EDWARD QUADROS

Summary

Affiliation: State University of New York
Country: USA

Publications

  1. ncbi request reprint The binding properties of the human receptor for the cellular uptake of vitamin B12
    Edward V Quadros
    Department of Biochemistry, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Biochem Biophys Res Commun 327:1006-10. 2005
  2. pmc A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome
    Vincent T Ramaekers
    Department of Paediatric Neurology, Centre Hospitalier Universitaire, Liege, Belgium
    Dev Med Child Neurol 50:346-52. 2008
  3. ncbi request reprint Transcobalamin deficiency due to activation of an intra exonic cryptic splice site
    Fares Namour
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, EMI INSERM 0014, Faculte de Medecine de Nancy, Cedex, France
    Br J Haematol 123:915-20. 2003
  4. ncbi request reprint Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect
    Sheldon P Rothenberg
    Department of Medicine, State University of New York Downstate Medical Center, Brooklyn 11203, USA
    N Engl J Med 350:134-42. 2004
  5. pmc Mapping the functional domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin-bound cobalamin
    Wenxia Jiang
    2Box 20, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    FASEB J 27:2988-94. 2013
  6. pmc The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system
    Shao Chiang Lai
    1Box 20, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    FASEB J 27:2468-75. 2013
  7. doi request reprint Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor
    Edward V Quadros
    Departments of Medicine Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Biochimie 95:1008-18. 2013
  8. pmc Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse
    Sílvia Fernàndez-Roig
    Departments of Medicine and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Nutr Metab (Lond) 9:41. 2012
  9. pmc Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12)
    Edward V Quadros
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Hum Mutat 31:924-9. 2010
  10. pmc Advances in the understanding of cobalamin assimilation and metabolism
    Edward V Quadros
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Br J Haematol 148:195-204. 2010

