone 39:1059-66. 2006
    ....
  15. pmc Mechanical signals as anabolic agents in bone
    Engin Ozcivici
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, NY 11794 2580, USA
    Nat Rev Rheumatol 6:50-9. 2010
    ..Mechanical targeting of the bone marrow stem-cell pool might, therefore, represent a novel, drug-free means of slowing the age-related decline of the musculoskeletal system...
  16. pmc Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulation
    Engin Ozcivici
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA
    PLoS ONE 5:e11178. 2010
    ..These data indicate that the osteogenic potential of bone marrow cells is retained by low-magnitude vibrations during disuse, an attribute which may have contributed to an enhanced recovery of bone morphology during reambulation...
  17. pmc Altered composition of bone as triggered by irradiation facilitates the rapid erosion of the matrix by both cellular and physicochemical processes
    Danielle E Green
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 8:e64952. 2013
    ....
  18. pmc The lipogenic gene spot 14 is activated in bone by disuse yet remains unaffected by a mechanical signal anabolic to the skeleton
    Jizu Zhi
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    Calcif Tissue Int 82:148-54. 2008
    ....
  19. pmc The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosis
    M Ete Chan
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA
    Curr Osteoporos Rep 11:36-44. 2013
    ..These cell, animal, and human studies may represent the foundation of a safe, non-drug means to protect and improve the musculoskeletal system of the elderly, injured, and infirmed...
  20. pmc Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesity
    Yen Kim Luu
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794 2580, USA
    J Bone Miner Res 24:50-61. 2009
    ....
  21. doi request reprint Regulation of mechanical signals in bone
    S Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    Orthod Craniofac Res 12:94-104. 2009
    ..Anabolic effects of high-frequency, low-magnitude vibrations, a mechanical intervention with a favorable safety profile, as well as the modulation of bone loss by genetic and epigenetic factors during disuse are highlighted...
  22. pmc High fat diet rapidly suppresses B lymphopoiesis by disrupting the supportive capacity of the bone marrow niche
    Benjamin J Adler
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, United States of America
    PLoS ONE 9:e90639. 2014
    ....
  23. ncbi request reprint Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissue
    Stefan Judex
    Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
    J Cell Biochem 94:982-94. 2005
    ..More detailed spatial and temporal correlations between altered mRNA levels and tissue plasticity may further delineate the molecules responsible for the control of bone mass and morphology...
  24. ncbi request reprint Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repair
    Michael Hadjiargyrou
    Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 277:30177-82. 2002
    ....
  25. ncbi request reprint Dynamic skeletal muscle stimulation and its potential in bone adaptation
    Y X Qin
    Orthopaedic Bioengineering Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 5281, USA
    J Musculoskelet Neuronal Interact 10:12-24. 2010
    ..A specific regimen of dynamic MS may be optimized in vivo to attenuate disuse osteopenia and serve as a biomechanical intervention in the clinical setting...
  26. ncbi request reprint Differentiation of the bone-tissue remodeling response to axial and torsional loading in the turkey ulna
    C Rubin
    Department of Orthopaedics, State University of New York at Stony Brook 11794 8181, USA
    J Bone Joint Surg Am 78:1523-33. 1996
    ..While it is clear that load influences bone mass and morphology, it is also clear that specific parameters within the strain environment have distinct strategic roles in defining this architecture...
  27. pmc Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults
    Jesse Muir
    Department of Biomedical Engineering, Stony Brook University, USA
    J Sci Med Sport 16:526-31. 2013
    ....
  28. pmc The mechanical consequences of load bearing in the equine third metacarpal across speed and gait: the nonuniform distributions of normal strain, shear strain, and strain energy density
    Clinton T Rubin
    Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 5281, USA
    FASEB J 27:1887-94. 2013
    ....
  29. ncbi request reprint Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantity
    Danielle E Green
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    J Bone Miner Res 27:749-59. 2012
    ..It is reasonable to presume that accelerating the recovery of these stem cell pools will enable the prompt repair of the skeletal system and ultimately reduce the susceptibility to fractures...
  30. pmc Automated separation of visceral and subcutaneous adiposity in in vivo microcomputed tomographies of mice
    Svetlana Lublinsky
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
    J Digit Imaging 22:222-31. 2009
    ....
  31. ncbi request reprint Ultrasonic wave propagation in trabecular bone predicted by the stratified model
    W Lin
    Department of Biomedical Engineering, State University of New York at Stony Brook, 11794-2580, USA
    Ann Biomed Eng 29:781-90. 2001
    ..These results agreed with the published experimental data and demonstrated that according to the stratified model, reflection and transmission were important factors in the ultrasonic propagation through the trabecular bone...
  32. pmc Dynamic parameters of balance which correlate to elderly persons with a history of falls
    Jesse W Muir
    Department of Biomedical Engineering, State University of New York, Stony Brook, New York, USA
    PLoS ONE 8:e70566. 2013
    ..334, compared to 0.645 for those with a fall history (p<0.001). A weighted amalgam of postural sway elements may identify individuals at greatest risk of falling, allowing interventions to target those with greatest need of attention. ..
  33. pmc Consequences of irradiation on bone and marrow phenotypes, and its relation to disruption of hematopoietic precursors
    Danielle E Green
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 5281, USA Electronic address
    Bone 63:87-94. 2014
    ..Therefore, the ability to maintain the bone marrow microenvironment would hinder much of the trabecular bone loss caused by radiation exposure, ultimately decreasing some comorbidities in patients exposed to radiation. ..
  34. ncbi request reprint Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesion
    Dirk W Sommerfeldt
    Department of Orthopaedics, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
    J Cell Biochem 84:301-8. 2002
    ..Based on these data, we hypothesize that prtb may function as an immediate early, serum-responsive, and adhesion-inducible gene with possible involvement in processes such as cell cycle control, adhesion, and proliferation...
  35. ncbi request reprint Establishing the compliance in elderly women for use of a low level mechanical stress device in a clinical osteoporosis study
    Marian T Hannan
    Research and Training Institute, Hebrew Rehabilitation Center for Aged and Harvard Medical School Division on Aging, Boston, Mass, USA
    Osteoporos Int 15:918-26. 2004
    ..Larger randomized controlled trials should evaluate the long-term efficacy of vibrating platform devices for treatment of low bone mass and osteoporosis in elderly individuals...

Research Grants11

  1. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton Rubin; Fiscal Year: 2009
    ..This research will provide the foundation to translate this work to the clinic as a safe, non-pharmacologic, intervention for the control of osteoporosis and obesity. ..
  2. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton Rubin; Fiscal Year: 2006
    ..abstract_text> ..
  3. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton Rubin; Fiscal Year: 2005
    ..abstract_text> ..
  4. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton Rubin; Fiscal Year: 2004
    ..abstract_text> ..
  5. INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATES
    Clinton Rubin; Fiscal Year: 2004
    ..Indeed, it is hoped that the most successful of these students will enter our own graduate training programs in the biomedical sciences. ..
  6. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton Rubin; Fiscal Year: 2000
    ..These experiments may yield new insights into the mechanisms by which mechanical factors control bone morphology, as well as lead to a novel treatment for osteoporosis. ..
  7. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton Rubin; Fiscal Year: 1999
    ..These experiments may yield new insights into the mechanisms by which mechanical factors control bone morphology, as well as lead to a novel treatment for osteoporosis. ..
  8. AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAIN
    Clinton T Rubin; Fiscal Year: 2010
    ..This research will provide the foundation to translate this work to the clinic as a safe, non-pharmacologic, intervention for the control of osteoporosis and obesity. ..