Research Topics
Species | Clinton T RubinSummaryAffiliation: State University of New York Country: USA Publications
Research Grants
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Detail Information
Publications
Transmissibility of 15-hertz to 35-hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosisClinton Rubin
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
Spine (Phila Pa 1976) 28:2621-7. 2003..Experiments were undertaken to determine the degree to which high-frequency (15-35 Hz) ground-based, whole-body vibration are transmitted to the proximal femur and lumbar vertebrae of the standing human...- Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safetyClinton Rubin
Department of Biomedical Engineering, State University of New York, Stony Brook, New York, USA
J Bone Miner Res 19:343-51. 2004..2g, 30 Hz) vibration applied during quiet standing can effectively inhibit bone loss in the spine and femur, with efficacy increasing significantly with greater compliance, particularly in those subjects with lower body mass... 
Adipogenesis is inhibited by brief, daily exposure to high-frequency, extremely low-magnitude mechanical signalsC T Rubin
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794, USA
Proc Natl Acad Sci U S A 104:17879-84. 2007..Translated to the human, this may represent the basis for the nonpharmacologic prevention of obesity and its sequelae, achieved through developmental, rather than metabolic, pathways...- Mechanical strain, induced noninvasively in the high-frequency domain, is anabolic to cancellous bone, but not cortical boneC Rubin
Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
Bone 30:445-52. 2002.... - Biology of bone and how it orchestrates the form and function of the skeletonD W Sommerfeldt
Center for Biotechnology, State University of New York, Stony Brook, USA
Eur Spine J 10:S86-95. 2001..Bone research remains interdisciplinary by nature, and a deeper understanding of bone biology will ultimately lead to advances in the treatment of diseases and injuries to bone itself... - The anabolic activity of bone tissue, suppressed by disuse, is normalized by brief exposure to extremely low-magnitude mechanical stimuliC Rubin
Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, New York 11794 2580 USA
FASEB J 15:2225-9. 2001..This work indicates that this noninvasive, extremely low-level stimulus may provide an effective biomechanical intervention for the bone loss that plagues long-term space flight, bed rest, or immobilization caused by paralysis... - Anabolism. Low mechanical signals strengthen long bonesC Rubin
Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794 2580, USA
Nature 412:603-4. 2001..As the strain levels generated by this treatment are three orders of magnitude below those that damage bone tissue, this anabolic, non-invasive stimulus may have potential for treating skeletal conditions such as osteoporosis... - Increased expression of matrix metalloproteinase-1 in osteocytes precedes bone resorption as stimulated by disuse: evidence for autoregulation of the cell's mechanical environment?C Rubin
Musculo Skeletal Research Laboratory, Program in Biomedical Engineering, Health Sciences Center, State University of New York, Stony Brook 11794 8181, USA
J Orthop Res 17:354-61. 1999..We believe that such autoregulation of the osteocyte's physical environment will accommodate subtle changes in the bone's functional environment without the need to add or resorb bone tissue... - Low-level mechanical signals and their potential as a non-pharmacological intervention for osteoporosisClinton Rubin
Department of Biomedical Engineering, State University of New York, Stony Brook, NY 11794 2580, USA
Age Ageing 35:ii32-ii36. 2006..Recent data indicate that extremely low-level mechanical signals are anabolic to bone, and thus may be used, non-invasively, as a form of 'passive' exercise to positively influence skeletal status... - Bone structure and B-cell populations, crippled by obesity, are partially rescued by brief daily exposure to low-magnitude mechanical signalsM Ete Chan
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794 5281, USA
FASEB J 26:4855-63. 2012.... - Low magnitude mechanical signals mitigate osteopenia without compromising longevity in an aged murine model of spontaneous granulosa cell ovarian cancerGabriel M Pagnotti
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
Bone 51:570-7. 2012..Further, these data reflect the numerous system-level benefits of exercise in general, and mechanical signals in particular, in the preservation of bone density and the suppression of cancer progression... - Low-level mechanical vibrations can influence bone resorption and bone formation in the growing skeletonLiqin Xie
Department of Biomedical Engineering, Psychology A, 3rd Floor, State University of New York at Stony Brook, Stony Brook, NY 11794-2580, USA
Bone 39:1059-66. 2006.... - Low-level vibrations retain bone marrow's osteogenic potential and augment recovery of trabecular bone during reambulationEngin Ozcivici
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA
PLoS ONE 5:e11178. 2010..These data indicate that the osteogenic potential of bone marrow cells is retained by low-magnitude vibrations during disuse, an attribute which may have contributed to an enhanced recovery of bone morphology during reambulation... 