Research Grants

  1. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The binding properties of the human receptor for the cellular uptake of vitamin B12
    Edward V Quadros
    Department of Biochemistry, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Biochem Biophys Res Commun 327:1006-10. 2005
    ....
  2. pmc A milk-free diet downregulates folate receptor autoimmunity in cerebral folate deficiency syndrome
    Vincent T Ramaekers
    Department of Paediatric Neurology, Centre Hospitalier Universitaire, Liege, Belgium
    Dev Med Child Neurol 50:346-52. 2008
    ..39; range 0.24-1.44) to 3.04pmol (SD 1.42; range 0.84-6.01; p=0.001) over 10 to 24 months. Decreasing the autoantibody titer with a milk-free diet in conjunction with folinic acid therapy may be advocated for these patients...
  3. ncbi request reprint Transcobalamin deficiency due to activation of an intra exonic cryptic splice site
    Fares Namour
    Laboratoire de Pathologie Cellulaire et Moleculaire en Nutrition, EMI INSERM 0014, Faculte de Medecine de Nancy, Cedex, France
    Br J Haematol 123:915-20. 2003
    ..Until now, genetic studies have been reported in only five patients with TC deficiency and the molecular defect was different in each of them, which gives evidence for a genetic heterogeneity of the disease...
  4. ncbi request reprint Autoantibodies against folate receptors in women with a pregnancy complicated by a neural-tube defect
    Sheldon P Rothenberg
    Department of Medicine, State University of New York Downstate Medical Center, Brooklyn 11203, USA
    N Engl J Med 350:134-42. 2004
    ..Since antiserum to folate receptors induces embryo resorption and malformations in rats, we hypothesized that autoantibodies against folate receptors in women may be associated with pregnancy complicated by a neural-tube defect...
  5. pmc Mapping the functional domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin-bound cobalamin
    Wenxia Jiang
    2Box 20, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    FASEB J 27:2988-94. 2013
    ..Jiang, W., Nakayama, Y., Sequeira, J. M., Quadros, E. V. Mapping the functional domains of TCblR/CD320, the receptor for cellular uptake of transcobalamin-bound cobalamin. ..
  6. pmc The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system
    Shao Chiang Lai
    1Box 20, SUNY Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    FASEB J 27:2468-75. 2013
    ..Lai, S.-C., Nakayama, Y., Sequeira, J. M., Wlodarczyk, B. J., Cabrera, R. M., Finnell, R. H., Bottiglieri, T., Quadros, E. V. The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system...
  7. doi request reprint Cellular uptake of cobalamin: transcobalamin and the TCblR/CD320 receptor
    Edward V Quadros
    Departments of Medicine Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Biochimie 95:1008-18. 2013
    ..This review describes the process, proteins involved and genes encoding these proteins...
  8. pmc Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse
    Sílvia Fernàndez-Roig
    Departments of Medicine and Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Nutr Metab (Lond) 9:41. 2012
    ..abstract:..
  9. pmc Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12)
    Edward V Quadros
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Hum Mutat 31:924-9. 2010
    ..262_264GAG (p.E88del), resulting in the loss of a glutamic acid residue in the low-density lipoprotein receptor type A-like domain. Inserting the codon by site-directed mutagenesis fully restored TCblR function...
  10. pmc Advances in the understanding of cobalamin assimilation and metabolism
    Edward V Quadros
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Br J Haematol 148:195-204. 2010
    ....
  11. pmc The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin
    Edward V Quadros
    Departments of Medicine and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA
    Blood 113:186-92. 2009
    ..The human gene first identified as 8D6A and more recently as CD 320 encoding TCblR is located at p13.2 on the short arm of chromosome 19, spans a length of 6.224 kb, and is composed of 5 exons and 4 introns...
  12. pmc Targeted delivery of saporin toxin by monoclonal antibody to the transcobalamin receptor, TCblR/CD320
    Edward V Quadros
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York, USA
    Mol Cancer Ther 9:3033-40. 2010
    ..These results indicate that preferential targeting of some cancer cells could be accomplished through the TCblR...
  13. pmc Characterization of the promoter region of TCblR/CD320 gene, the receptor for cellular uptake of transcobalamin-bound cobalamin
    Wenxia Jiang
    School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Gene 466:49-55. 2010
    ..These transcription factors are involved in cell proliferation and differentiation. Thus the cell cycle associated expression of TCblR appears to be tightly regulated in synchrony with the proliferative phase of the cell cycle...
  14. ncbi request reprint Congenital transcobalamin II deficiency due to errors in RNA editing
    Lian Qian
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA
    Blood Cells Mol Dis 28:134-42; discussion 143-5. 2002
    ..These findings were confirmed by replicate analyses and support the proposal that a variance in RNA editing is the likely mechanism for the mutations that resulted in the expression of a nonfunctional TCII protein in these patients...
  15. ncbi request reprint Identification of a 4-base deletion in the gene in inherited intrinsic factor deficiency
    Fawwaz Yassin
    Department of Medicine and Biochemistry, State University of New York Downstate Medical Center, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Blood 103:1515-7. 2004
    ..This mutation also eliminates a site for Bst XI endonuclease and introduces a site for BsaBI for identifying this deletion in hereditary IF deficiency...
  16. ncbi request reprint Autoantibodies to folate receptors in the cerebral folate deficiency syndrome
    Vincent T Ramaekers
    Division of Pediatric Neurology, Department of Pediatrics, University Hospital Aachen, Aachen, Germany
    N Engl J Med 352:1985-91. 2005
    ..Cerebral folate deficiency is a disorder in which autoantibodies can prevent the transfer of folate from the plasma to the cerebrospinal fluid...
  17. pmc Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2)
    Jean Louis Gueant
    INSERM U 724, Cellular and Molecular Pathology in Nutrition, Faculte de Medecine, University Henry Poincaré of Nancy, Vandoeuvre les Nancy, France
    J Med Genet 44:363-7. 2007
    ..A 776C-->G variant (dbSNP ID: rs1801198) in the transcobalamin gene (TCN2; MIM# 275350) decreases the cellular and plasma concentration of transcobalamin and thereby influences the cellular availability of vitamin B(12)...
  18. ncbi request reprint Mapping the functional domains of human transcobalamin using monoclonal antibodies
    Sergey N Fedosov
    Protein Chemistry Laboratory, Department of Molecular Biology, University of Aarhus, Denmark
    FEBS J 272:3887-98. 2005
    ..We conclude that conformational changes in TC upon Cbl binding are accompanied by the convergence of multiple domains, and only the assembled conformation of the protein (i.e. holo-TC) has high affinity for the receptor...
  19. ncbi request reprint Direct assay for cobalamin bound to transcobalamin (holo-transcobalamin) in serum
    Marius Ulleland
    Axis Shield ASA, Ulvenveien 87, PO Box 206 Økern, N 0510 Oslo, Norway
    Clin Chem 48:526-32. 2002
    ..However, no reliable or accurate methods for quantifying holo-transcobalamin are available. We report a novel holo-transcobalamin assay based on solid-phase capture of transcobalamin...

Research Grants6

  1. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2010
    ..abstract_text> ..