Mechanical signals as anabolic agents in boneEngin Ozcivici
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, NY 11794 2580, USA
Nat Rev Rheumatol 6:50-9. 2010..Mechanical targeting of the bone marrow stem-cell pool might, therefore, represent a novel, drug-free means of slowing the age-related decline of the musculoskeletal system...- The lipogenic gene spot 14 is activated in bone by disuse yet remains unaffected by a mechanical signal anabolic to the skeletonJizu Zhi
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
Calcif Tissue Int 82:148-54. 2008.... - Mechanical stimulation of mesenchymal stem cell proliferation and differentiation promotes osteogenesis while preventing dietary-induced obesityYen Kim Luu
Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794 2580, USA
J Bone Miner Res 24:50-61. 2009.... - Regulation of mechanical signals in boneS Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
Orthod Craniofac Res 12:94-104. 2009..Anabolic effects of high-frequency, low-magnitude vibrations, a mechanical intervention with a favorable safety profile, as well as the modulation of bone loss by genetic and epigenetic factors during disuse are highlighted... - Mechanical modulation of molecular signals which regulate anabolic and catabolic activity in bone tissueStefan Judex
Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 2580, USA
J Cell Biochem 94:982-94. 2005..More detailed spatial and temporal correlations between altered mRNA levels and tissue plasticity may further delineate the molecules responsible for the control of bone mass and morphology... - Transcriptional profiling of bone regeneration. Insight into the molecular complexity of wound repairMichael Hadjiargyrou
Department of Biomedical Engineering, State University of New York, Stony Brook, New York 11794, USA
J Biol Chem 277:30177-82. 2002.... - Dynamic skeletal muscle stimulation and its potential in bone adaptationY X Qin
Orthopaedic Bioengineering Research Laboratory, Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 5281, USA
J Musculoskelet Neuronal Interact 10:12-24. 2010..A specific regimen of dynamic MS may be optimized in vivo to attenuate disuse osteopenia and serve as a biomechanical intervention in the clinical setting... - Differentiation of the bone-tissue remodeling response to axial and torsional loading in the turkey ulnaC Rubin
Department of Orthopaedics, State University of New York at Stony Brook 11794 8181, USA
J Bone Joint Surg Am 78:1523-33. 1996..While it is clear that load influences bone mass and morphology, it is also clear that specific parameters within the strain environment have distinct strategic roles in defining this architecture... - Devastation of adult stem cell pools by irradiation precedes collapse of trabecular bone quality and quantityDanielle E Green
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
J Bone Miner Res 27:749-59. 2012..It is reasonable to presume that accelerating the recovery of these stem cell pools will enable the prompt repair of the skeletal system and ultimately reduce the susceptibility to fractures... - Automated separation of visceral and subcutaneous adiposity in in vivo microcomputed tomographies of miceSvetlana Lublinsky
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 2580, USA
J Digit Imaging 22:222-31. 2009.... - Ultrasonic wave propagation in trabecular bone predicted by the stratified modelW Lin
Department of Biomedical Engineering, State University of New York at Stony Brook, 11794-2580, USA
Ann Biomed Eng 29:781-90. 2001..These results agreed with the published experimental data and demonstrated that according to the stratified model, reflection and transmission were important factors in the ultrasonic propagation through the trabecular bone... - The mechanical consequences of load bearing in the equine third metacarpal across speed and gait: the nonuniform distributions of normal strain, shear strain, and strain energy densityClinton T Rubin
1Musculo Skeletal Research Laboratory, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 5281, USA
FASEB J 27:1887-94. 2013..T., Seeherman, H., Qin, Y.-X., Gross, T. S., The mechanical consequences of load bearing in the equine third metacarpal across speed and gait: the nonuniform distributions of normal strain, shear strain, and strain energy density... - The potential benefits and inherent risks of vibration as a non-drug therapy for the prevention and treatment of osteoporosisM Ete Chan
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA
Curr Osteoporos Rep 11:36-44. 2013..These cell, animal, and human studies may represent the foundation of a safe, non-drug means to protect and improve the musculoskeletal system of the elderly, injured, and infirmed... - Proline-rich transcript of the brain (prtb) is a serum-responsive gene in osteoblasts and upregulated during adhesionDirk W Sommerfeldt
Department of Orthopaedics, State University of New York at Stony Brook, Stony Brook, New York 11794 2580, USA
J Cell Biochem 84:301-8. 2002..Based on these data, we hypothesize that prtb may function as an immediate early, serum-responsive, and adhesion-inducible gene with possible involvement in processes such as cell cycle control, adhesion, and proliferation... - Gene expression patterns in bone after 4 days of hind-limb unloading in two inbred strains of miceNan Zhong
SUNY Stony Brook, NY
Aviat Space Environ Med 76:530-5. 2005.... - Establishing the compliance in elderly women for use of a low level mechanical stress device in a clinical osteoporosis studyMarian T Hannan
Research and Training Institute, Hebrew Rehabilitation Center for Aged and Harvard Medical School Division on Aging, Boston, Mass, USA
Osteoporos Int 15:918-26. 2004..Larger randomized controlled trials should evaluate the long-term efficacy of vibrating platform devices for treatment of low bone mass and osteoporosis in elderly individuals...
Research Grants
- AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAINClinton Rubin; Fiscal Year: 2009..This research will provide the foundation to translate this work to the clinic as a safe, non-pharmacologic, intervention for the control of osteoporosis and obesity. ..
- AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAINClinton Rubin; Fiscal Year: 2006..abstract_text> ..
- INTERDISCIPLINARY RESEARCH PROGRAM FOR UNDERGRADUATESClinton Rubin; Fiscal Year: 2004..Indeed, it is hoped that the most successful of these students will enter our own graduate training programs in the biomedical sciences. ..
- AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAINClinton Rubin; Fiscal Year: 2000..These experiments may yield new insights into the mechanisms by which mechanical factors control bone morphology, as well as lead to a novel treatment for osteoporosis. ..
- AUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAINClinton T Rubin; Fiscal Year: 2010..This research will provide the foundation to translate this work to the clinic as a safe, non-pharmacologic, intervention for the control of osteoporosis and obesity. ..